We yu dɔktɔ tɛl yu ɔ pɔsin we yu sabi gɛt vayral infɛkshɔn lɛk HIV, Epataytis C, ɔ COVID-19, yu kin fil fɔ fred smɔl bɔt di mɛrɛsin we dɛn go gi yu. Kwɛstyɔn dɛn lɛk, ‘Wetin na dɛn mɛrɛsin ya?’ ɛn ‘Aw dɛn kin afɛkt di bɔdi?’ kam na yu maynd. Protease inhibitors na pawaful klas ɔf mɛrɛsin dɛm we dɛn kin gi yu dɛn kayn tɛm ya. Pan ɔl we di nem kin kɔmplikt smɔl, di wok we dɛn de du rili impɔtant. Tide, wi go tɔk bɔt dis insay wan rili simpul we, insay wan we we yu go ɔndastand.
Wetin na dɛn protease inhibitor ya?
Fɔ tɔk am simpul wan, dɛn wan ya na wan kayn mɛrɛsin we dɛn kin gi fɔ mɛn vayral infɛkshɔn. Dɛn men wok na fɔ stɔp wan vayrɔs fɔ mek i nɔ mek kɔpi fɔ insɛf ɛn fɔ skata insay wi bɔdi. I tan lɛk se yu de kɔntrol aw di vayrɔs de skata.
Dɛn kin yuz dis mɛrɛsin mɔ as antiretroviral drug fɔ trit HIV/AIDS . Dɛn kin yuz am bak fɔ mɛn sik dɛn lɛk ɛpatitis C ɛn COVID-19.
Sɔntɛnde, dɛn kin gi dis mɛrɛsin in wan. Bɔt bɔku tɛm, we dɛn de trit sik dɛn lɛk HIV, dɛn kin gi am togɛda wit sɔm ɔda antivayrɔs mɛrɛsin dɛn, lɛk ‘kɔktɛl’. Wi kɔl dis Antiretroviral Therapy (ART) . Sɔntɛnde, dɛn kin yuz Protease Inhibitor as booster fɔ mek ɔda mɛrɛsin wok fayn.
Wetin na di men sik dɛm wae dɛn kin trit wit dis mɛrɛsin?
Di klas ɔf drɔgs we dɛn kɔl Protease Inhibitors na fɔ trit sɔm patikyula vayral infɛkshɔn dɛn nɔmɔ.
- HIV/AIDS: Dɛn kin yuz dɛn mɛrɛsin ya as men pat pan ART tritmɛnt fɔ kɔntrol HIV. Dɛn kin yuz dɛn bak fɔ post-exposure prophylaxis (PEP) fɔ mek dɛn nɔ gɛt di sik afta dɛn dɔn gɛt HIV (fɔ ɛgzampul, mami ɛn dadi biznɛs we nɔ sef).
- Epataytis C: Dɛn kin yuz dɛn tin ya togɛda wit ɔda antivayrɔs mɛrɛsin fɔ trit epataytis C vayrɔs infɛkshɔn.
- COVID-19: We pɔsin gɛt COVID-19, sɔntɛnde dɔktɔ dɛn kin gi am wan kɔmbaynshɔn fɔ tu kayn Protease Inhibitors fɔ mek di sik nɔ kam tranga.
Aw dis mɛrɛsin de wok insay di bɔdi?
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. Imajin se vayrɔs na pɔsin we want fɔ mek kek. fכ mek dis kek (i.e. nyu vayrus), i nid fכ kכt wan big protin strip insay sכm sכm pat dεm. dis sכm sכm pat dεm fכ protin na di ‘ingridiεnt dεm’ we dεn kin yuz fכ mek nyu vayrus dεm.
na ya, ‘Protease’ na enzym we de wok lεk ‘scissors’ we de kכt di big protin ribin.
Di mɛrɛsin we wi de gi, dat na...wetin ‘protease inhibitor’ de du na fכ blok di ‘scissors’ (protease enzyme) fכ wok. We di siza stɔp fɔ wok, di vayrɔs nɔ kin ebul fɔ kɔt di ‘ingridiɛnt’ dɛn we i nid fɔ mek nyu vayrɔs. Dɔn di vayrɔs nɔ kin ebul fɔ riplikɛt na di bɔdi ɛn mek kɔpi fɔ insɛf. Na dat na di simpul trut.
We di vayrɔs stɔp fɔ skata dis we, i kin izi fɔ wi bɔdi in imyun sistɛm fɔ fɛt di vayrɔs we lɛf ɛn kɔntrol di sik.
Wetin na di kayn Protease Inhibitors we dɛn kin yuz mɔ?
Bikɔs ɛni vayrɔs gɛt in yon spɛshal protease ɛnzaym, dɛn kin yuz difrɛn kayn protease inhibitor fɔ trit HIV, Epatitis C, ɛn COVID-19.
Wan izi we de fɔ no di nem dɛn fɔ dɛn mɛrɛsin ya.
- Bɔku tɛm, di mɛrɛsin fɔ HIV kin dɔn wit ‘-navir’ .
- di wan dεm we dεn gi fכ epataytis C de stat wit di sכfiks '-previr' .
Di tebul we de dɔŋ ya kin ɛksplen dis mɔ.
| Sik we dɛn de trit | Ɛgzampul dɛn bɔt drɔgs |
|---|---|
| Protease Inhibitors fɔ HIV | Atazanavir we dɛn kɔl Atazanavir Darunavir we dɛn kɔl Darunavir Lopinavir we dɛn kɔl Ritonavir we dɛn kɔl Saquinavir we dɛn kɔl Saquinavir |
| Protease Inhibitors fɔ Ɛpataytis C | Boceprevir we dɛn kɔl Boceprevir Glekaprevir we dɛn kɔl Glecaprevir Grazoprevir we dɛn kɔl Grazoprevir Simeprevir we dɛn kɔl |
| Protease Inhibitors fɔ COVID-19 | Wan kɔmbaynshɔn fɔ tu drɔgs, Nirmatrelvir ɛn Ritonavir (we dɛn kɔl Paxlovid®) . |
Aw a go pik di rayt mɛrɛsin fɔ mi?
Na di dɔktɔ we de trit yu kin disayd dis. I kin tink bɔt bɔku tin dɛn we i de disayd fɔ du dis.
- Yu vayral infεkshכn: if na HIV, epataytis C, כ COVID-19.
- Yu jenɛral wɛlbɔdi: Ilɛksɛf yu gɛt ɔda sik dɛn, lɛk dayabitis, ay blɔd prɛshɔn, kidni ɔ liva sik.
- Ɔda mɛrɛsin dɛn we yu de tek naw: Dis rili impɔtant bikɔs sɔm mɛrɛsin dɛn kin miks wit dɛn Protease Inhibitors ya.
- Yu dɔn tek ɛni ɔda mɛrɛsin fɔ dis sik bifo?
- Di kayn vayrɔs we yu gɛt: Sɔm kayn vayrɔs nɔ de ansa sɔm mɛrɛsin dɛn.
- Sɔm bad bad tin dɛn we kin apin to yu: Pik di mɛrɛsin we go fayn fɔ yu bɔdi ɛn we nɔ gɛt bɛtɛ sayd ɛfɛkt.
I rili impɔtant: I impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud vaytamɛn ɛn ɛbul mɛrɛsin) ɛn ɛni mɛrɛsin we yu gɛt. Dis kin ɛp fɔ mek yu nɔ gɛt bɔku denja sayd ɛfɛkt ɛn di drɔg intarakshɔn.
Wetin na di bɛnifit dɛn we pɔsin kin gɛt we i yuz dis mɛrɛsin?
Di bɛnifit dɛn we dɛn mɛrɛsin ya kin gi kin rili bɔku.
- As pat pan ART tritmɛnt, dɛn kin kɔntrol HIV te dɛn nɔ ebul fɔ no am na di bɔdi.
- I de ɛp fɔ mɛn di epataytis C infɛkshɔn kɔmplit wan .
- If yu gɛt COVID-19, i kin ɛp fɔ mek di sik nɔ kam tranga .
Wetin na di sayd ɛfɛkt ɛn prɔblɛm dɛn we kin apin?
Lɛk ɛni mɛrɛsin, Protease Inhibitors kin mek yu gɛt sayd ɛfɛkt. Bɔt, nɔto ɔlman kin gɛt dɛn. Dɔn bak, dɛn kin difrɛn difrɛn wan bay di mɛrɛsin we yu de tek ɛn aw yu gɛt wɛlbɔdi.
| Tayp fɔ di sayd ɛfɛkt | Ɛgzampul dɛn |
|---|---|
| Kɔmɔn sayd ɛfɛkt dɛn | |
| Prɔblɛm dɛn we de na di dijestiv sistɛm | Bɛlɛ de at, nɔs ɛn vɔmit, dayarɛa |
| Ɔda tin dɛn we pipul dɛn kin du | Skin rash, kɔf, taya, teist we nɔ fayn na di mɔt |
| Di bɔdi kin chenj | Kidni ston, chenj na di say we di fat de na di bɔdi (Lipodystrophy) . |
| Siriɔs bɔt sayd ɛfɛkt dɛn we nɔ kin apin so ɔltɛm | |
| Ifekt dεm pan di intanεt כgan dεm | Liva damej, blɔd we de kɔmɔt insay (inklud blɔd we de kɔmɔt insay di skel) . |
| Siriɔs tin dɛn we kin apin na di skin | Stevens-Johnson syndrome - na wan rash we de mek yu fil pen, we de blista ɔlsay na di bɔdi |
| Di chenj dɛn we de apin na di mɛtabolism | di shuga na di blɔd we de go ɔp (Hyperglycemia), di kɔlɔstrel we de go ɔp (Hyperlipidemia) . |
| Ɔda siriɔs tin dɛn we kin apin | Myocardial Infarction, Hemolytic Anemia, Prɔblɛm wit di ilɛktrik aktiviti na di at |
Aw lɔng a nid fɔ tek dis mɛrɛsin?
Dis kin dipen pan de sik wae yu gɛt.
- HIV: Bikɔs dɛn nɔ gɛt kɔmplit mɛrɛsin fɔ HIV yet, yu nid fɔ gɛt tritmɛnt fɔ di res ɔf yu layf. Di we aw dɛn kin trit am ɛn di mɛrɛsin dɛn kin chenj as tɛm de go.
- Epataytis C: Bɔrku tɛm, dis sik kin wɛl if dɛn trit am fɔ sɔm wik ɔr sɔm mɔnt.
- COVID-19: Dɛn kin gi antivayral tritmɛnt fɔ COVID-19 fɔ fayv dez.
Tin dɛn de we a kin du fɔ mek di tritmɛnt izi?
Yɛs, na fɔ tru. Sɔm tin dɛn de we yu kin du fɔ ridyus di sayd ɛfɛkt dɛn ɛn mek di tritmɛnt go bifo.
- Tek yu mɛrɛsin jɔs lɛk aw di dɔktɔ tɛl yu, na di rayt tɛm, ɛn nɔ skip wan doz.
- Drink bɔku wata.Dis kin ɛp fɔ mek tin dɛn lɛk kidni ston nɔ kam.
- Nɔ tek ɔda mɛrɛsin dɛn we go miks wit yu mɛrɛsin. Aks yu dɔktɔ bɔt dis.
- Sɔm mɛrɛsin dɛn nid fɔ tek wit it. Wi go luk pan dat mɔ.
Wetin mek sɔm Protease Inhibitors se fɔ tek am wit it?
Na rizin de fɔ dis. Sɔm protease inhibitor dɛm, mɔ di wan dɛm we dɛn tek wit fat it, kin bɛtɛ fɔ wi intestinal. Dis kin mek di mɛrɛsin wok fayn mɔ ɛn mɔ. So mek shɔ se yu aks yu dɔktɔ if yu fɔ tek yu mɛrɛsin bifo, afta, ɔ wit it.
Ustɛm yu nid fɔ go to dɔktɔ?
If yu gɛt ɛni nyu, sayd ɛfɛkt we yu nɔ bin de ɛkspɛkt, ɔ yu gɛt ɛni kwɛstyɔn bɔt yu tritmɛnt, nɔ shem fɔ tɔk to yu dɔktɔ.
If yu gɛt ɛni wan pan dɛn siriɔs sayd ɛfɛkt ya, go to dɔktɔ wantɛm wantɛm. Go na ɔspitul in Imejɛnsi Dipatmɛnt (ETU) kwik kwik wan.
- Fiva
- Kɔnfyushɔn ɔ chenj di we aw pɔsin de tink
- Yu yay ɔ yu skin kin yɔlɔ (Jaundice) .
- Lesions we de pen, we de blista, we de ɔlsay
- Bɛlɛ pen bad bad wan
- Siriɔs vɔmit we dɛn nɔ go ebul fɔ stɔp
Protease inhibitors na wan klas we rili impɔtant ɛn we de sev layf fɔ mɛn sik dɛn lɛk HIV ɛn Epatitis C. If yu gɛt ɛni kwɛstyɔn ɔ wɔri bɔt dis tritmɛnt, tɔk to yu dɔktɔ bɔt am opin wan. Dɛn kin ɛp yu fɔ mek wan tritmɛnt plan we go woke fayn fɔ yu.
Mɛsej we dɛn kin kɛr go na os
- Protease inhibitors na pawaful klas fɔ drɔgs we de kɔntrol vayral infɛkshɔn lɛk HIV, Epatitis C, ɛn COVID-19.
- Dɛn tin ya de wok bay we dɛn de stɔp di vayrɔs fɔ mek kɔpi fɔ insɛf insay di bɔdi ɛn fɔ skata.
- I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɛvri mɛrɛsin we yu de tek ɛn ɛvri sik we yu gɛt fɔ avɔyd sayd ɛfɛkt.
- Tek yu mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu, di rayt tɛm. Nɔ skip wan doz.
- If yu gɛt ɛni siriɔs sayd ɛfɛkt (fiva, yu skin yɔlɔ, yu gɛt bad bad brus), nɔ west yu tɛm ɛn go to dɔktɔ wantɛm wantɛm.
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