Yu dɔktɔ dɔn tɛl yu se yu bon dɛn wik smɔl, we min se yu gɛt ɔstioporosis, we na wan sik we de mek yu bon dɛn tan? I go bi se i dɔn tɛl yu fɔ bigin tek wan mɛrɛsin we dɛn kɔl bisphosphonate. We yu yɛri dis nem, yu kin fred smɔl, de wɔnda, "Wetin na dis mɛrɛsin? Wetin i go du?" Nɔ fred. Tide, wi go tɔk bɔt dis kayn mɛrɛsin we kin ɛp fɔ mek yu bon dɛn strɔng pan wan rili simpul we, insay wan we we yu go ɔndastand.
Fɔ tɔk am simpul wan, wetin na dɛn bisfosfɔnat ya?
Bisphosphonates na wan big klas fɔ drɔgs we dɛn kin yuz fɔ mɛn ɔstioporosis. Imajin se yu bon dɛn de wik smɔl smɔl as tɛm de go, lɛk wud we insɛkt dɔn it. Dɔn, ivin we yu fɔdɔm smɔl, dat kin mek yu bon dɛn brok mɔ ɛn mɔ. Ɔstioporosis na da kɔndishɔn de. So, bisphosphonates de stɔp yu bon dɛn fɔ wik mɔ, mek dɛn strɔng, ɛn ridyus di risk fɔ brok.
Dɔktɔ dɛn kin gi dis mɛrɛsin nɔto fɔ ɔstioporosis nɔmɔ, bɔt fɔ sɔm ɔda sik dɛn we kin afɛkt di bon dɛn we de na di bɔdi, ɛn insay sɔm kes dɛn we di blɔd kalsiɔm lɛvɛl nɔ kin bɔku (hypercalcemia).
Yu tink se dɛn mɛrɛsin ya de? Mek wi si.
Yes, na tu kayn bisfosfonayt de mɔ.
1. Bisfosfonat we dɛn kin tek bay mɔt
2. Injεkshכn insay wan vein (IV bisphosphonates) .
Di dɔktɔ go chɛk yu sik ɛn disayd us kayn we go fayn fɔ yu.
| Tayp fɔ mɛrɛsin | Drug dɛn we dɛn kin yuz bɔku tɛm (wit brand nem) . |
|---|---|
| Tablɛt dɛn we dɛn kin tek bay mɔt |
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| Injɛkshɔn dɛn we dɛn kin put insay di bɛlɛ (IV). |
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Us kɔndishɔn dɛn dɛn kin yuz bisfɔsfɔnat fɔ?
Dɛn dɔn gri fɔ dis mɛrɛsin mɔ fɔ trit dɛn sik ya:
- Ɔstioporosis na uman dɛn we dɔn pas 40 ia.
- Ɔstioporosis na man dɛn.
- Fɔ mek di bon dɛn nɔ tan.
- Glucocorticoid-induced osteoporosis kin kam bikɔs dɛn de yuz sɔm stɛroyd mɛrɛsin dɛn fɔ lɔng tɛm.
- Sɔm kansa kin mek di kalsiɔm lɛvɛl go ɔp na di blɔd (kansa-rilayt haypa kalsiɔm).
- Paget in sik na di bon na wan sik wae de afekt di bon dɛm.
- Wan kansa sik we dɛn kɔl multiple myeloma.
- Fɔ kes dɛm we kansa we kɔmɔt ɔdasay dɔn spre (mɛtastas) to di bon dɛm.
Sɔntɛnde, dɔktɔ dɛn kin yuz dis mɛrɛsin fɔ ɔda tin dɛn pas di wan dɛn we dɛn gri fɔ yuz am fɔ. Fɔ ɛgzampul, sɔntɛnde dɛn kin gi am to pikin ɛn big pipul dɛn we gɛt wan sik we dɛn kɔl osteogenesis imperfecta .
Aw dis mɛrɛsin de wok insay di bɔdi?
Fɔ ɔndastand dis, wi fɔ no smɔl bɔt wi bon dɛn fɔs. Wi bon dɛn nɔ jɔs de sidɔm na wan ples. Dɛn de chenj dɛn ples ɔltɛm. Lɛk wɔl usay dɛn kin pul ol brik dɛn ɛn bil nyu wan dɛn. Di bɔdi kin brok dɔŋ bay insɛf ɛn pul ol bon. Wi kin kɔl dis bon risɔpshɔn. Dɔn nyu bon kin fɔm na dɛn ples dɛn de.
As wi de ol, mɔ pan uman dɛn afta dɛn dɔn menɔpauz, dis prɔses nɔ de balans. dat min se, ol bon bigin fכ brok dכn εn kכl am fast fast pas aw nyu bon de fכm. Na da tɛm de di bon dɛn kin wik smɔl smɔl ɛn nɔ kin tan lɛk dat, ɛn dis kin mek dɛn gɛt ɔstioporosis.
di bisfosfonayt dεm de wok bay we dεn de slo di rεt we dεn de brok ol bon dεm εn pul dεm. In ɔda wɔd, dɛn "de pul di ol brik dɛn." dis de alaw mכr tεm fכ nyu bon fכmeshכn, we in tכn de inkrεs di כvala density fכ di bon dεm εn mek dεn strכng.
Aw a go yuz dis mɛrɛsin? Dis rili impɔtant!
Di we aw yu de yuz am kin difrɛn difrɛn wan bay di kayn mɛrɛsin we yu de gɛt.
If dɛn tek di pils dɛn wit mɔt...
Dis na di pat we yu nid fɔ tek tɛm wit pas ɔl . Di dɔktɔ go tɛl yu fɔ tek dɛn pils ya wan tɛm insay di de, wan tɛm insay di wik, ɔ wan tɛm insay di mɔnt. Bɔt, yu fɔ tek dɛn pils yaWan spɛshal we de fɔ du tin .
- Yu fɔ tek dis pil jɔs afta yu wek na mɔnin, bifo yu it ɔ drink ɛni ɔda tin .
- Di pil fɔ jɔs tek wit wan ful glas we gɛt klin wata . I nɔ gri fɔ tek dis pil wit ti, kɔfi, milk, ɔ frut drink.
- Afta yu dɔn tek di pil, yu nɔ fɔ ledɔm ɔ ledɔm fɔ at le 30 minit (i kin bi se na 60 minit). Yu fɔ sidɔm ɔ tinap stret.
- Dɔn bak, yu nɔ go ebul fɔ tek ɛni ɔda it, drink, ɔ mɛrɛsin insay dis 30-60 minit tɛm.
I rili impɔtant fɔ fala dɛn lɔ ya di rayt we. If nɔto dat, di bɔdi nɔ go tek di mɛrɛsin fayn ɛn i kin mek yu gɛt alɛji na yu trot ɛn yu bɛlɛ. Yu dɔktɔ go ɛksplen dis to yu ditayli.
If na injɛkshɔn we dɛn kin put insay di bɛlɛ...
Dɛn kin gi yu dis na ɔspitul ɔ klinik. Bɔku tɛm, dɛn kin gi dis vaysin wan tɛm insay di ia . Bɔt, i kin dipen pan di kɔndishɔn, dɛn kin gi am mɔ ɛn mɔ.
Yu wan du ɔda tin wit di mɛrɛsin?
Yɛs. We yu de tek dis mɛrɛsin, bɔku tɛm yu dɔktɔ go tɛl yu fɔ du dɛn tin ya:
- It it dɛn we gɛt bɔku kalsiɔm (e.g. milk, yogɔt, chiz, smɔl fish, grɛn vɛjitebul) .
- If yu nɔ gɛt bɛtɛ vaytamɛn D, tek wan vaytamɛn D sɔpɔtmɛnt .
- If yu nɔ gɛt inof kalsiɔm frɔm it, tek kalsiɔm pils .
Aw lɔng a fɔ tek dis mɛrɛsin?
Dis kin dipen pan yu kɔndishɔn ɛn aw yu bɔdi de ansa di mɛrɛsin. Bɔku tɛm, dɔktɔ dɛn kin stɔp di tɛm we dɛn kin tek di tablɛt dɛn we dɛn kin tek bay mɔt fɔ lɛk 5 ia ɛn di tɛm we dɛn kin gi di zoledronic acid injɛkshɔn insay di bɛlɛ fɔ lɛk 3 ia . Dis na fɔ protɛkt yu frɔm di sayd ɛfɛkt dɛm we nɔ kin apin so ɔltɛm we yu yuz dɛn mɛrɛsin ya fɔ lɔng tɛm. Bɔt sɔm pipul dɛn kin nid fɔ gɛt tritmɛnt fɔ lɔng tɛm. Yu dɔktɔ na di bɛst pɔsin fɔ disayd.
Lɛ wi lan bak bɔt di bad tin dɛn we kin apin to wi.
Lɛk ɛni mɛrɛsin, bisphosphonates kin mek yu gɛt sayd ɛfɛkt, bɔt nɔto ɔlman kin gɛt am.
| Tayp fɔ mɛrɛsin | Kɔmɔn pɔsibul sayd ɛfɛkt dɛn |
|---|---|
| Tablɛt dɛn we dɛn kin tek bay mɔt | Prɔblɛm dɛn we de na di dijestiv sistɛm. Fɔ ɛgzampul: GERD, ɔlsa na di trot ɛn bɛlɛ, gastritis. (Dis na di rizin we mek dɛn se fɔ tinap stret afta yu dɔn tek di pil!) |
| Injɛkshɔn dɛn we dɛn kin put insay di bɛlɛ | Di sayn dɛm fɔ kol ɔr flu, lɛk fiva, bɔdi we de at, ɛn bon ɛn mɔsul pen kin apin insay 1-3 de afta di vaysin. Dɛn kin kɔntrol dɛn tin ya wit mɛrɛsin lɛk paracetamol. |
| Riri rare bɔt kin gɛt siriɔs sayd ɛfɛkt (fɔ ɔl tu di ɔral ɛn IV) . | |
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Nɔ fred fɔ dɛn kayn sayd ɛfɛkt ya we nɔ kin apin so ɔltɛm. Di bɛnifit dɛn we pɔsin kin gɛt we i tek dis mɛrɛsin pas di prɔblɛm we i kin gɛt we i brok wan big bon lɛk di hip bikɔs ɔf ɔstioporosis.
Yu tink se dis mɛrɛsin rili de wok?
Yɛs, na fɔ tru. Stɔdi dɔn sho se dɛn mɛrɛsin ya kin mek di bon dɛn bɔku ɛn i kin ridyus di risk fɔ brok brok bad bad wan.
- Alendronate: I de ridyus di spayna fraktכs bay lεk 50% εn di hip εn כda frakshכn dεm bay lεk 30%.
- Risedronate: I de ridyus di spεnal εn כda frakshכn dεm bay lεk 40%.
- zoledronic acid: I de ridyus di spayna fraktכs bay lεk 70% εn hip εn כda frakshכn dεm bay lεk 35%.
Ustɛm a fɔ go to di dɔktɔ?
If yu tek dis mɛrɛsin, du wetin di dɔktɔ tɛl yu.I rili impɔtant fɔ go na di klinik dɛn di rayt tɛm. Dis go ɛp wi fɔ si if di mɛrɛsin de wok ɛn if ɛni sayd ɛfɛkt de. Yu dɔktɔ kin tɛl yu bak fɔ du DXA skan, we de sho aw yu bon dɛn de.
Mɛmba mɔ se:
If yu dɔn de tek bisphosphonates fɔ pas tri ia ɛn yu gɛt nyu pen na yu shɔl ɔ yu groin , nɔ ignore am. Tɛl yu dɔktɔ wantɛm wantɛm.
Dis mɛrɛsin na rili impɔtant mɛrɛsin wae kin ɛp yu fɔ liv yu layf fayn fayn wan ɛn protɛkt yu frɔm siriɔs prɔblɛm dɛm wae kin kam wae yu bon brok. If yu gɛt ɛni kwɛstyɔn ɔ wɔri bɔt dis, mek shɔ se yu tɔk bɔt am opin wan wit yu dɔktɔ.
Mɛsej we dɛn kin kɛr go na os
- Bisphosphonates na wan grup fɔ drɔgs we de mek di ɔstioporosis ɛn mek di bon dɛn strɔng.
- If yu de tek ɔral pils, fala di dɔktɔ in instrɔkshɔn dɛn ɛksaktɔli (ɛmti bɛlɛ na mɔnin, wit wata nɔmɔ, ɛn sidɔm stret afta yu tek am).
- I impɔtant fɔ gɛt inof kalsiɔm ɛn vaytamɛn D we yu de tek dis mɛrɛsin.
- Pan ɔl we sayd ɛfɛkt kin apin, bɔku pipul dɛn nɔ kin gɛt dɛn. Di bɛnifit dɛn we pɔsin kin gɛt we i tek dis mɛrɛsin pas di prɔblɛm dɛn we kin apin we pɔsin in bon brok.
- If yu gɛt ɛnitin fɔ wɔri bɔt ɔ fɔ fred bɔt mɛrɛsin, nɔ ɛva shem fɔ tɔk bɔt am wit yu dɔktɔ.
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