Nws nyuaj rau piav qhia txog kev ntshai thiab kev ntxhov siab uas ib tug neeg xav thaum kuaj pom tias muaj mob qog noj ntshav. Tab sis nrog rau kev nce qib ntawm kev tshawb fawb kho mob, niaj hnub no muaj cov txheej txheem kho mob qog noj ntshav zoo heev thiab ua tiav. Tsis zoo li yav dhau los, tam sim no muaj cov kev kho mob tshwj xeeb uas tsom thiab tawm tsam cov hlwb qog noj ntshav xwb. Niaj hnub no, peb tab tom tham txog txoj kev kho mob tseem ceeb heev uas siv rau mob qog noj ntshav hauv plab hnyuv. Ntawd yog Monoclonal Antibody Therapy.
Cov Monoclonal Antibodies no yog dab tsi?
Ua ntej peb nkag siab qhov no, cia peb los saib peb lub cev tiv thaiv kab mob. Thaum ib tug neeg sab nraud nkag los, xws li kab mob lossis tus kab mob, nkag mus rau hauv peb lub cev, peb lub cev tiv thaiv kab mob yuav tsim cov protein tshwj xeeb los nrhiav thiab rhuav tshem lawv. Peb hu cov tshuaj no ua cov tshuaj tiv thaiv kab mob. Nws zoo li ib pab tub rog tiv thaiv ib lub teb chaws.
Tam sim no xav txog tias cov tub rog no muaj "pab tub rog tshwj xeeb" uas tau kawm tshwj xeeb thiab paub yuav ua li cas tawm tsam tsuas yog ib lub hom phiaj xwb. Cov tshuaj Monoclonal Antibodies yog ib yam dab tsi zoo li ntawd. Cov no yog cov tshuaj tshwj xeeb uas tau tsim los ntawm kev tsim khoom hauv chav kuaj mob. Lawv tau tsim los nrhiav ib lub hom phiaj, txuas rau nws, thiab rhuav tshem nws. Hauv qhov no, lub hom phiaj ntawd yog lub hlwb mob qog noj ntshav.
Qhov zoo tshaj plaws ntawm kev kho mob no yog nws qhov kev ua tau zoo . Kev kho mob qog noj ntshav ib txwm zoo li lub foob pob. Txawm hais tias nws tua cov hlwb qog noj ntshav, nws kuj tseem tuaj yeem ua rau cov hlwb noj qab haus huv puas tsuaj. Yog vim li cas kev kho mob qog noj ntshav ua rau muaj kev phiv xws li plaub hau poob thiab qaug zog. Tab sis kev kho mob Monoclonal Antibody zoo li "lub foob pob hluav taws." Nws mus ncaj qha rau cov hlwb qog noj ntshav. Yog li ntawd, koj tuaj yeem cia siab tias yuav muaj kev phiv tsawg dua.
Cov tshuaj uas nres "txoj kab cawm siav" ntawm mob qog noj ntshav
Kab mob qog noj ntshav tsis yog ib pawg ntawm cov hlwb xwb. Nws zoo li lub Hoobkas me me. Nws xav tau kev noj haus kom loj hlob, kom loj dua. Yuav kom tau txais cov khoom noj no, cov hlwb qog noj ntshav tsim cov hlab ntsha tshiab rau lawv tus kheej. Hauv kev kho mob, peb hu cov txheej txheem no ua angiogenesis . Nws yog los ntawm cov hlab ntsha no uas kab mob qog noj ntshav tau txais cov khoom noj uas nws xav tau kom muaj sia nyob.
Yog li, qee cov monoclonal antibodies ua yog tiv thaiv cov hlab ntsha ntawd. Nws zoo li txiav tawm "kev muab" roj rau mob qog noj ntshav. Ib qho tshuaj tseem ceeb hauv pawg no yog Bevacizumab (Avastin) .
Avastin ua haujlwm li cas?
Cov qe ntshav qog tso tawm ib lub cim tshwj xeeb hu ua Vascular Endothelial Growth Factor (VEGF) . Thaum lub cim no tau txais, lub cev pib tsim cov hlab ntsha tshiab. Cov tshuaj Avastin ua haujlwm los ntawm kev thaiv lub cim VEGF ntawd. Qhov no tiv thaiv tus kab mob qog los ntawm kev tsim cov hlab ntsha tshiab. Tom qab ntawd, yog tsis muaj kev noj zaub mov, tus kab mob qog txoj kev loj hlob qeeb lossis nres.
Avastin yog ib txoj kev kho mob uas tau pom zoo rau mob qog noj ntshav hauv plab hnyuv uas tau kis mus rau lwm qhov ntawm lub cev. Txawm hais tias nws tsis kho tau mob qog noj ntshav tag nrho, kev tshawb fawb tau qhia tias Avastin, thaum muab nrog kev kho mob chemotherapy, ua rau cov neeg mob muaj sia nyob ntev dua li tsib lub hlis.
Qee cov tshuaj tshiab hauv pawg no suav nrog `Fruquintinib (Fruzaqla), `ramucirumab (Cyramza)` thiab `ziv-aflibercept (Zaltrap).` Cov no kuj ua haujlwm los ntawm kev cuam tshuam nrog VEGF signaling system.
Yuav ua li cas muab Avastin thiab nws cov kev phiv
Avastin yog ib yam tshuaj uas muab rau hauv cov hlab ntsha lossis IV. Feem ntau muab rau txhua ob mus rau peb lub lis piam nrog rau kev kho mob chemotherapy. Qhov tseem ceeb uas yuav tsum nco ntsoov yog tias cov tshuaj no ua rau cov txiaj ntsig ntawm kev kho mob chemotherapy zoo dua, tab sis tsis tau pom tias muaj txiaj ntsig zoo thaum muab ib leeg rau cov neeg mob uas muaj mob qog noj ntshav hauv plab hnyuv.
Nws yog ib qho tseem ceeb heev uas yuav tsum tham nrog koj tus kws kho mob txog txhua yam kev tsis xis nyob uas koj yuav ntsib ua ntej pib kho mob no thiab thaum lub sijhawm kho mob.
| Tej zaum yuav muaj cov kev mob tshwm sim ntawm Bevacizumab (Avastin) | |
|---|---|
| Cov kev mob tshwm sim uas feem ntau pom | |
| Xav tias nkees thiab tsis muaj sia nyob | Mob taub hau |
| Ntshav siab | Kev ntshaw noj mov |
| Mob plab (mob plab) | |
| Cov kev mob tshwm sim loj heev uas yuav tsum tau qhia rau tus kws kho mob tam sim ntawd | |
| Kev tho qhov ntawm txoj hnyuv loj (tej zaum yuav xav tau kev phais) | Kev puas tsuaj rau lub raum thiab muaj protein ntau ntxiv hauv cov zis |
| Mob plawv nres los yog mob hauv siab | Txo qhov txhab kho (yog li ntawd nws yuav tsum tsis txhob siv tam sim ntawd tom qab phais) |
| Teeb meem ntshav ntws ntau dhau los yog ntshav txhaws | |
Cov tshuaj uas tua qhov "hloov kev loj hlob" hauv cov hlwb qog noj ntshav
Cia peb tham txog lwm hom monoclonal antibody. Cov no tsis ua haujlwm li peb tau hais ua ntej. Cov tshuaj no ncaj qha tsom mus rau ib qho protein tshwj xeeb ntawm qhov chaw ntawm cov hlwb qog noj ntshav. Nws hu ua Epidermal Growth Factor Receptor (EGFR) .
Hais yooj yim xwb, EGFR no zoo li "lub hloov" uas qhia rau lub cell mob qog noj ntshav kom "loj hlob, loj hlob." Kwv yees li 75% ntawm cov mob qog noj ntshav hauv plab hnyuv muaj cov protein EGFR no.
Cov tshuaj cetuximab (Erbitux) thiab panitumumab (Vectibix) ua haujlwm los ntawm kev txuas rau "qhov hloov" hu ua EGFR thiab tua nws. Qhov no tiv thaiv lub cim ntuj uas qhia kom cov hlwb loj hlob los ntawm kev sib cuag nrog qhov hloov. Yog li ntawd, cov hlwb qog noj ntshav tsis loj hlob.
Erbitux thiab Vectibix siv rau leej twg?
Ob hom tshuaj no tau pom zoo rau mob qog noj ntshav hauv plab hnyuv uas tau kis mus rau lwm qhov ntawm lub cev. Tab sis muaj ib qho tseem ceeb heev . Ua ntej pib txoj kev kho mob no, koj yuav tsum muaj kev kuaj noob caj noob ces tshwj xeeb ('kev kuaj noob caj noob ces') ntawm koj cov qe ntshav qog noj ntshav. Qhov kev kuaj ntawd yog qhov txiav txim siab seb cov tshuaj no puas yuav ua haujlwm rau koj mob qog noj ntshav lossis tsis ua haujlwm. Qhov no tsis haum rau txhua tus.
Erbitux muab rau hauv cov hlab ntsha ib zaug ib lub lim tiam. Nws muab ib leeg lossis nrog cov tshuaj chemotherapy irinotecan (Camptosar). Vectibix muab txhua ob lub lim tiam, feem ntau yog ua ke nrog ntau lwm cov tshuaj chemotherapy.
| Tej zaum yuav muaj cov kev mob tshwm sim ntawm Erbitux thiab Vectibix | |
|---|---|
| Teeb meem ntawm daim tawv nqaij: cov pob khaus zoo li pob khaus, pob khaus ntawm daim tawv nqaij, daim tawv nqaij qhuav. (Nco ntsoov, qee zaum cov kev tsis haum ntawm daim tawv nqaij no tuaj yeem yog ib qho cim qhia tias cov tshuaj no ua haujlwm tawm tsam mob qog noj ntshav!) | Ua npaws |
| Xav tias nkees thiab tsis muaj sia nyob | Kab mob cem quav |
| Mob plab | Kev ua xua xws li ua pa nyuaj thiab ntshav siab qis |
| Cov kev tshwm sim uas tshwm sim thaum cov tshuaj raug muab rau hauv lub cev | |
Tag nrho cov kev kho mob no yog tshwj xeeb heev. Tsuas yog koj tus kws kho mob thiaj li txiav txim siab tau txoj kev kho mob zoo tshaj plaws rau koj raws li hom mob qog noj ntshav thiab koj txoj kev noj qab haus huv. Tsis txhob txiav txim siab raws li koj nyeem hauv internet lossis lwm tus neeg tau hais.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Monoclonal Antibody yog kev kho mob tshwj xeeb uas tsim los hauv chav kuaj mob uas tsom thiab tawm tsam tsuas yog cov hlwb qog noj ntshav xwb.
- Muaj ntau txoj kev ua haujlwm no. Qee cov tshuaj thaiv cov ntshav uas mus rau mob qog noj ntshav, thaum lwm cov tshuaj tiv thaiv cov cim uas cov hlwb qog noj ntshav tso tawm kom loj hlob.
- Cov kev kho mob no tsis zoo ib yam rau txhua tus. Ua ntej muab qee cov tshuaj, koj yuav tsum tau ua cov kev kuaj tshwj xeeb txog caj ces kom pom tias cov tshuaj puas yuav ua haujlwm rau koj tus mob qog noj ntshav.
- Ib yam li txhua yam tshuaj, cov tshuaj no muaj cov kev mob tshwm sim. Tsis txhob ntshai lawv, tab sis nrog koj tus kws kho mob tham txog lawv kom meej ua ntej pib kho.
- Tsuas yog koj tus kws kho mob thiaj li muab tau cov lus qhia zoo tshaj plaws thiab kev taw qhia txog koj txoj kev kho mob qog noj ntshav, yog li nws tseem ceeb heev uas yuav tsum ua raws li lawv cov lus qhia.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus