Yog tias koj tab tom tawm tsam mob qog noj ntshav, lossis yog tias koj muaj ib tus neeg koj hlub uas muaj mob qog noj ntshav, tej zaum koj yuav paub txog cov lus zoo li "chemotherapy" thiab "radiation therapy." Tej zaum koj twb tau hnov txog cov kev mob tshwm sim uas los nrog cov kev kho mob no. Tab sis hnub no peb yuav tham txog ib pawg tshuaj tshiab uas tsom mus rau cov hlwb qog noj ntshav thiab txo qhov kev puas tsuaj rau cov hlwb noj qab haus huv. Cov no hu ua PARP Inhibitors .
Hais yooj yim xwb, PARP Inhibitor no yog dab tsi?
Yuav kom nkag siab qhov no, peb yuav tsum xub nkag siab txog ib qho txheej txheem me me tab sis tseem ceeb heev uas tshwm sim hauv peb lub cev cov cell. Hauv txhua lub cell hauv peb lub cev muaj ib yam hu ua DNA. Xav txog nws zoo li daim ntawv loj uas tau sau txog txhua yam hauv peb lub cev yuav tsum ua haujlwm li cas. Qee zaum, cov nplooj ntawv ntawm daim ntawv DNA no raug puas tsuaj me ntsis.
Qhov no yog qhov uas ib hom protein hu ua PARP los ua lub luag haujlwm. "PARP" yog ib lo lus luv rau Poly (ADP-ribose) polymerase . PARP zoo li ib yam "kho" hauv peb cov cell. Thaum DNA puas lawm, cov protein PARP yuav mus kho nws. Qhov no yog qhov tseem ceeb rau kev ciaj sia ntawm cov cell noj qab haus huv.
Tiamsis qhov teeb meem yog, cov hlwb qog noj ntshav kuj siv lub tshuab PARP no kom zoo dua. Thaum cov DNA ntawm cov hlwb qog noj ntshav puas lawm, lawv kuj siv PARP no los kho nws. Yog li ntawd, cov hlwb qog noj ntshav tsis tuag, tab sis txuas ntxiv loj hlob thiab kis thoob plaws lub cev.
Ua ib qho kev daws teeb meem rau qhov no, cov kws kho mob siv cov tshuaj hu ua PARP Inhibitor. "Inhibitor" txhais tau tias "blocker." Cov tshuaj no ua yog "thaiv" lub tshuab PARP uas pab cov hlwb qog noj ntshav. Yog tsis muaj PARP kev pab, cov hlwb qog noj ntshav maj mam qaug zog, tsis tuaj yeem kho cov DNA uas puas lawm, thiab thaum kawg tuag.
Qhov no zoo li tua lub "system ciaj sia" ntawm cov qog nqaij hlav. Yog vim li cas txoj kev kho mob no thiaj li hu ua kev kho mob tsom mus rau ib qho chaw . Yog li ntawd, cov tshuaj no tsom mus rau qhov tsis muaj zog ntawm cov qog nqaij hlav.
Cov hom tshuaj PARP inhibitors tseem ceeb uas siv hauv ntiaj teb
Muaj ntau yam tshuaj PARP inhibitors uas tau pom zoo siv rau kev kho mob qog noj ntshav. Yog tias koj tus kws kho mob sau ib yam tshuaj no rau koj, tej zaum nws yuav nyob hauv daim ntawv teev npe no.
| Lub Npe Tshuaj General | Lub Npe Hom |
|---|---|
| Olaparib | Lynparza® |
| Niraparib | Zejula® |
| Rucaparib | Rubraca® |
| Talazoparib | Talzenna® |
Cov tshuaj no siv rau hom mob qog noj ntshav twg?
Cov tshuaj PARP inhibitors feem ntau yog siv rau cov mob qog nqaij hlav uas mob hnyav dua lossis tau kis mus rau lwm qhov ntawm lub cev (metastatic). Muaj ntau hom mob qog nqaij hlav uas lawv ua haujlwm tau zoo tshaj plaws.
- Mob qog noj ntshav hauv lub mis
- Mob qog nqaij hlav zes qe menyuam
- Mob qog nqaij hlav ntawm lub raj mis
- Mob qog nqaij hlav prostate
- Mob qog nqaij hlav peritoneal thawj zaug
- Mob qog nqaij hlav pancreatic
Kev sib raug zoo tshwj xeeb nrog BRCA gene mutations
Nov yog qee yam uas koj yuav tsum paub txog BRCA gene . BRCA yog lwm yam gene tseem ceeb uas pab kho DNA hauv peb cov cell thiab tiv thaiv mob qog noj ntshav. Tab sis qee tus neeg yuav muaj kev hloov pauv hauv BRCA gene no. Qhov no txhais tau tias ib qho ntawm lawv cov txheej txheem kho DNA tseem ceeb tsis ua haujlwm zoo. Vim li no, lawv muaj feem yuav mob qog noj ntshav ntau dua.
Xav txog lub tsheb zoo li muaj ob lub tshuab nres. BRCA yog ib qho, thiab PARP yog lwm qhov. Hauv cov cell mob qog noj ntshav uas muaj kev hloov pauv BRCA gene, ib lub tshuab nres (BRCA) twb tawg lawm. Yog li ntawd, cov cell mob qog noj ntshav ntawd yuav luag vam khom lwm lub tshuab nres (PARP) kom muaj sia nyob.
Tam sim no thaum peb muab cov tshuaj PARP Inhibitor, peb tua lub kaw lus nres thib ob ntawd thiab. Tom qab ntawd lub cell mob qog noj ntshav tsis muaj txoj hauv kev los kho nws cov DNA, thiab nws tsuas tuag xwb. Qhov no yog vim li cas PARP Inhibitors thiaj li ua tau zoo rau cov mob qog noj ntshav uas muaj kev hloov pauv ntawm BRCA gene.
Kuv yuav tau txais kev kho mob li cas thiab nws siv sijhawm ntev npaum li cas?
Ib qho yooj yim ntawm kev kho mob no yog tias nws txhua yam los ua cov tshuaj ntsiav (tshuaj ntsiav lossis ntsiav tshuaj). Yog li koj tsuas yog yuav tsum noj cov tshuaj no ib lossis ob zaug hauv ib hnub. Qee zaum cov tshuaj no ib leeg xwb yuav txaus. Lwm lub sijhawm, koj yuav tsum noj nws nrog rau lwm yam kev kho mob qog noj ntshav.
Piv txwv li, tom qab kev kho mob uas ua rau cov DNA ntawm cov hlwb qog noj ntshav puas tsuaj, xws li kev kho mob chemotherapy lossis kev kho mob hluav taws xob, koj tuaj yeem muab cov tshuaj PARP inhibitor. Tom qab ntawd, vim tias PARP tsis pab cov hlwb qog noj ntshav uas puas lawm kho lawv tus kheej, cov hlwb ntawd tau lees tias yuav tuag.
Lub sijhawm kho mob
Qhov no txawv ntawm ib tus neeg mus rau ib tus neeg.
- Muaj ib txhia neeg raug sau tshuaj no rau ib lub sijhawm tshwj xeeb, xws li ob lossis peb xyoos, tom qab kev kho mob chemotherapy tiav lawm.
- Muaj ib txhia neeg tseem noj cov tshuaj no mus ntxiv yog tias nws ua haujlwm rau lawv lub cev.
- Qee zaum, yog tias cov kev mob tshwm sim ntau dua li cov txiaj ntsig ntawm cov tshuaj, koj tuaj yeem tham nrog koj tus kws kho mob thiab tsum tsis txhob kho.
Yog li ntawd, nws yog ib qho tseem ceeb heev uas yuav tsum tham nrog koj tus kws kho mob seb koj yuav tsum noj tshuaj ntev npaum li cas thiab txiav txim siab.
Cov txiaj ntsig thiab qhov tsis zoo ntawm kev kho mob no yog dab tsi?
Cov tshuaj PARP inhibitors kho tsis tau mob qog noj ntshav tag nrho. Txawm li cas los xij, lawv tuaj yeem pab cov neeg mob uas muaj qee hom mob qog noj ntshav kom nyob ntev dua . Cov tshuaj no tswj kev loj hlob ntawm mob qog noj ntshav. Cov kws kho mob hu qhov no ua rau "tus nqi ciaj sia tsis muaj kev nce qib." Hais yooj yim, lawv ua rau lub sijhawm uas mob qog noj ntshav tseem tswj tau zoo yam tsis muaj kev mob hnyav zuj zus. Qee zaum, lawv tuaj yeem ua tau zoo dua li kev siv tshuaj kho mob qog noj ntshav.
Txawm li cas los xij, dhau sijhawm, qee cov qog nqaij hlav pib tsim "kev tiv thaiv" rau cov tshuaj no. Qhov no txhais tau tias cov tshuaj tsis ua haujlwm lawm. Qhov no tuaj yeem tshwm sim rau ntawm 40% thiab 70% ntawm cov neeg mob. Cov kws tshawb fawb tab tom sim nkag siab tias vim li cas qhov no tshwm sim thiab tab tom tshawb nrhiav txoj hauv kev tshiab los ua kom cov tshuaj no ua haujlwm tau zoo dua.
Cia peb kuj paub txog cov kev mob tshwm sim.
Ib yam li kev kho mob qog noj ntshav, cov tshuaj PARP inhibitors tuaj yeem ua rau muaj qee qhov kev mob tshwm sim. Tab sis tsis yog txhua tus neeg tau txais lawv. Thiab ntau yam ntawm cov no tuaj yeem tswj tau.
| Cov kev mob tshwm sim feem ntau | Yog vim li cas los yog muaj lus qhia ntxiv |
|---|---|
| Kev nkees thiab kev qaug zog | Feem ntau nws tuaj yeem tshwm sim los ntawm kev tsis muaj zog (anemia), uas yog kev txo qis ntawm cov qe ntshav liab hauv cov ntshav. |
| Kev los ntshav (piv txwv li, mob nqaij, ntshav ntswg) | Tej zaum yuav yog vim muaj cov platelets tsawg zuj zus. |
| Kev kis kab mob ntau zaus | Kev txo qis ntawm cov qe ntshav dawb tuaj yeem ua rau lub cev tiv thaiv kab mob tsis muaj zog. |
| Xeev siab thiab ntuav | Yuav noj lwm yam tshuaj los tswj cov no. |
| Mob plab, o, lossis cem quav | Nws tuaj yeem tswj tau los ntawm kev hloov pauv kev noj haus thiab, yog tias tsim nyog, siv tshuaj. |
| Kev hloov pauv ntawm saj hauv qhov ncauj (dysgeusia) | Khoom noj muaj saj txawv. |
| Poob phaus, kiv taub hau, mob taub hau | Cov no kuj yog cov xwm txheej uas tuaj yeem tshwm sim rau qee tus neeg. |
Tsis tshua muaj, qee cov tshuaj PARP inhibitors yuav ua rau muaj kev pheej hmoo ntawm kev mob qog ntshav hu ua mob qog ntshav myeloid acute . Txawm li cas los xij, qhov no yog ib qho mob tsis tshua muaj.
Thaum twg yuav tsum qhia rau koj tus kws kho mob tam sim ntawd
Yog tias koj noj tshuaj PARP inhibitor, nws yog ib qho tseem ceeb uas yuav tsum qhia rau koj tus kws kho mob yog tias koj muaj cov kev mob tshwm sim tshiab lossis mob hnyav zuj zus . Nws yuav hloov qhov koob tshuaj lossis sau lwm yam tshuaj los pab kho cov teeb meem xws li xeev siab.
Tshwj xeeb tshaj yog tias koj muaj cov tsos mob hauv qab no:Qhia rau koj tus kws kho mob lossis tsev kho mob tam sim ntawd:
- Cov cim qhia txog kev kis kab mob: kub taub hau, mob khaub thuas, thiab tshee hnyo.
- Cov tsos mob ntawm tus kab mob ntsws: Ua pa nyuaj, ua pa nrov nrov, hauv siab nruj, thiab lwm yam. (Qhov no yog ib qho mob ntsws o).
- Cov cim qhia txog cov ntshav txhaws: ceg o, mob, liab lossis mob hauv siab, ua pa nyuaj.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Cov tshuaj PARP Inhibitors yog ib hom "kev kho mob uas tsom mus rau" uas tsom mus rau qhov kho DNA ntawm cov hlwb qog noj ntshav thiab rhuav tshem lawv.
- Cov no tshwj xeeb tshaj yog zoo rau cov mob qog noj ntshav xws li mob qog noj ntshav hauv lub mis, zes qe menyuam, thiab prostate uas muaj kev hloov pauv BRCA gene.
- Txoj kev kho mob no tsis yog muab los ntawm kev txhaj tshuaj, tab sis yog cov ntsiav tshuaj/tshuaj ntsiav uas noj txhua hnub.
- Txawm hais tias qhov no tsis kho tau tus mob qog noj ntshav tag nrho los xij, nws pab cov neeg mob kom muaj sia nyob ntev dua los ntawm kev tswj kev loj hlob ntawm tus mob qog noj ntshav.
- Ib yam li lwm yam kev kho mob qog noj ntshav, cov no muaj cov kev mob tshwm sim. Kev qaug zog, xeev siab, thiab cov qe ntshav qis tuaj yeem tshwm sim.
- Nws yog ib qho tseem ceeb heev uas yuav tsum sib cuag nrog koj tus kws kho mob thoob plaws koj txoj kev kho mob thiab qhia txog tej yam tshwm sim tam sim ntawd.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus