Yana da wuya a faɗi baƙin cikin da kake ji idan ka ga wani ɗan uwa ko aboki na kud da kud yana manta komai a hankali kuma ya kasa yin ayyukan yau da kullun da kansa. Cutar Alzheimer cuta ce mai matuƙar ban tausayi. Har zuwa yanzu, akwai magunguna kawai da ke sarrafa alamun cutar, amma yanzu duniya tana magana game da sabon magani wanda ke kai tsaye kan dalilin wannan cuta. A yau muna magana ne game da wannan sabon bege, wanda shine maganin Anti-Amyloid.
A taƙaice dai, menene wannan maganin Anti-Amyloid?
A cikin kwakwalwar wani da ke fama da cutar Alzheimer, wani nau'in furotin da ake kira "beta-amyloid" yana taruwa ba tare da wani dalili ba. Ka yi tunanin hakan kamar wutar lantarki da ke ratsa wayar lantarki, wato yadda bayanai ke tafiya tsakanin ƙwayoyin jijiyoyi a cikin kwakwalwarmu. Wannan furotin na "beta-amyloid" yana taruwa kuma yana samar da "alamu" masu kama da tsatsa tsakanin waɗannan ƙwayoyin jijiyoyi. Wannan yana kawo cikas ga kwararar bayanai. Wannan shine babban dalilin rashin tunawa da hankali da rashin iya tunani sosai.
Wannan sabon nau'in magunguna, wanda ake kira anti-amyloid, yana aiki ta hanyar cire tarin ƙwayoyin cuta na 'beta-amyloid' daga kwakwalwa. Wannan yana nufin yana kai hari ga tushen cutar maimakon kawai rage alamun. Fatan shine ta hanyar cire waɗannan ƙwayoyin cuta, ƙwayoyin kwakwalwa za su iya aiki cikin koshin lafiya na tsawon lokaci.
Waɗannan a zahiri suna cikin rukunin magunguna da ake kira 'immunotherapy'. A taƙaice, ana ba da waɗannan magunguna a matsayin nau'in antibody (monoclonal antibody) wanda aka yi musamman a cikin dakin gwaje-gwaje. Lokacin da waɗannan antibody suka shiga jikinmu, suna gano waɗannan sunadaran 'beta-amyloid' masu cutarwa, suna manne musu, kuma suna lalata su.
Manyan magungunan hana amyloid guda biyu da aka amince da su a yanzu sune `donanemab (Kisunla)` da `lecanemab-irmb (Leqembi)`. Akwai kuma wani magani mai suna `aducanumab (Aduhelm),` amma yanzu kamfanin da ya ƙera shi ya janye shi daga kasuwa.
Ta yaya zan sami wannan maganin? Akwai wasu illoli?
Ana ba da wannan maganin ta hanyar maganin saline (jiko na IV) a cikin jijiya. Wannan yana ɗaukar kimanin awa ɗaya. Yawanci ana ba da 'Leqembi' duk bayan makonni biyu, kuma yawanci ana ba da 'Kisunla' duk bayan makonni huɗu. Za ku fara da ƙaramin allurai kuma a hankali ku ƙara shi zuwa ga maganin da likitanku ya umarta.
Amma kana buƙatar sanin babban haɗarin da ke tattare da wannan magani. Ana kiransa `ARIA (Amyloid-Related Imaging Abnormalities)`.
A taƙaice dai, wannan na iya haifar da kumburi a kwakwalwa ko ƙananan tabo na zubar jini a cikin kwakwalwa. Ko da yake wannan yakan magance shi da kansa, yana da muhimmanci a kula da wannan. Shi ya sa ya kamata a riƙa yin gwajin MRI na kwakwalwa akai-akai a duk lokacin da ake yin wannan magani.
| Nau'in illa | Bayani |
|---|---|
| ARIA (babban haɗari) | Kumburi ko ƙaramin zubar jini a cikin kwakwalwa. Wannan na iya haifar da ciwon kai, jiri, tashin zuciya, ruɗani, da matsalolin gani. |
| Sauran illolin da ke tattare da hakan | - Rashin lafiyan halayen - Ruwan sama - Gudawa |
| Kulawa ta musamman | Masana kimiyya suna zargin cewa wannan maganin na iya ƙara haɗarin zubar jini a kwakwalwa idan aka ba wa wani da ke shan magungunan rage radadi. Ya kamata ka yi magana da likitanka game da wannan. |
Yaya wannan maganin yake da tasiri sosai?
Ga ɓangaren mai wahala. Bincike ya nuna cewa waɗannan magunguna na iya cire alamun "beta-amyloid" a cikin kwakwalwa. Wannan abu ne mai kyau.
Duk da haka, har yanzu akwai bambancin ra'ayi game da yadda ƙwaƙwalwar majiyyaci da ikon yin ayyukan yau da kullun za su inganta bayan cire waɗannan alamun. Wasu bincike sun nuna cewa waɗannan na iya ɗan rage ci gaban cutar. Wannan ba yana nufin cewa cutar ta warke gaba ɗaya ba, amma yana rage jinkirin cutar daga ƙara muni.
Masana kimiyya sun yi imanin cewa za a iya tsammanin samun sakamako mafi girma idan aka fara wannan maganin a farkon matakin cutar , kafin a sami mummunan lahani ga kwakwalwa.
Wa zai iya samun wannan maganin?
Wannan ba magani bane da za a iya bai wa kowanne mai cutar Alzheimer. A halin yanzu, ana ba da shawarar waɗannan ga mutane ƙalilan ne kawai.
- Ga mutanen da ke cikin farkon cutar: Wato, waɗanda ke da cutar Alzheimer da wuri ko kuma waɗanda ke da wata cuta da ake kira 'ƙananan raunin fahimta'. Ba a san ko wannan zai yi amfani ga mutanen da ke da cutar da ta fi tsanani ba.
- Ga waɗanda aka tabbatar suna da amyloid plaques:Kafin likitanka ya rubuta maka wannan maganin, yana buƙatar tabbatar da ko waɗannan alamun suna nan a cikin kwakwalwarka. Wannan na iya haɗawa da gwajin PET ko kuma na'urar duba kashin baya.
Wa ba zai iya samun wannan maganin ba?
Ba a yi nazarin wannan maganin a gwaje-gwaje da yawa na asibiti ba, don haka yana iya zama da haɗari a ba wa mutanen da ke da waɗannan matsalolin lafiya wannan magani:
- Mutane suna shan magunguna da ke hana zubar jini (banda aspirin).
- Waɗanda suka taɓa fama da ciwon zuciya ko bugun jini a baya.
- Mutane masu fama da matsalar zubar jini.
- Mutane masu cutar koda ko hanta.
Wani abu kuma shi ne, waɗannan magunguna suna da tsada sosai . A ƙasa kamar Sri Lanka, yana iya zama da wahala ga mutane da yawa su sami waɗannan. Waɗannan ba su ma zama ruwan dare a yanzu ba.
Saƙon Ɗauka Gida
- Maganin hana amyloid wani sabon nau'in magani ne da ke cire alamun "beta-amyloid" da ke taruwa a cikin kwakwalwa kuma suna iya haifar da cutar Alzheimer.
- Wannan yana nufin magance matsalar da ke haifar da ita maimakon magance ta.
- Ana iya ba da wannan ga marasa lafiya waɗanda ke cikin matakin farko na cutar kuma waɗanda aka tabbatar suna da alamun cutar a cikin kwakwalwa.
- Saboda haɗarin kumburin kwakwalwa ko zubar jini a ARIA, kulawa akai-akai tare da duban MRI yana da mahimmanci yayin magani.
- Ka fahimci cewa wannan maganin har yanzu yana cikin matakin bincike, yana da tsada sosai, kuma yana samuwa ga mutane ƙalilan ne kawai .
- Idan wani ƙaunatacce yana da alamun cutar Alzheimer, abin da ya fi dacewa shi ne yin magana da likitanka game da ƙarin bayani da zaɓuɓɓukan magani da suka dace da kai.
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