Cia peb kawm txog Lynch Syndrome, uas ua rau koj muaj feem yuav mob qog noj ntshav ntau ntxiv.

Koj puas tau hnov ​​txog lo lus "Lynch Syndrome"? Qhov no tej zaum yuav yog ib lo lus tshiab rau koj. Tab sis nws yog ib qho tseem ceeb rau peb txhua tus kom paub. Hais yooj yim, Lynch Syndrome yog ib qho mob uas ua rau muaj kev pheej hmoo ntawm kev mob qog noj ntshav vim muaj qee qhov kev hloov pauv hauv peb cov noob caj noob ces. Tshwj xeeb, nws ua rau muaj kev pheej hmoo ntawm kev mob qog noj ntshav ua ntej hnub nyoog 50 xyoo. Yog li, cia peb tham txog qhov no kom meej me ntsis, puas yog?

Lynch Syndrome yog dab tsi tiag? Leej twg thiaj muaj tus mob no?

Lynch syndrome yog ib yam mob caj ces uas tau txais los ntawm noob caj ces . Qhov ntawd yog, nws yog tshwm sim los ntawm kev hloov pauv caj ces hauv cov noob caj ces uas peb tau txais los ntawm peb niam lossis txiv. Xav txog tias thaum peb cov hlwb faib, qee zaum qhov yuam kev me me tuaj yeem tshwm sim. Peb lub cev muaj cov noob caj ces tshwj xeeb uas nrhiav pom thiab kho cov yuam kev no. Cov no hu ua 'Mismatch Repair genes' (MMR genes). Ib tus neeg uas muaj Lynch syndrome muaj qhov tsis zoo hauv ib lossis ntau dua ntawm cov noob caj ces 'MMR' no. Tom qab ntawd, lwm qhov yuam kev tsis tuaj yeem kho tau thaum cov hlwb faib. Cov hlwb puas tsuaj no sib sau ua ke thiab dhau los ua mob qog noj ntshav .

Qhov no tuaj yeem tshwm sim rau txhua tus neeg. Vim nws yog caj ces. Qee zaum, txawm tias tsis muaj leej twg hauv tsev neeg tau muaj tus mob no ua ntej, ib tus neeg tuaj yeem muaj nws vim yog kev hloov pauv caj ces random. Qhov no txhais tau tias tsuas yog vim tsis muaj keeb kwm tsev neeg, nws tsis tau txhais hais tias nws yuav tsis tshwm sim.

Raws li cov ntaub ntawv hauv Tebchaws Meskas, kwv yees li ib tus neeg ntawm 279 tus neeg yuav muaj Lynch syndrome. Lawv hais tias muaj kwv yees li 4,000 tus neeg mob qog nqaij hlav colorectal thiab kwv yees li 1,800 tus neeg mob qog nqaij hlav endometrial yog tshwm sim los ntawm Lynch syndrome txhua xyoo. Nws yog ib qho tseem ceeb heev uas yuav tsum paub txog tus mob no hauv Sri Lanka thiab.

Cov tsos mob ntawm Lynch syndrome yog dab tsi?

Cov tsos mob yuav txawv nyob ntawm seb qhov mob hnyav npaum li cas thiab hom mob qog noj ntshav uas ua rau mob. Cov tsos mob feem ntau ntawm mob qog noj ntshav hauv plab hnyuv muaj xws li:

• Ntshav hauv koj cov quav.
• Cem quav .
• Mob plab los yog mob plab ntswj.
• Raws plab los yog quav me dua li qub.
• Muaj kev xav tias qaug zog heev ('Qaug zog').
• Xav tias puv lossis o.
• Xeev siab los yog ntuav.

Qhov tseem ceeb yog tias qee tus neeg yuav tsis pom muaj tsos mob dab tsi txog thaum mob qog noj ntshav loj heev. Yog li ntawd, yog tias koj muaj ib qho ntawm cov tsos mob no, koj yuav tsum mus ntsib kws kho mob tam sim ntawd .

Cov mob qog noj ntshav twg tuaj yeem ua rau muaj Lynch syndrome?

Qhov no yeej muaj peev xwm cuam tshuam rau ntau yam kab mob hauv lub cev. Nov yog qee hom mob qog noj ntshav uas tuaj yeem ua rau muaj Lynch syndrome:

• Mob qog nqaij hlav hauv hlwb
• Mob qog nqaij hlav thiab mob qog nqaij hlav ntawm lub plab - qhov no yog qhov tseem ceeb.
• Mob qog nqaij hlav ntawm lub zais zis
• Mob qog nqaij hlav
• Mob qog nqaij hlav zes qe menyuam
• Mob qog nqaij hlav pancreatic
• Mob qog nqaij hlav prostate
• Mob qog nqaij hlav
• Mob qog nqaij hlav me
• Mob qog noj ntshav hauv plab
• Mob qog nqaij hlav sab saud
• Mob qog nqaij hlav hauv tsev menyuam (endometrial) - Lwm hom mob qog nqaij hlav uas feem ntau cuam tshuam rau cov poj niam.

Qhov kev hloov pauv uas cov noob caj noob ces (`gene`) muaj nyob txiav txim siab seb lub cev twg muaj feem yuav mob qog noj ntshav ntau dua. Muaj tsib cov noob caj noob ces tseem ceeb uas cuam tshuam nrog Lynch syndrome. Lawv yog: `MLH1`, `MSH2`, `MSH6`, `PMS2` thiab `EPCAM`.

Kab mob qog nqaij hlav plab hnyuv uas tshwm sim los ntawm Lynch syndrome tuaj yeem tshwm sim sai dua (hauv 1-2 xyoos) dua li cov pej xeem feem ntau. Feem ntau nws yuav siv sijhawm li 10 xyoo rau kab mob qog nqaij hlav plab hnyuv kom tshwm sim. Tsis tas li ntawd, ib tus neeg uas tau muaj kab mob qog nqaij hlav plab hnyuv muaj feem yuav tshwm sim kab mob qog nqaij hlav dua . Muaj li ntawm 15% kev pheej hmoo hauv 10 xyoo ntawm kev phais rau kab mob qog nqaij hlav thawj zaug, li ntawm 40% kev pheej hmoo hauv 20 xyoo, thiab li ntawm 60% kev pheej hmoo tom qab 30 xyoo.

Dab tsi ua rau Lynch syndrome?

Raws li tau hais ua ntej lawm, qhov ua rau qhov no yog kev hloov pauv caj ces hauv ib lossis ntau dua ntawm tsib lub noob caj ces uas kho qhov yuam kev hauv peb cov DNA (lub "mismatch repair gene" lossis "MMR gene"). Tsib lub noob caj ces ntawd yog:

• `MLH1`
• `MSH2`
• `MSH6`
• `PMS2`
• `EPCAM`

Yog koj muaj Lynch syndrome, koj cov noob 'MMR' tsis tau txais cov lus qhia uas lawv xav tau los tshem tawm cov cell uas puas lawm. Tom qab ntawd cov cell uas puas lawm ntawd sib sau ua ke hauv cov nqaij thiab ua rau muaj mob qog noj ntshav.

Qhov no los ntawm ib tiam dhau ib tiam li cas?

Lynch syndrome yog ib yam mob "autosomal dominant". Hais yooj yim xwb, txawm tias tsuas yog ib tug niam txiv muaj cov noob hloov pauv xwb los, tus menyuam tuaj yeem tau txais nws . Qhov no txhais tau tias muaj 50% feem pua ​​uas tus menyuam yuav muaj tus mob no thiab.

Yog tias koj tau kuaj pom tias muaj Lynch syndrome, nws yog ib qho tseem ceeb uas yuav tsum qhia rau koj tsev neeg thiab txhawb kom lawv nrhiav kev pab tswv yim txog noob caj noob ces . Kev pab tswv yim txog noob caj noob ces tuaj yeem pab koj thiab koj tsev neeg nkag siab txog qhov mob thiab qhov kev pheej hmoo ntawm koj tus menyuam yuav tau txais nws. Kev kuaj noob caj noob ces kuj tuaj yeem ua tau los saib seb koj puas muaj Lynch syndrome gene mutation.

Yuav kuaj mob Lynch syndrome li cas?

Koj tus kws kho mob tuaj yeem kuaj mob Lynch syndrome los ntawm kev kuaj mob ua ntej yug me nyuam thiab kev kuaj noob caj noob ces. Kev kuaj noob caj noob ces kuj tuaj yeem ua tau tom qab koj tus menyuam yug los.

Kev kuaj noob caj ces suav nrog kev coj cov ntshav los yog kev siv daim ntaub so ntswg los kuaj seb puas muaj kev hloov pauv hauv cov noob caj ces uas tau hais ua ntej lawm hu ua "MLH1", "MSH2", "MSH6", "PMS2" lossis "EPCAM". Yog tias kev kuaj noob caj ces lees paub tias muaj kev hloov pauv zoo li no, tus kws kho mob yuav kuaj pom tias yog Lynch syndrome.

Cov kev kuaj twg siv los nrhiav cov mob qog noj ntshav uas cuam tshuam nrog Lynch syndrome?

Yog tias koj raug kuaj pom tias muaj Lynch syndrome, koj tus kws kho mob feem ntau yuav pom zoo kom kuaj ntau yam los xyuas seb puas muaj mob qog noj ntshav. Cov kev kuaj feem ntau yog:

• Kev kuaj mob plab hnyuv loj: Qhov no suav nrog kev ntxig ib lub raj (scope) nrog lub koob yees duab txuas rau ntawm lub qhov quav los kuaj sab hauv ntawm txoj hnyuv loj thiab lub qhov quav. Qhov no feem ntau ua ib xyoos ib zaug lossis txhua ob xyoos ib zaug.
• Kev siv tshuab ultrasound hauv qhov chaw mos: Muab ib lub cuab yeej me me (probe) ntxig rau hauv qhov chaw mos los kuaj xyuas cov zes qe menyuam thiab lub tsev menyuam. Qhov no kuj raug pom zoo ib zaug lossis ob zaug hauv ib xyoos.
• Kev Kuaj Zis: Yuav muab ib qho qauv ntawm koj cov zis coj mus kuaj seb puas muaj tej yam xws li mob qog hauv lub raum. Feem ntau yuav ua li no ib xyoos ib zaug.
• Kev kuaj mob qog nqaij hlav: Yog tias koj tus kws kho mob xav tias koj muaj qog nqaij hlav nyob qhov twg hauv koj lub cev, lawv yuav muab ib daim me me ntawm nws thiab kuaj hauv chav kuaj mob kom pom tias nws puas muaj cov qe ntshav qog nqaij hlav.
• Kev kuaj mob sab saud los yog kev kuaj mob capsule: Ib txoj kev kho mob uas siv ib lub raj me me, nyias (scope) los yog lub koob yees duab me me (ib lub raj me me, nyias uas nqos zoo li tshuaj ntsiav) los nrhiav mob qog noj ntshav hauv plab thiab txoj hnyuv me. Tej zaum yuav hais kom koj ua qhov no txhua peb txog tsib xyoos.

Yuav kho tus mob Lynch syndrome li cas?

Tus yuam sij rau kev kho mob Lynch syndrome yog kev kuaj pom thaum ntxov thiab phais tshem tawm cov qog nqaij hlav . Qhov no txhais tau tias yuav tsum tau mus kuaj mob tsis tu ncua thiab nrhiav pom mob qog nqaij hlav thaum ntxov, yog tias muaj.

Leej twg kho qhov no?

Nws yog qhov zoo tshaj plaws los nrhiav kev kho mob los ntawm pab pawg kws kho mob tshwj xeeb rau qhov mob zoo li no.Vim tias Lynch syndrome tuaj yeem cuam tshuam rau ntau lub cev, pab pawg kho mob yuav suav nrog ntau tus kws tshwj xeeb, suav nrog kws kho mob plab hnyuv, kws phais mob, kws kho mob poj niam, kws kho mob urologists, kws kho mob tawv nqaij, kws kho mob poj niam, kws kho mob thawj zaug, kws kho mob caj ces, kws pab tswv yim txog caj ces, thiab kws kho mob oncologists.

Kab mob cancer puas rov qab los tom qab kho tas?

Yog, txawm tias yog mob qog noj ntshav raug phais tshem tawm los xij, muaj ib qho kev pheej hmoo uas mob qog noj ntshav yuav rov qab los . Yog vim li ntawd nws thiaj li tseem ceeb uas yuav tsum tau kuaj ntxiv mus.

Ib txhia neeg uas muaj tus kab mob Lynch syndrome, vim lawv muaj feem yuav mob qog noj ntshav ntau dua, txiav txim siab phais kom tshem lub tsev menyuam (hysterectomy), zes qe menyuam (oophorectomy), lossis ib feem ntawm txoj hnyuv (colectomy lossis bowel resection surgery) thaum ntxov. Qhov no feem ntau yog kev txiav txim siab ntawm tus kheej, thiab yuav tsum tau ua raws li kev qhia ntawm tus kws kho mob.

Puas tiv thaiv tau Lynch syndrome?

Tu siab kawg li, Lynch syndrome yog ib yam mob uas muaj los ntawm noob caj noob ces, yog li ntawd nws tsis tuaj yeem tiv thaiv tau tag nrho . Txawm li cas los xij, cov neeg uas muaj Lynch syndrome tuaj yeem raug kuaj mob qog noj ntshav thoob plaws lawv lub neej, pib thaum lawv laus, yog li ntawd mob qog noj ntshav thiaj li pom tau thaum ntxov yog tias nws tshwm sim .

Yog koj muaj tus mob Lynch syndrome no, yuav muaj li cas? Koj yuav tau txais dab tsi?

Tam sim no tsis muaj kev kho rau Lynch syndrome. Txawm li cas los xij, qhov zoo tshaj plaws yog ua tiav yog tias pom tus mob qog noj ntshav thiab tshem tawm thaum ntxov, ua ntej nws kis mus rau lwm qhov ntawm lub cev . Yog li ntawd, nws yog ib qho tseem ceeb heev rau cov neeg uas muaj Lynch syndrome kom muaj kev kuaj mob txhua xyoo, xws li kev kuaj plab hnyuv.

Puas yog Lynch syndrome yuav ua rau muaj qog hauv kuv txoj hnyuv?

Cov neeg uas muaj tus kab mob Lynch syndrome yuav muaj ntau yam 'adenomas', ib hom qog uas tsis yog mob qog noj ntshav hauv lawv txoj hnyuv loj lossis qhov quav. Yog tias cov 'polyps' no tsis raug txheeb xyuas thiab tshem tawm, lawv tuaj yeem dhau los ua mob qog noj ntshav. Yog vim li ntawd nws thiaj li tseem ceeb uas yuav tsum tau kuaj xyuas cov hnyuv loj tas li kom paub seb puas muaj cov no thiab tshem tawm yog tias muaj.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Yog tias koj muaj Lynch syndrome, nws yog ib qho tseem ceeb uas yuav tsum tau kuaj xyuas txhua xyoo thiab kuaj mob raws sijhawm .

Yog koj pom muaj pob, cov qog tshiab, lossis daim tawv nqaij hloov pauv qhov twg ntawm koj lub cev, mus ntsib kws kho mob tam sim ntawd , vim tias cov no yuav yog cov cim qhia txog mob qog noj ntshav.

Kuv yuav tsum nug kuv tus kws kho mob li cas?

• Kuv yuav tsum tau kuaj mob qog noj ntshav ntau npaum li cas?
• Puas yog lub qog no nyob ntawm kuv daim tawv nqaij mob qog?
• Kuv muaj kev hloov pauv ntawm cov noob caj noob ces twg?
• Kuv puas tuaj yeem kuaj mob caj ces ua ntej kuv npaj yuav cev xeeb tub?

Lynch Syndrome thiab HNPCC puas yog tib yam?

Lynch syndrome thiab "HNPCC" (Hereditary Non-Polyposis Colorectal Cancer) qee zaum siv sib pauv los hais txog tib yam mob. Txawm li cas los xij, muaj qhov sib txawv me ntsis ntawm ob qho no hauv txoj kev uas lawv tau kis mus rau ntau tiam neeg.

Lynch syndrome yog tshwm sim los ntawm kev hloov pauv hauv 'MMR' gene. Tib qho kev hloov pauv gene kuj cuam tshuam rau cov neeg uas muaj 'HNPCC'. Txawm li cas los xij, lub npe 'HNPCC' yog muab thaum qhov mob no tshwm sim nrog keeb kwm tsev neeg . Qhov ntawd txhais tau tias 'HNPCC' yeej ib txwm tau txais los ntawm ib tiam dhau ib tiam. Lynch syndrome qee zaum tuaj yeem tshwm sim yam tsis muaj leej twg hauv tsev neeg muaj nws, thiab kuj tuaj yeem tshwm sim vim yog kev hloov pauv gene random. Yog vim li cas lub npe Lynch syndrome tam sim no siv dav.

Thaum kawg, tej yam yuav tsum nco ntsoov (Cov Lus Coj Mus Tsev)

Tsis muaj leej twg nyiam hnov ​​cov lus hais tias, "Koj muaj mob qog noj ntshav." Thaum koj pom tias koj muaj mob Lynch syndrome, tej zaum koj yuav tau hnov ​​cov lus ntawd los ntawm koj tus kws kho mob. Tab sis nws tsis tas yuav yog ib qho phem.

Thaum koj raug kuaj pom tias muaj Lynch syndrome, koj tus kws kho mob yuav ua haujlwm nrog koj los teem sijhawm kuaj mob tsis tu ncua kom pab kuaj pom mob qog noj ntshav thaum ntxov. Kev kuaj pom thiab kho mob thaum ntxov yog txoj hauv kev zoo tshaj plaws los txhim kho koj txoj kev muaj sia nyob . Ces koj tuaj yeem ua neej zoo siab thiab noj qab nyob zoo.

Yog li ntawd, es tsis txhob ntshai cov ntaub ntawv no, yuav tsum paub txog, nrhiav kev pab kho mob yog tias tsim nyog, thiab sim ua lub neej noj qab haus huv . Yog tias leej twg hauv koj tsev neeg muaj tus mob no, nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau lawv txog qhov no thiab.

Lynch syndrome, HNPCC, mob qog noj ntshav, kev hloov pauv caj ces, cov kab mob uas tau txais los ntawm noob caj ces, mob qog noj ntshav hauv plab hnyuv, mob qog noj ntshav hauv tsev menyuam