Nws yog ib qho ib txwm rau txhua tus neeg yuav ntshai thiab poob siab thaum lawv hnov cov lus "mob qog noj ntshav colorectal". Txawm li cas los xij, ua tsaug rau kev nce qib hauv kev kho mob niaj hnub no, muaj ntau yam kev kho mob tshiab thiab ua tiav uas tuaj yeem pab peb daws cov kab mob zoo li no. Hnub no, peb yuav tham txog txoj kev "tshuaj kho mob tsom mus rau" uas txawv ntawm kev siv tshuaj kho mob ib txwm muaj thiab tsom mus rau cov hlwb qog noj ntshav.
Hais yooj yim xwb, cov Monoclonal Antibodies no yog dab tsi?
Ua ntej peb nkag siab qhov no, cia peb los saib seb peb lub cev muaj lub cev tiv thaiv kab mob zoo kawg li cas. Thaum ib tug kab mob, xws li cov kab mob me me lossis ib tug kab mob me me, nkag mus rau hauv peb lub cev, peb lub cev tiv thaiv kab mob tsim cov protein tshwj xeeb uas tuaj yeem paub cov neeg nkag mus rau hauv peb lub cev, txuas nrog lawv, thiab rhuav tshem lawv. Peb hu cov no ua "cov neeg tiv thaiv," lossis cov tshuaj tiv thaiv kab mob kom meej dua.
Tam sim no, cov "(Monoclonal Antibodies)" no yog ib hom tshuaj tiv thaiv kab mob cuav uas ua nyob rau hauv chav kuaj mob siv cov thev naus laus zis tshwj xeeb. Cov no yog tsim los tawm tsam ib lub hom phiaj tshwj xeeb xwb. Yog xav kom meej meej, lawv tau tsim los paub txog ib yam tshwj xeeb, zoo li ib qho protein ntawm qhov chaw ntawm lub cell mob qog noj ntshav, txuas rau nws xwb, thiab rhuav tshem lub cell mob qog noj ntshav ntawd .
Qhov no zoo li ib tug tub rog uas tau kawm tshwj xeeb uas tuaj yeem nrhiav tau ib tug yeeb ncuab hauv ib qho chaw uas muaj neeg coob coob thiab tsuas yog tawm tsam tus yeeb ncuab ntawd xwb yam tsis ua rau lwm tus raug mob. Yog li ntawd, es tsis txhob ua rau cov hlwb zoo hauv lub cev puas tsuaj zoo li kev kho mob chemotherapy ib txwm muaj, txoj kev kho mob no yuav muaj tsawg dua cov kev mob tshwm sim vim nws tshwj xeeb dua.
Cov tshuaj uas tiv thaiv kev loj hlob ntawm cov hlab ntsha hauv mob qog noj ntshav (Angiogenesis Inhibitors)
Kab mob qog noj ntshav tsis yog ib yam dab tsi uas tsuas yog loj hlob xwb. Nws zoo li ib tsob nroj. Nws xav tau kev noj haus kom muaj sia nyob, kom loj hlob, thiab kom loj hlob. Yuav kom tau txais cov khoom noj no, cov qe ntshav qog noj ntshav yuav loj hlob cov hlab ntsha tshiab nyob ib puag ncig lawv tus kheej. Peb hu cov txheej txheem no "angiogenesis." Yog li, yog tias peb nres cov hlab ntsha uas muab cov "khoom noj thiab dej haus" no rau kab mob qog noj ntshav, peb tuaj yeem nres qhov kev loj hlob ntawm kab mob qog noj ntshav, puas yog? Ntawd yog qhov peb hu ua pawg tshuaj uas ua li ntawd.
Nov yog li cas Bevacizumab (Avastin) ua haujlwm:
Bevacizumab (lub npe lag luam: Avastin) yog ib hom tshuaj tseem ceeb hauv pawg no. Cov hlwb qog nqaij hlav xa ib lub teeb liab uas qhia rau lawv "tsim cov hlab ntsha." Lub teeb liab no hu ua vascular endothelial growth factor, lossis VEGF. Qhov Avastin ua yog thaiv lub teeb liab ntawd kom tsis txhob mus txog qhov chaw uas lawv xav tau. Hauv cov lus yooj yim, nws cuam tshuam "tsab ntawv los tsim cov hlab ntsha" uas tus mob qog nqaij hlav xa thiab rhuav tshem nws.
Qhov no tiv thaiv tus mob qog noj ntshav kom tsis txhob tsim cov hlab ntsha tshiab, uas ua rau tus mob qog noj ntshav qeeb zuj zus. Cov tshuaj no tau pom zoo rau tus mob qog noj ntshav hauv plab hnyuv uas tau kis mus rau lwm qhov ntawm lub cev. Txawm hais tias nws tsis tuaj yeem kho tus mob qog noj ntshav tag nrho, kev tshawb fawb tau pom tias Avastin, thaum muab nrog kev kho mob chemotherapy, tuaj yeem ncua lub sijhawm ciaj sia ntawm cov neeg mob li 5 lub hlis .
`Fruquintinib (Fruzaqla)`, `ramucirumab (Cyramza)`, thiab `ziv-aflibercept (Zaltrap)` yog qee cov tshuaj tshiab uas tseem tsom 'VEGF'.
Yuav muab tshuaj Avastin li cas? Cov kev mob tshwm sim yog dab tsi?
Avastin yog ib qho tshuaj txhaj rau hauv cov hlab ntsha (IV). Feem ntau nws raug muab txhua ob mus rau peb lub lis piam ua ke nrog kev kho mob qog noj ntshav.
Nws yog ib qho tseem ceeb heev uas yuav tsum paub txog cov kev mob tshwm sim ntawm cov tshuaj no.
| Hom kev phiv tshuaj | Kev piav qhia |
|---|---|
| Cov kev mob tshwm sim feem ntau |
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| Cov kev mob tshwm sim loj heev |
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Cov tshuaj uas cuam tshuam ncaj qha rau kev loj hlob ntawm cov hlwb qog noj ntshav
Cetuximab (Erbitux) thiab panitumumab (Vectibix) yog ob hom monoclonal antibodies. Cov no ua haujlwm txawv. Lawv tsom mus rau ib qho protein hu ua epidermal growth factor receptor (EGFR) ntawm qhov chaw ntawm cov hlwb qog noj ntshav.
Xav txog qhov 'EGFR' no ua ib qho 'On' switch uas qhia rau lub cell mob qog noj ntshav kom 'faib sai thiab loj hlob ntau dua.' Cov tshuaj 'Erbitux' thiab 'Vectibix' ua yog zaum ntawm qhov switch no thiab 'thaiv' nws. Tom qab ntawd, lub teeb liab ntuj uas qhia rau lub cell kom loj hlob tsis tuaj yeem tig lub switch. Ua li no, kev loj hlob ntawm cov cell mob qog noj ntshav raug tswj.
Cov tshuaj no muab rau leej twg?
Ob qho tib si Erbitux thiab Vectibix tau pom zoo los kho mob qog noj ntshav hauv plab hnyuv uas tau kis mus rau lwm qhov ntawm lub cev.
Cov tshuaj tiv thaiv Erbitux raug muab ib zaug ib lub lim tiam, ib leeg xwb los yog nrog cov tshuaj chemotherapy irinotecan (Camptosar). Cov tshuaj tiv thaiv Vectibix raug muab txhua ob lub lim tiam ua ke nrog lwm cov tshuaj chemotherapy.
Nws yog ib qho tseem ceeb heev uas ua ntej muab cov tshuaj no, yuav tsum kuaj xyuas kev hloov pauv caj ces tshwj xeeb rau koj cov hlwb qog noj ntshav kom pom tias cov tshuaj no puas yuav ua haujlwm rau cov qog noj ntshav ntawd. Cov no tsis haum rau txhua yam qog noj ntshav. Yog li ntawd, qhov kev kuaj no yeej ua tiav lawm.
Cov kev mob tshwm sim ntawm Erbitux thiab Vectibix yog dab tsi?
Cov tshuaj no kuj muaj cov kev mob tshwm sim tshwj xeeb.
| Cov kev mob tshwm sim feem ntau ntawm Erbitux thiab Vectibix | |
|---|---|
| Teeb meem ntawm daim tawv nqaij | Cov pob khaus zoo li pob khaus, tawv nqaij ua pob khaus, thiab tawv nqaij qhuav. Tab sis qhov txawv txawv yog, qee zaum cov kev tsis haum ntawm daim tawv nqaij txhais tau tias cov tshuaj no ua haujlwm zoo tiv thaiv mob qog noj ntshav. |
| Lwm yam kev mob tshwm sim |
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Cov Lus Qhia Txog Kev Coj Mus Tsev
- Cov Tshuaj Monoclonal Antibodies yog ib txoj kev kho mob siab heev uas tsom mus rau thiab tawm tsam cov hlwb qog noj ntshav. Lawv txawv ntawm kev kho mob chemotherapy ib txwm muaj.
- Muaj tej tshuaj uas txiav cov ntshav uas mus rau mob qog noj ntshav, thaum lwm yam tshuaj thaiv lub cev uas ua rau cov qe ntshav loj hlob.
- Tag nrho cov tshuaj no muaj lawv cov kev mob tshwm sim. Tham txog cov no nrog koj tus kws kho mob ua ntej pib kho.
- Cov kev kho mob no tsis haum rau txhua tus. Koj tus kws kho mob yuav txiav txim siab seb kev kho mob twg zoo tshaj plaws rau koj raws li hom mob qog noj ntshav uas koj muaj, nws kis mus deb npaum li cas, thiab cov txiaj ntsig ntawm kev kuaj noob caj noob ces tshwj xeeb.
- Yog koj lossis ib tug neeg hauv koj tsev neeg muaj mob qog noj ntshav, tsis txhob ntshai. Tham nrog koj tus kws kho mob qog noj ntshav txog txhua txoj kev kho mob uas muaj, lawv cov txiaj ntsig thiab qhov tsis zoo, thiab ua siab loj los ntsib kev kho mob.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus