Thaum koj tus kws kho mob qhia rau koj lossis ib tus neeg koj paub tias muaj tus kab mob viral xws li HIV, Hepatitis C, lossis COVID-19, koj yuav xav tias me ntsis txhawj txog cov tshuaj uas lawv yuav sau rau koj. Cov lus nug xws li, 'Cov tshuaj no yog dab tsi?' thiab 'Lawv cuam tshuam li cas rau lub cev?' los rau hauv siab. Cov tshuaj protease inhibitors yog ib pawg tshuaj muaj zog uas tuaj yeem sau rau koj thaum lub sijhawm zoo li no. Txawm hais tias lub npe yuav nyuaj me ntsis, lawv txoj haujlwm tseem ceeb heev. Hnub no, peb yuav tham txog qhov no hauv txoj kev yooj yim heev, hauv txoj kev uas koj tuaj yeem nkag siab.
Cov tshuaj protease inhibitors no yog dab tsi?
Hais yooj yim xwb, cov no yog ib hom tshuaj uas muab los kho cov kab mob viral. Lawv lub luag haujlwm tseem ceeb yog tiv thaiv tus kab mob kom tsis txhob ua daim qauv ntawm nws tus kheej thiab kis mus rau hauv peb lub cev. Nws zoo li tswj kev kis tus kab mob.
Cov tshuaj no feem ntau siv ua tshuaj antiretroviral los kho HIV/AIDS . Nws kuj tseem siv los kho cov kab mob xws li kab mob siab C thiab COVID-19.
Qee zaum cov tshuaj no tsuas yog muab rau ib leeg xwb. Tab sis feem ntau, thaum kho cov kab mob xws li HIV, nws raug muab ua ke nrog ntau lwm yam tshuaj tua kab mob, zoo li 'cocktail'. Peb hu qhov no ua Antiretroviral Therapy (ART) . Qee zaum, Protease Inhibitor siv los ua ib qho booster los ua kom lwm yam tshuaj ua haujlwm tau zoo dua.
Cov tshuaj no kho cov kab mob tseem ceeb li cas?
Cov tshuaj hu ua Protease Inhibitors tsuas yog pom zoo los kho ob peb yam kab mob viral xwb.
- HIV/AIDS: Cov tshuaj no yog siv ua ib feem tseem ceeb ntawm kev kho mob ART los tswj HIV. Lawv kuj siv rau kev tiv thaiv tom qab raug tus kab mob (PEP) kom tiv thaiv kev kis kab mob tom qab raug tus kab mob HIV (piv txwv li, kev sib deev tsis muaj kev nyab xeeb).
- Kab mob siab C: Cov no siv ua ke nrog lwm cov tshuaj tua kab mob los kho tus kab mob siab C.
- COVID-19: Thaum kis tus kab mob COVID-19, cov kws kho mob qee zaum yuav sau ntawv kom noj ob hom tshuaj Protease Inhibitors ua ke kom tiv thaiv tus kab mob kom tsis txhob hnyav zuj zus.
Cov tshuaj no ua haujlwm li cas hauv lub cev?
Yuav kom nkag siab qhov no, cia peb muab ib qho piv txwv me me. Xav txog tus kab mob yog ib tus neeg uas xav ua ib lub ncuav mog qab zib. Yuav kom ua tau lub ncuav mog qab zib no (piv txwv li tus kab mob tshiab), nws yuav tsum txiav ib daim protein loj ua tej daim me me. Cov protein me me no yog cov 'khoom xyaw' siv los ua cov kab mob tshiab.
Ntawm no, 'Protease' yog ib qho enzyme uas ua haujlwm zoo li 'txiav' uas txiav cov protein ribbon loj.
Cov tshuaj uas peb muab, uas yog...Qhov uas 'protease inhibitor' ua yog thaiv 'txiav' (protease enzyme) kom tsis txhob ua haujlwm. Thaum txiab tsis ua haujlwm lawm, tus kab mob tsis tuaj yeem txiav cov 'khoom xyaw' uas nws xav tau los ua cov kab mob tshiab. Tom qab ntawd tus kab mob tsis tuaj yeem rov ua dua hauv lub cev thiab ua cov ntawv theej ntawm nws tus kheej. Qhov ntawd yog qhov tseeb yooj yim.
Thaum tus kab mob tsis kis mus rau lwm tus li no lawm, nws yuav yooj yim dua rau peb lub cev tiv thaiv kab mob los tawm tsam tus kab mob uas tseem tshuav thiab tswj tau tus kab mob.
Cov tshuaj Protease Inhibitors uas siv ntau tshaj plaws yog dab tsi?
Vim tias txhua tus kab mob muaj nws tus kheej cov enzyme protease tshwj xeeb, ntau hom tshuaj protease inhibitors siv los kho HIV, Hepatitis C, thiab COVID-19.
Muaj ib txoj hauv kev yooj yim los txheeb xyuas cov npe ntawm cov tshuaj no.
- Cov tshuaj kho mob HIV feem ntau xaus rau hauv '-navir' .
- Cov uas muab rau tus kab mob siab C pib nrog cov lus tom qab '-previr' .
Lub rooj hauv qab no tuaj yeem piav qhia ntxiv qhov no.
| Kab mob uas tab tom kho | Piv txwv ntawm cov tshuaj |
|---|---|
| Cov tshuaj Protease Inhibitors rau HIV | Atazanavir Darunavir Lopinavir Ritonavir Saquinavir |
| Cov tshuaj Protease Inhibitors rau Hepatitis C | Boceprevir Glecaprevir Grazoprevir Simeprevir tshuaj |
| Cov tshuaj Protease inhibitors rau COVID-19 | Kev sib xyaw ua ke ntawm ob hom tshuaj, Nirmatrelvir thiab Ritonavir (hu ua Paxlovid®) |
Kuv yuav xaiv cov tshuaj zoo li cas rau kuv?
Qhov no yog tus kws kho mob uas kho koj txiav txim siab. Nws yuav tsum xav txog ntau yam thaum txiav txim siab.
- Koj tus kab mob viral: txawm tias nws yog HIV, hepatitis C, lossis COVID-19.
- Koj txoj kev noj qab haus huv dav dav: Seb koj puas muaj lwm yam kab mob, xws li ntshav qab zib, ntshav siab, kab mob raum lossis siab.
- Lwm cov tshuaj uas koj tab tom noj tam sim no: Qhov no tseem ceeb heev vim tias qee cov tshuaj tuaj yeem cuam tshuam nrog cov Protease Inhibitors no.
- Koj puas tau noj lwm yam tshuaj rau tus kab mob no ua ntej?
- Tus kab mob uas koj muaj: Qee cov kab mob tsis teb rau qee cov tshuaj.
- Tej zaum yuav muaj tej yam tsis zoo tshwm sim: Xaiv cov tshuaj uas haum rau koj lub cev tshaj plaws thiab muaj tej yam tsis zoo tshwm sim tsawg tshaj plaws.
Tseem Ceeb Heev: Nws yog ib qho tseem ceeb uas yuav tsum qhia rau koj tus kws kho mob txog txhua yam tshuaj uas koj noj (xws li cov vitamins thiab cov tshuaj ntsuab) thiab txhua yam mob uas koj muaj. Qhov no tuaj yeem pab tiv thaiv ntau yam kev phiv tshuaj thiab kev sib cuam tshuam ntawm cov tshuaj.
Cov txiaj ntsig ntawm kev siv cov tshuaj no yog dab tsi?
Cov txiaj ntsig ntawm cov tshuaj no muaj ntau heev.
- Ua ib feem ntawm kev kho mob ART, HIV tuaj yeem tswj tau mus txog rau qhov uas nws tsis pom hauv lub cev.
- Pab kho tau tus kab mob siab C kom zoo .
- Yog koj tau txais COVID-19, nws yuav pab tiv thaiv kom tus kab mob tsis txhob hnyav zuj zus .
Tej yam tshwm sim thiab teeb meem uas yuav tshwm sim yog dab tsi?
Ib yam li lwm yam tshuaj, cov tshuaj Protease Inhibitors tuaj yeem ua rau muaj kev phiv. Txawm li cas los xij, tsis yog txhua tus neeg tau txais lawv. Tsis tas li ntawd, lawv sib txawv nyob ntawm cov tshuaj koj noj thiab koj tus mob.
| Hom kev phiv tshuaj | Piv txwv |
|---|---|
| Cov kev mob tshwm sim feem ntau | |
| Teeb meem ntawm lub plab zom mov | Mob plab, xeev siab thiab ntuav, raws plab |
| Lwm yam ntxwv zoo sib xws | Tawv nqaij tawm pob, hnoos, qaug zog, saj tsis zoo hauv qhov ncauj |
| Kev hloov pauv ntawm lub cev | Pob zeb hauv lub raum, kev hloov pauv ntawm qhov chaw ntawm cov rog hauv lub cev (Lipodystrophy) |
| Cov kev mob tshwm sim loj tab sis tsis tshua muaj | |
| Cov teebmeem rau cov kabmob sab hauv | Kev puas tsuaj rau daim siab, kev los ntshav sab hauv (suav nrog kev los ntshav sab hauv lub taub hau) |
| Cov mob tawv nqaij loj heev | Stevens-Johnson syndrome - mob heev, ua pob khaus thoob plaws lub cev |
| Kev hloov pauv hauv cov metabolism | Cov ntshav qab zib nce ntxiv (Hyperglycemia), cov roj cholesterol nce ntxiv (Hyperlipidemia) |
| Lwm yam mob hnyav | Myocardial Infarction, Hemolytic Anemia, Teeb meem nrog kev ua haujlwm hluav taws xob ntawm lub plawv |
Kuv yuav tsum noj cov tshuaj no ntev npaum li cas?
Qhov no nyob ntawm seb koj muaj tus kab mob dab tsi.
- HIV: Vim tias tseem tsis tau muaj tshuaj kho tau tag nrho rau HIV, kev kho mob yuav tsum tau ua mus tas koj lub neej. Cov kev kho mob thiab cov tshuaj yuav hloov pauv raws sijhawm.
- Kab mob siab C: Feem ntau tus kab mob no kho tau tsuas yog siv sijhawm ob peb lub lis piam lossis ob peb lub hlis xwb.
- COVID-19: Kev kho mob COVID-19 feem ntau yog muab rau tsib hnub.
Puas muaj tej yam uas kuv ua tau los ua kom kev kho mob yooj yim dua?
Yog, tau kawg li. Muaj ob peb yam koj ua tau los txo cov kev mob tshwm sim thiab ua kom kev kho mob zoo dua.
- Noj koj cov tshuaj raws nraim li tus kws kho mob qhia rau koj, raws sijhawm, thiab tsis txhob hla ib koob tshuaj.
- Haus dej ntau.Qhov no pab tiv thaiv tej yam xws li pob zeb hauv lub raum.
- Tsis txhob noj lwm yam tshuaj uas yuav cuam tshuam nrog koj cov tshuaj. Nug koj tus kws kho mob txog qhov no.
- Muaj tej yam tshuaj uas yuav tsum tau noj nrog zaub mov. Peb mam li saib ntxiv txog qhov ntawd.
Vim li cas qee cov tshuaj Protease Inhibitors thiaj hais kom noj nrog zaub mov?
Muaj ib qho laj thawj rau qhov no. Qee cov tshuaj protease inhibitors, tshwj xeeb tshaj yog cov uas noj nrog pluas noj uas muaj roj ntau, peb cov hnyuv nqus tau zoo dua. Qhov no ua rau cov tshuaj ua haujlwm tau zoo dua. Yog li ntawd, nco ntsoov nug koj tus kws kho mob seb koj puas yuav tsum noj koj cov tshuaj ua ntej, tom qab, lossis nrog pluas noj.
Thaum twg koj yuav tsum mus ntsib kws kho mob?
Yog tias koj muaj tej yam tshiab tshwm sim tsis tau xav txog, lossis muaj lus nug txog koj txoj kev kho mob, tsis txhob yig nrog koj tus kws kho mob tham.
Yog tias koj muaj ib qho ntawm cov kev mob tshwm sim loj heev hauv qab no, nrhiav kev pab kho mob tam sim ntawd. Mus rau chav kho mob ceev (ETU) ntawm tsev kho mob sai li sai tau.
- Ua npaws
- Kev tsis meej pem lossis kev paub hloov pauv
- Qhov muag lossis daim tawv nqaij daj (Jaundice)
- Mob, ua pob khaus, thiab kis mus thoob plaws
- Mob plab heev
- ntuav heev uas tsis tuaj yeem nres
Cov tshuaj protease inhibitors yog ib hom tshuaj tseem ceeb heev thiab cawm tau txoj sia hauv kev tswj cov kab mob xws li HIV thiab Hepatitis C. Yog tias koj muaj lus nug lossis kev txhawj xeeb txog kev kho mob no, tham nrog koj tus kws kho mob txog nws qhib siab. Lawv tuaj yeem pab koj tsim ib txoj kev npaj kho mob uas ua haujlwm zoo tshaj plaws rau koj.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Cov tshuaj protease inhibitors yog ib pawg tshuaj muaj zog uas tswj tau cov kab mob xws li HIV, Hepatitis C, thiab COVID-19.
- Cov no ua haujlwm los ntawm kev tiv thaiv tus kab mob kom tsis txhob ua daim qauv ntawm nws tus kheej hauv lub cev thiab kis mus rau lwm tus.
- Nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob txog txhua yam tshuaj uas koj noj thiab txhua yam kab mob uas koj yuav tsum zam kom tsis txhob muaj cov kev mob tshwm sim.
- Noj koj cov tshuaj raws nraim li koj tus kws kho mob qhia rau koj, rau lub sijhawm zoo. Tsis txhob hla ib koob tshuaj xwb.
- Yog tias koj muaj tej yam mob tshwm sim loj heev (kub taub hau, tawv nqaij daj, mob nqaij heev), tsis txhob nkim sijhawm thiab nrhiav kev pab kho mob tam sim ntawd.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus