Wan simpul ɛksplen fɔ wan mɛrɛsin fɔ nɔs ɛn vɔmit: Serotonin Antagonist

Nɔs ɛn vɔmit we pɔsin kin gɛt we i de anestez we dɛn de du kemotɛrapi, redyushɔn tɛrapi, ɔ ɔpreshɔn na big prɔblɛm fɔ bɔku pipul dɛn. De diskɔmfɔt wae yu kin fil sɔmtɛm lɛk dis kin pasmak. So tide wi go tɔk bɔt wan spɛshal kayn mɛrɛsin we yu dɔktɔ go gi yu fɔ kɔntrol dis sik. Dɛn kɔl dɛn tin ya sɛrotonin antagonist . Lɛ wi si wetin na dɛn mɛrɛsin ya, aw dɛn de wok, ɛn wetin wi nid fɔ no we wi de yuz dɛn.

Wetin na dis sɛrotonin antagonist?

Fɔ tɔk am simpul wan, dɛn tin ya na grup fɔ mɛrɛsin we dɔktɔ gi fɔ mek pɔsin nɔ gɛt nɔys ɛn vɔmit ɛn fɔ mɛn am. We wi de tɔk bɔt mɛrɛsin, wi kin kɔl antiemetics di mɛrɛsin dɛn we dɛn kin gi fɔ nɔs. So, serotonin antagonist na wan pan dɛn kayn grup ya fɔ mɛrɛsin.

Dɛn kin kɔl dis klas fɔ drɔgs wit sɔm ɔda nem dɛn:

• Serotonin-rεsεptor antagonist dεm
• 5HT3 rεsεptכr antagonist dεm
• Serotonin blɔk dɛn

Pan ɔl we dɛn nem dɛn ya kin tan lɛk se dɛn kɔmplikt smɔl, dɛn ɔl min di sem tin. Dat min se dɛn kin blok wan kemikal we dɛn kɔl sɛrotonin na wi bɔdi sɔm tɛm. Wi go tɔk bɔt dat klia wan leta smɔl.

Wetin na di men kayn mɛrɛsin dɛn we de na dis kategori?

Bɔku kayn mɛrɛsin dɛn de we de insay dis kategori. Sɔntɛm yu dɔktɔ dɔn tɛl yu wan pan dɛn tin ya. Dɛn kin tek dɛn tin ya as pils ɔ as injɛkshɔn.

Pan dɛn wan ya , Ondansetron (Zofran®) na wan pan di mɛrɛsin dɛn we dɔktɔ dɛn kin gi fɔ stɔp fɔ nɔs, na Sri Lanka ɛn ɔlsay na di wɔl.

Us sityueshɔn dɛn dɛn kin yuz dis mɛrɛsin?

Dɛn dɔn gri fɔ dis mɛrɛsin mɔ fɔ mek yu nɔ gɛt nɔs ɛn vɔmit we sɔm tritmɛnt dɛn kin kam wit.

Di men tin dɛn we dɛn dɔn gri fɔ yuz:

• Nɔs we pɔsin kin gɛt bikɔs ɔf kemotɛrapi: We di mɛrɛsin dɛn we de agens kansa kam insay di bɔdi, i kin gɛt bɔku chans fɔ mek i nɔs ɛn vɔmit. Dɛn mɛrɛsin ya kin rili ɛp fɔ mek i nɔ gɛt am.
• Nɔs we pɔsin kin gɛt we i gɛt raytin: Nɔs kin apin bak we dɛn de yuz raytin fɔ pwɛl di kansa sɛl dɛn. Dɛn kin gi dɛn tin ya bak fɔ dɛn kes dɛn de.
• Nɔs afta dɛn dɔn du di ɔpreshɔn: Dɛn kin yuz dis mɛrɛsin bak fɔ kɔntrol di nɔys ɛn vɔmit we kin kam bikɔs ɔf di ifɛkt dɛn we anestezi kin du afta dɛn dɔn ɔpreshɔn.

Dɛn kin gi dis mɛrɛsin fayn fayn wan to big pipul ɛn pikin dɛn.

Ɔda tin dɛn we yu kin yuz (Off-label use):

Sɔntɛnde, dɔktɔ dɛn, bay di ɛkspiriɛns we dɛn gɛt pan mɛrɛsin, kin gi dɛn mɛrɛsin ya fɔ ɔda tin dɛn pas di wan dɛn we dɛn gri fɔ. Wi de kɔl dis ‘ɔf-lɛbul yus’.

• Fɔ trit nɔs afta dɛn dɔn ɔpreshɔn: Dɛn kin gi dis mɛrɛsin fɔ mek yu nɔ gɛt nɔs ɛn bak afta i dɔn apin.
• Mɔnin sik: Sɔm pipul dɛn kin gɛt mɔ bad bad nɔys ɛn vɔmit we dɛn gɛt bɛlɛ kwik kwik wan. If ɔda tritmɛnt dɛn nɔ wok, dɛn kin gi dis mɛrɛsin ɔnda dɔktɔ in tayt kia.

Aw dis mɛrɛsin de wok? Lɛ wi tek wan luk pan am bay sayɛns.

fכ כndastand dis, wi fכs nid fכ jכs כndastand wetin na ‘sεrotonin’ εn wetin na ‘sεrotonin rεsεpכta dεm’.

Tink bɔt am dis we: sɛrotonin na mɛsenja ɔ nyurotransmitta na wi bɔdi. Dis mɛsenja de ɛp fɔ rigul bɔku tin dɛn, lɛk aw wi de fil, aw wi de slip, ɛn aw wi de digest. i sɔprayz se 90% pan dis sεrotonin de na di wכl dεm na wi bεlε εn intestinal (gεstrointestinal sistεm).

Naw, aw nɔys kin apin? Bikɔs ɔf sɔntin lɛk kansa tritmɛnt, di sɛl dɛn na wi intestinal dɛn kin pul bɔku bɔku sɛrotonin wantɛm wantɛm. dis εksyכs sεrotonin de tay pan di rεsεpכta dεm na di intestכn dεm εn i de sεnd mεsej to di bren se "sכmtin we nכ sכmtεm de apin ya." di bren de intaprit dis mεsej as "nכs."

So wetin di ‘serotonin antagonist’ drɔg we wi de gi yu de du? Dis drɔg tan lɛk di rɔng ki we de na lɔk. I fit insay di lɔk (risɛptɔ), bɔt i nɔ de aktiv di lɔk. Dɔn bak, bikɔs i de insay di lɔk, i nɔ de alaw di rayt ki (serotonin) fɔ kam insay ɛn kɔnɛkt to di lɔk.

dat min se dis mεdisin de blכk di 5-HT3 rεsεp כta dεm we sεrotonin de biεn to. dis min se di sεrotonin we pasmak nכ gεt nכsay fכ go εn tay am. Dis kin mek di mɛsej we de na di bren kin stɔp, ɛn di filin fɔ nɔs ɛn vɔmit kin stɔp.

Wetin na di bad bad tin dɛn we kin apin to pɔsin?

Lɛk ɛni mɛrɛsin, dɛn mɛrɛsin ya kin mek sɔm smɔl smɔl tin dɛn we kin apin to pɔsin, bɔt bɔku tɛm dɛn tin ya nɔ kin rili siriɔs.

If dɛn sayd ɛfɛkt ya kin rili mɔna yu, tɔk to yu dɔktɔ bɔt am.

Ɛni spɛshal prɔblɛm dɛn de we yu fɔ wach bɔt?

Pan ɔl we dis kayn mɛrɛsin kin rili sef, sɔm tin dɛn de we wi nid fɔ tek tɛm mɔ bɔt.

Isyu dɛn we kin apin to pɔsin in at

Dɔktɔ dɛn kin tek tɛm bad bad wan we dɛn de gi dis mɛrɛsin to pipul dɛn we gɛt sɔm kayn at prɔblɛm bikɔs i kin gɛt smɔl ifɛkt pan di at ritm. If yu gɛt ɛni wan pan dɛn tin ya, mek shɔ se yu tɛl yu dɔktɔ.

• Lɔng QT sindrom
• Di at bit we nɔ de bit ɔltɛm (Ventricular arrhythmia) .
• Ɛni ɔda kayn at sik

Serotonin Syndrome - Dis na tin we rili impɔtant!

Dis na siriɔs, bɔt i nɔ kin apin so ɔltɛm, we kin apin we di sɛrotonin lɛvɛl na wi bɔdi kin bɔku pasmak.

Dis risk kin go ɔp if yu tek ɔda mɛrɛsin wae de afɛkt di sɛrotonin lɛvɛl (lɛk sɔm antidipreshan) wae yu de tek sɛrotonin antagonist. dis na biכs we dεn mεdikeshכn ya de blכk di sεrotonin rεsεpכta dεm, di כmכnt כf sεrotonin fri na di bכdi de inkrεs.

I rili impɔtant fɔ tɛl yu dɔktɔ if yu de tek dɛn mɛrɛsin ya:

• SSRI dɛn we dɛn kin yuz
• SNRI dɛn
• Mirtazapin we dɛn kɔl mirtazapin
• Monoamin oksidaz inhibito dεm (MAOIs) .

Wetin na di sayn dɛm wae de sho se yu gɛt sɛrotonin syndrome? Dɛn sayn ya kin kɔmɔt frɔm smɔl to siriɔs.

Yuz am we yu gɛt bɛlɛ (Pregnancy) .

dis mεdikal dεm nכ gεt bכku risk fכ bכn difεkt na di pikin we dεn yuz am we i bεlε. Bɔt dɛn dɔn ripɔt se smɔl inkris pan di risk fɔ bɔn sɔm prɔblɛm dɛn na di at ɛn bren. So, if yu nid dɛn mɛrɛsin ya we yu gɛt bɛlɛ, yu dɔktɔ go tɔk to yu fɔ lɔng tɛm bɔt di bɛnifit ɛn di bad tin dɛn we kin apin to yu bifo i disayd fɔ du sɔntin.

Ustɛm a fɔ kɔl mi dɔktɔ?

If yu kɔntinyu fɔ yuz dis mɛrɛsin, i impɔtant fɔ go to yu dɔktɔ ɔltɛm fɔ chɛk if di mɛrɛsin wok fayn. Apat frɔm dat, tɔk to yu dɔktɔ pan dɛn tin ya:

• If sayd ɛfɛkt de mɔna yu: If tin lɛk ed pen ɛn kɔnstipɛshɔn tu mɔna fɔ kɔntrol.
• If di nɔs ɛn vɔmit nɔ stɔp: If di nɔys nɔ stɔp ɔ i de wɔs pan ɔl we yu de tek mɛrɛsin.
• If yu want fɔ stɔp fɔ tek di mɛrɛsin: Nɔ ɛva stɔp fɔ tek di mɛrɛsin we yu nɔ aks yu dɔktɔ.

Nɔs na tin we rili de mek pɔsin vɛks. Bɔt di gud nyus na dat, mɛrɛsin dɛn de we go wok fayn, lɛk di wan dɛn we de mek pɔsin nɔ gɛt sɛrotonin, fɔ kɔntrol am. If yu gɛt ɛni kwɛstyɔn bɔt dis, nɔ fred fɔ aks yu dɔktɔ.