Nukae nye lãmenugbagbeviwo ƒe ku? (Lãmenugbagbeviwo ƒe Ku) - Mina míasrɔ̃ míaƒe ŋutilã ƒe ŋutinya wɔnuku sia?

Èbu alesi míaƒe ŋutilã wɔa yeyee gbesiagbe ŋu kpɔa? Ɣeaɖewoɣi la, míaƒe ŋutigbalẽ ƒuna, eye ne míexɔ abi la, ehayana eye ŋutigbalẽ yeye tsina. Esiawo katã megbe la, nuwɔna wɔnuku aɖe ŋutɔ eye wòle vevie ŋutɔ si woyɔna be "Lãmenugbagbeviwo ƒe Ku". Togbɔ be ŋkɔa aɖi vɔvɔ̃ vie hã la, le nyateƒe me la, enye nu vevi aɖe ŋutɔ si wòle be míaƒe ŋutilã nanɔ lãmesẽ me. Mina míaƒo nu tso eŋu le nya bɔbɔewo me egbea.

Na míakpɔe ɖa gbã, nukawoe nye lãmenugbagbevi siawo?

Kpuie ko la, lãmenugbagbeviwo le abe xɔtunu suesuesue siwo wɔ míaƒe ŋutilã ene. Le nyateƒe me la, lãmenugbagbevi siwo wu triliɔn 30 ye le míaƒe ŋutilã me. Abe ale si ko wòhiã be anyikpewo nate ŋu atu xɔ ene la, lãmenugbagbevi siawoe nye míaƒe ŋutilã ƒe akpa sia akpa, si me míaƒe ŋutigbalẽ, lãmekawo, aklã, dzi, kple ahɔhɔ̃ hã le. Akpa vevi etɔ̃ le lãmenugbagbevi ɖesiaɖe si.

• Lãmenugbagbevi ƒe lãkusi: Esiae nye nutsyɔnu tsɛ si ƒo xlã lãmenugbagbevi la. Ewɔa nu abe agbonudzɔla ene, eye wòkpɔa ŋusẽ ɖe nusiwo gena ɖe gaxɔa me kple esiwo dona le eme dzi.
• Lãmenugbagbeviwo: Esiae nye tsi si le lãmenugbagbevi la me. Afi siae lãmenugbagbevi la ƒe atikewo ƒe dɔwɔwɔ geɖe dzɔna le, abe protein wɔwɔ kple ŋusẽ wɔwɔ ene.
• Nucleus: Esiae nye lãmenugbagbevi la dzi kpɔkpɔ ƒe teƒe, abe ahɔhɔ̃a ene. Míaƒe domenyiŋusẽfianu ŋuti nyatakakawo, alo DNA, katã le nucleus sia me. Nucleus la hã zãa nyatakaka siwo le DNA sia me tsɔ wɔa RNA, si tsɔa gbedasi siwo hiã hafi lãmenugbagbevi la nate ŋu awɔ dɔ.

Nukatae lãmenugbagbevi siwo le míaƒe ŋutilã me kuna?

Susu geɖewo li siwo tae lãmenugbagbeviwo kuna ɖo. Esiawo dometɔ aɖewo nyo, ɖewo menyo nenema gbegbe o.

• Tsitsi: Abe alesi míele tsitsim ene la, lãmenugbagbeviwo hã ƒe agbenɔƒe aɖe nɔa anyi. Ne lãmenugbagbevi si le lãmesẽ me ma abe zi gbɔ zi 50-60 ene eye wòwɔ lãmenugbagbevi yeyewo vɔ la, lãmenugbagbevi ma magate ŋu ama o. Le ema megbe la, lãmenugbagbevi la kuna le dzɔdzɔme nu.
• Gbegblẽ: Lãmenugbagbevi aɖewo gblẽna ale gbegbe be womate ŋu adzra wo ɖo o. Ne edzɔ alea la, lãmenugbagbevi mawo kuna le dzɔdzɔme nu eye lãmenugbagbevi yeye siwo le lãmesẽ me va xɔna ɖe wo teƒe.
• Womazãe o: Ɣeaɖewoɣi, ne wole tsitsim la, lãmenugbagbevi aɖewo megahiã o. Le kpɔɖeŋu me, vidzĩ ƒe asibidɛwo ate ŋu aƒo ƒu ɖekae le gɔmedzedzea me, gake ne lãmenugbagbevi siwo le wo dome ku ko hafi woaklã.
• Dɔlélewo kple gotagomenuwo: Dɔlékuiwo, aɖinuwo, abixɔxɔ, kple atikewɔwɔ me nɔnɔme aɖewo hã ate ŋu ana lãmenugbagbeviwo nagblẽ eye woaku.

Mɔ vevi kawo dzie lãmenugbagbeviwo tona kuna?

Na míaƒo nu tso mɔ vevi etɔ̃ siwo dzi lãmenugbagbeviwo tona kuna ŋu. Ame etɔ̃ siawo to vovo kura tso wo nɔewo gbɔ. Esiawoe nye apoptosis, autophagy, kple necrosis.

1. Apoptosis - lãmenugbagbeviwo ƒe ku si wowɔ ɖoɖo ɖe eŋu

Woyɔa esia be "lãmenugbagbeviwo ƒe ku si ŋu wowɔ ɖoɖo ɖo." Nusi dzɔna le afisia enye be ne lãmenugbagbevi aɖe ɖo eƒe agbenɔƒe ƒe nuwuwu, alo ne egblẽ la, etsrɔ̃a eɖokui le ɖoɖo nu, evɔ megblẽa nu le lãmenugbagbevi siwo ƒo xlãe ŋu o.

Kpɔɖeŋu nyuitɔ kekeakee nye vidzĩa ƒe asibidɛwo ƒe mama le vidzidɔa me si megblɔ va yi. Le gɔmedzedzea me la, teƒe aɖe nɔa asibidɛawo dome abe ŋutigbalẽ ene. Ne lãmenugbagbevi siwo mehiã o siwo le wo dome ku le ɖoɖo nu le ``Apoptosis`` ƒe dɔwɔwɔ ta la, asibidɛawo ma nyuie. Ne nuwɔna sia medzɔ nyuie o la, vidzĩ aɖewo ƒe asibidɛwo ate ŋu abla ɖe wo nɔewo ŋu le wo dzidzi me (Syndactyly).

Nukae adzɔ ne ɖoɖo sia meva yi nyuie o?

• Ne apoptosis medzɔ nyuie o la:Bu nusi adzɔ ne lãmenugbagbevi xoxo siwo gblẽ la yi edzi nɔ agbe evɔ womeku o la ŋu kpɔ. Lãmenugbagbevi mawo adze mama gɔme le mɔ si dzi womate ŋu aɖu o nu. Esia koŋ tae kansa dzɔna ɖo. Kansa lãmenugbagbeviwo nye lãmenugbagbevi "makuna" siwo mekuna le ɣeyiɣi si wòle be woaku o.
• Ne apoptosis dzɔ akpa: Ɣeaɖewoɣi la, lãmenugbagbevi siwo le vevie na ŋutilãa kuna le nuwɔna sia me evɔ mele be woakuna o. Le kpɔɖeŋu me, le lãmekawo ƒe dɔlélewo abe Parkinson ƒe dɔléle alo Alzheimer ƒe dɔléle ene me la, ahɔhɔ̃meka veviwo (ahɔhɔ̃mekawo) kuna akpa. Esia kpɔa ŋusẽ ɖe tamebubu kple ʋuʋu ƒe ŋutete dzi.

2. Autophagy - Lãmenugbagbeviwo ‘ɖua’ wo ɖokui

Nya `Autophagy` gɔmee nye ``ameɖokuiɖuɖu.'' Esia hã nye ɖoɖo si wowɔ. Ke hã, lãmenugbagbevi bliboa mekuna le afisia o. Nusi dzɔna enye be lãmenugbagbevi la ŋutɔ ``ɖua'' akpa xoxo siwo gblẽ, kple esiwo ŋu viɖe aɖeke mele o le lãmenugbagbevi la me eye wògazãa nusiwo do tso eme la tsɔ tua akpa yeye siwo le lãmesẽ me.

Kpuie ko la, ele abe aƒe dzadzraɖo ene. Ètsɔa nu gbagbãwo ƒua gbe, xɔa nusiwo woate ŋu azã, eye nètua nu yeyewo.

Nu nyui kple nu gbegblẽ kawoe le esia ŋu?

• Akpa nyuia: Nu gbugbɔgawɔ sia kpena ɖe míaƒe dɔlélenutsiŋutete ŋu wògblẽa dɔlékuiwo abe dɔlékuiwo kple dɔlékuiwo ene siwo gena ɖe ŋutilãa me. Ate ŋu akpe ɖe ame ŋu hã be lãmenugbagbevi siwo le lãmesẽ me nagatrɔ zu kansa lãmenugbagbeviwo o eye wòakpɔ wo ta tso dɔlélewo abe dzidɔ ene me.
• Nusi gblẽ le eŋu: Ne kansa le ame aɖe ŋu xoxo la, ``Autophagy'' ƒe ɖoɖo sia ateŋu akpɔ ŋusẽ gbegblẽ ɖe ame dzi, elabena kansa lãmenugbagbeviwo ateŋu azã nunyiame si sɔ gbɔ tso nusiwo wogbugbɔ zãna sia me be woatsi kabakaba wu gɔ̃ hã.

Ame aɖewo dzea agbagba be yewoaɖu yewoƒe nuɖuɖu dzi alo tsia nu dɔ le agbagbadzedze be yewoagbugbɔ yewoƒe lãmenugbagbeviwo awɔ ɖekakpui me. Togbɔ be woxɔe se be esia doa ŋusẽ ``Autophagy'' ƒe dɔwɔwɔ hã la, womeɖo kpe edzi le dzɔdzɔmeŋutinunya me be ewɔa dɔ nyuie o. Nuɖuɖu ƒe mɔxexeɖenu sesẽwo ate ŋu agblẽ nu le wò lãmesẽ ŋu, eyata ele be nàƒo nu kple wò ɖɔkta godoo hafi awɔ nu ma tɔgbe.

3. Necrosis - Lãmenugbagbevi siwo kuna kpata

Aleae lãmenugbagbeviwo kuna ɖoɖo aɖeke manɔmee, le afɔku aɖe ta. Abe alesi `(Apoptosis)` le abe dzudzɔxɔxɔledɔme le ŋutifafa me ene la, `(Necrosis)` le abe ku le vo me ene.

Le abi, aɖi, dɔlékui, alo ʋu ƒe sisi yi teƒe aɖe ƒe bu ta la, lãmenugbagbeviwo gblẽna eye ‘wogbãna’. Emegbe lãmenugbagbevi la me nuwo dona doa goe eye wògblẽa nu le lãmenugbagbevi siwo le lãmesẽ me siwo ƒo xlãe ŋu. Esia nana abi nɔa teƒe ma eye lãmenugbagbevi geɖe wu tea kuku. Woyɔa esia be lãmekawo ƒe ku.

Nu vevi siwo gbɔ ame kuku tsona:

• Nuveviwɔame kple afɔkuwo
• Dɔlékuiwo abe dɔlékuiwo kple dɔlékuiwo ene
• Aɖinuwo kple atike vɔ̃ɖiwo zazã
• Ʋu kple ɔksidzin ƒe gege ɖe ŋutilã ƒe akpa aɖe me. Le kpɔɖeŋu me, le gangrene me la, ŋutigbalẽ ƒe lãkusiwo kuna. Le avascular necrosis me la, ƒumeŋuɖui kuna.