Koj puas paub txog tus mob tsis tshua muaj no hu ua Carney Complex?

Koj daim tawv nqaij puas tau hloov pauv sai sai, lossis koj puas tau pom cov pob lossis qhov tsis zoo txawv txawv? Los yog koj puas tau pom cov pob me me ntawm koj lub cev? Tej zaum koj yuav txhawj me ntsis. Qee zaum peb tsis tau ua tib zoo saib xyuas cov tsos mob no. Txawm li cas los xij, tom qab cov tsos mob no, tej zaum yuav muaj ib qho mob tsis tshua muaj hu ua Carney Complex uas xav tau kev saib xyuas tshwj xeeb. Tsis txhob txhawj, peb yuav tham txog qhov no yooj yim thiab hauv txoj kev uas koj tuaj yeem nkag siab.

Carney Complex yog dab tsi tiag?

Hais yooj yim xwb, Carney Complex yog ib yam mob uas cuam tshuam rau peb cov xim tawv nqaij thiab ua rau muaj cov qog nqaij hlav uas tsis yog mob qog noj ntshav (benign), uas yog, cov qog nqaij hlav uas feem ntau tsis txaus ntshai, tsim nyob rau hauv lub cev cov nqaij sib txuas thiab cov qog endocrine. Qhov no feem ntau yog tshwm sim los ntawm kev ua rau caj ces. Uas yog, nws yog tshwm sim los ntawm kev hloov pauv (kev hloov pauv) hauv ib qho gene uas tau txais los ntawm niam txiv mus rau cov menyuam.

Puas muaj lwm lub npe rau qhov no?

Yog, Carney Complex kuj muaj ntau lub npe hu ua lwm yam. Koj tus kws kho mob yuav siv ib lub npe no:

• Kab mob Carney
• Kab mob NAME - Cov tsiaj ntawv NAME sawv cev rau nevi (cov pob zoo li cim yug), atrial myxoma (ib hom qog uas tshwm sim hauv lub plawv), myxoid neurofibromas (ib hom qog uas cuam tshuam nrog cov hlab ntsha), thiab ephelides (cov pob).
• LAMB syndrome - Qhov no kuj sawv cev rau lentigines (cov pob xim av), atrial myxoma, thiab blue nevi (cov cim xiav ntawm lub cev yug).

Leej twg thiaj muaj tus mob Carney syndrome? Nws tshwm sim ntau npaum li cas?

Carney Complex yog ib yam mob uas tshwm sim rau cov neeg uas yug los muaj kev hloov pauv tshwj xeeb ntawm cov noob caj noob ces. Txawm li cas los xij, ntau tus neeg yuav tsis paub tias lawv muaj tus mob no kom txog thaum cov tsos mob tshwm sim. Txawm hais tias cov tsos mob no tuaj yeem tshwm sim txhua lub sijhawm thaum yau, feem ntau cov kws kho mob kuaj pom tias cov neeg muaj hnub nyoog li ntawm 20 xyoo.

Yog hais txog qhov no tshwm sim ntau npaum li cas, Carney Complex yeej yog ib qho mob tsis tshua muaj . Xav txog seb muaj tsawg dua 750 tus neeg hauv ntiaj teb uas tau kuaj pom tias muaj tus mob no. Yog li ntawd, tsis tas yuav ntshai txog nws, tab sis nws yog ib qho tseem ceeb uas yuav tsum paub.

Vim li cas qhov Carney Complex no thiaj li tshwm sim? Yog vim li cas?

Carney Complex yog ib qho kab mob caj ces.. Qhov mob no feem ntau yog tshwm sim los ntawm kev hloov pauv hauv ib lub noob hu ua '(PRKAR1A gene)'. Cov DNA hauv cov noob no qhia peb lub cev txog yuav ua li cas los tsim ib qho enzyme uas tswj ib qho protein. Xav txog cov noob no ua chav tswj hwm tseem ceeb ntawm lub Hoobkas. Yog tias muaj kev hloov pauv hauv '(PRKAR1A gene)' no, cov protein uas cuam tshuam nrog cov enzyme ntawd yuav tsis tuaj yeem tswj tau zoo. Tom qab ntawd cov cell pib loj hlob tsis tuaj yeem tswj tau thiab ntau dhau. Yog li ntawd cov khoom zoo li qog pib tsim.

Feem ntau, kwv yees li 70% , Carney Complex yog tshwm sim los ntawm tus menyuam tau txais qhov kev hloov pauv caj ces no los ntawm ib tug ntawm lawv niam lawv txiv. Txawm li cas los xij, rau qee tus neeg, qhov mob no yog tshwm sim los ntawm kev hloov pauv caj ces tshiab, txhais tau tias nws tsis yog tau txais los ntawm niam txiv.

Cov kev hloov pauv caj ces no puas yog tib qho ua rau muaj qhov no xwb?

Tsis yog txhua tus neeg uas muaj Carney Complex yuav muaj kev hloov pauv ntawm cov noob caj noob ces. Cov kws tshawb fawb ntseeg tias qhov mob no kuj tseem yuav yog los ntawm kev hloov pauv ntawm ib feem ntawm cov chromosome (lub molecule uas muaj cov noob caj noob ces). Txawm li cas los xij, kev tshawb fawb txog qhov no tseem tab tom ua mus.

Cov tsos mob tseem ceeb ntawm Carney Complex yog dab tsi?

Yog tias koj muaj Carney syndrome, koj yuav pom qee qhov kev hloov pauv ntawm koj cov xim tawv nqaij.

• Cov quav hnav thiab cov lentigines: Cov no tuaj yeem tshwm sim txhua qhov chaw ntawm lub cev, tab sis feem ntau pom ntawm:
• Nyob ib ncig ntawm lub qhov muag
• Daim di ncauj ntswj.
• Nyob ib ncig ntawm thaj chaw mos. Cov pob no yuav zoo li cov pob me me xim av, xim zoo li taum kas fes.
• Cov pob liab xiav: Qee zaum cov cim yug me nyuam xiav lossis dub tuaj yeem tshwm sim ntawm daim tawv nqaij.

Cov tsos mob ntxiv rau qhov kev hloov pauv ntawm daim tawv nqaij yog dab tsi?

Ib txhia neeg uas muaj Carney Complex yuav mob plawv myxomas. Cov no tuaj yeem ua rau muaj kev phom sij heev thiab xav tau kev saib xyuas tshwj xeeb. Tsis tas li ntawd, cov qog nqaij hlav tuaj yeem tshwm sim rau ntau qhov chaw. Piv txwv li:

• Cov pob txha
• Lub mis
• Qhov chaw mos
• Cov qog tsim cov tshuaj hormones (endocrine system) - piv txwv li, cov qog thyroid thiab cov qog adrenal.
• Lub paj hlwb
• Tawv nqaij
• Sab saud ntawm lub caj pas (oropharynx)

Qhov tseem ceeb yog tias feem ntau cov qog uas loj hlob li no tsis yog mob qog noj ntshav (benign). Qhov ntawd txhais tau tias lawv tsis ua rau muaj kev phom sij ntau. Txawm li cas los xij, qee zaum, qee cov qog tuaj yeem dhau los ua mob qog noj ntshav (malignant) . Yog vim li ntawd nws thiaj li tseem ceeb kom mus kuaj mob tsis tu ncua.

Qhov no puas yog ib yam kab mob sib kis tau?

Tsis yog, tsis yog li ntawd. Carney Complex tsis yog ib yam kab mob sib kis tau . Koj yuav tsis kis tau los ntawm ib tus neeg uas muaj tus mob no.

Yuav kuaj mob no li cas thiaj paub tseeb? (Kev kuaj mob)

Yog koj lossis koj tus kws kho mob xav tias koj muaj Carney Complex, koj tus kws kho mob yuav kuaj koj lub cev ua ntej. Lawv kuj yuav nug txog koj keeb kwm tsev neeg. Tej zaum yuav xav tau kev kuaj noob caj noob ces kom paub tseeb tias koj tau kuaj mob.

Cov kev kuaj twg siv los kuaj mob?

Nyob ntawm seb koj lossis koj tus menyuam muaj cov tsos mob li cas, cov kws kho mob yuav pom zoo kom kuaj ntau yam. Qee qhov ntawm cov no suav nrog:

• Echocardiogram: Qhov no yog kev ntsuas los xyuas seb lub plawv ua haujlwm li cas. Qhov no tseem ceeb heev rau kev kuaj xyuas cov qog nqaij hlav hauv plawv.
• Kev kuaj ntshav thiab zis: Cov kev kuaj no yog ua los xyuas qee cov tshuaj hormones.
• Ntau yam kev kuaj duab: Cov kev kuaj xws li ultrasound, CT scan, MRI, thiab X-ray yog siv los saib seb puas muaj qog nqaij hlav hauv lub cev.
• Kev kuaj daim tawv nqaij: Yog tias muaj qhov mob lossis kev loj hlob ntawm daim tawv nqaij, yuav muab ib qho qauv me me ntawm daim tawv nqaij coj mus kuaj hauv qab lub tshuab kuaj mob me me.
• Kev kuaj noob caj noob ces: Qhov no yog qhov tseem ceeb los xyuas kom meej tias puas muaj kev hloov pauv hauv '(PRKAR1A gene)'.

Cov kev kho mob rau Carney Complex yog dab tsi?

Tus kws kho mob yuav pom zoo kom kho raws li cov tsos mob tshwj xeeb uas koj lossis koj tus menyuam muaj. Feem ntau:

• Phais plawv qhib kom tshem tawm cov qog nqaij hlav hauv plawv: Cov qog nqaij hlav hauv plawv tuaj yeem ua rau muaj kev phom sij thiab yuav tsum tau phais kom tshem tawm.
• Kev phais kom tshem tawm cov qog ntawm daim tawv nqaij lossis qee cov qog: Cov qog ntawm daim tawv nqaij lossis cov qog ntawm cov qog hormone kuj raug tshem tawm los ntawm kev phais, yog tias tsim nyog.

Koj tus kws kho mob yuav nrog koj tham txog cov kev kho mob uas zoo tshaj plaws rau koj.

Qhov no puas kho tau tag nrho?

Kab mob Carney Complex yog ib yam mob uas yuav kho tau mus ib txhis . Qhov no txhais tau tias nws tsis tuaj yeem kho tau tag nrho. Tab sis tsis txhob txhawj, cov kws kho mob tuaj yeem pab koj tswj koj cov tsos mob thiab ua lub neej noj qab haus huv. Rau qhov no, kev kho mob kom zoo thiab kev saib xyuas mob tsis tu ncua yog qhov tseem ceeb heev.

Puas muaj txoj hauv kev los txo qhov kev pheej hmoo ntawm kev mob no?

Tsis muaj ib txoj kev twg los tiv thaiv tau tus kab mob Carney Complex vim nws yog ib yam mob uas los ntawm noob caj noob ces. Txawm li cas los xij, yog tias koj cev xeeb tub, koj tuaj yeem ua qhov kev kuaj hu ua genetic amniocentesis kom pom tias koj tus menyuam puas muaj kev hloov pauv noob caj noob ces.

Kuv yuav paub li cas yog tias kuv muaj feem yuav muaj tus kab mob no?

Yog tias muaj leej twg hauv koj tsev neeg - tshwj xeeb tshaj yog koj niam koj txiv - muaj Carney Complex, nws yog ib qho tseem ceeb heev uas yuav tsum tham nrog koj tus kws kho mob txog qhov no kom thiaj li ua tau cov kev kuaj mob tsim nyog.

Yog tias kuv muaj Carney Complex, kuv yuav tsum xav li cas?

Yog koj muaj mob Carney Complex, koj yuav tsum qhia rau koj tus kws kho mob tam sim ntawd yog tias koj muaj cov tsos mob tshiab. Koj tus kws kho mob kuj tseem yuav pom zoo kom kuaj xyuas koj cov tshuaj hormones thiab kev noj qab haus huv tag nrho. Piv txwv li:

• Ib xyoos ib zaug echocardiogram .
• Kev kuaj ntshav.
• Kev ntsuam xyuas ntawm endocrine system.
• Kev kuaj xyuas daim tawv nqaij.
• Rau cov txiv neej, kev kuaj mob noob qes lossis ultrasound.

Kuv yuav tau nyob nrog tus mob no ntev npaum li cas?

Raws li tau hais ua ntej lawm, Carney Complex yog ib yam mob uas yuav kho tau mus ib txhis . Koj tus kws kho mob yuav yog tus khub tseem ceeb heev rau kev tswj koj cov tsos mob thiab kom noj qab nyob zoo.

Yuav hais li cas txog lub neej ntev ntawm cov neeg uas muaj tus kab mob no?

Cov neeg uas muaj Carney Complex tuaj yeem ua neej nyob tau ib lub neej li qub , tab sis qhov tseem ceeb tshaj plaws yog mus kuaj mob tsis tu ncua thiab ua raws li cov lus qhia ntawm kws kho mob.

Cov qog nqaij hlav puas rov qab los tom qab kho tas?

Yog, hmoov tsis zoo, qee zaum cov qog tuaj yeem rov tshwm sim tom qab kho mob. Yog vim li cas kev kuaj mob tsis tu ncua yog qhov tseem ceeb.

Carney Complex puas yog mob qog noj ntshav?

Feem ntau, cov qog uas tshwm sim hauv Carney Complex yog cov qog tsis muaj teeb meem loj . Qhov no txhais tau tias lawv tsis ua rau muaj kev puas tsuaj loj. Txawm li cas los xij, dhau sijhawm, qee cov qog tuaj yeem dhau los ua mob qog noj ntshav / mob qog noj ntshav . Yog li ntawd, nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob txog cov tsos mob tshiab thiab kom tau txais txhua qhov kev kuaj mob tsim nyog.

Cov teeb meem dab tsi uas yuav tshwm sim los ntawm Carney Complex?

Yog, qhov mob no tuaj yeem ua rau muaj qee yam teeb meem.

• Yog tias koj muaj ib qho qog hauv koj lub qog pituitary (ib feem ntawm lub endocrine system), nws tuaj yeem cuam tshuam rau koj lub cev tsim cov tshuaj hormones loj hlob. Yog tias cov tshuaj hormones loj hlob ntau dhau, cov xwm txheej hauv qab no tuaj yeem tshwm sim:
• Mob pob qij txha
• Kev hloov pauv ntawm lub ntsej muag
• Kev loj hlob tsis zoo ntawm tes thiab taw (acromegaly)
• Yog tias cov qog tsim nyob rau hauv lwm cov qog endocrine, lawv tuaj yeem ua rau muaj cov mob xws li:
• Cushing's syndrome
• Mob qog nqaij hlav Sertoli uas loj hlob hauv cov noob qes ( large cell calcifying Sertoli cell tumor )
• Kab mob qog nqaij hlav ntawm cov qog adrenal uas muaj xim thawj zaug (primary pigmented nodular adrenocortical disease )
• Schwannomas(Ib hom qog uas loj hlob ntawm cov hlab ntsha)
• Cov qog hauv cov thyroid ( cov qog hauv cov thyroid caj pas)

Txawm hais tias qhov no yuav zoo li nyuaj me ntsis los xij, nws yog txhua yam cuam tshuam nrog lub cev hormones. Yog vim li ntawd nws thiaj li pom zoo kom kuaj xyuas koj cov tshuaj hormones tsis tu ncua.

Thaum twg ib tug neeg uas muaj mob Carney Complex yuav tsum mus ntsib kws kho mob?

Ua raws li koj tus kws kho mob cov lus qhia kom meej. Tsis txhob hla dhau qhov kev kuaj mob uas tau teem tseg thiab kev teem sijhawm rov qab mus ntsib kws kho mob rau txhua qhov laj thawj . Yog tias koj muaj cov tsos mob tshiab, qhia rau koj tus kws kho mob tam sim ntawd.

Qhov no puas ua rau muaj xwm txheej ceev?

Yog, qee zaum muaj xwm txheej ceev tshwm sim. Cov qog nqaij hlav, tshwj xeeb tshaj yog cov uas tsim nyob rau hauv lub plawv, tuaj yeem thaiv cov ntshav ntws. Qhov no tuaj yeem ua rau muaj cov mob hnyav xws li mob stroke , lub plawv tsis ua haujlwm , lossis lub plawv nres tam sim ntawd . Yog li ntawd, nrhiav kev kho mob tam sim ntawd yog tias koj muaj ib qho ntawm cov tsos mob no:

• Kev hloov pauv hauv koj lub plawv dhia
• Hnoos los yog ua pa nrov nrov
• qaug zog ntau zaus
• Ua tsis taus pa
• Kev o ntawm lub cev - tshwj xeeb tshaj yog nyob rau hauv lub plab, pob luj taws, lossis taw.

Cov Lus Xaus Kawg coj mus tsev

Carney Complex yog ib qho mob caj ces tsawg heev uas ua rau daim tawv nqaij tsis zoo thiab muaj qog nqaij hlav hauv ntau qhov ntawm lub cev, tshwj xeeb tshaj yog lub plawv thiab endocrine system. Yog tias cov qog nqaij hlav no ua rau muaj teeb meem, cov kws kho mob tuaj yeem phais tshem tawm.

Txawm hais tias qhov no yog ib qho mob uas yuav kav ntev mus ib txhis los xij, los ntawm kev ua raws li cov lus qhia kho mob kom zoo thiab mus kuaj mob tsis tu ncua, koj lossis koj tus menyuam tuaj yeem ua neej noj qab nyob zoo. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum mloog koj tus kws kho mob hais thiab ua raws li qhov ntawd. Tsis txhob txhawj, koj tsis nyob ib leeg, thiab cov kws kho mob yeej npaj txhij los pab koj.

Carney Complex, cov tawv nqaij ua pob, cov tawv nqaij tsis muaj xim, cov qog hauv lub cev, cov kab mob caj ces, teeb meem hormonal, kab mob plawv, PRKAR1A gene