Fɛɛrɛ laban min bɛ kɛ ka baara kɛ ni aw yɛrɛ ka selilɛriw ye walasa ka kansɛri kɛlɛ (CAR T-cell Therapy) .

Yala aw delila k’a miiri ko an farikolo bɛ se ka kansɛri kɛlɛ a yɛrɛ ma wa? Tiɲɛ na, an farikolo bɛ ni farikolo tangacogo hakilitigiba ye min bɛ wele ko farikolo tangalan. A yɔrɔ kɛrɛnkɛrɛnnen dɔ b’a la min bɛ wele ko T-cells, olu bɛ i n’a fɔ sɔrɔdasiw. U ka baara ye ka dunanw ka tumuw ni farikolokisɛw fɛnɲɛnamafagalanw sɔrɔ ani k’u tiɲɛ, minnu bɛ don farikolo la. Nka tuma dɔw la, kansɛribanakisɛw bɛ namara kɛ kosɛbɛ. U bɛ dogo o T-cell ninnu na, k’u lafili ani ka bonya farikolo kɔnɔ. O waati suguw la, an bɛna kuma furakɛli kura kabakoma dɔ kan, min bɛ an yɛrɛ ka T-cellw dɛmɛ ka kansɛribanakisɛw dɔn ani k’u tiɲɛ, n’a ye “dege kɛrɛnkɛrɛnnen” di u ma.

N’an y’a fɔ cogo nɔgɔman na, CAR T-cell furakɛli ye mun ye?

Hali n’a tɔgɔ bɛ se ka kɛ ko a ka gɛlɛn, o hakilina ka nɔgɔn kosɛbɛ. CAR T-cell furakɛli ye farikolo tangacogo suguya dɔ ye. O ye ka i yɛrɛ ka T-cell dɔw ta ka u jamu caman sɛmɛntiya laboratuwari kɔnɔ.

Aw ka miiri aw ka T-cell la i n’a fɔ polisiw. Kansɛribanakisɛw bɛ i n’a fɔ sonw minnu bɛ u yɛrɛ dogo. A ka c’a la, polisiw tɛ se ka o sonw dɔn. CAR T-cell furakɛli bɛ i n’a fɔ ka lunɛti kɛrɛnkɛrɛnnen di i ka polisiw (T cells) ma. O filɛlikɛlan in bɛ wele ko ‘Chimeric Antigen Receptor’ (CAR) . A bɛ dilan laboratuwari kɔnɔ ka nɔrɔ T-cellw la.

Sisan, ni o filɛlikɛlan kɛrɛnkɛrɛnnen in donna, T-cellw bɛ se ka farikolojɔlifɛn kɛrɛnkɛrɛnnenw (antigènes) dɔn tigitigi kansɛribanakisɛw sanfɛ. Kansɛribanakisɛ minnu tun dogolen don fɔlɔ, olu bɛ ye ka jɛya sisan. T-cell minnu ye o fanga belebelew sɔrɔ, olu bɛ sɔrɔ ka taa ɲɛfɛ ka bin kansɛribanakisɛw kan k’u tiɲɛ. Nin furakɛli in ye dɛmɛba ye joli kansɛri suguya dɔw kɛnɛyali la pewu ani ka mɔgɔ wɛrɛw dɛmɛ u ka mɛn kansɛri fɛ.

Nin furakɛli in bɛ joli kansɛri suguya jumɛnw furakɛ?

Sisan, CAR T-cell furakɛli bɛ kɛ joli kansɛri suguya dɔw dɔrɔn de la minnu ma furakɛli wɛrɛw jaabi (i n’a fɔ chimiothérapie) walima minnu seginna ka na furakɛli kɔfɛ. Ikomi hali bi a ye fura kura ye kosɛbɛ, a tɛ di kansɛri bɛɛ ma.

Tablo min bɛ duguma, o b’a jira kansɛri suguya minnu furakɛli in dabɔra sisan.

Nin furakɛli kɛcogo in bɛ kɛ cogo di?

O wale bɛɛ bɛ Kɛ cogo damadɔ la. A bɛ iko sɔrɔdasiw dege kɛlɛ kama, ka tila k’u bila ka segin kɛlɛyɔrɔ la.

Taabolo fɔlɔ : Aw bɛ aw ka T-cellw lajɛ

Fɔlɔ, aw farikolo ka kan ka joli kuru finmanw lajɛ, kɛrɛnkɛrɛnnenya la T selilɛriw. o bɛ kɛ ni fɛɛrɛ ye min bɛ wele ko leukapheresis . O ye ka i joli ci masin dɔ fɛ, o min bɛ joli kuru finmanw dɔrɔn bɔ ɲɔgɔn na, ka joli tɔ segin i fari la. O bɛ i n’a fɔ joli dili, nka joli yɔrɔ dɔ dɔrɔn de bɛ ta ka tɔ segin.

2. Taabolo : Aw bɛ T-cellw ci laboratuwari la ka u sɛmɛntiya

O kɔfɛ, T-cell minnu bɔra i la, olu bɛ ci laboratuwari kɛrɛnkɛrɛnnen dɔ la. O yɔrɔ la, dɔnnikɛlaw bɛ baara kɛ ni jamu ye walasa ka an kumana CAR (Chimeric Antigen Receptor) min kan ka tɛmɛ, o don T-cell kɔnɔ. O kɔfɛ, nin CAR T selilɛri kura minnu fanga ka bon kosɛbɛ, olu bɛ falen laboratuwari kɔnɔ fo ka se u miliyɔn caman sɔrɔli ma. O kɛcogo bɛ dɔgɔkun saba fo dɔgɔkun wɔɔrɔ ta.A bɛ se ka waati dɔ ta.

3. Taabolo: Ka i farikolo labɛn

Fo ka se CAR T-cellw ma laboratuwari kɔnɔ, aw ka dɔgɔtɔrɔ bɛ se ka furakɛli wɛrɛw kɛ aw ye (bridging therapy), i n’a fɔ chimiothérapie, walasa ka aw ka kansɛri kunbɛn.

O kɔfɛ, tile damadɔ sanni CAR T-cell kura dabɔlenw ka di aw ma, aw bɛna chimiothérapie hakɛ dɔgɔman di aw ma. A bɛ fɔ a ma ko chimiothérapie lymphodepleting . O bɛ baara kɛ ni i farikolo farikolo tangalan minnu bɛ yen, olu dɔgɔyali ye, ka sigida ɲuman dilan walasa CAR T-cell kura minnu ka bon kosɛbɛ, olu ka baara kɛ.

4. Taabolo : Ka super T cellules segin farikolo la

O de ye koba ye. I n’a fɔ aw bɛ kɔgɔjilaji di cogo min na, CAR T-cell kura dabɔlenw bɛ pikiri kɛ aw fari la jolisira fɛ (jolisira fɛ - IV). O bɛ kɛ miniti 5 ni miniti 30 cɛ. Ni o farikolokisɛw donna farikolo la dɔrɔn, u bɛ daminɛ ka caya u yɛrɛ ma, ka kansɛribanakisɛw ɲini ka u tiɲɛ. Ikomi o farikolokisɛw bɛ to farikolo la ka mɛn ani ka kansɛri kɛlɛ, dɔw b’o furakɛli wele ko “fura ɲɛnama”.

Mun bɛ kɛ furakɛli kɔfɛ? Farati jumɛnw bɛ o la?

Ikomi nin ye furakɛli barikamaba ye, tuma dɔw la, kɔlɔlɔ jugumanw bɛ se ka sɔrɔ. O la, aw bɛna to dɔgɔtɔrɔso la dɔgɔkun kelen fo tile tan ɲɔgɔn furakɛli kɔfɛ. Dɔgɔtɔrɔw ni dɔgɔtɔrɔso baarakɛlaw bɛna aw kɔlɔsi kosɛbɛ.

Kɔnɔnafiliba minnu bɛ sɔrɔ a la

Nin furakɛli in kɔlɔlɔba fila de bɛ yen ani minnu ka teli ka kɛ. Hali ni o kow bɛ se ka kɛ farati ye, dɔgɔtɔrɔso jɛkuluw labɛnna ka ɲɛ walasa k’u furakɛ.

O furakɛli bɛ ɲɛ sɔrɔ cogo di?

CAR T-cell furakɛli ye jigiya kura lase mɔgɔ caman ma minnu bɛ joli kansɛri kɛlɛ, kɛrɛnkɛrɛnnenya la minnu ma furakɛli wɛrɛw jaabi.

• Misali la, denmisɛn minnu ye nin furakɛli in kɛ denmisɛnniw ka jolidɛsɛ jugumanba (ALL) la, olu ka ca ni 85% ye, u ka kansɛri yafara pewu furakɛli kɔfɛ. Wa, u 60% tun tɛ kansɛri sɔrɔ hali bi san kelen furakɛli kɔfɛ.

O fɛɛrɛ in bɛ ka wuli hali bi. Diɲɛ fan bɛɛ la, ɲininikɛlaw b’a ɲini tuma bɛɛ ka furakɛli in ɲɛ ka taa a fɛ, ka dɔ bɔ a kɔlɔlɔw la, ani k’a lajɛ ni a bɛ se ka kɛ kansɛri suguya wɛrɛw la.

Aw ka kan ka taa dɔgɔtɔrɔso la tuma jumɛn?

Nin furakɛli in kɔlɔlɔw, kɛrɛnkɛrɛnnenya la, sitokiniw bɔli ni hakili gɛlɛyaw, olu bɛ se ka mɔgɔ ka ɲɛnamaya bila farati la . O la sani aw ka bɔ dɔgɔtɔrɔso la, aw ka dɔgɔtɔrɔ ɲininka aw ka kan ka aw janto a taamasiɲɛ minnu na kɛrɛnkɛrɛnnenya la.

Ni bana taamasiɲɛw i n’a fɔ farigan, farigan, kungolodimi, ani kɔnɔboli tora senna, o bɛ se ka kɛ bana jugu dɔ taamasiɲɛ ye. Ni o don, aw bɛ dɔgɔtɔrɔ wele joona walima aw bɛ taa dɔgɔtɔrɔso ka kɔrɔtɔko ɲɛmɔgɔso la (ETU).

Ni joli kansɛri bɛ aw walima aw dɔnbaga dɔ la, aw bɛ kuma aw ka dɔgɔtɔrɔ fɛ walasa ka a dɔn ni CAR T-cell furakɛli bɛnnen don aw ma. Hali ni nin furakɛli in tɛ bɛɛ ta ye, a bɛ se ka kɛ fɛn ye min bɛ mɔgɔ bɛnnen ka ɲɛnamaya Changer.