Ðe wò ɖɔkta ŋlɔ blanuiléle ƒe atike na wòa? Alo ɖe ame aɖe si nènya zãa atike sia? Togbɔ be ŋutinya geɖe le hadomegbenɔnɔ me ku ɖe atike sia ŋu hã la, ame nenie nya alesi wòkpɔa ŋusẽ ɖe ahɔhɔ̃a dzi kple nusi dzɔna le esia ta ŋutɔŋutɔ? Ame geɖe vɔ̃na na atike sia, gake nusi tae vɔvɔ̃ ma ɖoe nye manyamanya. Eyata, mina míase esia gɔme bɔbɔe eye eme nakɔ egbea, abe ɖe míele nu ƒom na mía xɔlɔ̃ aɖe ene.

Nukawoe nye blanuilélenutsitike siawo?

Togbɔ be woyɔa atike siawo be ‘blanuilélenutsitikewo’ hã la, menye ɖeko wozãa wo tsɔ daa blanuiléle, si nye tagbɔdɔ si nana wotsia dzimaɖi vevie kple mɔkpɔkpɔbuɖeame ƒe seselelãmewo o. Woto atike siawo vɛ zi gbãtɔ le ƒe 1950-awo me. Egbea la, tsɔ kpe ɖe blanuiléle ŋu la, woda asi ɖe atike siawo hã dzi na nɔnɔmewo abe OCD (Obsessive-Compulsive Disorder), Social Phobia, Panic Disorder, GAD (Generalized Anxiety Disorder), kple PTSD (Posttraumatic Stress Disorder) ene.

Tsɔ kpe ɖe eŋu la, ɖɔktawo ate ŋu aŋlɔ atike sia na amewo ɣeaɖewoɣi na nɔnɔmewo abe vevesese atraɖii, alɔ̃madɔmadɔ, kple taɖuame ene. Woyɔa esia be ‘off-label’ zazã. Esia fia be womeda asi ɖe atike la dzi le se nu haɖe na dɔléle ma o, gake ɖɔktaa xɔe se be dɔa aɖe vi na dɔnɔa.

Aleke atike sia kpɔa ŋusẽ ɖe míaƒe ahɔhɔ̃ dzii?

Kpuie ko la, atike siawo wɔa dɔ to atike aɖewo ƒe agbɔsɔsɔ si le míaƒe ahɔhɔ̃ me tɔtrɔ me. Míeyɔa atike siawo be ahɔhɔ̃mekawo ƒe dɔwɔwɔ . Esiawoe kpɔa ŋusẽ ɖe nu geɖe dzi, abe míaƒe seselelãme, seselelãme, alɔ̃dɔdɔ, kple nuɖuɖudzroame ene.

Bu eŋu ale. Lãmenugbagbevi siwo le míaƒe ahɔhɔ̃ me zãa ‘dɔla’ siawo siwo woyɔna be ahɔhɔ̃mekawo tsɔ ɖoa ​​dze kple wo nɔewo. Lãmetsiŋusẽ ƒe lãmenugbagbevi ɖeka ɖea asi le dɔla sia ŋu, eye wòtsɔa gbedasia yia lãmenugbagbevi si kplɔe ɖo gbɔ. Ne wotsɔ gbedasia ɖo ɖa vɔ la, wogbugbɔa amedɔdɔa yia lãmenugbagbevi gbãtɔa me kaba (woyɔa esia be gbugbɔgaxɔ ).

Nusi blanuilélenutsitikewo koŋ wɔnae nye be wohea wo gbugbɔgaxɔ ƒe ɖoɖo ma ɖe megbe vie. Emegbe dɔla ma (le kpɔɖeŋu me, serotonin) nɔa dometsotso si le lãmeka ƒe lãmenugbagbevi eveawo (sinapse) dome la me ɣeyiɣi didi wu. Ekema ate ŋu awɔ dɔ ɣeyiɣi didi wu eye míaƒe seselelãme nanyo ɖe edzi.

Atike ƒomevi siwo wozãna zi geɖe siwo xea mɔ na dɔlélea gbugbɔgaxɔ

Blanuilélenutsitike siwo woŋlɔna na ame wu fifia la le ƒuƒoƒo sia me. Woma wo ɖe hatsotso vevi geɖewo me.

1. SSRI (Serotonin Gbugbɔgaxɔ Mɔxenu Tiatia) .

Esiawoe nye atike gbãtɔ siwo ɖɔktawo ŋlɔna na amewo zi geɖe. Abe alesi ŋkɔa ɖee fia ene la, esiawo koŋ tɔa ŋku ahɔhɔ̃mekawo ƒe dɔwɔwɔ si nye serotonin . Serotonin le vevie na nuwo abe míaƒe seselelãme, nuwɔna, kple ŋkuɖoɖonudzi ene.

Ne ènya dze atike sia nono gɔme ko la, ate ŋu axɔ kwasiɖa geɖe, ɣeaɖewoɣi vaseɖe ɣleti 2-3, hafi nàkpɔ emetsonu bliboa. Eyata ele vevie be nàgbɔ dzi ɖi. Azɔ hã, mègadzudzɔ atike sia nono kpata wò ɖɔkta ƒe aɖaŋuɖoɖo manɔmee gbeɖe o. Esia wɔwɔ ate ŋu ahe dzesi siwo medzea ame ŋu o (antidepressant discontinuation syndrome) vɛ.

Serotonin Syndrome - Nane si ŋu wòle be woatsi dzi ɖo!

Ɣeaɖewoɣi la, ne èno atike bubu siwo nana serotonin ƒe agbɔsɔsɔ dzina ɖe edzi, abe SSRI ene la, serotonin ƒe agbɔsɔsɔ si le ahɔhɔ̃a me ate ŋu adzi ɖe edzi madzemadzee. Esia ate ŋu anye afɔku.

2. SNRI (Serotonin-Norepinephrine ƒe Gbugbɔgaxɔ Mɔxenu) .

Esiawo nye atike siwo de ŋgɔ vie wu siwo va le SSRI-tikeawo megbe. Wokpɔa ŋusẽ ɖe ahɔhɔ̃meka siwo nye serotonin kple norepinephrine siaa dzi . Norepinephrine le vevie na míaƒe susu kple ŋudzɔnɔnɔ. Esia tae wozãa atike siawo ɣeaɖewoɣi tsɔ daa vevesese atraɖii (e.g., suklidɔ ƒe ahɔhɔ̃mekawo ƒe dɔléle, fibromyalgia).

• Kpɔɖeŋu siwo bɔ: Duloxetine (Cymbalta), Venlafaxine (Effexor) .
• Nusiwo wògblẽna le ame ŋu zi geɖe: lãmetutudɔ, nu me ƒuƒu, ɖeɖiteameŋu, alɔ̃dɔdɔ, taɖuame, fifia.

3. NDRIs (Norepinephrine kple Dopamine ƒe Gbugbɔgaxɔ Mɔxenu) .

Atike sia nana ahɔhɔ̃meka siwo nye norepinephrine kple dopamine ƒe agbɔsɔsɔ dzina ɖe edzi . Dopamine le vevie na míaƒe dzidzɔkpɔkpɔ, ʋiʋli, kple susu tsɔtsɔ ɖe nu ŋu.

• Kpɔɖeŋu vevitɔ: Bupropion (Wellbutrin). Esia nye atike si ate ŋu akpe ɖe ŋuwò hã be nàdzudzɔ atamanono.
• De dzesii etɔxɛe: Gbɔdɔdɔ ƒe nugbegblẽ le ame ŋu mesɔ gbɔ o wu blanuilélenutsitike bubuwo. Gake mesɔ na amesiwo ate ŋu axɔ alɔ̃madɔmadɔ o.

Ƒomevi bubuwo, xoxo gake wogakpɔtɔ le vevie

Togbɔ be womegazãa atike siawo le afisiafi fifia o hã la, woate ŋu aɖe vi ŋutɔ na ame aɖewo siwo mewɔa nu ɖe ​​atike yeyewo ŋu o. Ke hã, woƒe nugbegblẽ le ame ŋu geɖe.

Blanuilélenutsitike siwo nye tricyclic kple tetracyclic (TCAs) .

Esiawo nye atike xoxo siwo wozãna tso ƒe 1950-awo me. Togbɔ be wowɔa dɔ abe atike yeyewo ene hã la, woƒe nugbegblẽ le ame ŋu geɖe wu. Le kpɔɖeŋu me, woate ŋu ana ame nadɔ alɔ̃, nu me naƒu, ame ƒe lolo nadzi ɖe edzi, eye dzi ƒe tsotso natrɔ.

• Kpɔɖeŋu siwo bɔ: Amitriptyline, Nortriptyline, Clomipramine.

Monoamine oxidase mɔxexeɖedɔlékuiwo (MAOIs) .

Esiawo hã nye atike xoxowo ŋutɔ eye ƒã hafi wozãa wo. Ne èle esiawo zãm la , ele be nàɖɔ ŋu ɖo vevie le nusi nèɖuna ŋu. Elabena ne èɖu nuɖuɖu siwo me amino acid ‘Tyramine’ le (e.g., cheese si tsi, soya-mi, lã aɖewo, atikutsetse aɖewo) la, wò ʋu ƒe sisi ate ŋu adzi ɖe edzi afɔkutɔe. Azɔ hã, esiawo nono kple blanuilélenutsitike bubuwo nye afɔku gã aɖe.

Nunyiametike siwo woate ŋu ano atsɔ akpe ɖe atikewo zazã ŋu

Esiawo menye atikewo o, ke boŋ nuɖuɖu kpeɖeŋutɔ alo nunyiametike siwo ate ŋu akpe ɖe ame ŋu le atikewɔwɔ ƒe nɔnɔme aɖewo me. Womekafui be woazã wo ɖeɖeko na blanuiléle o. Gake woate ŋu azã wo kpe ɖe atikewɔwɔ veviwo ŋu, abe alesi wò ɖɔkta ɖo aɖaŋue ene.

• SAMe (S-adenosyl-methionine): Atike si ŋutilã wɔna si kpena ɖe ame ŋu wòwɔa ahɔhɔ̃mekawo.
• Omega-3 Fatty Acids: Esiawo, vevietɔ esiwo le tɔmelãmi me, ate ŋu akpe ɖe ame ŋu be ahɔhɔ̃a ƒe dɔdzẽ aɖewo dzi naɖe akpɔtɔ.
• Vitamin D: Numekukuwo ɖee fia be kadodo le vitamin sia si wokpɔna tso ɣe ƒe keklẽ me ƒe anyimanɔmanɔ kple blanuiléle dome.

Gake ɖo ŋku edzi be menyo be nàxɔ nusiawo le wò ŋutɔ wò didi nu o. Ðo dze kple wò ɖɔkta eye nàzã wo ne elɔ̃ ɖe edzi ko. Elabena ɣeaɖewoɣi la, esiawo ate ŋu awɔ dɔ kple atike bubu siwo nèzãna.