Sɔm tɛm dɛn de we wi kin fil se wi nɔ want fɔ du natin, ɛn wi kin rili fil bad ɛn wi kin gɛt lod. Dat na nɔmal tin. Bɔt if dis filin kɔntinyu fɔ pas tu wiks, if ɔltin tan lɛk se i nɔ gɛt op ɛn i nɔ gɛt op, i kin bi sɔntin we dip pas fɔ jɔs fil bad. Wi de tɔk bɔt pwɛl hat, ɔr lɛk aw dɔktɔ dɛn kin kɔl am , ‘Major Depressive Disorder’ . Dis na de sik wae de kam pan pɔrsin wae gɛt dis maynia sik na di wɔl. Bɔt nɔ wɔri, nɔto yu wan de tɔk bɔt dis ɛn aks fɔ ɛp.
Wetin rili na pwɛl hat?
Fɔ tɔk am simpul wan, pwɛl hat na wan maynd sik wae kin afɛkt yu maynd. I nɔto mental sik ɔ na figmɛnt fɔ yu imajineshɔn. Na rial mɛdikal kɔndishɔn. Pan ɔl we dɛn nɔ no wan wan tin we kin mek i apin, sayɛnsman dɛn biliv se i kin bi bikɔs ɔf tin dɛn we kin apin to pɔsin, lɛk di chenj dɛn we di kemikal dɛn kin chenj na di bren, di tin dɛn we kin apin to pɔsin in jɛnɛtiks, ɛn di tin dɛn we kin apin na layf we kin mek pɔsin fil bad.
Fɔ no dis sik, yu fɔ gɛt sɔm pan dɛn sik ya fɔ at le tu wiks insay wan row:
- Wan dip sɔri-at ɛn ɛmti tin we kin mek pɔsin fil lɛk se i kin las ɔl di de.
- Fɔ lɔs intres pan tin dɛn we yu bin de ɛnjɔy trade.
- Fɔ fil se i taya bad bad wan, i nɔ gɛt layf.
- Slip kin chenj (dɛn kin slip bɔku ɔ nɔ kin slip atɔl).
- Chenj na di apɛtit (we yu nɔ want fɔ it ɔ yu de it pasmak).
- Fɔ ɔndastand yusɛf, fɔ fil se yu nɔ gɛt wan valyu.
- I nɔ kin izi fɔ mek yu pe atɛnshɔn to yu.
De impɔtant tin na dat dis na sik wae dɛn kin ebul fɔ mɛn fayn fayn wan wit tritmɛnt, so i nɔr kin ɛva let fɔ aks fɔ ɛp.
Aw dɛn bin de du tritmɛnt trade? Ol we fɔ mɛn mɛrɛsin
Fɔ lɔng tɛm, lɛk 50 ia so, we i kam pan aw fɔ mɛn pwɛl hat, sayɛnsman dɛn bin de pe atɛnshɔn mɔ pan di kemikal dɛn we de na wi bren we dɛn kɔl nyurotransmitta. Tink bɔt dɛn as di ‘sayn’ dɛn we de alaw di nɛv sɛl dɛn na wi bren fɔ tɔk to dɛnsɛf. If dɛn signal ya nɔ de wok fayn, wi kin ambɔg wi maynd.
Bɔku ol mɛrɛsin dɛm, we dɛn kɔl ‘antidipreshan’, dɛn bin mek fɔ balans di aktiviti fɔ tri kemikal mɛsenja dɛn patikyula : sɛrotonin, norepinephrine, ɛn dopamine . Dɛn mɛrɛsin ya dɔn gɛt gud rizɔlt fɔ bɔku pipul dɛn, bɔt nɔto fɔ ɔlman.
Wetin mek dis mɛrɛsin nɔ de wok fɔ ɔlman?
Na dis na di prɔblɛm. Na lɛk tri pan ɛvri tɛn pipul dɛm wae gɛt pwɛl hat nɔr kin gɛt bɔrku rilif ivin afta dɛn dɔn chenj nɔr to jɔs wan mɛrɛsin, bɔt tu. Dɔktɔ dɛn kin kɔl dis sikDɛn kɔl am ‘Treatment-Resistant Depression’.
Dis na di rizin we mek, insay di las tu dikɔs ɔ so, sayɛnsman dɛn dɔn chenj di we aw dɛn de tink bɔt pwɛl hat kpatakpata. Dɛn dɔn no se pwɛl hat nɔto jɔs prɔblɛm wit dɛn tri kemikal mɛsenja dɛn we wi bin dɔn tɔk bɔt. Di bayoloji na di bren rili kɔmpleks pas dat. Ɛn dat de opin wan nyu we fɔ fɛn nyu drɔgs.
Lɛ wi luk di difrɛns bitwin di tritmɛnt dɛn we dɛn bin de yuz trade trade ɛn di tritmɛnt dɛn we dɛn bin de yuz tide dis we.
| Tin | Di tritmɛnt dɛm wae dɔn ol (bɔku pan di mɛrɛsin wae de mek pɔrsin fil bad) . | Di las tritmɛnt dɛn |
|---|---|---|
| Men gol | Nyurotransmitta dεm lεk sεrotonin, norepinephrine, εn dopamine | כda signal sistεm dεm εn nyural sεkyut dεm na di bren, lεk GABA rεsεpכta dεm |
| Rizult tɛm | I kin tek sɔm wiks ɔ wan mɔnt. | Fast rizulyt insay sɔm awa ɔ dez |
| Aw fɔ gi | Bɔku tɛm dɛn kin tek di pils dɛn we dɛn kin tek ɛvride | IV infushɔn ɔ nos sprɛy |
Di laytst mɛrɛsin we de wok kwik kwik wan
Di aidia wae se pwɛl hat sik kin tek sɔm wik ɔr mɔnt fɔ wɛl de chenj. Nyu tritmɛnt dɛn we dɛn kin du kwik kwik wan dɔn mek di bɔda dɛn fɔ wetin dɛn kin du na dis wok bɔku.
Wan spɛshal mɛrɛsin fɔ pwɛl hat afta dɛn bɔn pikin
Insay 2019, dɛn bin gri fɔ mek wan mɛrɛsin we dɛn kɔl Brexanolone . Dɛn mek am spɛshal wan fɔPɔstpartum Diprɛshɔn na wan kayn big big pwɛl hat sik.
- Aw i kin wok? pan ɔl we i nɔ klia 100% ɛksaktɔli aw i de wok, na sɛntetik kɔpi fɔ wan stɛroyd we wi bɔdi kin mek bay insɛf. I de wok bay we i de afɛkt di riseptɔ dɛn na di bren we dɛn kɔl GABA, we de ɛp fɔ kɔntrol wi maynd.
- Aw yu kin tek am? Dis mɛrɛsin nɔr izi fɔ tek lɛk ɔda mɛrɛsin wae de mek pɔrsin fil bad. Dɛn fɔ gi am as IV infushɔn (lɛk salin) fɔ 60 awa , na ɔspitul, ɔnda dɔktɔ in sɔpɔtishɔn.
- Rizɔlt dɛn? I sɔprayz fɔ no se di tin dɛn we kin apin kin rili kwik. Yu pwɛl hat sik kin bigin fɔ stɔp jɔs lɛk aw dɛn dɔn dɔn di tritmɛnt.
Semweso, dɛn de kɔntinyu fɔ du risach pan ɔda nyu mɛrɛsin dɛm wae kin gi kwik rizɔlt fɔ pwɛl hat wae nɔr kin gɛt tritmɛnt, dat min se wi kin ɛkspɛkt fɔ gɛt ivin bɛtɛ tritmɛnt tumara bambay.
So, wetin a fɔ du?
If yu de rid dis atikul ɛn yu gɛt ɛni wan pan dɛn sik ya, duya nɔ sɔfa yu wan. Nɔ disayd se yu gɛt sik bay we yu luk na di Intanɛt.
Di bɛst tin we yu kin du na fɔ go to yu dɔktɔ we yu kin abop pan ɛn tɔk bɔt dis.
Na yu dɔktɔ nɔmɔ go ebul fɔ no di sik we yu gɛt ɛn no di bɛst tritmɛnt fɔ yu. Dis kin inklud kɔvɛnshɔnal mɛrɛsin, advays/tɛrapi, ɔr fɔ rifer to pɔsin we sabi bɔt mɛntɛl hεlth if nid de. Mɛmba se if yu aks fɔ ɛp, dat de sho se yu gɛt trɛnk.
Mɛsej we dɛn kin kɛr go na os
- Major Depressive Disorder nɔto wikɛd tin, na rial mɛrɛsin wae nid fɔ trit.
- Pan ɔl we ol mɛrɛsin kin ɛp bɔku pipul dɛn, dɛn nɔ kin wok fɔ ɔlman.
- We sayɛns dɔn go bifo, naw dɛn dɔn gɛt mɔdan tritmɛnt dɛn we de tɔch ɔda signal sistɛm dɛn na di bren ɛn gi rizɔlt kwik kwik wan.
- Naw, dɛn dɔn gɛt tritmɛnt dɛn we rili fayn ɛn we kin wok kwik kwik wan fɔ sɔm patikyula sik dɛn, lɛk di pwɛl hat we pɔsin kin gɛt afta i bɔn.
- Nɔ ɛva no yusɛf ɔ tek mɛrɛsin fɔ yusɛf. If yu tink se yu gɛt pwɛl hat, go to dɔktɔ wantɛm wantɛm.
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