Nukae nye wò LDH ƒe agbɔsɔsɔ? (LDH - Lactate Dehydrogenase Test) Mina míanya nu tso esia ŋu bɔbɔe!

Egbea míele nu ƒom tso dodokpɔ aɖe si ate ŋu agblɔ nyatakaka vevi geɖe na mí tso míaƒe ŋutilã ƒe lãmesẽ ŋu. Ðewohĩ èse `LDH` dodokpɔa ŋu nya kpɔ. Ðewohĩ ɖɔkta aɖe bia tso asiwò gɔ̃ hã be nàwɔ dodokpɔ sia. Eyata, mina míakpɔ nusi `LDH` sia nye kple nusi nàteŋu asrɔ̃ tso dodokpɔ sia me bɔbɔe ŋutɔ.

Nukae nye lactate dehydrogenase (LDH)?

Eyata, gbã la, mina míakpɔ nusi `Lactate Dehydrogenase` nye ɖa. Míeyɔa esia hã be `(LDH)` kpuie. Kpuie ko la, esia nye enzyme vevi aɖe ŋutɔ le míaƒe ŋutilã me. Enzyme nye protein ƒomevi aɖe si naa atikewo ƒe dɔwɔwɔ kabakaba eye wòkpena ɖe mía ŋu le míaƒe ŋutilã me. Bu eŋu abe kpeɖeŋutɔ sue siwo nana míaƒe ŋutilã wɔa dɔ bɔbɔe ene.

`LDH` enzyme sia kpena ɖe míaƒe lãmenugbagbeviwo ƒe gbɔgbɔ ŋu koŋ . Eyae nye be, `LDH` sia kpena ɖe ame ŋu le ɖoɖo vevi ŋutɔ si nye sukli (ne míagblɔe kpuie la, sukli) xɔxɔ le nuɖuɖu si míeɖuna me eye wòwɔa ŋusẽ si míaƒe ŋutilã ƒe lãmenugbagbeviwo hiã. Esia le abe kpekpeɖeŋu nana be míawɔ ami na lãmenugbagbevi siwo wɔa dɔ abe elektrikdɔwɔƒe suewo ene le míaƒe ŋutilã me ene.

Ènya be enzyme sia si nye `LDH` le míaƒe ŋutilã ƒe lãkusi ɖesiaɖe kloe mea? Gake ebɔ ɖe lãmekawo, aklã, ayiku, kple ʋumenugbagbevi dzĩwo me wu . Ne lãmenugbagbevi yeyewo va le míaƒe ŋutilã me la, woɖea lãmenugbagbevi xoxowo alo "ku"wo ɖa. Esia sɔ. Ne woɖe lãmenugbagbevi xoxowo ɖa la, wotsɔa `LDH` aɖewo tso lãkusi mawo me dea míaƒe ʋu alo ŋutilã me tsi bubuwo me. Eyata esɔ be `LDH` aɖewo nanɔ ʋu alo ŋutilã me tsi bubu me.

Eyata nukae nye LDH (lactate dehydrogenase) dodokpɔ sia?

Enyo, fifia la, susu vi aɖe va su asiwò le nusi `LDH` nye ŋu. `LDH` dodokpɔ dzidzea `LDH` ƒe agbɔsɔsɔ le wò ʋu alo ŋutilã me tsi bubuwo me. Eléa ŋku ɖe wò ŋutilã ƒe lãkusiwo ŋu koŋ be nu gblẽ le wo ŋu hã .

Abe alesi míedzro eme va yi ene la, esɔ be `LDH` ƒe agbɔsɔsɔ aɖe nanɔ wò ʋu me. Gake ne lãkusi aɖe si le wò ŋutilã me gblẽ alo xɔ abi , `LDH` si sɔ gbɔ tso lãkusi ma si gblẽ me la ado ɖe wò ʋu alo ŋutilã me tsi bubuwo me. Eyata, ne wò `LDH` ƒe agbɔsɔsɔ sɔ gbɔ wu alesi wòle dzɔdzɔmee la, ate ŋu afia be dɔléle si nɔa anyi didi , dɔléle sesẽ aɖe , alo abi aɖe gblẽ nu le wò ŋutilã ƒe lãkusi aɖewo ŋu.

Gake nu ɖeka si dzi wòle be míaɖo ŋkui enye be esesẽ be woanya lãkusi si tututu `LDH` dodokpɔ ɖeɖe dzaa gblẽ . Elabena `LDH` le teƒe geɖe le míaƒe ŋutilã me. Eyata zi geɖe la, ɖɔktawo ɖea gbe be woawɔ dodokpɔ bubu geɖewo kpe ɖe `LDH` dodokpɔa ŋu be woatsɔ anya dɔlélea nyuie.

Wotsɔ ŋkɔ bubu geɖewo hã yɔa `LDH` dodokpɔ sia:

• `LD` dodokpɔ
• Lactic dehydrogenase ƒe dɔlékuiwutike
• Lactic acid si nye dehydrogenase si woyɔna be dehydrogenase

Ɣekaɣie wòhiã be woado LDH kpɔ?

Ðɔktawo zãa LDH dodokpɔa tsɔ dea dzesi lãmesẽkuxi vovovowo heléa ŋku ɖe wo ŋu. Susu vevi siwo ta wowɔa dodokpɔ siae nye:

• Kpɔe ɖa be wò ŋutilã ƒe lãkusiwo gblẽ hã .
• Lé ŋku ɖe dɔlélewo abe ʋusɔgbɔdɔ , ŋutinuwo ƒe dɔlélewo (e.g. aklã, ayiku), kple nɔnɔme siwo gblẽa nu le lãmenugbagbeviwo ŋu, abe dɔlékui aɖewo ene ŋu .
• Da kansa ƒomevi aɖewo ƒe sesẽme kpɔ .
• Kpɔe ɖa be kansa aɖewo dada (e.g. atikewɔmɔnu) kpɔa dzidzedze alo womekpɔa dzidzedze o hã.

Esi wònye be wowɔa `LDH` dodokpɔa le nɔnɔme vovovo geɖewo me ta la, ne wobia tso asiwò be nàwɔ dodokpɔ sia la, anyo be nàbia wò ɖɔkta nusita wole wò dom kpɔ hã.

Amekae wɔa LDH dodokpɔ sia?

Zi geɖe la, ʋumenugbagbeviɣidɔdala si wona hehee be wòaɖe ʋue wɔa ʋudodokpɔ hena LDH . Gake lãmesẽdɔwɔla ɖesiaɖe si wona hehee be wòaɖe ʋu ate ŋu awɔ esia. Emegbe woɖoa ʋua ɖe nudokpɔƒe. Afimae atikewɔƒe ƒe dzɔdzɔmeŋutinunyala aɖe léa ŋku ɖe kpɔɖeŋua ŋu eye wòzãa mɔ̃ tɔxɛwo (analyzers) tsɔ dzidzea LDH ƒe agbɔsɔsɔ.

Ɣeaɖewoɣi la, ehiãna be ɖɔktawo nadzidze LDH ƒe agbɔsɔsɔ le ŋutilã me tsi bubuwo me, ke menye ʋu ɖeɖeko me o. Le kpɔɖeŋu me, wò ahɔhɔ̃mekawo me tsi (CSF), dɔgbo me tsi , alo dɔgbo me tsi . Le nɔnɔme siawo me la, ɖɔkta si xɔ hehe tɔxɛ aɖe axɔ eƒe kpɔɖeŋu.

Aleke wòle be madzra ɖo ɖe LDH dodokpɔ ŋu?

Zi geɖe la, mehiã be nàdzra nu tɔxɛ aɖeke ɖo ɖe LDH ʋudodokpɔ ŋu o.

Gake ne woɖe tsi bubu aɖe tso ŋutilã me tsi bubu me abe alesi míegblɔe va yi ene la, ate ŋu ahiã be woawɔ dzadzraɖo aɖewo. Wò ɖɔkta aɖe nya sia me na wò ɣemaɣi.

Nukae dzɔna le LDH dodokpɔ me?

Ne èdo ʋu la, esiae dzɔna zi geɖe:

• Ànɔ zikpui dzi. Ekema lãmesẽdɔwɔla adi ʋuka aɖe le wò alɔnu si me woate ŋu aɖe ʋu le bɔbɔe. Zi geɖe la, woɖea ʋua tso wò abɔta ƒe eme.
• Ne wonya ke ɖe ʋuka aɖe ŋu ko la, wokɔa teƒea ŋu nyuie eye wotsɔa dɔlékuiwutike dea eme.
• Emegbe, wotsɔa aŋe sue aɖe dea ʋukaa me eye woɖea ʋu sue aɖe. Le ɣeyiɣi sia me la, àte ŋu ase le ɖokuiwò me be yeƒe lãme gbã vie, abe anyidi ƒe ɖuɖu ene .
• Ne wotsɔ aŋea de eme vɔ la, woƒoa ʋu sue aɖe nu ƒu ɖe dodokpɔmɔ̃ me.
• Ne woɖe ʋua vɔ la, woɖea aŋea ɖa eye wotsɔa kotoklobo alo gaze kakɛ aɖe dana ɖe teƒea eye wozinɛ vie be ʋua natɔ.
• Emegbe wotsɔa aŋɔ ƒoa teƒea. Emae nye ema.

Zi geɖe la , dɔ sia katã mexɔa aɖabaƒoƒo atɔ̃ o . Enye dɔ si wowɔna kabakaba ŋutɔ.

Abe alesi míegblɔe va yi ene la, ɣeaɖewoɣi la, ŋutilã me tsi bubuwo ate ŋu ahiã be woatsɔ adzidze `LDH`. Nya mawo dometɔ aɖewoe nye:

• Ahɔhɔ̃mekawo ƒe Tsi (CSF) .
• Pleural Fluid ƒe tsi
• Tsi si le dɔgboa me

Ne ele be nàwɔ dodokpɔ sia ƒomevi la, mègatsi dzi o. Wò ɖɔkta aɖe alesi wowɔa dodokpɔae kple nusiwo wòle be nànya me na wò tsitotsito.

Nukae dzɔna le LDH dodokpɔa megbe?

Ne woɖe wò ʋu alo ŋutilã me tsi bubu aɖe vɔ la, woaɖoe ɖe nudokpɔƒe be woadoe kpɔ. Ne dodokpɔa me tsonu vɔ ko la, wò ɖɔkta adzro dodokpɔa me tsonu me kpli wò.

Ðe afɔku aɖewo le LDH dodokpɔ mea?

Ʋudodo nye nusi bɔ ŋutɔ le atikewɔwɔ ŋuti numekuku me. Metsɔa afɔku boo aɖeke ɖe asi o . Ðewohĩ abi kple abi aɖewo anɔ afisi woɖe ʋua le. Gake ema nu ayi kaba.

Ɣeyiɣi didi kae wòaxɔ hafi manya LDH dodokpɔa me tsonu?

Zi geɖe la, ele be wò LDH dodokpɔ me tsonu nanɔ anyi le ŋkeke ɖeka alo eve me , gake ɣeaɖewoɣi la, ate ŋu axɔ ɣeyiɣi didi vie.

Ne èna wowɔ dodokpɔ sia le kɔdzi alo xɔ si me wokpɔa dɔnɔwo gbɔ kpata le la, àte ŋu akpɔ dodokpɔa me tsonu le gaƒoƒo ʋɛ aɖewo ko me .

Nukae nye LDH dodokpɔ me tsonu?

Ʋudodokpɔ ŋuti nyatakaka, si nye `LDH` dodokpɔ ƒe nyatakaka, zi geɖe la, nyatakaka siawo nɔa eme:

• Ʋudodokpɔa ƒe ŋkɔ, alo nusi wodzidze le wò ʋu me.
• Asixɔxɔ (i.e., xexlẽme) si le wò ʋudodokpɔ me tsonu ŋu.
• Dodokpɔ ma ƒe didime si sɔ.
• Nyatakaka siwo fia nenye be wò dodokpɔa me tsonu sɔ, mesɔ o, alo lolo alo le sue.

Nukae nye LDH (lactate dehydrogenase) ƒe agbɔsɔsɔ si sɔ?

Nusiwo sɔ na `LDH` ateŋu ato vovo vie tso nudokpɔƒe ɖeka yi bubu. Ne èxɔ wò ʋudodokpɔ ŋuti nyatakaka la, agblɔ nusi sɔ na `LDH` na nudokpɔƒe ma eme kɔ.

Gake le goawo katã me la, asixɔxɔ siwo sɔ na LDH dodokpɔe nye esiawo:

• Le ŋutsuwo gome : 135 – 225 units le lita ɖeka me (U/L).
• Le nyɔnuwo gome : Units le lita ɖeka me (U/L) 135 – 214.

Zi geɖe la, LDH ƒe agbɔsɔsɔ si le ɖevi suewo me le mama dedie nu sɔa gbɔ wu ame tsitsiwo tɔ.

Ne nya aɖe le asiwò ku ɖe wò dɔwɔwɔ me tsonu ŋu la, kpɔ egbɔ be yebia wò ɖɔkta.

Nukae wòfia ne nye LDH ƒe agbɔsɔsɔ sɔ gbɔ?

Ne wò LDH ƒe agbɔsɔsɔ sɔ gbɔ wu alesi wòle be wòanɔ la, anɔ eme godoo be efia be lãmenugbagbevi aɖewo gblẽ le wò ŋutilã me.Efia be nane dzɔ. Dɔléle si nɔa anyi ɣeyiɣi didi (si nɔa anyi didi), nudzɔdzɔ kpata (si nu sẽ), alo dɔlékui aɖe ate ŋu ahe nugbegblẽ ma vɛ.

Atikewɔwɔ me nɔnɔme siwo ate ŋu ana LDH ƒe agbɔsɔsɔ nadzi ɖe edzi dometɔ aɖewoe nye:

• Ʋusɔgbɔdɔ
• Ayikudɔléle
• Aklãdɔléle
• Aklãdɔléle
• Lãmetsiwo ƒe abixɔxɔ
• Lãmetsiwo ƒe dɔmawɔmawɔ nyuie
• Ƒu ƒe gbagbã
• Dzidɔ
• Dɔgbo ƒe dɔléle
• Dɔlékui aɖewo , abe taɖuame , tagbɔdɔ , mononucleosis (mono ), kple HIV .
• Kansa ƒomevi aɖewo , le kpɔɖeŋu me, metastatic melanoma , multiple myeloma, ʋumenugbagbeviɣidɔ , vidzidɔ me kansa , kple ʋumenugbagbeviɣidɔ .

Azɔ hã, ne LDH ƒe agbɔsɔsɔ sɔ gbɔ wu esi sɔ la, ate ŋu afia be kansa dada mele dɔ wɔm nyuie o .

Togbɔ be LDH dodokpɔa ate ŋu aɖee afia ne wò ŋutilã ƒe lãkusiwo gblẽ alo ne dɔléle aɖe le ŋuwò hã la, mate ŋu agblɔ afisi tututu nusiwo gblẽ le ŋuwò na wò o . Azɔ hã, ne ʋumenugbagbevi dzĩawo me gblẽ le ʋudodo (hemolysis) me la, LDH ƒe xexlẽme ate ŋu asɔ gbɔ alakpatɔe ɣeaɖewoɣi . Eyata ne wò numekukua me tsonu ɖee fia be wò LDH ƒe agbɔsɔsɔ sɔ gbɔ la, anɔ eme be ahiã be wò ɖɔkta nawɔ dodokpɔ geɖe wu be wòate ŋu anya dɔlélea nyuie.

Ðe wòle be matsi dzi ne nye LDH ƒe agbɔsɔsɔ sɔ gbɔa?

Ne wò LDH dodokpɔ me tsonu ɖee fia be wò LDH ƒe agbɔsɔsɔ sɔ gbɔ hã la, mefia kokoko be dɔléle sesẽ aɖe le ŋuwò o . Mega tsi dzi o.

Nu bubu geɖewo li siwo ate ŋu ana LDH ƒe agbɔsɔsɔ nadzi ɖe edzi:

• Kamedede vevie .
• Atike aɖewo , le kpɔɖeŋu me aspirin , atike siwo naa alɔ̃dɔdɔ ame , atike muamewo , kple procainamide .

Azɔ hã, ɖewohĩ vodada aɖe do le kpɔɖeŋuwo xɔɣi, wo tsɔtsɔ yi teƒe bubuwo, alo dodokpɔ me.

Ne èle nyametsotso wɔm le wò dɔwɔwɔ me tsonu ŋu la, wò ɖɔkta abu nu geɖe ŋu, abe atike siwo zãm nèle fifia, wò lãmesẽ ŋutinya, kple dzesi siwo le fu ɖem na wò ene.Agblɔ na wò hã nenye be èhiã dodokpɔ bubuwo alo mèhiã o.

Ne nya aɖe le asiwò ku ɖe wò dɔwɔwɔ me tsonu ŋu la, mègavɔ̃ be yeaƒo nu kple wò ɖɔkta o.

Nukae wòfia ne nye LDH ƒe agbɔsɔsɔ le sue?

Ƒã ŋutɔ be `LDH` dodokpɔ me tsonu naɖiɖi wu alesi wòle dzɔdzɔmee .

LDH ƒe agbɔsɔsɔ si bɔbɔ alea ate ŋu afia domenyiŋusẽfianu ƒe nɔnɔme si mebɔ kura o si woyɔna be Lactate Dehydrogenase A ƒe anyimanɔmanɔ - Glycogen Storage Disease XI, alo Lactate Dehydrogenase B ƒe anyimanɔmanɔ.

Azɔ hã, amesiwo ɖua vitamin C fũ akpa ƒe LDH dodokpɔ me tsonu ate ŋu aɖiɖi alakpatɔe .

Nya kawoe wòle be mabia nye ɖɔkta?

Ne wodo LDH kpɔ la, anyo be nàbia wò ɖɔkta nya siawo abe esiawo ene:

• Nukae nèsusu be ate ŋu anye nusi gbɔ nye `LDH` ƒe ɖoƒe kɔkɔ la tso?
• Ðe wòhiã be mawɔ dodokpɔ geɖe wu be manya nusi tututu gbɔ nye LDH ƒe agbɔsɔsɔ si sɔ gbɔ tso?
• (Ne kansa dɔnɔe nènye) Nukae nye `LDH` ƒe agbɔsɔsɔme gblɔ tso nye kansa ƒe sesẽme kple eƒe ŋgɔdonya ŋu?
• (Ne wole dɔléle aɖe dam na wò) Nukae nye `LDH` ƒe agbɔsɔsɔ gblɔ tso alesi nye nɔnɔmea le nu wɔm ɖe atikewɔwɔ ŋui ŋu?

Nu vevitɔ kekeake si wòle be wòanɔ susu me na wò (Take-Home Message) .

Enye nusi sɔ be nàvɔ̃ vie eye nàtsi dzimaɖi ne èkpɔ dodokpɔ me tsonu si mesɔ o. Gake ɖo ŋku edzi be, esi wò `LDH` (lactate dehydrogenase) ƒe agbɔsɔsɔ sɔ gbɔ ta la, mefia kokoko be dɔléle sesẽ aɖe le ŋuwò eye nèhiã atikewɔwɔ o.

Wò ɖɔkta agblɔ na wò godoo nenye be ehiã be nàwɔ dodokpɔ geɖe wu atsɔ adi nusi gbɔ agbɔsɔsɔ sia si mesɔ o tso alo mehiã o. Mègavɔ̃ alo nàhe ɖe megbe le nyawo biabia wò ɖɔkta ŋu o . Wole afima be yewoakpe ɖe ŋuwò. Ƒo nu tso nusianu si le asiwò ku ɖe wò lãmesẽ ŋu na wo.

` LDH, lactate dehydrogenase, enzyme, lãmenugbagbeviwo ƒe gbegblẽ, ʋudodokpɔ, lãmesẽ, dɔléle didi