Yu no se sɔntɛnde di blɔd we de pas na yu veins kin klɔt we yu nɔ nid? If dis kayn blɔd klɔt go na di bren, i kin mek pɔsin gɛt strok, ɛn if i go na di at, i kin mek pɔsin gɛt at atak. So tide wi go tɔk bɔt wan spɛshal kayn mɛrɛsin we dɔktɔ dɛn kin yuz fɔ mek dɛn nɔ gɛt dɛn bad bad tin ya. Dɛn kɔl dɛn tin ya Dayrɛkt Thrombin Inhibitors.
Fɔ tɔk am simpul wan, wetin na dɛn Dairekt Thrombin Inhibitors ya?
Dis na wan klas ɔf drɔgs we de mek blɔd nɔ klɔt. Dɛn na wetin wi kin kɔl "blɔd thinners." Bɔt di we aw dɛn de wok difrɛn smɔl. di aidia fכ mek dεn dכg dεm ya na bays pan wan protin we de insay di saliva fכ lich. Yu go dɔn yɛri se dɛn bin de yuz lich bak fɔ mɛn pipul dɛn trade.
Bɔku pipul dɛn na di wɔl kin day bikɔs ɔf at sik. Di men rizin fɔ dat na we blɔd kin klɔt. So dɔktɔ dɛn kin gi pipul dɛn mɛrɛsin lɛk dis fɔ sev pipul dɛn frɔm dis prɔblɛm.
Us kɔndishɔn dɛn kin yuz dis mɛrɛsin fɔ?
Dis klas ɔf drɔgs, we dɛn kɔl dairekt thrombin inhibitors, dɛn kin yuz bɔku tɛm fɔ mek blɔd nɔ klɔt ɔ trit difrɛn mɛrɛsin dɛn. Lɛ wi tek wan luk pan wetin dɛn bi.
| Di sik stetmɛnt | Wan simpul ɛksplen |
|---|---|
| Akyu korona sindrom (we blɔd nɔ de flɔ na di at) . | di vein dεm we de gi bכdi to di at blכk כ di bכdi fכ fכlכ slo. |
| Trombosaytopenia we di hεparin indyuz (HIT) . | Wan kɔmplikeshɔn we wan ɔda tin we de mek blɔd tan we dɛn kɔl ɛparin kin kam wit. |
| Venɔs tromboɛmbolizm (VTE) . | Blɔd we de klɔt na wan vein na di bɔdi. |
| Atrial Fibrilɛshɔn (Afib) . | Risk fɔ mek blɔd klɔt ɛn strok bikɔs ɔf di at bit we nɔ de bit ɔltɛm. |
| Afta dɛn dɔn du ɔpreshɔn fɔ riples di hip | Ridyus di risk fɔ mek blɔd klɔt afta di ɔpreshɔn. |
| bכdi we de kכlכt na dip vein na di leg (Dip vein thrombosis - DVT) . | Blɔd kin klɔt, mɔ na di dip vein dɛn na di leg dɛn. |
| Wan blɔd we de klɔt na di lɔng dɛn (Pulmonary embolism) . | Wan blɔd we kin klɔt ɔdasay na di bɔdi kin travul go na di lɔng dɛn ɛn i kin lod. |
Apat frɔm dat, dɛn kin gi yu dis mɛrɛsin we dɛn de du tritmɛnt lɛk angioplasty, we kin opin di at dɛn na di at.
Us mɛrɛsin dɛn de insay dis kategori?
Bɔku kayn dairekt thrombin inhibitor drɔgs de we dɛn kin yuz naw na Sri Lanka ɛn di wɔl.
- Argatroban (dɛn kin gi dis as IV injɛkshɔn) .
- Bivalirudin (dεn kin gi dis bak as injεkshכn we dεn kin gi insay di bכdi - IV injεkshכn) .
- Dabigatran (dis na wetin yu tek as pill)
Aw dis mɛrɛsin de wok insay di bɔdi?
I rili simpul. As di nem sho, dis drɔg de go stret to wan ɛnzaym we dɛn kɔl Thrombin ɛn mek i nɔ wok.
Naw yu kin de aks wetin na dis Thrombin. Fɔ tɔk am simpul wan, Thrombin na wan impɔtant tin we de mek blɔd klɔt na wi bɔdi. I tan lɛk se di men chɛf de pripia it. Wetin dis mɛrɛsin de du na fɔ ol da chɛf de na sayd. Dɔn di we aw di blɔd de klɔt nɔ de apin fayn fayn wan. So di fɔmɛshɔn fɔ blɔd we nɔ nid fɔ klɔt kin stɔp. Yu ɔndastand?
Bɔt sɔntɛnde dis mɛrɛsin kin mek pɔsin blɔd bɔku. Wan spɛshal injɛkshɔn de we kin rivɛns di ifɛkt dɛn we di pil we dɛn kɔl Dabigatran gɛt. Dɛn kɔl am `Idarucizumab`. Bɔt no spɛshal mɛrɛsin nɔ de fɔ di mɛrɛsin we dɛn kin put insay di bɛlɛ. Bɔt we dɛn dɔn stɔp di mɛrɛsin, di tin dɛn we i kin du go dɔn afta sɔm tɛm.
Aw lɔng a nid fɔ tek dis mɛrɛsin?
I kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Sɔm pipul dɛn kin jɔs nid fɔ tek am fɔ shɔt tɛm, lɛk wan mɔnt afta dɛn dɔn du ɔpreshɔn fɔ chenj dɛn hip. Bɔt pɔsin we gɛt bɔku prɔblɛm fɔ gɛt blɔd kin nid fɔ tek dis mɛrɛsin fɔ di res ɔf in layf . Yu dɔktɔ go disayd ustɛm fɔ du.
Wetin na di bɛnifit dɛn we dis kayn mɛrɛsin gɛt?
Dis nyu klas fɔ drɔgs gɛt bɔku bɛnifit dɛn pas ol drɔgs.
- Di rizulyt na di sem: Bikɔs dɛn tin ya kin jɔs afɛkt Thrombin dairekt wan, yu kin ɛkspɛkt di sem rizɔlt frɔm di sem doz ɛvri tɛm.
- Nɔbɔdi nɔ de go dɔŋ di pletlɛt dɛn: Nɔ lɛk sɔm ol mɛrɛsin dɛn, dɛn mɛrɛsin ya nɔ de mek di pletlɛt dɛn go dɔŋ, we de ɛp fɔ mek di blɔd klɔt.
- Yu nɔ nid fɔ mek dɛn tɛst yu blɔd ɔltɛm: Sɔm mɛrɛsin dɛn lɛk Warfarin, yu nid fɔ du blɔd tɛst ɔltɛm fɔ chɛk aw yu blɔd de klɔt kwik kwik wan. Bɔt dis mɛrɛsin nɔ nid dat.
- Fɔs sayd ɛfɛkt: Dabigatran, we dɛn tek as pil, gɛt smɔl risk fɔ blɔd ɛn intarakshɔn wit ɔda mɛrɛsin dɛn we yu kɔmpia am wit Warfarin.
- I izi fɔ yuz: I rili izi fɔ yuz bikɔs yu jɔs gɛt fɔ tek wan pil wan ɔ tu tɛm insay di de.
- Wan ɔda tin we yu kin du: Dɛn tin ya na fayn tin fɔ di wan dɛn we nɔ kin ebul fɔ yuz mɛrɛsin lɛk Ɛparin.
Aw dis mɛrɛsin de wok fayn? Ɛn wetin na di prɔblɛm dɛn we kin apin?
Risach dɔn sho se dis mɛrɛsin sef ɛn i wok lɛk Warfarin ɔ Heparin. Bɔt dɛn nɔr fayn fɔ pipul dɛm wae gɛt sɔm kayn hat valv sik dɛm.
Bɔt di tin we impɔtant pas ɔl na ya na dat di tɛm we dis mɛrɛsin de na di bɔdi kin ridyus. Fɔ ɛgzampul, we yu tek wan doz fɔ Warfarin, lɛk 50% pan am kin de na di bɔdi fɔ 20-60 awa. Bɔt if yu tek Dabigatran, dɛn kin pul 50% pan am na di bɔdi insay 12-14 awa.
Wetin dis min? Yu nɔ go ebul fɔ mis wan de fɔ tek dis mɛrɛsin. If yu mis wan de fɔ tek am, di risk fɔ mek yu gɛt blɔd klɔt kin go ɔp bad bad wan.
Sɔm sayd ɛfɛkt dɛn we pɔsin kin gɛt
Lɛk ɛni mɛrɛsin, dis wan kin gɛt sayd ɛfɛkt, sɔm pan dɛn kin siriɔs.
| Sayd ɛfɛkt we pɔsin kin gɛt | Tɔk bɔt |
|---|---|
| Blɔd we de kɔmɔt pasmak | Blɔd we de kɔmɔt na di gɔm, blɔd we de kɔmɔt na yu nos, ɔ wund we nɔ de stɔp fɔ blɔd. |
| Indigestion (Dyspepsia) we nɔ de it fayn (Dyspepsia) . | Bɛlɛ de at, nɔ fil fayn. |
| Chenj in kɔlɔ na di urine | Yurin de tɔn brawn ɔ pink. |
| Ɛd we de at, we yu de tɔn diziz | Jɛnɛral ed pen ɔ diziz. |
| Chɛst pen, i nɔ izi fɔ blo | Dɛn tin ya kin bi siriɔs sayn dɛm. |
| Fiva, infεkshכn (Sepsis) . | Siriɔs kɔndishɔn dɛn we infɛkshɔn kin kam wit. |
Ustɛm a fɔ go to di dɔktɔ?
If yu gɛt ɛni sayd ɛfɛkt we yu de yuz dis mɛrɛsin, tɛl yu dɔktɔ wantɛm wantɛm.
Na mɔtalman, if yu de blɔd pasmak (fɔ ɛgzampul, if yu nɔ ebul fɔ stɔp fɔ blɔd frɔm wund, if yu gɛt blɔd na yu stɔl, if yu gɛt blɔd na yu nos we de mek yu gɛt kɔnkyushɔn) ɔ if yu gɛt ɔda siriɔs sayn dɛn (bɔku pen na yu chɛst, i nɔ izi fɔ blo), go na di ɔspitul Imejɛnsi Dipatmɛnt (ETU) we de nia yu ɛn nɔ de te.
Fɔ dɔn, nid nɔ de fɔ fred fɔ mek yu blɔd klɔt. Mɔdan drɔgs lɛk dairekt thrombin inhibitor kin kɔntrol da risk de bɔku bɔku wan. Bɔt yu dɔktɔ go disayd us mɛrɛsin go fayn fɔ yu ɛn aw lɔng yu fɔ tek am. So fala yu dɔktɔ in advays ɔltɛm.
Mɛsej we dɛn kin kɛr go na os
- Direct Thrombin Inhibitors na nyu klas fɔ drɔgs we de mek blɔd nɔ klɔt.
- dis dεm de wok bay we dεn de mek di trombin, we na wan kכl εnzym we de mek di bכdi kכlכt, nכ de wok dairekt wan.
- If yu yuz dis mɛrɛsinNɔ ɛva skip wan doz fɔ mɛrɛsin. If yu du dat wantɛm wantɛm, dat kin mek yu blɔd klɔt mɔ ɛn mɔ.
- If yu notis se yu de blɔd pasmak ɔ ɔda tin dɛn we nɔ kɔmɔn, go to yu dɔktɔ wantɛm wantɛm.
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