Lɛ wi lan bɔt wi bɔdi in ‘guardian’ jin dɛm (Tumor Suppressor Genes) we de put di brek pan kansa!

Yu dɔn ɛva tink se smɔl smɔl gad dɛn de insay wi bɔdi we de ɛp fɔ mek kansa nɔ kam? Yɛs, na tru. Tide wi go tɔk bɔt wan rili impɔtant kayn jin we de kɔntrol di kansa sɛl dɛn na wi bɔdi. Dɛn tin ya tan lɛk ‘gadman dɛn’ na wi bɔdi.

Wetin na dɛn ‘tumor suppressor genes’ ya?

Fɔ tɔk am simpul wan, dɛn ``Tumor Suppressor Genes`` ya na wan big grup fɔ jin dɛm we de protɛkt wi bɔdi frɔm kansa. Dɛn jin ya de wok lɛk di brek dɛn we de na motoka. Dɛn jin ya de mek wan spɛshal kayn prɔtin. dis protin dεm de stכp di sεl dεm fכ gro tu kwik, we kin mek i gεt kεnsar, εn put "brek" pan am.

Imajin wetin go apin if dis jin we de stɔp kansa gɛt sɔm kayn chenj , dat na chenj. Dɔn i tan lɛk se yu pul di brek na motoka ɛn step pan di aksilarayt. di sεl dεm we de gro kwik kwik wan we i nכ de kכntrol. Na da tɛm de di risk fɔ gɛt kansa kin bɔku.

Aw ɛksaktɔli dɛn jin ya de wok na wi bɔdi?

fכ כndastand aw dεn ``Tumor Suppressor Genes'' ya de wok, wi fכs nid fכ no sכm bכt di rilayshכn bitwin ``DNA'', jin dεm, εn sεl dεm.

εvri wan pan di trilyכn sεl dεm na wi bכdi gεt ``DNA''. insay dis ``DNA'' na jin dεm. Dɛn jin ya de tɛl di sɛl dɛn wetin fɔ du, ustɛm fɔ sheb, ɛn ustɛm fɔ stɔp fɔ sheb.

Naw imajin se if wan ɔ mɔ jin dɛn na wan sɛl chenj , dat min se dɛn chenj, dɛn jin dɛn de we dɔn chenj kin stɔp fɔ mek prɔtin, ɔ dɛn kin bigin fɔ mek prɔtin we nɔmal. We dat apin, dɛn prɔtin dɛn de we nɔmal kin stɔp fɔ gi instrɔkshɔn to di sɛl dɛn, ɔ dɛn kin gi instrɔkshɔn we nɔ rayt. Insay kansa, dɛn nyu instrɔkshɔn ya kin mek di sɛl dɛn sheb ɛn bɔku we dɛn nɔ ebul fɔ kɔntrol, ɛn leta dɛn kin mek tumbu dɛn .

So, wetin dεn jin dεm ya we de sכpres kεnsar de du na fכ kכntrכl di kכmpleks prכsεs we dεn kכl di sεl saykl. Dat na:

• i de mek di sεl dεm nכ de divayd εn mכltiply kwik kwik wan, we de mek di tכmכro dεm fכm. Dis rili impɔtant.
• Nɔmal wan di sɛl dɛn kin liv fɔ sɔm tɛm ɛn afta dat dɛn kin day. wi kכl dis "programmed sεl dεd / apoptosis." Dat min se i de ɛp ol sɛl dɛn we dɔn pwɛl fɔ day bay dɛnsɛf.
• Ripa di damej pan DNA we kin apin we di sεl dεm divayd fast pas nכmal.
• i de εp fכ mek di kansa tכmכro dεm nכ spre כlsay na di bכdi, dat na fכ mek dεn nכ bi ``mεtastas.''

Fɔ tɔk am simpul wan, na dɛn jin ya de mek shɔ se di sɛl dɛn na wi bɔdi de wok ɔganayz ɛn kɔntrol. Lɛk trafik polis ɔfisa.

Wetin mek dɛn jin ya kin chenj? Wetin na di rizin dɛn?

Tu men rizin dɛn de we mek dɛn jin ya we de mek pɔsin nɔ gɛt kansa kin chenj.

1. Di muteshon dɛn we dɛn kin gɛt frɔm dɛn mama ɛn papa:

Sɔm pipul dɛn kin gɛt dɛn tin ya we dɛn kin chenj dɛn jɛnɛtiks frɔm dɛn mama ɛn papa. Dis min se di mutated jin bin de insay di eg ɔ sperm sɛl we gi yu pikin. Fɔ ɛgzampul, wan sik we dɛn kɔl Li-Fraumeni syndrome kin kam we pɔsin gɛt wan jin we dɔn chenj we de mek pɔsin nɔ gɛt kansa frɔm in mama ɔ papa.

Sɔntɛnde, pɔsin we dɛn bɔn wit wan jin we dɔn chenj kin gɛt ɔda jin we dɔn chenj leta we i dɔn day. If yu gɛt tu kayn jin dɛn we dɔn chenj, dat kin mek yu gɛt sɔm kayn kansa, lɛk kansa na yu bɔdi. Bɔt i impɔtant fɔ mɛmba se if yu gɛt dɛn jin ya, dat nɔ min se yu go gɛt kansa .

2. Muteshon dεm we dεn kin gεt:

Bɔku tɛm, as wi de ol, dɛn jin ya we de fɛt kansa kin chenj. Wi bɔdi tan lɛk wan layn we de mek tin dɛn kwik kwik wan. We dɛn mek nyu jin, mistek kin apin sɔntɛnde. As tɛm de go, if dɛn nɔ ripɛnt dis prɔses fayn fayn wan, dɛn mistek ya kin gɛda. Na dɛn kayn mistek ya kin mek di jin dɛm we de fɛt kansa stɔp fɔ wok.

Wetin na di kayn mutated tumor suppressor genes? Lɛ wi luk sɔm ɛgzampul dɛn.

Naw, di wan dɛn we de stɔdi bɔt mɛrɛsin dɔn no pas 1,000 jin dɛn we dɔn chenj we kin mek pɔsin nɔ gɛt kansa ɛn we kin mek pɔsin gɛt kansa. Na sɔm pan di men ɛgzampul dɛn we wi kin yɛri bɔt bɔku tɛm:

• (p53) Jin: dεn fכnshכn se di chenj dεm, כ mכtεshכn dεm na dis jin de sho se i gεt mכr dan 50% pan כl di kεnsar dεm . Dis min se dis na wan jin we rili impɔtant.
• (RB1) jin: Dis na di fכs egzampl fכ mכtεshכn insay wan kεnsar supεrεsכr jin we de mek kεnsar. rεsכch dεn sho se dis ``(RB1)`` jin de mכt insay pipul dεm we gεt kכmכn kεnsar lεk brεst kεnsar εn prכstat kεnsar.
• (CDKN2a) jin: Dis jin de chenj insay pipul dεm we gεt hεridita mεlanoma (wan kayn kεnsar na di skin) εn pankrεas kεnsar. Dɛn kin si am bak pan 25% to 30% pan ɔl di kansa dɛm we pipul dɛn kin gɛt we dɛn de liv. Fɔ ɛgzampul, dɛn kin si am pan bɔdi kansa, lɔng kansa, blad kansa, ɛn pankrias kansa.
• (BRCA1) ɛn (BRCA2) jin dɛm: Yu go dɔn yɛri bɔt dɛn jin ya. pipul dεm we gεt brεst kεnsar εn ovarian kεnsar, εn di wan dεm we gεt ovarian kεnsar leta na layf, gεt mכtεshכn na di jin ``BRCA1''. Pipul dεm we gεt brεst kεnsar we dεn kin gεt bכdi kin gεt mכtεshכn bak na di jin ``BRCA2''. Dɛn chenj ya kin mek pɔsin gɛt kansa na in bɔdi, ovarian, ɛn ɔda kansa dɛn. Sɔntɛnde, dɔktɔ dɛn kin se yu fɔ tɛst yu jɛnɛtiks if pɔsin na yu famili dɔn gɛt kansa na in bɔdi ɔ ovarian.
• (APC) jin: .Pipul dεm we dεn bכn wit εridayt kכndishכn lεk Gardner sεndrכm כ Turcot sεndrכm gεt wan mכtayt vεshכn fכ dis ``(APC)`` jin. Risach pipul dεn lεnk dis mutated ``(APC)`` jin to kכlכrektal kεnsar εn liva kεnsar.
• (PTEN) jin: Dis (PTEN) jin de chenj pan pipul dɛm we gɛt difrɛn kayn kansa, lɛk bɔdi kansa, prɔstat kansa, ed ɛn nɛk squamous carcinoma, ɛn fɔlikul tayroyd kansa.

Dis na jɔs sɔm ɛgzampul dɛn. Bɔku ɔda jin dɛn de we tan lɛk dis.

Yu tink se dɛn de du tɛst fɔ no if dɛn jin ya dɔn chenj?

Yɛs, tɛst dɛn de we dɛn kin du fɔ no bɔt sɔm jɛnɛtiks, dat na, sɔm chenj dɛn we kin apin na dɛn jin dɛn ya we kin mek pɔsin nɔ gɛt kansa. Bɔt nɔto ɔlman nid fɔ gɛt dɛn tɛst ya.

Udat fit fɔ tɛst di jɛnɛtiks?

Di Nashɔnal Kɛnsa Instityut bin tɔk se bɔku rizin dɛn de we mek yu kin tink bɔt fɔ du tɛst fɔ yu jɛnɛtiks fɔ si if yu gɛt kansa:

• If yu bin gɛt kansa bifo yu ol 50 ia.
• If yu dɔn gɛt sɔm difrɛn kayn kansa.
• If yu gɛt kansa na yu tu ɔgan sistɛm (fɔ ɛgzampul, kansa na ɔl tu di kidni dɛm, ɔ kansa na ɔl tu yu bɔdi).
• If sɔm fɔs digri fambul dɛn na yu famili dɔn gɛt di sem kayn kansa. Fɔs digri fambul dɛn na yu mama ɛn papa, yu brɔda ɛn sista dɛn, ɛn yu pikin dɛn. Sɔm pipul dɛn we de stɔdi bɔt dis kin tɔk se dɛn fɔ tɛst dɛn fambul dɛn we gɛt sɛkɔn ɛn tɔd digri bak.
• If sɔm pipul dɛn na yu famili dɔn gɛt kansa ɔ dɛn gɛt am naw.
• If yu gɛt wan patikyula kayn kansa wae nɔr kin apin to pipul dɛm wae yu ej ɔr yu man ɔr uman. Fɔ ɛgzampul, man in bɔdi kansa.
• If yu gɛt chenj na yu bɔdi we gɛt fɔ du wit sɔm kayn kansa sik dɛn we yu kin gɛt frɔm yu mama ɛn papa. fכ egzampl, Nyurofibromatosis Tayp 1 na wan kεnsar we dεn kin gεt wit כda sik dεm, lεk tכmכro dεm we nכ de kכnsa we dεn kכl nyurofibromas.
• If yu kɔmɔt na wan patikyula trayb ɔ etnik grup, yu no se dɛn kin gɛt sɔm kayn kansa we dɛn kin gɛt frɔm dɛn mama ɛn papa, ɛn yu gɛt wan ɔ mɔ pan dɛn tin ya we wi dɔn tɔk bɔt. fכ egzampl, stכdi dεn sho se di `(BRCA1/2)` jin mכtεshכn de mכr kכmכn pan `(Ashkenazi Ju)` (pipul dεm we kכmכt na Sεntral εn Istan Yuropian Ju dεm).

Wi go ebul fɔ no ɔltin kɔrɛkt wan frɔm dɛn tɛst dɛn ya?

Dis na tin bak we rili impɔtant. Ivin if yu du jenɛtik tɛst fɔ kansa, yu nɔ go gɛt klia ansa.Dɔn bak, if yu gɛt wan chenj na yu jɛnɛtiks, dat nɔ min se yu go gɛt kansa. I jɔs min se yu kin gɛt mɔ risk fɔ gɛt kansa.

If yu de wɔri bɔt yu risk fɔ gɛt kansa, i go fayn fɔ mek yu go to yu dɔktɔ ɛn tɔk bɔt yu ɔl yu wɛlbɔdi, aw yu de liv yu layf, ɛn aw yu famili gɛt mɛrɛsin. Dɔn yu dɔktɔ kin tɛl yu fɔ du tɛst fɔ chɛk yu kansa we go fayn fɔ yu. Nɔto ɔltɛm dɛn tɛst ya na jenɛtik tɛst.

So, wetin na di impɔtant tin dɛn we wi fɔ mɛmba? (Mɛsej we dɛn kin tek go na os)

Okay, so na di men tin dɛm fɔ mɛmba bɔt di ``Tumor Suppressor Genes'' we wi bin tɔk bɔt:

• Dɛn jin ya de wok lɛk di men shild we de protɛkt yu frɔm kansa .
• Dɛn kin kɔntrol di rit we yu sɛl dɛn de sheb, kil ol ɔ damej sɛl dɛn, ɛn mek di DNA we dɔn pwɛl bak.
• If dɛn jin ya chenj , di sɛl dɛn kin sheb ɛn bɔku we dɛn nɔ ebul fɔ kɔntrol, ɛn dis kin mek dɛn gɛt kansa tɔŋ dɛn.
• Di wan dɛn we de stɔdi bɔt mɛrɛsin dɔn fɛn pas 1,000 dɛn kayn jin dɛn ya we de mek pɔsin nɔ gɛt kansa.
• Dɛn kin tɛst dɛn jɛnɛtiks fɔ no dɛn jɛnɛtiks chenj ya, bɔt dɛn nɔ fayn fɔ ɔlman.
• If yu de wɔri ɔ yu gɛt ɛnitin fɔ wɔri bɔt aw yu go gɛt kansa, i go fayn fɔ mek yu go to dɔktɔ fɔ advays. Dɔn yu dɔktɔ go tɛl yu wetin yu go du fɔ ridyus yu risk fɔ gɛt kansa ɛn us tɛst yu go nid.

So, a op se yu fain dis infɔmeshɔn yusful. Si yu bak wit wan ɔda impɔtant wɛlbɔdi tip lɛk dis!

` Tumor Suppressor Jin dεm, kεnsar, jεnεtik mכtεshכn, DNA, sεl dεm, jεnεtik tεst, kεnsar risk