Èbu alesi nyatakakawo zɔa mɔ yia ŋgɔ kple megbe le míaƒe ahɔhɔ̃ me ŋu kpɔa? Ele abe amedɔdɔ suewo ƒe ha aɖe si le dɔ wɔm ɖekae be yewoawɔ dɔ wɔnuku aɖe ene. Míeyɔa dɔla siawo be ahɔhɔ̃mekawo ƒe dɔwɔwɔ. Ɣeaɖewoɣi la, le atikewɔwɔ ƒe nɔnɔme aɖewo ta la, gbedasiwo ɖɔliɖɔli sia ate ŋu atɔtɔ vie. Ɣemaɣie atike aɖewo va kpena ɖe mía ŋu. Egbea míele nu ƒom tso atike mawo dometɔ ɖeka si woyɔna be dopamine antagonists ŋu.
Kpuie ko la, nukawoe nye dopamine-nutsitike siawo?
Be míase esia gɔme la, ele be míanya nusi dopamine nye gbã. Dopamine nye ahɔhɔ̃meka vevi aɖe ŋutɔ le míaƒe ahɔhɔ̃ me. Ekpena ɖe mía ŋu míeɖua nu geɖe dzi, siwo dometɔ aɖewoe nye míaƒe tamesusuwo, seselelãmewo, kple míaƒe ʋuʋu.
Azɔ tsɔe be ‘gaƒoɖokui’ suesuesuewo le míaƒe ahɔhɔ̃menugbagbeviwo ŋu. Míeyɔa esiawo be ‘xɔlawo’. Dɔla dopamine la le abe ‘safui’ ene. Ne safui sia ge ɖe gaƒoɖokui (xɔla) ma me la, lãmenugbagbevi ma va zua ‘dɔwɔwɔ’, si fia be edzea eƒe dɔ wɔwɔ gɔme.
Enyo, eyata nukae atike si woyɔna be ‘dopamine antagonist’ wɔna? Atike sia le abe ‘aʋatso safui’ si nàte ŋu ade gaxɔ ma me ene, gake màte ŋu aʋu gaxɔa o. Eyae nye be, atike sia gena ɖe gaƒoɖokui `(xɔla)` si wòle be dopamine naɖo la me, eye wò `(xea mɔ na)`e.
Ne míagblɔe kpuie la, bu zikpui aɖe si le kplɔ̃ɖoƒe aɖe si dzi woŋlɔ agbalẽvi ɖo be ‘Wodzrae ɖo’ ŋu kpɔ. Ame aɖeke menɔ anyi ɖe afima o, gake màte ŋu anɔ anyi ɖe afima o, alo? Aleae atike sia wɔa dɔe. Enaa dopamine xɔla la megawɔa dɔ o, si wɔnɛ be dopamine ŋutɔŋutɔ megena ɖe eme hewɔa dɔ o.
Esi wònye be ekpɔa ahɔhɔ̃menugbagbevi aɖewo ƒe dɔwɔwɔ dzi alea ta la, atike sia ɖea vi ŋutɔ le tagbɔdɔléle aɖewo kple dzesi bubuwo dzi ɖuɖu me.
Nɔnɔme kawo mee wozãa atike sia na?
Woate ŋu ama atike siwo tsia dopamine nu ɖe hatsotso vevi eve me, gake nɔnɔme aɖewo li siwo me atike aɖewo wɔa dɔ le hatsotso eveawo siaa me.
1. Atike siwo tsia tagbɔdɔléle nu: Atike siwo wozãna tsɔ daa tagbɔdɔléle kple nɔnɔme siwo do ƒome kplii.
2. Atike siwo tsia ʋumenugbagbeviɣidɔ nu: Atike siwo wonana be woadzudzɔ ʋuʋudedi kple ʋuʋudedi.
Mina míalé ŋku ɖe nɔnɔme vevi siwo wotsɔ atike siawo da dɔe ŋu.
| Atikewo ƒe hatsotso | Nɔnɔme siwo ŋu woda dɔ na |
|---|---|
| Tagbɔdɔlékuiwutikewo |
|
| Atike siwo tsia ʋusɔgbɔdɔ nu |
|
Atike ƒomevi kawoe le hatsotso siawo me?
Atike ƒomevi geɖewo li siwo dzena le hatsotso siawo me. Zi geɖe la, womaa tagbɔdɔlélenutsitikewo ɖe "dzidzime" eve me. Eyae nye atike xoxo siwo ŋu woke ɖo gbã (dzidzime gbãtɔ) kple atike yeye siwo ŋu woke ɖo emegbe, siwo ƒe nugbegblẽ le ame ŋu ʋɛ aɖewo (dzidzime evelia).
Dzidzime gbãtɔ (Typical) ƒe atikewo
Esiawo nye atike xoxoawo dometɔ aɖewo. Wo dometɔ aɖewoe nye:
- `Klorpromazine ƒe atike`
- `Haloperidol (Haldol®) ƒe atike si wotsɔna ƒoa ƒui`
- `Fluphenazine ƒe atike`
- `Perphenazine ƒe atike`
- `Prochlorperazine ƒe atike`
Dzidzime evelia (Atypical) ƒe atikewo
Esiawo nye atike yeyewo vie.
- `Olanzapine (Zyprexa®) ƒe atike si wotsɔna ƒoa ƒui`
- `Risperidone (Risperdal®) ƒe atike si wotsɔna ƒoa ƒui`
- `Quetiapine (Seroquel®) ƒe atike si wotsɔna ƒoa ƒui`
- `Aripiprazole (Abilify®) ƒe dɔlékuiwutike`
- `Klozapine (Clozaril®)`
Atike siwo wua ʋumenugbagbeviɣidɔ na ʋuʋudedi kple ʋuʋudedi
Ðewohĩ èkpɔ atike siawo dometɔ aɖewo siwo woŋlɔ ɖe etame le tagbɔdɔlélewo ƒe ŋkɔwo me. Nusitae nye be woate ŋu awɔ nu siawo evea siaa.
- `Metoclopramide (Reglan®) ƒe atike si wotsɔna ƒoa ƒui`
- `Prochlorperazine ƒe atike`
- `Olanzapine ƒe atike`
- `Haloperidol`
- `Domperidone` (Atike sia mele Sri Lanka le afisiafi o, eye mɔɖeɖe tɔxɛ aɖe koe woate ŋu axɔ)
Vevietɔ: Esiawo nye kpɔɖeŋu ʋɛ aɖewo ko. Ðewohĩ wò ɖɔkta meŋlɔ atike siwo le ŋkɔ sia me na wò o. Mègazã ame bubu ƒe atike, adzudzɔ enono, alo atrɔ agbɔsɔsɔme si wozãna wò ɖɔkta ƒe aɖaŋuɖoɖo manɔmee gbeɖe o.
Viɖe kawoe le atike siawo ŋu?
Dopamine-nutsitikewo nye atikewo ƒe hatsotso aɖe si ŋu viɖe le ŋutɔ.
Le tagbɔdɔléle gome la:
Le amesi ŋu dɔléle aɖe abe tagbɔdɔléle ene le gome la, atike sia ate ŋu aɖe agbe . Ate ŋu aɖe afɔku si le amesiwo ŋu nɔnɔme siawo le ƒe nuvevi wɔwɔ wo ɖokui alo ame bubuwo ƒe ŋlɔmiwɔwɔ dzi akpɔtɔ. Ate ŋu ana mɔnukpɔkpɔ geɖe wu nasu wo si be woanɔ agbe si sɔ, awɔ dɔ, eye woakpɔ dzidzɔ kple woƒe ƒomewo.
Le ʋuʋudedi kple ʋuʋudedi gome la:
Le mía gome la, aɖuɖɔtoe ate ŋu anye nusi mebɔ o si nu yina le ɣeyiɣi aɖe megbe. Gake bu kansadɔnɔ aɖe ŋu kpɔ. Aɖuɖɔtoe kple aɖuɖɔtoe si wokpɔna le atikewɔɣiwo nu sẽ ale gbegbe be ate ŋu ade woƒe agbe afɔku me gɔ̃ hã. Le ɣeyiɣi siawo tɔgbe me la, ne atike bubuwo mewɔa dɔ o la, atike siawo siwo xea mɔ na dopamine ate ŋu ana gbɔdzɔe gã aɖe nasu wo si.
Ðe eƒe nugbegblẽ le ame ŋu alo afɔku aɖewo lia?
Ẽ, abe atike bubu ɖesiaɖe ene la, atike siawo ate ŋu agblẽ nu le ame ŋu. Gake menye amesiamee xɔa nugbegblẽ siawo katã o. Enɔ te ɖe nu geɖe dzi, abe atike si nèno, agbɔsɔsɔme si nàno, kple wò ŋutilã ƒe nɔnɔme ene. Nu vevitɔe nye be màgavɔ̃ esia o eye nàƒo nu kple wò ɖɔkta gaglãa.
| Nusiwo ate ŋu agblẽ le ame ŋu | Numeɖeɖe bɔbɔe aɖe |
|---|---|
| Atike si naa ame ƒe dzi dzea eme | Esia bɔ le atikeawo zazã gɔmedzedze ƒe gɔmedzedze. Esia dzi aɖe akpɔtɔ ne ŋutilãa va le atikeawo zãm. |
| Ʋuʋu ƒe Dɔlélewo | - Akathisia: 1999 me.Dziɖeleameƒo si nye be yemate ŋu anɔ teƒe ɖeka o, seselelãme si nye be ele be yeayi edzi anɔ tsatsam. - Dystonia: lãmekawo ƒe tete kpata, ʋuʋu (e.g., kɔ ƒe ʋuʋu yi axa ɖeka). - Tardive Dyskinesia: Mo, nu, alo aɖe ƒe ʋuʋu si dzi womeɖu o si ate ŋu adzɔ ne wozã atike la ɣeyiɣi didi. |
| Ʋusɔgbɔdɔ si Le Orthostatic Hypotension | Sese le ɖokuiwò me be taɖuame alo ta le ƒoƒom ne ètsi tre zi ɖeka tso anyinɔƒe alo mlɔ anyi. Esia tsoa ʋu ƒe sisi ƒe ɖiɖi kpata gbɔ. |
| Lãmetsiŋusẽ ƒe Tɔtrɔwo | Lãmetsi si nye prolactin ƒe dzidziɖedzi ate ŋu ana nyɔnuwo nadzudzɔ woƒe dzinukpɔkpɔ eye tsi si le abe notsi ene nado le woƒe no me ne womele no nam o. |
| Ahɔhɔ̃mekawo ƒe Dɔléle Vɔ̃ɖi | Esia nye nɔnɔme si mebɔ kura o gake ate ŋu ade ame ƒe agbe afɔku me. Ne dzesiwo abe asrã sesẽ, lãmekawo ƒe ʋuʋu, kple susu ƒe ʋuʋu ene do mo ɖa zi ɖeka la, ele be nàyi kɔdzi ƒe Atikewɔwɔ Kpata (ETU) enumake. |
Wò ɖɔkta agblɔ nu geɖe tso nugbegblẽ siawo ŋu na wò eye wòaɖo aɖaŋu na wò le nusi nàte ŋu awɔ be woaɖe wo dzi akpɔtɔ ŋu.
Nyabiase bubu aɖewo ate ŋu anɔ asiwò
Ɣeyiɣi didi kae wòhiã be mano atike sia?
Enɔ te ɖe nɔnɔme si ŋu wole atike wɔm na wò dzi. Ne ehiã ko hafi wonoa atike aɖewo, abe atike siwo tsia ʋuʋudedi nu ene. Gake ahiã be nàno tagbɔdɔléle ƒe atikewo ƒe geɖe, alo wò agbemeŋkekewo katã gɔ̃ hã. Wò ɖɔkta atso nya me le ɣeyiɣi didi si tututu wòle be nàno wo ŋu.
Ðe mate ŋu awɔ dɔ alo aku ʋu esime mele atike sia nom?
Esia nye nyabiase vevi aɖe ŋutɔ. Atike siawo dometɔ aɖewo ate ŋu ana ame nadɔ alɔ̃ vevie alo ɖeɖi nate ame ŋu . Eyata ele be nàbia wò ɖɔkta godoo be ele dedie be nàku ʋu alo azã mɔ̃wo esime nèle atike siawo nom. Aɖo aɖaŋu nyuitɔ kekeake wò.
Dopamine ƒe dɔlékuiwutikewo nye atike vevi aɖe ŋutɔ si kpe ɖe ame miliɔn geɖe ƒe agbenɔnɔ ŋu wònyo ɖe edzi. Togbɔ be woƒe nugbegblẽ le ame ŋu hã la, ne wokpɔ wo dzi nyuie le ɖɔkta ƒe mɔfiafia te la, viɖe siwo dona tso eme la ƒo wo ta sãsãsã.
Gbedasi si Wotsɔ Yi Aƒeme
- Atike siwo woyɔna be dopamine antagonists xea mɔ na lãmenugbagbevi siwo le ahɔhɔ̃a me siwo xɔa dopamine gbedasiwo.
- Wozãa esiawo koŋ tsɔ daa tagbɔdɔlélewo abe tagbɔdɔléle kple ʋuʋudedi/ʋuʋudedi sesẽ ene.
- Togbɔ be esiawo nye atike siwo wɔa dɔ ŋutɔ hã la, woate ŋu ahe nugbegblẽ le ame ŋu abe alɔ̃dɔdɔ kple ʋuʋu ƒe kuxiwo ene vɛ.
- Mègadze atike sia gɔme, adzudzɔ, alo atrɔ eƒe agbɔsɔsɔme gbeɖe wò ɖɔkta ƒe aɖaŋuɖoɖo manɔmee o.
- Ne èse veve aɖe si mebɔ o esime nèle atikeawo zãm la, mègavɔ̃ be yeagblɔe na wò ɖɔkta o.
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