Yala an bɛna kunnafoni sɔrɔ gundola-cogo (opsonization) kan min bɛ farikolo juguw minɛ wa?

Yala i delila ka miiri kɛlɛ hakɛ min bɛ sen na an farikolo kɔnɔ tuma bɛɛ wa? Banakisɛ minnu bɛ bɔ kɛnɛma, banakisɛw i n’a fɔ banakisɛw, kansɛribana minnu bɛ yiriwa farikolo kɔnɔ, walima an yɛrɛ ka farikolokisɛw minnu bɛ kɔrɔya ka sa... An bɛɛ bɛ ni lafasalitɔnba ye walasa k’an farikolo tanga ninnu bɛɛ ma. An b’o wele ko farikolo tangacogo. A bɛ iko kɛlɛbolo min bɛ an ka jamana lakana. Nka, nin kɛlɛbolo in b’a dɔn cogo di ko jɔn ye jugu ye ani jɔn ye teri ye? Bi an bɛna kuma taabolo dɔ kan min ka di kosɛbɛ, a ka gɛlɛn dɔɔnin, nka a nafa ka bon kosɛbɛ, min bɛ dɛmɛ don o la.

Opsonization ye mun ye? An k’a faamu cogo nɔgɔman na.

Nin daɲɛ in bɛ se ka fɔ ko a ka gɛlɛn dɔɔnin, nka a hakilina ka nɔgɔn kosɛbɛ. Opsonization, n’an y’a fɔ cogo nɔgɔman na, o ye fɛɛrɛ ye min fɛ an farikolo tangalanw bɛ "marke" ani ka fɛnw minɛ minnu bɛ kojugu kɛ an na, i n’a fɔ banakisɛw walima farikolokisɛ tiɲɛnenw.

Miiri k’a filɛ nin ye. Son dɔ bolila ka dogo i ka so kɔnɔ. Polisiw bɛ na a ɲini, nka a sɔrɔli ka gɛlɛn. Nka, ni mɔgɔ dɔ nana ka stika manamananan dɔ nɔrɔ son ka fini na do? O tuma na fɛ, polisiw bɛ se ka son in dɔn nɔgɔya la ani k’a minɛ hali dibi la. O de bɛ Kɛ ni nin wale in ye min bɛ Weele ko opsonization (opsonization). Protéine suguya kɛrɛnkɛrɛnnen dɔ bɛ nɔrɔ banakisɛw ni farikolokisɛw la minnu man ɲi, an farikolo lafasalitɔnw tɛ se ka minnu dɔn nɔgɔya la. I n’a fɔ o stika manamananan dɔrɔn. O kɔ fɛ an ka lafasalitɔnw bɛ Nà nin fɛn "marked" ninnu Ye, k'u Minɛ k'u Tiɲɛ.

O daɲɛ bɔra Gɛrɛkikan daɲɛ na min kɔrɔ ye ko “ka dumuni duman kɛ.” I n’a fɔ an bɛ dumuni kɛ ka diya ani k’a fɛ k’a dun cogo min na, o kɛcogo in bɛ an ka farikolo tangalanw taamasiyɛn cogo la min b’a to u b’a fɛ ka tumuw "dun".

O la, nin "marker" ninnu ye jɔnw ye minnu bɛ wele ko Opsonins?

Aw hakili bɛ o "stickers shiny" minnu na an ye kuma minnu kan ka tɛmɛ wa? O stika ninnu ye an bɛ min wele ko opsonins furakɛli la. Olu ye farikolojɔlan kɛrɛnkɛrɛnnenw ye minnu bɛ panpan hɔrɔnya la an joli ni an ka farikolojidɛsɛ la. Ni farikolo tangalanw bɛ baara kɛ, u bɛ baara kɛ ani ka nɔrɔ o banakisɛw walima o farikolokisɛw la minnu man ɲi.

O opsonin ninnu bɛ Weele fana ko "bridge molecules" barisa u bɛ dancɛ Kɛ tumu ni farikolo tangalan cɛ min bɛ Nà a Tiɲɛ. O bɔrɔ in b’a to farikolo tangalan bɛ se ka banakisɛ minɛ nɔgɔya la ani k’a minɛ.

Daɲɛba min ye Fagocytosis ye, o kɔrɔ ye mun ye?

Fagositɔsi ye daɲɛ ye min bɛ fɔ ka "fɛn dɔ munumunu ni a tiɲɛni ɲɛfɔ farikolokisɛw fɛ." N'an y'a Fɔ cogo nɔgɔman na, o ye "cellular engulfment" ye. An farikolo lafasalitɔn dɔw, i n’a fɔ nɔgɔbɔlanw, olu bɛ fɛnw minɛ, ka u dun, ka u sɔgɔ, ka u tiɲɛ. An bɛ o seliw Weele ko "munumunu" seliwA bɛ wele ko fagocytes (fagositɛriw).

O fagositɛriw bɛ mun dun?

• Tumu : Binkanni fɛn o fɛn bɛ bɔ kɛnɛma, i n’a fɔ banakisɛw, banakisɛw, ɲɛgɛnw.
• Banakisɛfagalanw: An yɛrɛ ka farikolokisɛw minnu tiɲɛna tumu dɔ fɛ.
• Kɔnɔnatumu salenw walima minnu kɔrɔla: Kɔnɔnatumu minnu sera u si laban na, wa nafa tɛ u la tuguni.
• Kansɛribanakisɛw: Kɔnɔnatumu minnu bɛ bonya cogo la min tɛ bɛn ani ka farikolo tiɲɛ.
• Kɔnɔnatumuw: Yɔrɔ misɛnnin minnu bɛ to ni seliluw sara.

Ko caman bɛ yen "taamaʃyɛn" min bɛ Weele ko opsonization (opsonization) nafa ka bon walasa nin dumunikɛcogo in ka Kɛ ka ɲɛ.

O fagositɛriw bɛ baara kɛ cogo di?

O fagositɛriw bɛ i n’a fɔ robo fitininw. U ka taamasiɲɛw tɛ kelen ye an farikolo la minnu b’a fɔ u ye u b’a fɛ ka min munumunu ani u man kan ka min munumunu. An ka nin taamaʃyɛn sugu ninnu Faamu dɔrɔn tabali kɔnɔ i n’a fɔ nin.

Opsonin suguya jumɛnw bɛ yen?

An farikolo bɛ baara kɛ ni opsonin suguya wɛrɛw ye walasa ka jugu suguya wɛrɛw dɔn. Misaliba dɔw filɛ nin ye:

• Banakisɛfagalanw: Olu ye an ka farikolo tangalanw ka sɔrɔdasi kɛrɛnkɛrɛnnenw ye. Ni tumu (antigène) min tun dɔnna ka kɔrɔ, o bɔra kokura, u bɛ nɔrɔ banakisɛ in na, i n’a fɔ kilisi bɛ don dakun na cogo min na. Ni a sirilen don, banakisɛfagalan fana bɛ kɛ i n’a fɔ opsonin. Kɛrɛnkɛrɛnnenya la, immunoglobuline G (IgG) ni Immunoglobuline M (IgM) banakisɛfagalanw bɛ o baara kɛ ka ɲɛ.
• Fɛn minnu bɛ ɲɔgɔn dafa: Nin ye farikolojɔli dumuniw dalajɛlen ye minnu bɛ an farikolo tangalanw dɛmɛ ka baara kɛ ɲɔgɔn fɛ. Ni o sigida in kɛra baara ye, a bɛ farikolojɔlifɛn minnu dilan (misali la, C3b ani C4b ) olu dɔw bɛ taa ka nɔrɔ banakisɛw sanfɛ. Olu bɛ Kɛ i n’a fɔ opsonin barikamaba.
• Fosfatidilisɛrini sirili opsoninw : Nin tɔgɔ in ka gɛlɛn dɔɔni. N’an y’a fɔ cogo nɔgɔman na, a bɛ nin cogo in na. Ni selilu dɔ bɛ ɲini ka sa (apoptose), mɔlikulu dɔ bɛ bɔ a ka selilɛri kɔnɔ. Nin ye "dumuni-n" taamaʃyɛn ye an ye min Fɔ ka Tɛmɛ. Nin ye opsonin suguya kɛrɛnkɛrɛnnen ye min bɛ siri o taamasiɲɛ na.
• Opsonin wɛrɛw : Ka fara ninnu kan, farikolojɔlifɛn damadɔ wɛrɛw bɛ yen minnu bɛ baara kɛ i n’a fɔ opsonin. Misali la, fibronectin ni mannose sirili lectin.

Mun na opsonization nafa ka bon?

O wale in nafa ka bon kosɛbɛ an ka ɲɛnamaya la. Kunba fila de b’o la.

1. Tumu namaratɔw minɛ: Banakisɛ dɔw bɛ datugulan belebeleba dɔ kɛ u lamini na min bɛ i n’a fɔ furakisɛ. O b’a to u minɛni ka gɛlɛn an ka fagositɛriw ma k’u munumunu. U bɛ sɛgɛn ka bɔ i n’a fɔ safunɛ. Nka ni opsoninw (kɛrɛnkɛrɛnnenya la C3b ni farikolo tangalanw) nana ka nɔrɔ nin furakisɛ in sanfɛ, fagositɛriw bɛ "bololanɛgɛ" sɔrɔ u bɛ se ka min minɛ. O kɔfɛ, u bɛ munumunu nɔgɔya la ka tiɲɛ.

2. Aw ye aw farikolo saniya: Kɔnɔnatumu miliyari caman bɛ sa ani fɛn kuraw bɛ sɔrɔ an fari la don o don. Ni o farikolokisɛ salenw tora ten, u bɛ se ka toli ka kɛ baga ye farikolo la, ka bana suguya caman lase mɔgɔ ma. K’a sababu kɛ opsonization (opsonization) kɛcogo ye, o farikolokisɛ minnu bɛ sa, olu bɛ "marked" kɛ, wa fagocytic cellules bɛ na u bɔ joona. O la, o ye dɛmɛba ye walasa an farikolo ka kɛnɛya ani ka saniya.

Mun bɛ kɛ ni fɛn dɔ ma ɲɛ o kɛcogo la?

I n’a fɔ a bɛ kɛ cogo min na ni sistɛmu bɛɛ ye, o opsonization kɛcogo in bɛ se ka kɛ cogo jugu la. Bana minnu bɛ sɔrɔ jamu fɛ, fura dɔw nɔfɛkow, walima kun wɛrɛw bɛ se ka nin sigida in baarakɛcogo tiɲɛ. O kɔ, gɛlɛya suguba fila bɛ se ka sɔrɔ.

• Sebaliya ka fɛn juguw tiɲɛ: Ni opsoninw ma dilan ka ɲɛ, walima ni fagositɛriw tɛ se k’u dɔn, tumuw, farikolokisɛ tiɲɛnenw ani kansɛribanakisɛw bɛ daminɛ ka dalajɛ farikolo la. O bɛ se ka kɛ sababu ye ka banakisɛw sɔrɔ tuma caman, minnu ka jugu ani ka kansɛri sɔrɔli farati bonya .

• Fɛn minnu man kan ka tiɲɛ, olu tiɲɛni: Tuma dɔw la, fili dɔ kosɔn nin sigida in na, opsoninw bɛ daminɛ ka nɔrɔ an yɛrɛ ka farikolokisɛ kɛnɛmanw sanfɛ. O kɔfɛ, fagositɛriw bɛ na o farikolokisɛ kɛnɛmanw tiɲɛ, k’a miiri k’u ye “juguw” ye. an bɛ nin bana in wele ko farikolo tangalanw ( autoimmune disorders ) . Misali la, bana minnu bɛ i n’a fɔ lupus . Sɛgɛsɛgɛliw y’a jira ko fili minnu bɛ kɛ o kɛcogo la, olu fana bɛ se ka kɛ sababu ye ka hakilibanaw sɔrɔ i n’a fɔ Alzheimer .

Ni siga bɛ aw la nin bana suguya in na, a ka fisa aw ka taa dɔgɔtɔrɔso la sisan ani ka laadilikan ɲini.

Yala opsonization bɛ se ka banaw furakɛ wa?

Nin ye furakɛli yɔrɔ ye min ka di kosɛbɛ sisan. Dɔnniyakɛlaw bɛ ka ɲinini kɛ ni nin opsonization kɛcogo in bɛ se ka kunbɛn ani ka banaw furakɛ.

• Kansɛri ta fan fɛ: Kansɛribanakisɛw ye farikolokisɛ suguya ye min hakili ka di kosɛbɛ, a bɛ se ka a yɛrɛ tanga farikolo tangalanw ma. An bɛ ka sɛgɛsɛgɛli kɛ n’an bɛ se ka opsonin dilannenw dilan minnu bɛ nɔrɔ kansɛribanakisɛw sanfɛ dɔrɔn ani ka farikolo tangalanw dɛmɛ k’u tiɲɛ.
• Banakisɛw kama: Sɛgɛsɛgɛli bɛ senna walasa ka fɛɛrɛw tigɛ walasa ka banakisɛw "laɲini" ani ka u faga, kɛrɛnkɛrɛnnenya la minnu bɛ se ka banakisɛfagalanw kɛlɛ.
• Banakisɛ minnu bɛ sɔrɔ farikolo tangalanw fɛ: A ɲinina ka furaw dilan minnu bɛ farikolokisɛ kɛnɛmanw ka opsonization bali.

Ani fana, opsonophagocytic killing assays (OPKA) ye sɛgɛsɛgɛliw ye minnu bɛ kɛ ka boloci nafa jateminɛ. U bɛ banakisɛfagalan minnu bɛ bɔ boloci fɛ, olu seko suman ka banakisɛ dɔ "tag" ani ka kɛ sababu ye ka a tiɲɛ fagositɛriw fɛ.

O la, opsonization ye wale barikamaba ye min bɛ kɛ makun na, a tɛ ye, an farikolo kɔnɔ, nka a bɛ an ka ɲɛnamaya lakana. A bɛ i n’a fɔ kunnafonidilaw ka ɲɛmɔgɔso min bɛ laɲini ɲumanw jira an ka lafasalitɔnw na.