Tej zaum koj yuav tau pom ib tug neeg hauv koj tsev neeg, ib tug txheeb ze lossis ib tug phooj ywg uas tau kho mob qog noj ntshav. Tej zaum koj yuav tau hnov txog kev kho mob hu ua "Chemotherapy" thaum koj tau kho mob li no. Tej zaum koj kuj paub tias thaum lub sijhawm kho mob chemo no, cov qe ntshav dawb uas tawm tsam cov kab mob hauv lub cev yuav txo qis. Hauv qhov xwm txheej zoo li no, hauv tsab xov xwm no, peb yuav tham txog ib yam tshuaj tshwj xeeb uas cov kws kho mob siv los pab peb lub cev tiv thaiv kab mob. Ntawd yog G-CSF.
G-CSF yog dab tsi tiag?
Hais yooj yim xwb, G-CSF yog ib yam tshuaj uas pab peb lub cev tsim cov qe ntshav dawb ntau dua, tshwj xeeb yog ib hom hu ua "neutrophils."
Xav txog tias peb lub cev zoo li ib lub tebchaws. Ces cov neutrophils no zoo li cov tub rog hauv lub tebchaws ntawd. Nws yog cov tub rog no hu ua neutrophils uas tawm tsam cov kab mob sab nraud, uas yog, cov yeeb ncuab zoo li cov kab mob thiab cov kab mob, thiab tiv thaiv peb ntawm cov kab mob thiab kev kis kab mob. Yog li yuav ua li cas yog tias cov tub rog no txo qis? Peb lub tebchaws, uas yog, peb lub cev, yooj yim raug kab mob.
Txawm hais tias lub npe G-CSF yuav zoo li nyuaj me ntsis, yog tias peb muab nws cais ua pawg, nws lub ntsiab lus yooj yim heev.
- Granulocyte: Qhov no yog lub npe muab rau ib hom qe ntshav dawb. Neutrophils kuj yog ib hom granulocyte.
- Colony-Stimulating Factor: Qhov no yog ib yam dab tsi uas "txiav txim" lossis "txhawb nqa" cov hlwb. Zoo li tus thawj tswj hwm lub Hoobkas muab cov haujlwm rau cov neeg ua haujlwm, cov protein no mus rau peb cov pob txha thiab hais tias, "Okay, pib ua cov neutrophils tam sim no."
Yog li ntawd, yam uas cov tshuaj no hu ua G-CSF ua yog nws mus rau cov pob txha , uas yog qhov zoo li daim txhuam cev hauv peb cov pob txha, thiab nws qhia cov hlwb qia nyob ntawd, "Nej yuav tsum sai sai ua neutrophils, thiab cov neutrophils uas nyob ntawd yuav tsum faib thiab nthuav dav." Tom qab ntawd cov tub rog neutrophil tshiab no koom nrog cov ntshav thiab pib ua haujlwm los tiv thaiv peb.
Qhov tseem ceeb yog tias, txawm hais tias G-CSF yog ib yam tshuaj uas tsim los ntawm kev siv tshuaj, nws ua raws li cov txheej txheem ntawm cov protein uas tsim tawm hauv peb lub cev.
G-CSF siv rau hauv cov xwm txheej twg?
G-CSF feem ntau yog siv los kho thiab tiv thaiv ib qho mob hu ua "neutropenia." Neutropenia tsuas yog tus lej neutrophils qis dua li qub hauv cov ntshav.
Hauv kev kho mob qog noj ntshav (Chemotherapy)
Cov tshuaj chemotherapy siv rau hauv kev kho mob qog noj ntshav yog tsim los tua cov hlwb qog noj ntshav uas faib sai sai. Txawm li cas los xij, cov tshuaj no tsis tuaj yeem paub tsis yog cov hlwb qog noj ntshav xwb, tab sis kuj tseem paub cov hlwb noj qab haus huv uas faib sai sai hauv peb lub cev. Yog li, vim tias neutrophils, uas tsim tawm hauv cov pob txha pob txha, kuj yog ib hom hlwb uas faib sai sai, lawv kuj raug puas tsuaj los ntawm cov tshuaj chemo.
Qhov no zoo li tshuaj tsuag tshuaj tua nroj kom tshem tau cov nroj tsuag, tab sis nws kuj ua puas rau cov nroj tsuag zoo.
Qhov no yog vim li cas cov neutropenia feem ntau tshwm sim tom qab chemotherapy. Yog tias qhov mob no hnyav zuj zus, txawm tias yog kev kis kab mob me me tuaj yeem ua rau tuag taus. Hauv cov xwm txheej zoo li no, cov kws kho mob pom zoo kom siv G-CSF los txo qhov kev pheej hmoo ntawm kev kis kab mob thiab rov qab kho lub cev tiv thaiv.
Hauv kev hloov pauv ntawm cov hlwb
Hauv qee hom mob qog noj ntshav thiab cov teeb meem ntshav, yuav tsum tau hloov cov hlwb noob (stem cell transplant). G-CSF siv ua ntej thiab tom qab txoj kev kho mob no.
- Ua ntej hloov hlwb: Thaum tus neeg mob tau txais G-CSF, cov pob txha pob txha tsim ntau cov hlwb noob thiab tso lawv tawm rau hauv cov ntshav. Cov kws kho mob mam li sau cov hlwb noob noj qab haus huv ntawd los ntawm cov ntshav.
- Thaum lub sijhawm hloov hlwb: Tom ntej no, kev siv tshuaj kho mob qog nqaij hlav lossis kev kho mob hluav taws xob ntau yuav rhuav tshem cov hlwb tsis zoo uas tseem tshuav hauv lub cev.
- Tom qab kev hloov pauv: Thaum kawg, cov noob hlwb noj qab haus huv uas tau sau ua ntej yuav rov qab coj mus rau hauv lub cev. Cov noob hlwb no tom qab ntawd yuav dhau los ua cov noob hlwb tshiab, noj qab haus huv.
Yog tias koj yog tus pub cov noob hlwb (stem cell donor), tej zaum koj yuav tsum tau txhaj tshuaj G-CSF ua ntej txoj kev kho mob.
Lwm yam mob uas ua rau cov neutrophils qis
Cov theem neutrophil kuj tseem yuav qis vim muaj tej yam mob uas muaj thaum yug los (mob neutropenia hnyav txij thaum yug los) lossis thaum tsis paub qhov ua rau (idiopathic neutropenia). Hauv cov xwm txheej zoo li no, G-CSF yog siv los ua kom cov theem neutrophil nce ntxiv.
Cov hom G-CSF thiab lawv muab li cas
G-CSF muaj nyob rau hauv kev ua lag luam nrog ntau lub npe. Ob hom uas siv ntau tshaj plaws yog:
1. Filgrastim: Qhov no yog hom tshuaj uas ua haujlwm luv luv. Feem ntau yuav tsum tau txhaj tshuaj txhua hnub.
2. Pegfilgrastim: Qhov no yog ib hom tshuaj uas ua haujlwm ntev, yog li ntawd feem ntau txaus kom txhaj ib zaug ntawm ob zaug ntawm kev kho mob chemotherapy.
Cov tshuaj no muaj nyob rau hauv ntau hom tshuaj thiab cov tshuaj biosimilars. Piv txwv li, koj tus kws kho mob yuav qhia tau koj txog cov npe xws li Neupogen®, Neulasta®, Nivestym®, thiab Zarxio®.
| Hom G-CSF | Tus naj npawb ntawm cov sijhawm muab (feem ntau) |
|---|---|
| Filgrastim (lub sijhawm luv luv) | Txhua hnub (ob peb hnub los yog ob peb lub lim tiam) |
| Pegfilgrastim (ntev ntev) | Ib zaug rau ib lub voj voog chemo |
Cov tshuaj no muab rau lub cev li cas?
Feem ntau G-CSF yog muab ua tshuaj txhaj rau hauv qab daim tawv nqaij , tab sis qee zaum nws kuj tuaj yeem muab ua tshuaj txhaj rau hauv IV .
- Tej zaum koj yuav tau mus rau lub tsev kho mob txhua hnub kom tau txhaj tshuaj tiv thaiv kab mob.
- Los yog, ib tug kws tu mob yuav qhia koj lossis ib tug neeg hauv tsev neeg yuav txhaj tshuaj tiv thaiv kab mob li cas hauv tsev. Nws tsis nyuaj ua luaj.
Puas yog txhua tus neeg xav tau G-CSF?
Tsis yog. G-CSF tsis yog muab rau txhua tus neeg uas tab tom kho mob chemotherapy lossis cov neeg uas muaj cov neutrophils qis. Ib yam li lwm yam tshuaj, G-CSF muaj cov txiaj ntsig zoo thiab qee qhov kev pheej hmoo ntawm cov kev phiv. Koj tus kws kho mob yuav xav txog ntau yam ua ntej sau cov tshuaj no.
- koj lub hnub nyoog
- Koj txoj kev noj qab haus huv tag nrho
- Hom mob qog noj ntshav uas koj muaj
- Hom tshuaj chemotherapy uas koj tab tom txais
- Seb koj twb muaj cov tsos mob ntawm neutropenia (xws li kub taub hau)
Yog li ntawd, qhov kev txiav txim siab seb puas xav tau G-CSF los tsis xav tau yog tus kws kho mob uas kho koj. Koj tsis tas yuav txhawj txog qhov ntawd.
Cov txiaj ntsig thiab tej zaum yuav muaj kev phiv los ntawm G-CSF
Yog tias pom zoo kom siv G-CSF, nco ntsoov tias cov txiaj ntsig ntau dua li cov kev pheej hmoo.
Cov txiaj ntsig tseem ceeb:
- Qhov kev pheej hmoo ntawm kev kis kab mob hnyav, uas tej zaum yuav ua rau tuag taus tau raug txo qis heev.
- Cov neutrophil qis tuaj yeem tiv thaiv kev kho mob chemotherapy kom tsis txhob ncua lossis txo cov koob tshuaj , ua rau kev kho mob qog noj ntshav txuas ntxiv mus raws li tau npaj tseg.
Tej zaum yuav muaj tej yam tshwm sim tsis zoo
Feem ntau cov kev mob tshwm sim tsuas yog ib ntus xwb thiab ploj mus tom qab tsis noj G-CSF lawm.
| Cov teebmeem sab nraud | Kev piav qhia thiab kev tswj hwm |
|---|---|
| Cov kev mob tshwm sim feem ntau | |
| Mob hauv cov pob txha thiab cov leeg | Qhov no yog qhov tshwm sim ntau tshaj plaws. Nws zoo li "mob plab loj hlob" vim tias cov pob txha pob txha tam sim ntawd tsim ntau lub hlwb dhau lawm. Koj tuaj yeem nug koj tus kws kho mob txog kev noj tshuaj tua kab mob xws li paracetamol. |
| Kev qaug zog | Tej zaum koj yuav nkees vim koj lub cev siv zog ntau dua los tsim cov hlwb tshiab. So kom txaus. |
| Mob taub hau, xeev siab, raws plab | Feem ntau cov no tsis hnyav heev. Tus kws kho mob yuav sau ntawv kom muab tshuaj rau cov no. |
| Liab, khaus, lossis mob ntawm qhov chaw txhaj tshuaj | Qhov no feem ntau yuav ploj mus li ib hnub lossis ob hnub. |
| Cov tsos mob hnyav (tab sis tsis tshua muaj) uas yuav tsum tau qhia rau kws kho mob tam sim ntawd | |
| Cov cim qhia txog kev kis kab mob | Kub taub hau, mob khaub thuas, mob caj pas, hnoos. Tej zaum cov no yog cov cim qhia tias muaj kev kis kab mob. Qhia rau koj tus kws kho mob tam sim ntawd. |
| Cov tsos mob ntawm kev ua xua | Mob pob khaus ntawm daim tawv nqaij, khaus, o ntawm lub ntsej muag lossis daim di ncauj, ua pa nyuaj. Qhov no yog xwm txheej ceev. Mus rau chav kho mob ceev (ETU) tam sim ntawd. |
| Mob ntse heev rau sab laug sab saud ntawm lub plab | Qhov no yuav yog ib qho tsos mob ntawm qhov teeb meem tsis tshua muaj nrog lub po. |
| O ntawm ob txhais ceg tam sim ntawd, ua pa nyuaj | Cov no tej zaum yuav yog cov cim qhia txog cov mob uas tsis tshua muaj tab sis loj heev xws li cov hlab ntsha xau lossis ARDS. Nrhiav kev kho mob tam sim ntawd. |
Tej yam yuav tsum nco ntsoov thaum noj G-CSF
- Qhia koj tus kws kho mob txog koj keeb kwm mob nkeeg. Nco ntsoov qhia rau nws txog lwm yam kab mob uas koj muaj thiab lwm yam tshuaj uas koj noj (xws li cov vitamins).
- Tsis pom zoo kom noj G-CSF yog tias koj cev xeeb tub, tab tom sim cev xeeb tub, lossis pub niam mis . Tham nrog koj tus kws kho mob txog qhov no.
- Tsis txhob txhawj txog cov kev mob tshwm sim. Yog tias koj muaj tej yam kev mob tshwm sim, qhia rau koj tus kws kho mob lossis tus nais maum. Lawv yuav pab koj tswj hwm lawv.
- Mus kuaj ntshav raws sijhawm. Koj tus kws kho mob yuav kuaj koj cov neutrophil thiab txiav txim siab seb yuav tsum tau kho ntev npaum li cas.
G-CSF yog ib qho tseem ceeb heev rau kev kho mob qog noj ntshav. Nws muab kev txhawb nqa zoo rau kev kho mob chemotherapy kom muaj kev nyab xeeb thiab ua tiav zoo dua. Yog tias koj muaj lus nug ntxiv txog qhov no, thov tsis txhob yig nug koj tus kws kho mob.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- G-CSF yog ib yam tshuaj uas ua rau lub cev tsim cov qe ntshav dawb hu ua neutrophils ntau ntxiv.
- Qhov no txo qhov kev pheej hmoo ntawm kev kis kab mob loj uas tuaj yeem tshwm sim thaum lub sijhawm kho mob chemotherapy.
- Mob pob txha thiab mob nqaij yog qhov mob tshwm sim feem ntau thiab feem ntau tuaj yeem tswj tau.
- Yog koj kub taub hau, ua pa nyuaj, lossis muaj cov tsos mob ua xua hnyav, qhia rau koj tus kws kho mob tam sim ntawd lossis mus rau tsev kho mob.
- Yog tias koj muaj kev txhawj xeeb txog cov tshuaj no, tsis txhob yig los tham nrog koj tus kws kho mob.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus