Tej zaum ib tug kws kho mob tau tham nrog ib tug neeg hauv tsev neeg lossis phooj ywg txog 'kev hloov hlwb hlwb'. Los yog tej zaum koj tau raug qhia txog kev kho mob no rau ib qho mob xws li mob ntshav dawb. Nws yog ib qho ib txwm muaj uas yuav ntshai thiab ntxhov siab me ntsis thaum koj hnov lub npe no. Tab sis qhov no yog ib qho kev kho mob tseem ceeb heev uas tuaj yeem cawm tau ntau tus neeg txoj sia. Yog li hnub no, cia peb tham yooj yim thiab meej meej txog qhov 'Kev Hloov hlwb hlwb Allogeneic' no yog dab tsi, nws ua li cas, thiab dab tsi yog qhov txaus ntshai.
Hauv lwm lo lus, kev hloov pauv hlwb allogeneic yog dab tsi?
Qhov no yooj yim to taub heev. Kev hloov hlwb hlwb allogeneic yog thaum koj cov hlwb hlwb uas muaj mob raug tshem tawm thiab hloov nrog cov hlwb hlwb los ntawm tus neeg pub dawb uas noj qab nyob zoo thiab sib haum. Cov hlwb hlwb no yog ib hom hlwb tshwj xeeb uas pom muaj nyob hauv peb cov pob txha uas tuaj yeem loj hlob mus ua txhua hom hlwb ntshav (cov hlwb ntshav liab, cov hlwb ntshav dawb, thiab cov hlwb ntshav).
Thaum cov qe ntshav dawb no nkag mus rau hauv koj lub cev, lawv mus rau koj cov pob txha thiab pib tsim cov qe ntshav tshiab. Qhov no yog ib txoj kev kho mob zoo uas tuaj yeem kho tau qee yam kab mob loj heev. Cov kws kho mob feem ntau siv txoj kev kho mob no thaum lwm yam kev kho mob tsis ua haujlwm lossis thaum tus kab mob rov tshwm sim dua.
Kev kho mob no siv rau cov mob twg?
Kev hloov pauv hlwb Allogeneic feem ntau yog siv rau cov kab mob ntsig txog cov ntshav thiab lub cev tiv thaiv kab mob.
| Cov mob tseem ceeb tau kho |
|---|
| Kab mob qog ntshav Lymphoblastic loj heev (ALL) |
| Kab mob ntshav dawb Acute Myeloid Leukemia (AML) |
| Aplastic Anemia - Kev ua haujlwm tsis zoo ntawm cov pob txha |
| Lymphoma - mob qog nqaij hlav ntawm cov qog ntshav |
| Myelodysplastic Syndrome |
| Cov qog nqaij hlav Myeloproliferative (MPN) |
| Kab mob hlwb Sickle |
Koj npaj li cas ua ntej kev kho mob?
Vim qhov no yog ib qho kev kho mob loj, cov kws kho mob yuav ua ntau qhov kev kuaj xyuas los xyuas koj lub cev kom noj qab haus huv ua ntej ua qhov txheej txheem kom paub tseeb tias koj tuaj yeem nyiaj tau cov kev mob tshwm sim ntawm kev kho mob.
Cov kev ntsuam xyuas tseem ceeb uas tau ua
Koj pab neeg kho mob yuav ua ntau yam kev kuaj mob, xws li:
- Kev suav cov ntshav tag nrho (CBC): Xyuas koj cov qe ntshav liab, qe ntshav dawb, thiab cov platelet.
- Echocardiogram: Saib seb lub plawv ua haujlwm zoo li cas.
- Electrocardiogram (EKG): Xyuas seb lub plawv ua haujlwm li cas.
- Kev kuaj mob siab thiab lub raum ua haujlwm.
- Kev Kuaj Mob Pob Txha: Yog tias koj muaj mob qog noj ntshav, yuav muab ib qho qauv me me ntawm koj cov pob txha coj mus kuaj. Qhov no pab soj ntsuam kev hloov pauv ntawm tus kab mob thiab qhov kev pheej hmoo ntawm tus kab mob rov qab los tom qab kev kho mob.
Kev Kho Mob Ua Ntej Hloov Pauv
Tom qab cov kev kuaj no, koj yuav raug xa mus rau tsev kho mob thiab muab kev kho mob hu ua 'conditioning'. Qhov no suav nrog kev siv tshuaj kho mob hnyav thiab/lossis kev kho mob hluav taws xob thoob plaws lub cev . Qhov no muaj peb lub hom phiaj:
1. Tua cov hlwb qog nqaij hlav uas tseem tshuav nyob hauv koj lub cev.
2. Ua chaw rau koj cov pob txha kom cov hlwb tshiab loj hlob.
3. Ua rau koj lub cev tiv thaiv kab mob tsis muaj zog. Qhov no ua rau koj lub cev tsis muaj peev xwm tawm tsam (tsis lees txais) cov hlwb tshiab.
Cov txheej txheem no feem ntau siv sijhawm ib lossis ob lub lis piam.
Muaj dab tsi tshwm sim thaum lub sijhawm hloov pauv stem cell?
Qhov no tsis mob heev. Koj pab neeg kho mob yuav muab ib lub raj me me hu ua lub catheter central venous (CVC) ntxig rau hauv ib txoj hlab ntsha loj hauv koj lub hauv siab sab saud. Cov hlwb tshiab yuav raug muab rau koj lub cev los ntawm lub raj no.
Nws yog ib qho txheej txheem yooj yim, ib yam li kev pub ntshav. Cov noob caj noob ces noj qab haus huv hauv lub hnab saline raug txhaj rau hauv koj cov ntshav los ntawm lub raj CVC. Los ntawm qhov ntawd, lawv mus rau koj cov pob txha.
Cov txheej txheem no siv sijhawm li 30 txog 60 feeb. Thaum lub sijhawm no, pab pawg kho mob yuav zaum ntawm koj ib sab thiab saib xyuas koj cov cim qhia tseem ceeb. Lawv kuj tseem yuav saib xyuas ze rau txhua yam kev mob tshwm sim. Cov kev mob tshwm sim tsis tshua muaj thiab feem ntau yog me me. Piv txwv li, koj yuav hnov me ntsis tshee hnyo, ua pa nyuaj, lossis kub taub hau.
Qhov teeb meem tseem ceeb ntawm kev kho mob no yog dab tsi?
Qhov teeb meem loj tshaj plaws thiab hnyav tshaj plaws ntawm kev hloov pauv allogeneic yog kab mob graft-versus-host (GVHD) .
Hais yooj yim xwb, qhov no yog thaum cov qe ntshav dawb tshiab uas noj qab nyob zoo los ntawm tus neeg pub (qhov graft) pib tawm tsam cov qe ntshav dawb thiab cov nqaij hauv koj lub cev (tus tswv tsev). Nws zoo li ib pab tub rog tshiab tawm tsam cov neeg hauv koj lub tebchaws. Tus mob no tuaj yeem cuam tshuam rau daim tawv nqaij, daim siab, thiab lub plab zom mov. Tab sis koj tsis tas yuav txhawj, cov kws kho mob tuaj yeem muab cov tshuaj tsim nyog rau koj los tswj thiab kho tus mob no.
Tom qab kho tas lawm, yuav ua li cas? Yuav siv sijhawm ntev npaum li cas mam li rov zoo?
Tom qab hloov hlwb, koj yuav tsum tau nyob hauv tsev kho mob ob peb lub lis piam. Lub sijhawm ntawd, pab pawg kws kho mob yuav saib xyuas koj zoo. Koj yuav txuas ntxiv mus noj cov tshuaj tiv thaiv kab mob kom tiv thaiv koj lub cev tsis pub cov hlwb tshiab hloov hlwb. Tej zaum koj yuav xav tau kev hloov ntshav kom txog thaum cov hlwb tshiab muaj peev xwm tsim cov hlwb tshiab.
Cov txheej txheem uas cov hlwb tshiab nkag mus rau hauv cov pob txha thiab pib ua cov hlwb ntshav tshiab hu ua 'engraftment' . Qhov no tuaj yeem siv sijhawm li 10 txog 14 hnub. Txawm li cas los xij, nws tuaj yeem siv sijhawm ntau lub hlis txog ib xyoos lossis ntau dua rau koj lub cev tiv thaiv kab mob kom rov zoo. Thaum lub sijhawm no, nws yog ib qho tseem ceeb heev uas yuav tsum tiv thaiv koj tus kheej ntawm kev kis kab mob.
Nws yuav siv sijhawm ob xyoos lossis ntau dua kom rov zoo tag nrho, yog li qhov no yog ib txoj kev taug kev uas yuav tsum tau ua siab ntev thiab ua raws li koj tus kws kho mob cov lus qhia.
Cov tsos mob dab tsi uas yuav tsum tau mus ntsib kws kho mob tam sim ntawd?
Thaum koj mus tsev tom qab kho mob tas, koj yuav tsum tau ua tib zoo saib xyuas koj lub cev. Yog tias koj muaj ib qho ntawm cov tsos mob hauv qab no, hu rau koj pab neeg kho mob tam sim ntawd .
| Pawg tsos mob | Cov yam ntxwv uas yuav tsum tau saib xyuas |
|---|---|
| Tej zaum yuav muaj cov tsos mob ntawm tus kab mob graft-versus-host (GVHD) | |
| Kev zom zaub mov | Mob plab, raws plab, xeev siab, thiab ntuav. |
| Tawv nqaij thiab qhov muag | Khaus thiab tev tawv nqaij, tawv nqaij thiab/lossis qhov muag daj (jaundice). |
| Tej zaum yuav muaj cov cim qhia tias muaj kab mob | |
| Cov yam ntxwv dav dav | Kub taub hau txog 38 Celsius (100.4 Fahrenheit) lossis siab dua, mob khaub thuas, hnoos, txham, ntswg ntws. |
| Lwm yam nta | Kiv taub hau , ua pa nyuaj, tso zis ntau zaus, lossis kub hnyiab thaum tso zis. |
Qhov txawv ntawm allogeneic thiab autologous transplants yog dab tsi?
Qhov sib txawv tseem ceeb ntawm ob qho no yog qhov chaw ntawm cov hlwb noob.
Kev hloov pauv Allogeneic: Cov hlwb noob tau txais los ntawm lwm tus (tus neeg pub).
Kev hloov pauv los ntawm koj tus kheej: Cov noob hlwb raug coj los ntawm koj (koj cov noob hlwb raug coj ua ntej koj tau txais kev kho mob chemotherapy muaj zog, thiab tom qab ntawd rov muab tso rau hauv koj lub cev).
Kev hloov pauv allogeneic tuaj yeem kho tau qee yam kab mob uas ua rau tuag taus. Qhov no feem ntau ua tau los ntawm kev siab zoo ntawm cov neeg txawv teb chaws. Cov no yog cov neeg uas pub cov hlwb stem cell. Qee zaum cov neeg pub yog cov tswv cuab hauv tsev neeg. Muaj kev pheej hmoo koom nrog hauv kev txais cov hlwb pub dawb. Siv sijhawm los nkag siab txog cov txiaj ntsig thiab kev pheej hmoo ntawm txoj kev kho mob no. Koj tus kws kho mob tuaj yeem pab koj ntsuas qhov kev pheej hmoo thiab cov txiaj ntsig kom koj tuaj yeem ntseeg siab rau koj qhov kev txiav txim siab.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Kev hloov hlwb allogeneic yog ib txoj kev siv cov hlwb noj qab haus huv los ntawm lwm tus neeg los kho cov kab mob ntshav hnyav xws li mob leukemia.
- Ua ntej kev kho mob, lub cev tau npaj los ntawm kev kho mob muaj zog xws li chemotherapy.
- Muaj kev pheej hmoo tias cov hlwb ntawm tus neeg pub yuav tawm tsam tus neeg mob lub cev (kab mob graft-versus-host), tab sis cov kws kho mob ceev faj heev txog qhov no.
- Yuav siv sijhawm ntev heev kom rov zoo tag nrho, thiab kev ua raws li cov lus qhia kho mob thiab kev kuaj mob tsis tu ncua yog qhov tseem ceeb thaum lub sijhawm no.
- Tham nrog koj tus kws kho mob txog tej lus nug, kev ntshai, lossis kev txhawj xeeb uas koj muaj. Qhov ntawd yog qhov chaw zoo tshaj plaws kom tau txais cov ntaub ntawv tseeb tshaj plaws thiab kev pab.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus