Kev kho mob qog noj ntshav puas tuaj yeem cuam tshuam rau koj lub plawv? Cia peb tham txog kev ua rau lub plawv puas tsuaj!

Koj puas tau kho mob qog noj ntshav? Los yog koj puas paub ib tug neeg uas koj paub tau kho mob zoo li no? Qee zaum kev kho mob qog noj ntshav tuaj yeem muaj kev cuam tshuam me me rau peb lub plawv. Qhov ntawd yog qhov peb yuav tham txog hnub no. Peb hu qhov no ua rau mob plawv . Tsis txhob txhawj, cia peb nkag siab qhov no yooj yim.

Yog li ntawd, cardiotoxicity yog dab tsi?

Hais yooj yim xwb, qhov ua rau lub plawv puas tsuaj yog qhov ua rau peb lub plawv puas tsuaj los ntawm qee yam kev kho mob qog noj ntshav lossis cov tshuaj kho mob qog noj ntshav. Nco ntsoov tias, qee zaum qhov teeb meem no tuaj yeem tshwm sim txawm tias ntau xyoo tom qab kev kho mob qog noj ntshav. Qhov kev pheej hmoo no tshwj xeeb tshaj yog rau cov neeg laus uas tau kho mob qog noj ntshav thaum lawv tseem hluas, uas yog, thaum lawv tseem yog menyuam yaus. Tsis yog txhua txoj kev kho mob qog noj ntshav ua rau qhov no, tab sis muaj qee qhov kev kho mob uas muaj kev pheej hmoo siab dua ntawm kev ua rau lub plawv puas tsuaj.

Qhov mob no ua rau koj lub plawv nyuaj rau tso ntshav kom thoob plaws hauv koj lub cev. Qee zaum mob hnyav, qhov no tuaj yeem ua rau muaj kab mob plawv hu ua cardiomyopathy , uas ua rau koj lub plawv nyuaj rau tso ntshav.

Leej twg yuav raug cuam tshuam los ntawm cardiotoxicity tshaj plaws?

Qhov tseeb, txhua tus neeg uas tau kho mob qog noj ntshav muaj feem yuav mob plawv. Txawm li cas los xij, qhov kev pheej hmoo siab dua rau cov neeg uas tau siv qee yam tshuaj lossis tau kho mob hluav taws xob rau thaj tsam hauv siab.

Tsis tas li ntawd xwb, raws li tau hais ua ntej lawm, tus mob no feem ntau tshwm sim ntawm cov neeg uas tau kho mob qog noj ntshav thaum lawv tseem yog menyuam yaus, uas yog, thaum lawv laus. Nws nyuaj rau hais tias qhov no feem ntau tshwm sim li cas ntawm cov neeg uas tau kho mob qog noj ntshav thaum lawv laus. Txawm li cas los xij, raws li qee qhov kev tshaj tawm, kwv yees li 20% ntawm cov neeg no yuav ntsib kab mob plawv, thiab ntawm 7% thiab 10% yuav muaj kab mob cardiomyopathy lossis lub plawv tsis ua haujlwm. Yog li nws tseem ceeb heev uas yuav tsum paub txog qhov no.

Qhov kev mob plawv no cuam tshuam li cas rau koj lub cev?

Kev ua rau lub plawv tsis ua haujlwm zoo tuaj yeem ua rau muaj ntau yam teeb meem ntawm lub plawv. Cia peb saib seb lawv yog dab tsi:

• Cardiomyopathy: Qhov no yog thaum cov leeg nqaij ntawm lub plawv tsis muaj zog thiab lub plawv tsis tuaj yeem tso ntshav tau zoo.
• Mob plawv dhia tsis xwm yeem lossis mob plawv nres: Tej zaum koj twb tau hnov ​​txog qhov no lawm. Nws tuaj yeem tshwm sim los ntawm kev txhaws ntawm cov hlab ntsha uas muab ntshav mus rau lub plawv.
• Kab Mob Ntshav Qab Zib (Coronary Artery Disease): Kev nqaim lossis thaiv cov hlab ntsha uas nqa ntshav mus rau lub plawv.
• Kev Ua Tsis Taus Lub Plawv: Lub plawv tsis muaj peev xwm tso ntshav kom txaus rau lub cev xav tau.
• Kab Mob Plawv: Cov plawv tsis ua haujlwm zoo.
• Lub plawv dhia tsis xwm yeem (Arrhythmia):Lub plawv dhia tsis xwm yeem, txawm tias dhia qeeb qeeb, nrawm nrawm, lossis tsis muaj suab nrov.
• Cov kua dej nyob ib puag ncig lub plawv.
• Ntshav Siab Qis Los Yog Siab.
• Lub Plawv Qis.
• Constrictive Pericarditis: Hauv qhov mob no, lub membrane sab nraud ntawm lub plawv tuab zuj zus, txo qhov chaw rau lub plawv kom nthuav dav dawb.

Cov tsos mob ntawm cardiotoxicity yog dab tsi?

Muaj ntau yam tsos mob ntawm kab mob plawv uas cuam tshuam nrog kev ua rau lub plawv tsis ua haujlwm zoo. Yog tias koj muaj ib lossis ntau yam ntawm cov no, nws yog ib qho tseem ceeb uas yuav tsum txhawj xeeb:

• Mob plab: Lub plab nthuav dav mus tom ntej, zoo li lub plab nthuav dav.
• Mob Hauv Siab: Lub hauv siab yuav hnov ​​​​​​tias nruj lossis nqaim.
• Kiv taub hau.
• Lub Plawv Ntshaw: Xav txog koj lub siab zoo li koj lub plawv dhia hauv koj lub hauv siab, lossis ntaus nrov nrov.
• Ua tsis taus pa lossis ua tsis taus pa: Koj xav tias ua tsis taus pa thiab ua pa dawb paug txawm tias tom qab ua me ntsis kev ua ub ua no lawm los xij.
• Ob txhais ceg o thiab cov kua dej khaws cia (edema): Qhov o tshwm sim, tshwj xeeb tshaj yog nyob rau hauv ob txhais ceg thiab pob luj taws.

Dab tsi yog cov ua rau mob plawv (cardiotoxicity) tseem ceeb?

Muaj qee yam kev kho mob qog noj ntshav uas ua rau mob plawv. Qhov tseem ceeb tshaj plaws ntawm cov no yog:

• Cov tshuaj Anthracyclines: Piv txwv li , Doxorubicin (Adriamycin®) . Cov no yog ib hom tshuaj chemotherapy uas feem ntau siv los kho cov mob qog noj ntshav xws li leukemia, lymphoma, mob qog noj ntshav hauv lub mis, sarcoma, lossis multiple myeloma .
• Trastuzumab (Herceptin®): Qhov no yog ib hom tshuaj kho mob uas siv los kho mob qog noj ntshav hauv lub mis, qog noj ntshav hauv plab, lossis qog noj ntshav ntawm qhov chaw sib txuas ntawm cov hlab ntsha hauv plab. Muaj kev pheej hmoo ntawm kev mob plawv thiab lub plawv dhia ceev, tshwj xeeb tshaj yog thaum cov tshuaj no muab ua ke nrog tshuaj anthracycline.
• Kev Kho Mob Hluav Taws Xob rau Hauv Siab: Qhov no kuj siv los kho cov kab mob xws li mob qog noj ntshav hauv lub mis lossis mob ntshav dawb .

Cov kws kho mob kuaj mob cardiotoxicity no li cas?

Cov kws kho mob feem ntau saib seb koj lub plawv nqus ntshav tau zoo npaum li cas los txiav txim seb koj puas muaj teeb meem plawv. Qhov no ntsuas los ntawm kev sim hu ua Left Ventricular Ejection Fraction (LVEF) . Lawv kuj saib seb koj lub plawv ua haujlwm zoo npaum li cas. LVEF ntsuas seb cov ntshav raug nqus tawm ntawm lub chamber qis ntawm sab laug ntawm koj lub plawv (Left Ventricle) ntau npaum li cas ib zaug.

Muaj ntau yam kev kuaj uas cov kws kho mob siv los ntsuas cov no:

• Echocardiogram: Qhov no yog qhov kev kuaj duab tseem ceeb uas feem ntau siv los nrhiav kev ua rau lub plawv puas tsuaj. Nws siv cov electrodes thiab cov nthwv dej ultrasound los xyuas koj lub plawv dhia thiab txoj kev uas cov ntshav ntws los ntawm koj lub plawv. Nws zoo ib yam li kev luam theej duab uas tau ua rau cov niam cev xeeb tub, tab sis qhov no yog rau lub plawv.
• Kev Ntsuas MRI Rau Lub Plawv: Qee cov kws tshwj xeeb hais tias qhov no yog qhov kev kuaj mob zoo tshaj plaws rau kev kuaj mob plawv. Nws siv cov hlau nplaum, cov nthwv dej xov tooj cua, thiab lub khoos phis tawj tshwj xeeb los thaij duab ntxaws ntxaws ntawm koj lub plawv thiab ntsuas seb cov ntshav ntws li cas los ntawm nws.
• Kev Ntsuas Kev Nyuaj Siab Hauv Lub Plawv: Qhov kev ntsuas no ntsuas seb koj lub plawv teb li cas rau kev ua ub ua no hnyav. Koj raug hais kom taug kev ntawm lub treadmill lossis caij tsheb kauj vab uas nres. Thaum lub sijhawm no, koj txuas nrog lub tshuab uas ntsuas koj lub plawv dhia thiab ntshav siab.
• Multigated Acquisition Scan (MUGA): Qhov kev kuaj no ntsuas qhov ua haujlwm ntawm koj lub plawv (ventricles). Siv cov tshuaj radioactive tracer uas muaj kev nyab xeeb rau qhov no. Nws pom tseeb ntawm daim scan. Tus kws kho mob saib seb cov tshuaj tracer no txav mus los li cas hauv koj cov hlab ntsha, thiab tom qab ntawd xam koj cov ejection fraction.
• Kev Ntsuas CT ntawm Lub Plawv: Kev ntsuas CT siv cov duab X-ray los ntawm ntau lub kaum sib txawv los tsim ib daim duab ntxaws ntxaws ntawm lub plawv. Qhov kev kuaj no tuaj yeem pab tau zoo heev, tshwj xeeb tshaj yog rau cov neeg uas xav tias muaj teeb meem plawv tom qab kev kho mob hluav taws xob rau hauv siab.

Yuav kho tus mob cardiotoxicity no li cas?

Nyob ntawm seb koj tab tom noj cov tshuaj dab tsi, koj tus kws kho mob yuav pom zoo kom tsum qee cov tshuaj lossis txo lawv cov tshuaj noj. Koj tus kws kho mob kuj tseem yuav sau ntawv kom koj lub plawv ua haujlwm tau zoo dua. Piv txwv li:

• ACE inhibitors: Piv txwv li , Lisinopril (Zestril®) lossis Fosinopril Sodium (Monopril®)Okay. Cov no ua yog qhib koj cov hlab ntsha thiab ua kom cov ntshav ntws tau yooj yim dua.
• Cov tshuaj Beta-blockers: Piv txwv li , metoprolol (Lopressor®) lossis atenolol (Tenormin®) . Cov no ua rau cov ntshav ntws ntau ntxiv thiab ua rau lub plawv dhia qeeb.
• Digoxin, tseem hu ua Digitalis (Lanoxin®): Qhov no ua rau lub plawv dhia qeeb thiab pab kom lub plawv dhia zoo dua.
• Cov tshuaj diuretics (tseem hu ua cov tshuaj ntsiav dej): Piv txwv li , Furosemide (Lasix®) . Cov no ua haujlwm los ntawm kev tshem tawm cov kua dej ntau dhau (dej) ntawm lub cev los ntawm cov zis.
• Cov Tshuaj Qhib Cov Ntsha: Piv txwv li , Isosorbide Dinitrate (Isordil®) . Cov no ua haujlwm los ntawm kev nthuav (qhib) cov hlab ntsha, ua rau cov ntshav ntws tau yooj yim dua.

Puas muaj dab tsi peb ua tau los txo qhov kev pheej hmoo ntawm kev mob plawv?

Qhov tseeb, tsis muaj ib txoj hauv kev twg los tiv thaiv kom tsis txhob muaj teeb meem plawv. Txawm li cas los xij, yog tias koj raug kuaj pom tias muaj mob qog noj ntshav, nws yog ib qho tseem ceeb heev uas yuav tsum tham txog qhov zoo thiab qhov tsis zoo ntawm cov kev kho mob, uas yog, kev pheej hmoo thiab cov txiaj ntsig ntawm kev noj qab haus huv, nrog koj tus kws kho mob.

Tsis tas li ntawd xwb, kev kuaj mob plawv tsis tu ncua thaum lub sijhawm kho mob qog noj ntshav tuaj yeem pab nrhiav pom kev ua rau lub plawv puas tsuaj thaum ntxov. Xav txog seb, yog tias muaj teeb meem, thaum ntxov paub tias nws yog dab tsi, nws yuav muaj feem ntau dua los kho tau zoo.

Puas kho tau qhov teeb meem cardiotoxicity no?

Qee zaum, yog. Muaj tej zaum uas kev ua rau lub plawv tsis zoo tuaj yeem thim rov qab. Kev tshawb fawb tau qhia tias kev ua rau lub plawv tsis zoo tom qab siv tshuaj hu ua Trastuzumab tuaj yeem thim rov qab.

Txawm li cas los xij, kev ua rau lub plawv tsis zoo los ntawm kev siv cov tshuaj anthracyclines feem ntau nyuaj rau kho. Nws yuav tsum tau kho mob mus sij hawm ntev. Ib yam li ntawd, kev ua rau lub plawv tsis zoo uas cuam tshuam nrog kev siv tshuaj tua kab mob hauv siab kuj nyuaj heev rau kho. Qee zaum kev kho mob mus sij hawm ntev, thiab txawm tias phais, yuav tsum tau ua.

Thaum twg kuv yuav tsum nrhiav kev pab kho mob tam sim ntawd? Yuav ua li cas thaum muaj xwm txheej ceev?

Yog koj muaj tej yam tsos mob ntawm tus mob plawv loj, hu rau 911 tam sim ntawd kom tau tsheb thauj neeg mob, lossis mus rau chav kho mob ceev ze tshaj plaws. Yuav tsum paub txog cov tsos mob no:

• Lub plawv dhia ceev ceev los yog lub plawv dhia ceev ceev uas tsis tu ncua.
• Kiv taub hau, xav tias lub taub hau me me, lossis tsaus muag.
• Ua pa luv luv lossis mob hauv siab sai sai.
• O ntawm caj pas lossis daim di ncauj.
• Ob txhais ceg lossis ko taw o txawv txawv.
• Qhov hnyav nce ntau tshaj 1.5 kg (3 phaus) hauv ib lub lim tiam.

Yog tias koj muaj cov tsos mob no , nws yog ib qho tseem ceeb uas yuav tsum nrhiav kev pab kho mob tam sim ntawd yam tsis tas nkim sijhawm, vim tias cov no yuav yog cov cim qhia txog tus mob hnyav, xws li mob plawv nres.

Thaum kawg, cov lus tseem ceeb tshaj plaws coj mus tsev!

Zoo, peb tau tham ntau txog kev ua rau lub plawv puas tsuaj. Hais yooj yim xwb, kev ua rau lub plawv puas tsuaj yog kev puas tsuaj rau lub plawv los ntawm kev kho mob qog noj ntshav. Nws yog qhov tshwm sim ntau rau cov neeg uas tau txais qee yam tshuaj chemotherapy, tshuaj kho mob tsom mus rau lub hom phiaj, lossis kev kho mob hluav taws xob rau lub hauv siab.

Txawm hais tias qee hom kev ua rau lub plawv tsis ua haujlwm zoo tuaj yeem thim rov qab tau, lwm yam yuav tsum tau kho mob ntev. Qhov tseem ceeb tshaj plaws yog tham nrog koj tus kws kho mob txog cov txiaj ntsig thiab kev pheej hmoo ntawm koj txoj kev kho mob yog tias koj tab tom kho mob qog noj ntshav. Tsis tas li ntawd, kev kuaj lub plawv tsis tu ncua thaum lub sijhawm kho mob tuaj yeem pab txheeb xyuas txhua yam teeb meem thaum ntxov thiab pib kho mob sai dua.

Tsis txhob ntshai, tab sis yuav tsum paub. Saib xyuas koj lub plawv. Yog tias koj muaj tej yam tsos mob txawv txawv, tsis txhob tsis quav ntsej lawv. Nrhiav kev pab kho mob tam sim ntawd.

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