Sɔmbɔdi na yu famili, sɔntɛm yu papa, yu mama, ɔ pɔsin we yu sabi, gɛt dis sik we dɛn kɔl Pakinsin? Yu go mɔs dɔn fil bad we yu si dɛn an dɛn de shek shek, i nɔ izi fɔ waka, dɛn bɔdi de stif, ɛn dɛn fes nɔ de fil fayn igen. I nɔ rili izi fɔ liv wit dis sik. Bɔt di bɛst tin na dat, wit di advans mɛdikal sayɛns tide, wit di rayt mɛrɛsin, yu kin kɔntrol dɛn sik ya bɔku bɔku wan ɛn liv gud layf. So tide, lɛ wi tɔk rili simpul ɛn fayn bɔt di mɛrɛsin dɛn we dɛn kin gi fɔ di sik we dɛn kɔl Pakinsin.
Fɔs, lɛ wi si, wetin rili na Pakinsin sik?
Lɛ wi ɔndastand dis simpul wan. Pakinsin na wan sik wae gɛt fɔ du wit wi nervɔs sistɛm. Speshali, wi bren. Na wan sik we de go bifo ɛn i kin wɔs smɔl smɔl as tɛm de go . wan εria de na wi bren we dεn kכl `substantia nigra` we de kכntro di muvmεnt. Di nεv sεl dεm na dis εria de pwεl εn sכmtεm dεn de day.
dis nεv sεl dεm de prodyuz wan rili imכtant kεmikכl mεsenja, we na `nyurotransmitta`, fכ wi bכdi. I nem na dopamin . Dis dopamin impɔtant fɔ mek wi bɔdi in muvmɛnt smol smol ɛn kɔntrol am. So we dεn nεv sεl dεm de dכn, di lεvεl fכ dopamin na di bren de dכn. Na dat mek sɔm kayn sayn dɛm lɛk fɔ shek, wae i nɔr kin izi fɔ waka, ɛn fɔ stiff kin kam pan dis sik wae de kam pan pɔrsin.
De tin wae impɔtant pas ɔl na fɔ de mɛrɛsin wae dɛn kin gi fɔ dis sik wae de mɛk pɔrsin gɛt dis sik kin kɔntrol dɛn kayn sik ya. Naw, no mɛrɛsin nɔ de fɔ dis sik. Bɔt dɛn mɛrɛsin ya kin ɛp bɔrku fɔ kɔntrol de sik ɛn fɔ mek yu liv bɛtɛ layf.
Men mɛrɛsin fɔ di sik we dɛn kɔl Parkinson
We dɛn de trit di sik we dɛn kɔl Pakinsin, bɔku tɛm, dɔktɔ dɛn kin yuz bɔku mɛrɛsin dɛn we dɛn jɔyn togɛda, pas fɔ yuz wan mɛrɛsin. Dɛn tin ya kin difrɛn fɔ di pɔrsin in sik, in ej, ɛn stej wae de sik de. Lɛ wi tek wan luk pan di men kayn mɛrɛsin dɛn.
1. Lɛvodopa ɛn Kabidopa
Dis na di men ɛn di bɛst mɛrɛsin fɔ di sik we dɛn kɔl Pakinsin. Dɛn kin kɔl am bak di gold standad.
- Levodopa: We dis mɛrɛsin go insay wi bɔdi, i de go insay di bren ɛn tɔn to dopamine. Dat min se dis mɛrɛsin de mek di dopamin we dɔn dɔn na di bren kam bak.
- Carbidopa: Bɔt prɔblɛm de. If wi tek levodopa nɔmɔ, bɔku pan am kin pwɛl bay di ɛnzaym dɛn we de na wi bɔdi bifo i rich na di bren. Fɔ stɔp dis, dɛn kin gi wan mɛrɛsin we dɛn kɔl kabidopa togɛda wit lɛvodopa. Kabidopa de alaw mɔ pan di lɛvodopa fɔ rich na di bren sef wan. Dɔn bak, kabidopa kin ɛp fɔ ridyus di sayd ɛfɛkt dɛn we pɔsin kin gɛt we i tek lɛvodopa nɔmɔ, lɛk fɔ nɔs ɛn vɔmit.
Dis kɔmbayn mɛrɛsin kin woke fayn fayn wan fɔ di sayn dɛm fɔ bradykinesia, stiffness, ɛn tremor.
| Tayp fɔ mɛrɛsin | Kɔmɔn Brand Nem dɛn na Sri Lanka |
|---|---|
| Levodopa-Carbidopa kɔmbaynshɔn | Sinemet®, Rytary®, Parkopa®, Dhivy®, ɛn ɔda pipul dɛn |
2. Dopamin Agonist dɛn
Dis kayn mɛrɛsin tan lɛk aktɔ. Dat min se, i nɔto rili dopamin. Bɔt i kin go na di bren ɛn akt lɛk dopamin. i de mek di dopamin risεptor dεm na di bren, we de gi di bren di filin se dopamin de.
Dɛn kin gi dɛn mɛrɛsin ya we di sik bigin, mɔ to di wan dɛn we yɔŋ. Sɔntɛnde dɛn kin ɛp fɔ mek di lɛvodopa wok fɔ lɔng tɛm.
- Pramipeksol (Mirapex®) we dɛn kɔl .
- Ropinirol (Requip®) we dɛn kɔl .
- Rotigotin (Nyupro®) we dɛn kɔl .
3. Ɛnzaym Inhibitɔ dɛn
Nɔ fred we yu yɛri dis nem. I rili simpul. Wi bin dɔn tɔk bifo tɛm se ɛnzaym dɛn de na wi bɔdi we de brok dopamin. Wetin dɛn drɔgs ya de du na fɔ stɔp di wok we dɛn ɛnzaym dɛn de du. Dɔn di dopamin we de na di bren nɔ kin pwɛl fɔ lɔng tɛm.
Tu men kayn dɛn de:
- MAO-B inhibitor dεm: dεn ya de blכk di akshכn fכ `MAO-B`, we na wan mכtalman εnzym we de brok dכn dopamin na di bren. Ɛgzampul dɛn: `Selegilin`, `Rasagilin`.
- COMT inhibitors: dεn ya de inhibit di εnzym `COMT` we de brok dכn dopamin, we de fכm frכm levodopa. Bikɔs ɔf dis, di ifɛkt we lɛvodopa gɛt kin las fɔ lɔng tɛm. Ɛgzampul dɛn: `Ɛntakapon`, `Opikapɔn`.
4. Amantadin we gɛt di sik
Sɔm sik pipul dɛm wae de tek mɛrɛsin lɛk lɛvodopa fɔ lɔng tɛm kin gɛt muvmɛnt wae dɛn nɔr want, wae de jerky (dyskinesia). Dɛn kin yuz amantadin mɔ fɔ mɛn dɛn sik ya. I sɔprayz fɔ no se fɔs dɛn bin mek am as mɛrɛsin fɔ fɛt di vayrɔs. Bɔt leta dɛn kam fɔ no se i kin ɛp bak fɔ gɛt di sik we dɛn kɔl Pakinsin.
5. Antikolinergic Mεdikeshכn dεm
Dis mɛrɛsin kin ɛp mɔ fɔ mek pɔsin shek ɛn rigid.Kɔntrol. we di dopamin na wi bren dכn, di ifekt fכ כda `nyurotransmitta` we dεn kכl asetilkolin de inkrεs. Dɛn drɔgs ya de blok di ifɛkt we da asɛtilkɔlin de gɛt. Ɛgzampul dɛn: `Bɛnztropin`, `Triheksifenidil`.
Mɛrɛsin fɔ ɔda sayn dɛm we nɔ gɛt natin fɔ du wit muvmɛnt
Pakinsin sik nɔr kin jɔs afɛkt aw pɔrsin de muv. I kin mek ɔda prɔblɛm dɛn bak, lɛk fɔ gɛt bɛlɛ, fɔ gɛt prɔblɛm wit slip, fɔ gɛt pwɛl hat, ɛn fɔ lɛ i nɔ ebul fɔ du mami ɛn dadi biznɛs. Yu dɔktɔ go gi yu mɛrɛsin fɔ ɛni wan pan dɛn tin ya.
| Di sayn we de sho se di sik de | Di kayn mɛrɛsin dɛn we dɛn kin gi pɔsin |
|---|---|
| Erectile dysfunction we nɔ de wok fayn | Mɛrɛsin dɛn lɛk Sildenafil (Viagra®) . |
| Fɔ slip pasmak na de (Hypersomnia) . | Modafinil (Provigil®) we gɛt di sik. |
| Banbɛlɛ | Di tin dɛn we de mek di stɔl soft, lɛk polyethylene glycol (MiraLax®) . |
| Taya | Methylphenidate (Ritalin®) we dɛn kɔl . |
| Dimɛnshɔnal sik | Di wan dɛn we de stɔp di kɔlinesterase |
| Pwɛl hat/Wan wɔri | SSRI dɛn (Sɛlektiv Sɛrotonin Riuptek Inhibitɔ dɛn) . |
| Saykosis/Halusineshɔn | Antisaykotik mεdikeshכn dεm lεk pimavanserin |
Lɛ wi lan bak bɔt di bad tin dɛn we dɛn mɛrɛsin ya kin du.
Lɛk ɛni mɛrɛsin, di mɛrɛsin dɛn we de mek pɔsin gɛt Pakinson kin gɛt sayd ɛfɛkt. I impɔtant fɔ no bɔt dɛn tin ya bifo tɛm. Bɔt nɔto ɔlman kin gɛt dɛn bad bad tin ya. Dɔn bak, sɔm pan dɛn tin ya kin go as dɛn de kɔntinyu fɔ yuz di mɛrɛsin.
| Tayp fɔ mɛrɛsin | Kɔmɔn sayd ɛfɛkt dɛn |
|---|---|
| Levodopa we dɛn kɔl Levodopa | Nɔs, vɔmit, diziz, ed we de at, de slip, postural hypotension. Mental kɔnfyushɔn ɛn hallucinations kin apin pan ol pipul dɛm. |
| Dopamin Agɔnis dɛn | Hallucinations, mental konfyushɔn, slip, nɔs, dray mɔt, diziz. Dɛn tin ya kin apin mɔr pan di fɔs dez we yu bigin fɔ tek di mɛrɛsin ɛn afta dat dɛn kin stɔp. |
| Di tin dɛn we de mek di enzym inhibitors | (COMT inhibitors): dayarɛa, muvmɛnt we dɛn nɔ kin kɔntrol (dyskinesia). (MAO-B inhibitors): Chɛst pen, nɔs, dray mɔt, diziz. |
| Amantadin we dɛn kɔl am | I nɔ kin izi fɔ pe atɛnshɔn, kɔnfyushɔn na yu maynd, nɔ kin slip, yu kin drim bad bad drim, yu leg dɛn kin swel. |
| Antikolinɛrijik dɛn | Mɔt dray, yu nɔ de si fayn, yu kin slip, yu kin gɛt bɛlɛ, yu nɔ kin ebul fɔ pis, yu nɔ kin mɛmba prɔblɛm. |
I rili impɔtant: Nɔ stɔp fɔ tek Levodopa ɔ ridyus di doz wantɛm wantɛm if yu dɔktɔ nɔ advays yu fɔ ɛni rizin. If yu du dat, i kin mek yu gɛt siriɔs, layf de pan denja we dɛn kɔl `parkinsonism hyperpyrexia syndrome`.
Yu tink se mɛrɛsin nɔ go du fɔ yu? Wetin bak dɛn go ebul fɔ du?
Fɔ tru, mɛrɛsin na jɔs wan pat pan di fɛt. If yu du sɔm ɔda tin dɛn wit mɛrɛsin, yu go ebul fɔ kɔntrol yu sik dɛn fayn fayn wan ɛn kɔntinyu fɔ gladi.
Fizik Tɛrapi
Dis na sɔntin we wi fɔ du fɔ tru. Dɛn gɛt program dɛn de fɔ mɛn pipul dɛn we gɛt dis sik we dɛn kɔl Parkinson. Dɛn tin ya go ɛp yu, .
- Yu kin mek yu bɔdi balans ɛn waka fayn fayn wan.
- I kin mek di bɔdi tinap tranga wan.
- I kin ɛp bɔku fɔ mek yu kɔntinyu fɔ liv aktif layf.
We yu de du ɛksasaiz
Ɛksesaiz na di bɛst we fɔ kɔntrol di sik we dɛn kɔl Pakinsin. Ɛksesaiz na di wangren tin we sayɛns dɔn pruv se i kin mek di sik nɔ go bifo kwik kwik wan. I bɛtɛ fɔ du at le 150 minit ɛksesaiz fɔ yu at ɛn blɔd insay di wik. Tin dɛn lɛk fɔ rayd baysikul, bɔksin, ɛn fɔ du ɛksɛsayz to myuzik kin rili ɛp.
Fɔ tek kia ɔf mental wɛlbɔdi
Wae yu de liv wit wan sik wae de teik lɔng tɛm lɛk Pakinsin, e kin fayn fɔ fil pwɛl hat, wɔri, ɛn wɔri. So, if yu de fil dis kayn we, i impɔtant fɔ mek yu nɔ shem fɔ am ɛn aks fɔ ɛp frɔm pɔsin we sabi bɔt mental wɛlbɔdi biznɛs, lɛk pɔsin we de stɔdi bɔt pɔsin in maynd .
Ustɛm yu fɔ go to yu dɔktɔ bak?
We yu de yuz di mɛrɛsin fɔ Pakinson, i impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ chɛk if di mɛrɛsin de wok ɛn if nyu sayn dɛn dɔn kam. Mek shɔ se yu go to yu dɔktɔ mɔ pan dɛn kayn tin ya.
- If yu gɛt sayd ɛfɛkt dɛn we yu nɔ go ebul fɔ bia wit .
- If yu sik nɔr de bɛtɛ ɔr de wɔs .
- If yu fil fɔ stɔp yu mɛrɛsin . (Nɔ ɛva mek dis disizhɔn yu wan!)
Mɛsej we dɛn kin kɛr go na os
- Di mɛrɛsin fɔ di sik we dɛn kɔl Pakinsin nɔ kin ebul fɔ mɛn di sik ɔltogɛda, bɔt dɛn kin kɔntrol di sayn dɛm ɛn ɛp fɔ mek in layf bɛtɛ.
- Levodopa na di men ɛn di bɛst mɛrɛsin fɔ dis.
- Lɛk ɔl di mɛrɛsin dɛn, sayd ɛfɛkt kin apin. Tɔk opin wan wit yu dɔktɔ bɔt dɛn.
- Nɔ stɔp fɔ tek mɛrɛsin ɔ chenj di doz if yu dɔktɔ nɔ advays yu fɔ ɛni rizin. I kin denja.
- Apat frɔm mɛrɛsin, fɔ trit yu bɔdi ɛn ɛksesaiz ɔltɛm rili impɔtant fɔ kɔntrol di sik.
- Tek kia ɔf yu maynd wɛl bɔdi insay dis joyn. Aks pɔsin we sabi du in wok if nid de.
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