Muaj ib qho protein txawv txawv nyob hauv koj cov ntshav? Cia peb tham txog MGUS (Monoclonal Gammopathy of Undetermined Significance)!

Tej zaum koj twb mus ntsib kws kho mob lawm, lossis tsuas yog mus kuaj ntshav xwb, thiab lawv tau qhia koj txog ib yam kab mob uas muaj lub npe txawv txawv uas koj tsis tau hnov ​​dua li. MGUS (ib txhia hu ua M-Gas) yog ib yam mob uas ua rau koj ntshai me ntsis thaum koj hnov ​​lub npe, tab sis tsis paub meej tias nws yog dab tsi. Yog li hnub no, cia peb tham txog MGUS (Monoclonal Gammopathy of Undetermined Significance) hauv txoj kev yooj yim uas koj nkag siab tau.

MGUS (Monoclonal Gammopathy of Undetermined Significance) yog dab tsi?

Hais yooj yim xwb, MGUS yog ib yam mob uas cuam tshuam rau ib hom cell tshwj xeeb hu ua plasma cells, uas yog ib feem ntawm peb cov ntshav thiab pom muaj nyob rau hauv cov pob txha. Tam sim no koj yuav xav paub tias cov plasma cells no yog dab tsi. Cov plasma cells no yog cov tswv cuab tseem ceeb heev ntawm peb lub cev lub cev tiv thaiv kab mob. Lawv txoj haujlwm tseem ceeb yog tsim cov protein hu ua antibodies uas pab peb lub cev tiv thaiv nws tus kheej ntawm kab mob.

Tiamsis rau ib tug neeg uas muaj MGUS, cov hlwb ntshav no hloov me ntsis, thiab es tsis txhob ua cov tshuaj tiv thaiv kab mob tiag tiag uas lawv yuav tsum tsim, lawv tsim ib hom protein txawv txawv hu ua "M proteins." Cov M proteins no tsis ua dab tsi rau peb lub cev. Feem ntau, cov M proteins no tsis ua rau muaj kev phom sij ntau, thiab ntau tus neeg uas muaj MGUS tsis muaj tsos mob dab tsi. Feem ntau, tus kws kho mob pom qhov mob no los ntawm kev sib tsoo thaum lawv kuaj ntshav lossis kuaj zis rau lwm yam laj thawj.

Txawm li cas los xij, tsis tshua muaj mob MGUS uas yuav loj zuj zus thiab ua rau mob qog ntshav lossis lwm yam mob ntshav loj heev. Yog vim li ntawd cov kws kho mob, thaum lawv paub tias koj muaj MGUS, yuav kuaj ntshav thiab zis txhua 6 lub hlis lossis ib xyoos ib zaug kom pom tias nws puas loj zuj zus.

Leej twg raug kev cuam tshuam ntau tshaj plaws los ntawm qhov xwm txheej no?

Txawm hais tias leej twg los yeej muaj tus mob no hu ua MGUS los xij, qee tus neeg yuav muaj tus mob no ntau dua.

• Cov neeg uas muaj hnub nyoog tshaj 50 xyoo yuav muaj feem ntau dua rau tus mob MGUS. Qhov kev pheej hmoo no yuav nce me ntsis thaum koj laus zuj zus. Ib tug neeg uas muaj hnub nyoog tshaj 50 xyoo muaj feem li ntawm 3% txog 5% uas yuav muaj tus mob no. Yog koj saib cov neeg uas muaj hnub nyoog tshaj 75 xyoo, qhov no yog li ntawm 5%.
• MGUS feem ntau tshwm sim rau cov neeg dub .
• Cov txiv neej muaj feem yuav mob MGUS ntau dua li cov poj niam.
• Cov neeg uas muaj keeb kwm raug tshuaj tua kab lossis tshuaj tua kab kuj muaj kev pheej hmoo.

MGUS cuam tshuam li cas rau kuv lub cev?

Zoo li peb tau tham txog ua ntej lawm, MGUS yog tshwm sim los ntawm koj cov pob txha tsim cov qe ntshav dawb uas tsis zoo li qub. Xav txog nws zoo li cov qe ntshav dawb ntawm ib tus neeg noj qab nyob zoo zoo li cov tub rog uas tau kawm tiav. Lawv tsim cov riam phom hu ua cov tshuaj tiv thaiv kab mob uas tshwj xeeb rau txhua tus kab mob. Cov tshuaj tiv thaiv kab mob no yog cov uas pab peb paub thiab tawm tsam cov kab mob uas nkag mus rau hauv peb lub cev, tiv thaiv peb ntawm kab mob.

Tiam sis hauv MGUS, cov hlwb ntshav no ua rau "vwm" me ntsis thiab lawv ua cov protein M. Cov protein M no sib sau ua ke hauv peb cov ntshav thiab mus ncig thoob plaws peb lub cev. Qee zaum cov protein M txawv txav no sib sau ua ke hauv peb cov ntshav thiab zis thiab tuaj yeem ua rau koj lub raum, lub plawv, thiab cov hlab ntsha puas tsuaj. Tsis yog li ntawd xwb, tab sis thaum muaj cov protein M ntau dhau hauv koj cov ntshav, koj lub cev lub peev xwm los tawm tsam cov kab mob kuj tuaj yeem txo qis. Qhov no txhais tau tias koj yuav muaj feem mob yooj yim dua.

MGUS puas yog mob qog noj ntshav?

Nov yog ib lo lus nug uas ntau tus neeg nug. Tsis yog, MGUS tsis yog mob qog noj ntshav nws tus kheej. Txawm li cas los xij, nws yog ib qho mob uas tuaj yeem hloov mus ua mob qog noj ntshav. Hauv lwm lo lus, MGUS tuaj yeem xav tias yog ib qho mob "ua ntej mob qog noj ntshav" uas ua ntej mob qog noj ntshav.

Kev tshawb fawb tau qhia tias kwv yees li 20% ntawm cov neeg uas muaj MGUS yuav mob qog ntshav hu ua multiple myeloma . Qhov no txhais tau tias tsis yog txhua tus neeg uas muaj MGUS yuav mob qog ntshav, tab sis kwv yees li ib ntawm tsib tus neeg muaj feem yuav mob qog ntshav.

Tsis tas li ntawd xwb, qee tus neeg uas muaj MGUS kuj yuav muaj lwm hom mob qog ntshav lossis cov kab mob loj uas cuam tshuam nrog cov ntshav. Piv txwv li:

• Kab mob Amyloidosis
• Waldenstrom macroglobulinemia
• Kab mob leukemia lymphocytic ntev (CLL)

Tseem Ceeb: Tsis yog txhua tus neeg uas muaj MGUS yuav mob qog noj ntshav. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum tau mus kuaj mob tsis tu ncua vim muaj kev pheej hmoo.

Cov tsos mob ntawm MGUS yog dab tsi?

Raws li peb tau hais ua ntej lawm, feem ntau MGUS tsis ua rau muaj cov tsos mob tshwj xeeb. Qhov ntawd yog ib qho teeb meem loj tshaj plaws nrog nws. Txawm li cas los xij, tsis tshua muaj neeg yuav muaj cov tsos mob. Yog tias lawv ua, lawv yuav muaj cov tsos mob xws li:

• Ib qho kev xav tingling hauv cov ceg.
• Kev xav tias tsis muaj zog thiab tsis muaj sia nyob .
• Muaj kev xav tias tsis muaj zog lossis tsis muaj zog nyob rau qee qhov chaw.

Cov tsos mob no tuaj yeem yog cov tsos mob ntawm ntau lwm yam mob, yog li ntawd tsis txhob xav tias koj muaj MGUS tsuas yog vim koj muaj ib lossis ob yam ntawm cov no. Txawm li cas los xij, yog tias koj muaj cov tsos mob tsis tu ncua, nws yog qhov zoo tshaj plaws mus ntsib kws kho mob.

Dab tsi ua rau muaj MGUS?

Qhov tseeb, cov kws kho mob tseem tsis tau paub meej tias vim li cas cov hlwb ntshav hauv peb cov pob txha hloov pauv thiab pib ua cov protein M. Qhov ntawd yog qhov "Tsis Paub Tseeb" ntawm lub npe kab mob hais.

Txawm li cas los xij, muaj qee yam uas xav tias yuav pab txhawb rau qhov mob no:

• Kev hloov pauv ntawm cov noob caj noob ces: Qee qhov kev hloov pauv hauv peb cov noob caj noob ces tuaj yeem ua rau qhov no.
• Muaj cov kab mob autoimmune:Qhov no txhais tau hais tias cov neeg uas muaj kab mob uas lub cev tiv thaiv kab mob tawm tsam cov hlwb ntawm lub cev (xws li mob rheumatoid arthritis) yuav muaj feem ntau dua rau MGUS.
• Kev Kho Mob Rau Cov Kab Mob Autoimmune: Qee cov tshuaj noj rau cov kab mob no kuj tuaj yeem muaj cov nyhuv.
• Kev raug hluav taws xob ntau heev.
• Kev raug tshuaj tua kab thiab tshuaj tua kab.

Cov no yog cov yam uas ua rau muaj kev pheej hmoo uas tau txheeb xyuas tam sim no, tab sis txawm tias ib tus neeg uas tsis muaj ib qho ntawm cov no tuaj yeem mob MGUS.

Cov kws kho mob kuaj mob MGUS li cas?

Feem ntau, MGUS raug kuaj pom los ntawm txoj kev xav xwb. Tus kws kho mob yuav kuaj koj cov ntshav thiab zis seb puas muaj cov protein M. Tsis tas li ntawd xwb, lawv yuav saib ntau yam ntxiv los ntsuas seb MGUS puas yuav ua rau mob qog noj ntshav lossis lwm yam teeb meem ntshav loj. Cov yam ua rau muaj kev pheej hmoo no yog:

• Tus nqi ntawm M protein hauv koj cov ntshav: Tus nqi ntawm M protein ntau npaum li cas, qhov kev pheej hmoo ntau npaum li ntawd.
• Hom protein M hauv koj cov ntshav: Kuj tseem muaj ntau hom protein M sib txawv. Qee hom muaj kev phom sij dua lwm hom.
• Tus nqi ntawm cov saw hlau dawb (FLC) hauv koj cov ntshav: FLC kuj yog ib hom protein uas cov hlwb plasma tsim tawm. Kev kuaj FLC nrhiav cov kev sib sau ua ke tsis zoo ntawm cov no.

Kev tshawb fawb qhia tau hais tias ib tug neeg uas muaj tag nrho peb yam ntawm cov yam txaus ntshai no muaj 58% feem pua ​​​​​​ntawm kev mob leukemia hauv 20 xyoo. Ib yam li ntawd, ib tug neeg uas tsis muaj ib yam ntawm cov yam txaus ntshai no muaj 5% feem pua ​​​​​​ntawm kev mob leukemia hauv 20 xyoo. Yog li cov kev kuaj no tuaj yeem pab koj tus kws kho mob nkag siab txog koj qib kev pheej hmoo.

Yuav kho tus mob MGUS li cas?

Qhov xov xwm zoo yog tias feem ntau cov neeg uas muaj MGUS tsis tas yuav kho mob. Vim tias, zoo li peb tau hais lawm, feem ntau cov neeg tsis muaj teeb meem dab tsi nrog nws thiab tsis muaj tsos mob dab tsi tshwm sim.

Txawm li cas los xij, vim MGUS tuaj yeem hloov mus ua mob qog noj ntshav, koj tus kws kho mob yuav kuaj xyuas qib M protein hauv koj cov ntshav thiab zis txhua 6 lub hlis lossis ib xyoos ib zaug. Qhov no hu ua "kev tos saib xyuas." Zoo li tus neeg saib xyuas, tus kws kho mob tab tom saib xyuas seb puas muaj dab tsi hloov pauv.

Qee zaum, cov neeg uas muaj tus kab mob MGUS yuav muaj feem yuav pob txha poob lossis pob txha tawg ntau dua. Yog tias koj muaj feem yuav raug tus kab mob no, koj tus kws kho mob yuav muab tshuaj rau koj kom koj cov pob txha muaj zog thiab lwm yam tshuaj los pab kom pob txha ceev dua.

Puas tiv thaiv tau tus mob MGUS?

Tu siab kawg li, tsis tau. Peb tsis tuaj yeem tiv thaiv qhov mob hu ua MGUS no. Vim tias nws yog tshwm sim los ntawm qee qhov kev hloov pauv hauv peb cov noob caj noob ces (kev hloov pauv noob caj noob ces), uas los ntawm cov hlwb plasma tsis zoo uas tsim, thiab cov hlwb ntawd pib tsim cov protein M. Cov kev hloov pauv noob caj noob ces no yog yam uas peb tsis tuaj yeem tswj hwm.

Yog koj muaj MGUS, yuav ua li cas?

Feem ntau, cov neeg uas muaj tus kab mob MGUS feem ntau tuaj yeem ua neej nyob li qub yam tsis muaj tsos mob dab tsi. Tsuas yog muaj ib feem me me xwb thiaj li muaj cov mob qog ntshav lossis lwm yam kab mob ntshav uas peb tau tham ua ntej.

Yog koj cov ntshav thiab zis kuaj pom tias koj muaj M protein, koj yuav tsum tau kuaj ntshav thiab zis dua txhua 6 txog 12 lub hlis. Qhov no yog los pab koj cov kws kho mob saib xyuas koj tus mob kom pom tias nws puas zuj zus tuaj. Qhov no yuav zoo li ua rau koj ntxhov siab me ntsis, tab sis nws tseem ceeb heev rau koj txoj kev nyab xeeb.

Kuv yuav saib xyuas kuv tus kheej li cas?

Txawm hais tias tsis paub meej tias yog vim li cas thiaj ua rau muaj MGUS, peb tau tham txog kev sib txuas ntawm cov kab mob autoimmune, lawv cov kev kho mob, cov tshuaj tua kab mob ntau, thiab cov tshuaj tua kab. Nws kuj tseem pom ntau dua rau cov neeg hnub nyoog tshaj 50 xyoo.

• Yog koj txhawj xeeb tias koj muaj MGUS, nrog koj tus kws kho mob tham txog tej yam uas ua rau koj muaj feem yuav mob thiab tham txog kev kuaj mob yog tias tsim nyog.
• Yog koj twb muaj MGUS lawm, ua raws li koj tus kws kho mob cov lus qhia kom meej. Mus kuaj mob raws sijhawm.
• Yog koj muaj cov tsos mob tshiab, xws li tsis muaj zog, tsis muaj zog, thiab tsis hnov ​​​​​​lus zoo li peb tau tham ua ntej, qhia rau koj tus kws kho mob tam sim ntawd.

MGUS yog ib yam mob uas txawm tias kev kho mob tseem tsis tau nkag siab tag nrho. Raws li lub npe qhia, tseem muaj ntau yam uas peb tsis paub txog nws. Piv txwv li, nws tsis meej tias qee tus neeg uas muaj tus mob no tau mob qog ntshav lossis mob ntshav loj li cas thaum lwm tus tsis paub.

Tiamsis cov kws kho mob maj mam tshawb nrhiav cov lus zais no. Yog tias koj muaj MGUS, cov kws kho mob tam sim no tuaj yeem kwv yees tau qee yam uas koj yuav muaj kab mob loj npaum li cas. Nws yog ib qho tseem ceeb uas yuav tsum tham nrog koj tus kws kho mob txog tej yam uas yuav ua rau koj muaj feem yuav muaj MGUS. Raws li cov ntaub ntawv ntawd, koj tuaj yeem txiav txim siab seb puas tsim nyog rau koj mus kuaj mob.

Thaum kawg, tej yam uas yuav tsum nco ntsoov

Tsis txhob ntshai thaum koj hnov ​​lub npe MGUS (Monoclonal Gammopathy of Undetermined Significance). Qhov tseem ceeb tshaj plaws yog kom paub txog qhov no.

• MGUS tsis yog mob qog noj ntshav, tab sis nws yog ib yam mob uas tuaj yeem ua rau mob qog noj ntshav.
• Muaj coob tus neeg tsis muaj tsos mob thiab tsis xav tau kev kho mob.
• Qhov tseem ceeb tshaj plaws yog kev kuaj xyuas tsis tu ncua ntawm lub sijhawm .
• Yog tias muaj cov tsos mob tshiab tshwm sim, qhia rau koj tus kws kho mob tam sim ntawd.
• Tham nrog koj tus kws kho mob txog tej lus nug lossis kev txhawj xeeb uas koj muaj. Lawv yeej npaj txhij los pab koj.

Vam tias cov ntaub ntawv no tau pab koj nkag siab zoo dua txog MGUS. Nco ntsoov tias, koj tsis yog tib leeg xwb, koj cov kws kho mob thiab cov neeg koj hlub nrog koj nyob.

MGUS , Monoclonal Gammopathy of Undetermined Significance, M protein, Plasma cells, Pob Txha, Mob Cancer Ntshav, Cov Kab Mob Ntshav, Multiple Myeloma