Lɛ wi lan mɔ bɔt di ɔmon we dɛn kɔl Leptin, we de ɛp yu fɔ kɔntrol yu wet.

Yu dɔn ɛva wɔnda wetin mek wi kin angri, aw wi kin fil ful afta wi dɔn it, ɛn wetin mek i izi fɔ sɔm pipul dɛn fɔ gɛt mɔ wet pan ɔl we i nɔ kin izi fɔ ɔda pipul dɛn fɔ lɛf fɔ it? Tide wi go tɔk bɔt wan smɔl kemikal mɛsenja we dɛn mek insay wi bɔdi we gɛt fɔ du wit ɔl dis. Dɛn kɔl am Leptin. Fɔ tɔk di kɔrɛkt tin, lɛptin na ɔmon we wi fat sɛl dɛn (adipose tissue) de pul we de ɛp wi fɔ mek wi bɔdi wet fɔ lɔng tɛm.

Wetin na Lɛptin? Lɛ wi tek wan simpul luk.

Imajin se yu bɔdi fat de mek wan ɔmon we dɛn kɔl Lɛptin. So, di men wok we Leptin de du na fɔ kɔntrol wi angri ɛn gi wi di filin fɔ "inaf, a ful" (satiety) afta wi dɔn it. I tan lɛk smɔl manija we de kɔntrol wi bɔdi wet.

Sayɛnsman dɛn bin fɛn di ɔmon we dɛn kɔl lɛptin insay 1994. Dat min se bɔku tin stil de fɔ no bɔt am. Dɛn dɔn ɔlrɛdi de du risach if dɛn kin yuz lɛptin fɔ mɛn yu wet kɔntrol, Alzaima sik, riprodaktiv wɛlbɔdi, ɛn infertility.

"Ah... if leptin de kɔntrol di wet, wi nɔ fɔ ebul fɔ kɔntrol lɛptin bak?" yu kin tink. Bɔt, di tru tin na dat, dis ɔmon nɔ izi fɔ kɔntrol lɛk aw wi want.

Wetin lɛptin de du fɔ wi bɔdi?

Di men wok we lɛptin de du na fɔ ɛp fɔ mek wi bɔdi wet nɔ chenj. Mɔ spesifik wan, i de ɛp fɔ mek wi gɛt balans fɔ lɔng tɛm bitwin di it we wi de it ɛn di we aw wi bɔdi de yuz ɛnaji. Dat min se i de ɛp fɔ mek wi nɔ fil angri we wi bɔdi nɔ nid ɛnaji (kalori).

Leptin de wok mɔ pan di haypothalamus, we na wan pat pan wi bren we de kɔntrol wi angri ɛn di balans we wi gɛt fɔ gɛt ɛnaji. כltu, lεptin-sεnsitiv rεsεpכta dεm de bak na כda pat dεm na wi bכdi.

Bɔt na sɔntin we wi fɔ ɔndastand. Leptin nɔto ɔmon we de mek wi fil angri afta wi dɔn it wan it. Bifo dat, i de ɛp wi fɔ kɔntinyu fɔ gɛt wet bay we i de chenj di it we wi de it as tɛm de go , i de kɔntrol aw wi de yuz trɛnk, ɛn ɛp wi fɔ kɔntrol wi wet.

Dɛn kin fil di tin dɛn we lɛptin kin du mɔ we yu de tray fɔ lɛf fɔ it bɔku bɔku it. Tink bɔt am, we yu bɔdi fat de go dɔŋ, yu lɛptin lɛvɛl sɛf de go dɔŋ. Dɔn di bren kin gɛt signal we se, "O, di bɔdi nɔ gɛt inof it, i tan lɛk se wi de fast." Dis na di rizin we mek sɔntɛnde yu kin rili angri ɛn yu kin want fɔ it difrɛn it dɛn. Dɔn dɛn kin tɛmpt yu fɔ it tumɔs. Dis kin mek i nɔ izi fɔ lɛ yu lɛf fɔ it bɔku bɔku it dɛn.

Sayɛnsman dɛn stil de du risach bɔt Leptin. Dɛn biliv se Leptin kin afɛkt wi:

• Metabolism we dɛn kin yuz fɔ mek tin dɛn
• εndokrin sistεm - dat na wi כmon sistεm
• Imyun sistεm - di sistεm we de protεkt frכm sik

Aw dɛn kin kɔntrol di lɛptin lɛvɛl?

di wayt adipos tisu na wi bכdi de mek εn kכmכt lεptin. dis wayt adipos tisu na di men kayn fεt we de na wi bכdi. Fɔ tɔk am simpul wan, na di fat we de na yu bɔdi.

Bikɔs na di fat sɛl dɛn de mek Leptin, di kayn we aw di Leptin de na yu blɔd gɛt sɔntin fɔ du wit di fat we de na yu bɔdi. Dat min se, if yu gɛt smɔl bɔdi fat, yu nɔ gɛt bɛtɛ Leptin. If yu gɛt mɔ bɔdi fat, yu gɛt mɔ Leptin. I simpul, nɔto so?

If yu bɔdi fat mas de go ɔp as tɛm de go, yu lɛptin lɛvɛl go go ɔp. di kכnvεshכn, if yu bכdi fεt mas dכn, yu lεptin lεvεl go dכn.

Wetin kin apin if lɛptin bɔku?

Bɔku tɛm, di lɛptin lɛvɛl kin bɔku pan pipul dɛn we fat. Dɛn kɔl dis haypalɛptinemia. We di lɛptin lɛvɛl kin ɔp ɔltɛm, wi bren nɔ kin ansa lɛptin fayn fayn wan. Dɛn kɔl dis lɛptin rɛsistɛns .

Bɔku ɔda tin dɛn de we kin gɛt fɔ du wit di sik we dɛn kɔl hyperleptinemia:

• Pwɛl at
• Fɔ it adikshɔn
• Nyurodijɛnɛraytiv dizayd dɛn
• Nɔn-alcoholic fat liva sik
• Rabson-Mendenhall syndrome - Dis na wan jεnεtik kכndyushכn we rili rεs.

Wetin na Leptin Resistance?

If yu gɛt Leptin Resistance, yu bren nɔ de ansa to Leptin nɔmal wan. Imajin, Leptin de kip de sen signal to di bren se "A don it inof it, a ful," bכt i lεk se di bren nכ de kia. So, yu nɔ de fil se yu ful-ɔp. Bikɔs ɔf dis, yu kin kɔntinyu fɔ it, pan ɔl we yu gɛt bɔku fat we yu dɔn kip na yu bɔdi.

Nɔto dat nɔmɔ, bɔt bikɔs Leptin nɔ de wok fayn, di bren de tink se di bɔdi de angri ɛn i de angri. Dɔn, fɔ mek wi nɔ gɛt trɛnk, di bren de ridyus wi ɛnaji, ɛn i de ridyus di nɔmba fɔ di kalori dɛn we wi de yuz we wi de rɛst. Fɔ tɔk am simpul wan, wi Basal Metabolic Rate (BMR) de ridyus.

So yu si, di leptin resistance de mek yu fil angri ɔltɛm, ɛn i de mek yu BMR dɔŋ bak. We dɛn tu tin ya kam togɛda, di wet we pɔsin kin gɛt kin wɔs mɔ ɛn mɔ.

Naw, sayɛnsman dɛn de du risach bɔt mɛrɛsin dɛn we go ebul fɔ mɛn di wan dɛn we nɔ gɛt lɛptin.

Wetin na di sayn dɛm wae de sho se yu gɛt Leptin Resistance?

di men sayn dεm we de sho se di lεptin rεsistεns na fכ fil כltεm fכ angri pasmak (hyperphagia) εn fכ it pasmak. Dɛn sayn ya kin apin ivin we bɔku fat de na di bɔdi.

Bɔt ɔda tin ɛn tin dɛn de we kin mek pɔsin gɛt dɛn sik ya. Nɔto di wan nɔmɔ we nɔ gɛt lɛptin. As sayɛnsman dɛn stil de lan bɔt lɛptin, i pɔsibul se dɛn go fɛn mɔ sayn dɛn we de sho se pɔsin nɔ ebul fɔ fɛt lɛptin tumara bambay.

Wetin kin apin if lɛptin go dɔŋ?

We pɔsin nɔ gɛt lɛptin na wan tin we nɔ kin apin so ɔltɛm. Di men sik we gɛt fɔ du wit am na we dɛn bɔn am wit lɛptin we nɔ de. Dis na jεnεtik kכndyushכn we de de we dεn bכn am. Pipul dεm wae gεt dis kכndyushכn nכ de prodyuz lεptin frכm dεn fεt tisu.

We lɛptin nɔ de, di bɔdi kin tink se fat nɔ de na di bɔdi. Dis kin mek pɔsin nɔ ebul fɔ kɔntrol am, i kin angri pasmak ɛn i kin want fɔ it. Fɔ dis rizin, pikin dɛn we dɛn bɔn wit lɛptin dɛfisiɛns kin gɛt siriɔs fat (klas III fat) we dɛn rili yɔŋ, ɛn dɛn kin delay fɔ bɔn pikin.

Ɔda sik dɛm wae kin gɛt fɔ du wit dis sik:

• Dislipidemia - na di imbalans pan di fεt dεm lεk kכlestכl εn triglisεrayd dεm
• Fat liva sik
• Baktri infekshɔn dɛn we kin kam bɔku tɛm
• Hyperinsulinemia - we min se yu de mek tumɔs insulin
• haypogonadotropik haypogonadism - dat na, di lכw sεks כmon lεvεl

Us kayn tɛst dɛn kin du fɔ chɛk di lɛptin lɛvɛl?

Dɛn kin no di lɛptin lɛvɛl wit blɔd tɛst. Bɔt, dɔktɔ dɛn nɔ kin tɛst ɔlman in lɛptin lɛvɛl. Dɛn kin se yu fɔ du lɛptin tɛst pan dɛn kayn tin ya:

• If yu yɔŋ pikin gɛt klas III fat .
• If yu fat ɛn yu de angri ɔltɛm .

Aw di nɔmal lɛptin lɛvɛl fɔ tan lɛk?

di lεptin lεvεl kin nכmal wan frכm:

• Fɔ uman dɛn: 0.5 to 15.2 nanogram pan wan mililita (ng/mL) .
• Fɔ man dɛn: 0.5 to 12.5 nanogram pan wan mililita (ng/mL) .

Bɔt mɛmba se dɛn nɔmal rɛnj ya kin difrɛn smɔl bitwin difrɛn lɛbɔraytri dɛn. So, i bɛtɛ fɔ chɛk di nɔmal rɛnj na yu ripɔt. Ɔ, i bɛtɛ fɔ aks yu dɔktɔ bɔt am.

Aw a go mek mi lɛptin lɛvɛl go ɔp?

Fɔ tɔk tru, na smɔl tin nɔmɔ wi kin du fɔ mek wi lɛptin lɛvɛl go ɔp fɔ mek wi nɔ angri ɛn nɔ want fɔ it. Bikɔs, lɛk aw wi bin dɔn tɔk, di lɛptin we yu gɛt gɛt fɔ du wit di fat we yu gɛt na yu bɔdi.

Wan stɔdi dɔn sho se pipul dɛn we nɔ kin slip bɛtɛ kin gɛt di ɔmon we dɛn kɔl ghrelin we kin mek dɛn angri ɛn di ɔmon we dɛn kɔl lɛptin kin smɔl. So, fɔ gɛt inof, kwaliti slip kin ɛp fɔ rigul yu ɔmon dɛn.

Sayɛnsman dɛn de chɛk bak di rilayshɔn bitwin lɛptin ɛn wan kayn fat we dɛn kɔl triglisɛrɛyd. Sɔm risach dɔn sho se di ay triglisɛrɛyd lɛvɛl kin afɛkt di we aw lɛptin de wok. Bɔt difrɛn we dɛn stil de tink bɔt dis. Sɔm sayɛnsman dɛn tink se wan plan fɔ it we de mek di triglisɛrɛyd go dɔŋ kin ɛp fɔ mek di lɛptin lɛvɛl bɛtɛ. Bɔt ɔda pipul dɛn nɔ gri wit dis.

Us it dɛn we gɛt bɔku Lɛptin?

Dis na di say we bɔku pipul dɛn kin mek mistek. Lεptin na כmon we de kכmכt insay wi bכdi, nכto nyutriεnt we wi kin gεt frכm it lεk vaytam in C כ protin. So, notin nɔ de we dɛn kɔl it dɛn we gɛt lɛptin.

Fɔ dɔn, sɔm pan di impɔtant tin dɛn we wi fɔ mɛmba

Leptin na rili nyu tin we dɛn dɔn fɛn, so sayɛnsman dɛn stil de lan mɔ bɔt am, mɔ aw i kin afɛkt pɔsin we fat ɛn we i de lɔs in wet. as yu si, as yu bכdi de lכs fεt, di lεptin lεvεl dεm de dכn, we de sho se yu bכdi de "fast," we de mek i at fכ lכs weit.

If yu de wɔri bɔt yu wet ɔ yu nid fɔ gayd yu bɔt aw fɔ lɔs yu wet fayn fayn wan, i go fayn fɔ mek yu tɔk to yu dɔktɔ. Yu kin tɔk bak to wan dɔktɔ we de mɛn yu bɔdi bɔt di program dɛn we yu kin du fɔ mɛn yu wet.

Mɛmba se ɔl dis na fɔ ɛp yu fɔ gɛt wɛlbɔdi. I impɔtant fɔ no bɔt yu bɔdi.

` Lεptin, weit kכntrכl, כmon, angri, fat, fεt, mεtabolism