Mina míasrɔ̃ nu tso Hepcidin, si kpɔa iron si le ŋutilã me dzi la ŋu ko?

Èse ŋkɔ Hepcidin kpɔa? Ðewohĩ mèwɔe kpɔ o. Gake esia nye nusi wɔa akpa vevi aɖe ŋutɔ le míaƒe ŋutilã me. Ne míagblɔe tututu la, Hepcidin siae nye esi koŋ kpɔa iron ƒe agbɔsɔsɔ si le míaƒe ŋutilã me dzi. Eyata egbea, mina míaƒo nu tso Hepcidin sia ŋu, kple nusi wòwɔna ɖe míaƒe ŋutilã ŋu, bɔbɔe kple xɔlɔ̃wɔwɔ ƒe mɔnu.

Nukae nye Hepcidin? Kpuie ko la,...

Hepcidin nye lãmetsi aɖe si wowɔna le míaƒe ŋutilã me. Lãmetsiŋusẽ le abe dɔla sue aɖe si kpɔa míaƒe ŋutilã ƒe dɔwɔwɔ ɖesiaɖe dzi eye wòtsɔa nyatakakawo yia ŋgɔe ene. Eyata lãmetsi sia si woyɔna be hepcidin ye afia alesi míaƒe ŋutilã zãa iron, iron agbɔsɔsɔme si ŋutilã hiã, kple alesi gbegbe wòhiã be wòadzrae ɖo.

Iron nye tomenu vevi aɖe na míaƒe ŋutilã. Ènya be iron nye nu vevi aɖe si nana protein si nye hemoglobin si le míaƒe ʋumenugbagbevi dzĩwo me la wɔa? Hemoglobin siae blana ɖe oxygen ŋu eye wòtsɔnɛ yia míaƒe lãmekawo kple ŋutinuwo me le ŋutilã bliboa me. Ewɔa dɔ abe oxygen taksi ene!

Menye ema ɖeɖeko o, iron hã hiã hafi woate ŋu awɔ protein si nye myoglobin, si naa oxygen míaƒe lãmekawo kple dzi.

Eyata, woyɔa hepcidin sia ɣeaɖewoɣi be "gayibɔ dzi ɖuɖu ƒe aƒetɔ." Nusitae nye be ekpɔa iron agbɔsɔsɔme si míaƒe lãmenugbagbeviwo hiã be woawɔ nu veviwo abe hemoglobin kple ʋumenugbagbevi dzĩwo wɔwɔ ene dzi. Bu eŋu kpɔ, nukae adzɔ ne gayibɔ mesɔ gbɔ ɖe mía me o? Ʋusɔgbɔdɔ si me iron mele o ate ŋu adze ame dzi. Ema fia be ŋutilãa mewɔa ʋumenugbagbevi dzĩwo wòsɔa gbɔ o. Le go bubu me la, ne gayibɔ sɔ gbɔ ɖe mía si akpa ya ɖe? Ema hã gblẽa nu le ŋutilãa ŋu ŋutɔ, abe aɖi ene, eye ɣeaɖewoɣi la, edea ame ƒe agbe afɔku me gɔ̃ hã.

Afikae wowɔa hepcidin sia le le míaƒe ŋutilã me?

Míaƒe aklã me koŋue wowɔa hepcidin le . Ne wonya wɔe ko la, egena ɖe míaƒe ʋukawo me.

Nuka tututue Hepcidin wɔna?

Míegblɔ va yi be hepcidin ye nye "iron ƒe ɖoɖowɔwɔ ƒe aɖaŋuɖola." Eyae nye be ekpena ɖe mía ŋu be iron ƒe homeostasis nanɔ míaƒe ŋutilã me, si fia be iron ƒe agbɔsɔsɔ nɔa agbɔsɔsɔ si sɔ me, menye sue akpa alo agbɔsɔsɔ akpa o.

Míekpɔa iron tso nuɖuɖu siwo míeɖuna me. Míekpɔa iron tso nuɖuɖuwo abe lã, tɔmelã, amagbewo, kple nukuwo ene me. Gake to vovo na tomenu bubuwo la, mɔ si anɔ míaƒe ŋutilã me si anɔ anyi ɖaa si dzi wòato aɖe iron si sɔ gbɔ la ɖa o. Le kpɔɖeŋu me, ne sodium sɔ gbɔ ɖe mía me akpa la, ado le aɖuɖɔ me. Gake agbɔsɔsɔ sue aɖe koe iron buna tso míaƒe ŋutilã me, to ʋu ƒe gege alo ne lãmenugbagbeviwo ku me.

Ke boŋ míaƒe ŋutilã dzraa gayibɔ ɖo, be míazã ne ehiã. Iron le mía si wodzra ɖo ɖe teƒewo abe míaƒe ƒumeŋuɖui, ƒumeŋuɖui, kple aklã ene . Iron si katã le ŋutilãa me ƒe 70% lɔƒo le ʋumenugbagbevi dzĩ mawo siwo ŋu míeƒo nu tsoe va yi me.

Eyata, hepcidin siae nye nusi doa alɔ dɔwɔwɔ siwo kpena ɖe gayibɔ dzraɖo ŋu, tsɔnɛ tso teƒe ɖeka yia bubu, eye wògazãnɛ ake la ŋu ŋutɔ. Ewɔa esia to gayibɔ si le míaƒe lãmenugbagbeviwo me dzi ɖuɖu me ale be wòanɔ anyi ne ehiã, eye hã be gayibɔ si sɔ gbɔ la nagazu kuxi na ŋutilãa o.

Hepcidin kpɔa gome le:

• Iron ƒe xɔxlɔ̃ dzi ɖuɖu: Iron ƒe xɔxlɔ̃ nye alesi iron si tso nuɖuɖu siwo míeɖuna me gena ɖe míaƒe ʋukawo me tso míaƒe dɔgbo suea me. Ne eɖo ʋuka me vɔ ko hafi ŋutilãa ate ŋu azã gayibɔa. Eyata hepcidin kpɔa iron agbɔsɔsɔme si yia ʋukawo me kple agbɔsɔsɔme si wodzrana ɖo dzi.
• Iron Gbugbɔgazã le Macrophages Me: Macrophages nye ʋumenugbagbevi ɣi ƒomevi aɖe si le abe míaƒe ŋutilã ƒe asrafowo dzadzraɖo ene. Woawoe tsrɔ̃a ʋumenugbagbevi dzĩ xoxo siwo le kukum eye woɖea mɔ na ʋumenugbagbevi dzĩ yeyewo. Míaƒe ƒumeŋuɖui wɔa ʋumenugbagbevi dzĩ yeyewo abe ŋkeke 120 ɖesiaɖe ene. Eyata ne macrophages tsrɔ̃ ʋumenugbagbevi dzĩ xoxo siawo la, woxɔa gayibɔ si le hemoglobin si le wo me la me. Hepcidin ye tsoa nya me nenye be wodzra gayibɔ ma ɖo ɖe macrophages la me alo woagaɖe asi le eŋu ake ɖe ŋutilãa me.
• Iron si wodzra ɖo ƒe dodo: Wodzraa iron ɖo ɖe míaƒe aklã me lãmenugbagbeviwo (siwo woyɔna be hepatocytes) kple míaƒe dɔgbo sue (si woyɔna be enterocytes ) ƒe lãmenugbagbeviwo me. Hepcidin kpɔa ŋusẽ ɖe edzi nenye be gayibɔ ma nɔa lãmenugbagbevi mawo me alo woɖea asi le eŋu be woazã.

Aleke hepcidin kpɔa iron ƒe xɔxlɔ̃ dzii?

Nusi doa dzidzɔ na ame ŋutɔŋutɔe nye be hepcidin meɖɔa gayibɔ ƒe xɔxlɔ̃ ɖo to dɔwɔwɔ aɖeke gɔmedzedze me o. Ke boŋ ewɔa esia to dɔwɔwɔ siwo kpena ɖe gayibɔ ƒe xɔxlɔ̃ ŋu la nu tsotso me.

Hepcidin wɔa dɔ kple protein aɖe si woyɔna be ferroportin . Ferroportin sia le abe "iron transporter" si le míaƒe ŋutilã me ene. Eƒe dɔe nye be wòaɖe gayibɔ ɖa le eƒe nudzraɖoƒewo (macrophages, hepatocytes, enterocytes) eye wòaʋuʋu iron ayi ŋgɔ kple megbe le ŋutilã ƒe lãmenugbagbeviwo dome. Ferroportin ye tsɔa gayibɔ tso dɔgbo suea me yia ʋukawo me ale be ŋutilãa nate ŋu azãe.

Hepcidin blana ɖe ferroportin sia ŋu. Emegbe ferroportin gblẽna. Ne edzɔ alea la, gayibɔ si ate ŋu atsɔ ferroportin ayi ʋua me hafi la tsia teƒe siwo wodzrae ɖo la ke.

Bu eŋu ale:

* Ne hepcidin dzi ɖe edzi , eva sesẽna na ferroportin be wòatsɔ iron ayi ʋua me. Esia fia be gayibɔ ƒe xɔxlɔ̃ dzi ɖena kpɔtɔna.

* Ne hepcidin mesɔ gbɔ oFerroportin ate ŋu atsɔ iron ayi ʋua me bɔbɔe. Esia fia be gayibɔ ƒe xɔxlɔ̃ dzina ɖe edzi.

Èse egɔmea? Ele bɔbɔe ŋutɔ, alo?

Nu kawoe kpɔa ŋusẽ ɖe Hepcidin ƒe agbɔsɔsɔ si le míaƒe ŋutilã me dzi?

Hepcidin agbɔsɔsɔme si le wò ŋutilã me la nɔa te ɖe dzesi siwo wò ŋutilã ɖona ɖa dzi. Le susu vovovowo ta la, wò ŋutilã xɔa dzesiwo be wòawɔ hepcidin si sɔ gbɔ alo wu nenema.

Nu mawo dometɔ aɖewoe nye esi:

• Iron bliboa le ŋutilãa me: Ne iron mesɔ gbɔ ɖe ŋutilãa me o la, enaa dzesi ŋutilãa be wòawɔ hepcidin si mesɔ gbɔ o. Ne iron sɔ gbɔ ɖe ŋutilãa me la, enaa dzesi ŋutilãa be wòawɔ hepcidin geɖe.
• Ʋumenugbagbevi dzĩwo wɔwɔ: Ne ŋutilãa hiã hemoglobin geɖe be wòawɔ ʋumenugbagbevi dzĩwo la, hepcidin ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna. Esiae nye esime ferroportin te ŋu ɖea iron doa goe eye wòkpena ɖe ame ŋu wòwɔa lãmenugbagbevi yeyewo.
• Oxygen ƒe agbɔsɔsɔ si bɔbɔ (Hypoxia): Hypoxia nye ne wò lãmekawo mekpɔ oxygen si sɔ o. Ne oxygen ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ la, ŋutilãa naa dzesi ŋutilãa be wòaɖe Hepcidin dzi akpɔtɔ. Esia naa Ferroportin, si ɖea iron doa goe tsɔ wɔa hemoglobin. Hemoglobin ye tsɔa oxygen toa ʋumenugbagbevi dzĩwo me.
• Dzoxɔxɔ si tso abi alo dɔlékui aɖe gbɔ: Le ɣeyiɣi siawo tɔgbe me la, hepcidin ƒe agbɔsɔsɔ dzina ɖe edzi. Nusitae nye be woatɔ te gayibɔ ƒe dodo ɖe ŋutilãa me. Dɔlékui geɖe siwo gblẽa nu le ame ŋu, abe dɔlékuiwo ene, zãa iron tsɔ tsina. Eyata to hepcidin dzi ɖeɖe kpɔtɔ, iron dzi ɖeɖe kpɔtɔ me la, èxea mɔ na dɔlékui mawo be iron nagaxɔ wo o. Smart, alo?

Nɔnɔme kawoe dzɔna ne hepcidin ƒe agbɔsɔsɔ mesɔ o?

Fifia ènya alesi gbegbe hepcidin le vevie. Eyata ne ekɔ akpa alo bɔbɔ akpa la, ate ŋu ahe kuxiwo vɛ.

Ne hepcidin sɔ gbɔ akpa la , ɖewohĩ ŋutilãa mate ŋu axɔ iron wòsɔ gbɔ o, si ahe nɔnɔmewo abe iron ƒe anyimanɔmanɔ ene vɛ.

Ne hepcidin mesɔ gbɔ o la , ŋutilãa ate ŋu axɔ iron fũ akpa, si ana iron nagbɔ eme.

Dɔléle siwo do ƒome kple hepcidin ƒe agbɔsɔsɔ si mede ame dzi o

Ne hepcidin ƒe agbɔsɔsɔ le sue la, woate ŋu akpɔ nɔnɔme siwo gbɔna:

• Ʋusɔgbɔdɔ si me iron mele o: Esiae nye ʋusɔgbɔdɔ ƒomevi si bɔ wu si do ƒome kple hepcidin ƒe ɖiɖi. Ɣeaɖewoɣi la, womate ŋu ade dzesi hepcidin ƒe agbɔsɔsɔ o. Esia ɖee fia be ŋutilãa le agbagba dzem be yeatsɔ iron ayi ʋua me to ferroportin ƒe dodo me.
• Domenyiŋusẽ ƒe ʋumenugbagbeviɣidɔ:Esia nye domenyiŋusẽfianu ƒe dɔléle. Le lãmenugbagbeviwo ƒe tɔtrɔ ta la, aklãa wɔa hepcidin ƒe agbɔsɔsɔ sue aɖe ŋutɔ. Esia wɔnɛ be ŋutilãa xɔa gayibɔ fũ akpa. Dzi, aklã, kple dɔgbo me koŋue gayibɔ sia si sɔ gbɔ ɖo la nɔa.
• Ʋusɔgbɔdɔ siwo me iron sɔ gbɔ ɖo: Esiawo nye ʋusɔgbɔdɔ ƒomevi aɖe. Gake le go sia me la, menye gayibɔ ƒe anyimanɔmanɔ le eme o, ke boŋ gayibɔ si gbɔ eme. Kuxi siwo doa mo ɖa le ʋumenugbagbevi dzĩwo wɔwɔ me hea hepcidin ƒe wɔwɔ dzi ɖena kpɔtɔna. Esia wɔnɛ be ferroportin ɖea gayibɔ si sɔ gbɔ akpa.
• Aklãdɔlékui C: Esia nye aklã me dɔlékui aɖe si dɔlékui (HCV) hena vɛ. Dɔlékui sia ɖea ŋutilã ƒe ŋutete be wòawɔ hepcidin dzi kpɔtɔna.
• Suklidɔ ƒomevi evelia: Numekuku aɖewo ɖee fia be suklidɔ ƒomevi eve le amesiwo ŋu suklidɔ ƒomevi eve le la ƒe hepcidin ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ, si wɔnɛ be iron sɔa gbɔ ɖe wo dzi. Insulin, si nye suklidɔ ƒe atike si bɔ, ate ŋu anye nusi gbɔ wòtso.

Dɔléle siwo do ƒome kple hepcidin ƒe agbɔsɔsɔ si dzi ɖe edzi

Hepcidin ƒe agbɔsɔsɔ si dzi ɖe edzi do ƒome kple ʋusɔgbɔdɔ si me iron mele o. Eyae nye ʋusɔgbɔdɔ si medzɔna ne iron mesɔ gbɔ o. Esiawo ate ŋu atso domenyiŋusẽfianu ƒe nɔnɔmewo gbɔ, si nana hepcidin dona fũu akpa.

Hepcidin ƒe agbɔsɔsɔ dzina ɖe edzi le nɔnɔme siwo woyɔna be ʋusɔgbɔdɔ si tso dɔdzẽ me alo ʋusɔgbɔdɔ si tso dɔléle si nɔa anyi didi (ACD) hã me . Le ACD me la, dɔdzẽ nana ŋutilãa ɖea protein aɖe si woyɔna be cytokine . Protein sia dzia hepcidin ƒe agbɔsɔsɔ ɖe edzi.

Dɔléle aɖewo siwo ate ŋu ado ƒome kple ACD dometɔ aɖewoe nye:

• Dɔlékui siwo nɔa anyi didi
• Crohn ƒe dɔlélea
• Kansa
• Ayikudɔ si nɔa anyi didi

Eyata àte ŋu akpɔe, Hepcidin nye nu vevi aɖe ŋutɔ si kpɔa iron zazã le míaƒe ŋutilã me dzi. Ne Hepcidin tɔ te iron ƒe dodo la, ekpɔa míaƒe ŋutilã ƒe ŋutete be wòawɔ hemoglobin kple ʋumenugbagbevi dzĩwo dzi. To mɔ sia dzi la, Hepcidin kpɔa ŋusẽ ɖe oxygen agbɔsɔsɔme si le ŋutilã bliboa me dzi le mɔ si mele tẽ o nu. Hepcidin hã xea mɔ na ŋutilãa be megaxɔa iron fũ o. Elabena gayibɔ fũ ate ŋu ahe kuxi sesẽwo vɛ le ɣeyiɣi didi aɖe megbe.

Nusiwo dzi wòle be míaɖo ŋkui tso ŋutinya sia me (Take-Home Message) .

Enyo, eyata míeƒo nu geɖe tso Hepcidin ŋu egbea, alo? Ne míagblɔe kpuie la:

• Hepcidin nye lãmetsi aɖe si wowɔna le aklã me.
• Esiae nye nu vevitɔ si kpɔa gayibɔ ƒe agbɔsɔsɔ si le míaƒe ŋutilã me dzi. Ele abe "Gayibɔ Aƒetɔ" ene.
• Míehiã iron be míate ŋu awɔ hemoglobin, si nye nusi tsɔa oxygen yia ŋutilã bliboa me.
• Hepcidin ƒe agbɔsɔsɔ, .Wotoa protein aɖe si woyɔna be ferroportin dzi kpɔa iron ƒe xɔxlɔ̃, edzadzraɖo, kple eƒe dodo dzi.
• Ne hepcidin mesɔ gbɔ o la , woate ŋu axɔ iron si sɔ gbɔ ɖe lãme na ame , si ana iron nagbɔ eme . Esia ate ŋu ahe nɔnɔmewo abe domenyiŋusẽfianu ƒe ʋumenugbagbeviɣidɔ ene vɛ.
• Ne hepcidin dzi ɖe edzi , ate ŋu aɖe iron ƒe xɔxlɔ̃ dzi akpɔtɔ, si ana ʋusɔgbɔdɔ si me iron mesɔ gbɔ ɖo o (ɣeaɖewoɣi la, dɔdzẽ gbɔe wòtsona).
• Be ŋutilãa nanɔ lãmesẽ me la, ele be iron ƒe agbɔsɔsɔ kple Hepcidin ƒe agbɔsɔsɔ nada asɔ.

Eyata ne iron ƒe kuxi aɖewo le ŋuwò, alo ne dzesiwo abe ʋusɔgbɔdɔ ene le ŋuwò la, anyo wu be nàyi ɖɔkta gbɔ aɖaɖo aɖaŋu na wò. Ele vevie ŋutɔ hã be nànɔ ŋudzɔ ɖe nu siawo tɔgbe ŋu.

` Hepcidin, iron, ʋusɔgbɔdɔ, lãmetsiŋusẽ, hemoglobin, aklã, ferroportin