Thaum koj hnov lub npe no, tej zaum koj yuav xav txog Paj Huam, puas yog? Tab sis qhov no tsis yog ib zaj dab neeg txog paj huam. POEMS syndrome yog ib qho mob ntshav tsis tshua muaj uas tuaj yeem cuam tshuam rau peb lub cev cov hlab ntsha, ntau yam kabmob, lub cev hormonal, thiab daim tawv nqaij tib lub sijhawm. Nws nyuaj me ntsis rau kev kuaj mob, vim tias cov tsos mob cuam tshuam nrog nws tuaj yeem zoo ib yam li cov tsos mob ntawm ntau lwm yam kab mob. Yog vim li cas nws thiaj li tseem ceeb heev uas yuav tsum paub txog qhov no.
Vim li cas qhov no thiaj hu ua POEMS?
Nws tau txais nws lub npe los ntawm thawj cov ntawv ntawm tsib ntawm cov tsos mob tseem ceeb thiab cov cim qhia ntawm tus kab mob. Cia peb saib seb lawv yog dab tsi.
| Tsab Ntawv | Lub ntsiab lus thiab kev piav qhia yooj yim |
|---|---|
| P | Polyneuropathy: Qhov no hais txog kev puas tsuaj rau cov hlab ntsha thoob plaws lub cev, tshwj xeeb tshaj yog nyob rau hauv ob txhais ceg. |
| O | Organomegaly: Kev loj hlob ntawm qee cov kabmob hauv lub cev, xws li lub siab, tus po, lossis cov qog ntshav, dhau qhov loj li qub. |
| E | Endocrinopathy: Ib qho teeb meem ntawm kev ua haujlwm ntawm cov qog (endocrine system) hauv peb lub cev uas tsim cov tshuaj hormones. |
| M | Monoclonal protein: Kuj hu ua M-protein. Muaj cov protein txawv txav ntau hauv cov ntshav. |
| S | Kev hloov pauv ntawm daim tawv nqaij:Tej yam zoo li daim tawv nqaij tsis muaj xim thiab daim tawv nqaij tuab. |
Muaj tej lub sij hawm uas yuav siv sij hawm ntau lub hlis los kuaj mob kom paub qhov mob no, vim tias cov tsos mob no yooj yim to taub nrog ntau lwm yam kab mob thaum noj cais.
Cov tsos mob ntawm tus kab mob POEMS yog dab tsi?
Tam sim no cia peb saib kom meej txog cov tsos mob ntawm txhua feem ntawm POEMS uas tau tham saum toj no.
- P - Kev puas tsuaj rau cov hlab ntsha (Polyneuropathy): Qhov no yog thawj qhov uas ntau tus neeg pom. Cov ntiv taw thiab cov taw ntawm ko taw yuav hnov mob loog, khaus, thiab yuav hnov mob kub hnyiab lossis mob ntse . Raws li lub sijhawm dhau mus, qhov mob no tuaj yeem kis mus rau tes. Lub zog ntawm tes txo qis, thiab koj yuav tsis tuaj yeem tuav dab tsi hauv koj txhais tes. Hauv cov xwm txheej hnyav, nws yuav nyuaj rau sawv ntsug, taug kev, thiab txawm tias ua pa.
- O - Organomegaly: Koj lub siab, tus po, lossis cov qog ntshav yuav o. Qhov no tuaj yeem ua rau muaj cov tsos mob xws li xav tias puv nkaus, mob plab lossis o, thiab qaug zog heev .
- E - Kev hloov pauv Hormonal (Endocrinopathy): Kev hloov pauv Hormonal tuaj yeem ua rau muaj tej yam xws li txo qis kev ntshaw kev sib deev, cov kua mis tawm ntawm lub mis (rau ob leeg poj niam thiab txiv neej), thiab o ntawm tes thiab taw .
- M - Cov protein M txawv txav: Cov protein no tuaj yeem sib sau ua ke hauv cov ntshav thiab ua rau cov pob txha tsis muaj zog lossis puas tsuaj , uas tuaj yeem ua rau mob pob txha.
- S - Kev hloov pauv ntawm daim tawv nqaij: Daim tawv nqaij yuav tsaus dua li qub. Qee zaum daim tawv nqaij yuav tuab zuj zus, thiab tej zaum yuav muaj tej pob liab tshwm sim rau ntawm lub hauv siab. Kuj tseem yuav muaj cov plaub hau loj hlob ntxiv rau ntawm lub ntsej muag thiab ob txhais ceg, thiab cov rau tes yuav dawb .
Vim li cas ho muaj tej yam zoo li no tshwm sim?
Qhov ua rau qhov no tseem tsis tau paub meej, tab sis cov kws kho mob thiab cov kws tshawb fawb ntseeg tias nws muaj feem cuam tshuam nrog kev ua haujlwm tsis zoo ntawm ib hom cell hauv peb lub cev hu ua plasma cells .
Hais yooj yim xwb, cov qe ntshav dawb uas tsis zoo no tso cov protein M-protein uas peb tau tham txog rau hauv cov ntshav. Cov qe ntshav dawb uas tsis zoo no thiab cov protein M-protein ua ke ua rau ntau qhov ntawm lub cev puas tsuaj. Tsis tas li ntawd xwb, cov neeg mob no kuj muaj cov protein hu ua Vascular Endothelial Growth Factor (VEGF) ntau hauv lawv cov ntshav. Cov protein VEGF no ua rau cov kua dej tawm ntawm cov hlab ntsha mus rau hauv cov nqaij ib puag ncig. Cov kua dej ntxiv no ua rau o, cov kab mob loj hlob, thiab cov hlab ntsha puas tsuaj.
Qhov teeb meem no puas yuav loj heev?
Yog, POEMS syndrome qee zaum tuaj yeem hnyav sai sai, ua rau muaj teeb meem txaus ntshai rau lub neej.
Ib txhia ntawm lawv yog:
- Kab mob Capillary Leak Syndrome: Kev ua haujlwm tsis zoo ntawm lub cev tuaj yeem tshwm sim vim muaj cov kua dej ntau dhau los ntawm cov hlab ntsha.
- Kab Mob Ntsws Txwv: Ua pa nyuaj vim lub ntsws tsis nthuav dav zoo.
- Mob Ntshav Siab (Pulmonary Hypertension): Muaj kev siab ntau dhau hauv cov hlab ntsha uas nqa ntshav mus rau lub ntsws.
Yog li ntawd, yog tias koj muaj cov tsos mob, nws yog ib qho tseem ceeb heev uas yuav tsum nrhiav kev pab kho mob thiab pib kho sai li sai tau.
Tus kws kho mob nrhiav tau qhov no li cas?
Thaum koj mus ntsib kws kho mob, nws yuav mloog koj cov tsos mob kom zoo zoo. Tom qab ntawd nws yuav kuaj koj lub cev thiab pom zoo kom kuaj ntau zaus kom paub tseeb tias koj muaj mob.
| Kev Ntsuas | Koj tab tom kuaj xyuas dab tsi? |
|---|---|
| Kev kuaj ntshav thiab zis | Cov qib M-protein lossis VEGF raug kuaj xyuas rau cov hlwb plasma uas tsis zoo. |
| Kev kuaj duab (X-ray, CT scan) | Lawv tab tom nrhiav seb M-protein puas tau ua rau pob txha puas tsuaj. |
| Kev kuaj mob pob txha | Kuaj xyuas cov qe ntshav dawb uas tsis zoo hauv cov pob txha. |
| Kev kuaj mob hluav taws xob ntawm lub cev (EMG) | Koj txoj kev ua haujlwm ntawm cov hlab ntsha raug ntsuas. |
Ntxiv rau, kev kuaj ua pa, echocardiograms, thiab kev kuaj hormone yuav raug ua nyob ntawm koj cov tsos mob.
Cov kev kho mob rau qhov no yog dab tsi?
Lub hom phiaj tseem ceeb ntawm kev kho mob yog los tswj cov tsos mob thiab cov qe ntshav dawb uas tsis zoo. Muaj ntau yam kev kho mob rau qhov no.
- Kev kho mob qog noj ntshav: Kev kho mob no rhuav tshem cov hlwb plasma uas tsis zoo lossis nres lawv txoj kev loj hlob.
- Kev kho mob tiv thaiv kab mob: Cov tshuaj no pab siv koj lub cev tiv thaiv kab mob los rhuav tshem cov hlwb plasma tsis zoo.
- Kev Kho Mob Hluav Taws Xob: Kev kho mob hluav taws xob rhuav tshem cov hlwb plasma uas tsis zoo.
- Kev hloov hlwb ntawm koj tus kheej: Qhov no suav nrog kev tshem tawm cov hlwb plasma uas tsis zoo ntawm koj lub cev thiab hloov lawv nrog cov hlwb stem cell noj qab nyob zoo.
- Kev Kho Mob Lub Cev: Kev puas tsuaj ntawm cov hlab ntsha tuaj yeem ua rau nws nyuaj rau kev taug kev thiab ua cov haujlwm txhua hnub. Kev tawm dag zog kho mob lub cev tuaj yeem pab koj rov qab muaj zog.
- Kev txhawb nqa kev puas siab puas ntsws: Kev nyob nrog ib yam kab mob uas tsis tshua muaj thiab kho tsis tau zoo li no tuaj yeem ua rau nyuaj siab heev. Qhov no tuaj yeem ua rau muaj mob xws li kev ntxhov siab thiab kev nyuaj siab. Kev nrhiav kev pab los ntawm tus kws pab tswv yim tuaj yeem pab tswj hwm qhov kev ntxhov siab no.
Koj muaj peev xwm nyob nrog tus kab mob no tau ntev npaum li cas?
Qhov no yog ib qho teeb meem uas ntau tus neeg muaj. Yog tias kuaj pom tus kab mob thaum ntxov thiab kho kom zoo, ntau tus neeg tuaj yeem nyob tau 10 xyoo lossis ntau dua tom qab kuaj pom. Tam sim no muaj cov tshuaj tshiab los kho tus kab mob no. Txawm li cas los xij, qhov no tuaj yeem txawv ntawm ib tus neeg mus rau ib tus neeg. Tus neeg zoo tshaj plaws kom tau txais kev piav qhia zoo tshaj plaws thiab kev nkag siab txog koj tus mob yog koj tus kws kho mob. Yog li tham nrog nws txog nws.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- POEMS syndrome yog ib qho mob ntshav tsis tshua muaj tab sis loj heev uas cuam tshuam rau ntau lub cev.
- Lub npe no yog los ntawm cov ntawv pib ntawm nws cov yam ntxwv tseem ceeb: Polyneuropathy , Organomegaly , Endocrinopathy , M -protein, thiab Kev hloov pauv ntawm daim tawv nqaij .
- Yog tias koj tsis muaj zog, o, lossis hloov pauv ntawm daim tawv nqaij hauv koj ob txhais ceg, tsis txhob tsis quav ntsej lawv.
- Kev kuaj mob tuaj yeem nyuaj thiab siv sijhawm ntau, tab sis tam sim no muaj cov kev kho mob zoo heev los tswj tus mob.
- Yog koj muaj tej yam tsos mob txawv txawv, mus ntsib koj tus kws kho mob tam sim ntawd kom tau lus qhia.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus