Toxic Hepatitis: Tek tɛm wit mɛrɛsin, rɔm, ɛn kemikal!

Di liva na wan pan di ɔgan dɛn we impɔtant ɛn big pas ɔl na wi bɔdi. I de wok lɛk big faktri insay wi bɔdi. Di liva de du bɔku impɔtant wok dɛn lɛk fɔ filta di pɔyzin dɛn we de kam insay di bɔdi, fɔ ɛp fɔ digest, ɛn fɔ kip ɛnaji. Bɔt yu no se sɔm pan di mɛrɛsin dɛn we wi kin tek ɛvride, di rɔm we wi kin drink, ɔ sɔm kemikal dɛn we wi nɔ no se kin kam insay wi bɔdi kin pwɛl dis liva we de wok tranga wan, dat na, i kin bi ‘pɔyzin’? Tide wi de tɔk bɔt dis siriɔs sik we dɛn kɔl ‘Toxic Hepatitis’ na mɛrɛsin, we na liva pɔyzin.

Fɔ tɔk am simpul wan, wetin na Tɔxik Ɛpataytis?

Pɔyzin Epataytis, ɔ liva pɔyzin, na we pɔyzin, we na sɔntin we de ambɔg wi bɔdi, de pwɛl di liva sɛl dɛn ɛn mek di liva swel. Insai mεdikal, wi kin kכl dis swel ``inflammation.`` Dis tכxik tin kin enta wi bכdi insay difrεn we dεm.

• We wi de swɛla: Na we wi de tek bɔku pan sɔm pan di mɛrɛsin dɛn we wi de tek, we wi de drink rɔm, ɔ we wi swɛla ɔda kemikal.
• We yu blo: Na we yu blo pɔyzin kemikal dɛn we dɛn miks na di ays na sɔm faktri dɛn, garaj dɛn, ɔ pent shɔp dɛn.
• Bay we i de absɔp tru di skin: Strɔng kemikal dɛn lɛk sɔm peshɛnt sayd dɛn kin go insay di bɔdi tru di skin we i tɔch.

Dis na aw wi liva kin pwɛl we i de tray fɔ filta di pɔyzin dɛn we de kam insay di bɔdi. We dis damej de apin as tɛm de go, di liva kin ivin nɔ de wok fayn fɔ ɔltɛm.

Yu tink se men kayn Pɔyzin Ɛpataytis de?

Yes, dεn kin sheb dis kכndyushכn to tu men tכp dεm dipכnt pan aw i kin apin.

• Acute Toxic Hepatitis: Dis na wan sik we kin apin wantɛm wantɛm. Di sayn dɛm kin bigin fɔ sho insay sɔm awa ɔr dez afta dɛn dɔn it di pɔyzin tin. Fɔ ɛgzampul, dis sik kin apin if yu tek bɔku mɛrɛsin (ɔvados).
• Chronic Toxic Hepatitis: Dis na wan sik wae de kam sloslo as tɛm de go. Sɔmtɛm, e kin tek sɔm wik, mɔnt, ɔr ivin sɔm ia fɔ mek di sayn dɛn de sho. Pipul wae kin drink rɔm fɔ lɔng tɛm kin gɛt dis sik.

Dɔn bak, wan klasification de bay wae de kɔz dis sik. Wi kin yuz di tebul we de dɔŋ fɔ ɔndastand dis klia wan.

Wetin na di sayn dɛm wae de sho se yu liva dɔn pwɛl?

Di men ɛn di tin we pipul dɛn sabi pas ɔl fɔ gɛt liva sik na we di yay ɛn di skin de yɔlɔ. Wi kin kɔl dis jaundice bak , ɛn pan mɛrɛsin dɛn kin kɔl am ``Jaundice.'' Apat frɔm dis, bɔku ɔda sayn dɛm kin apin.

• Pen na di rayt say na di bɛlɛ, dɔŋ di rib dɛn
• Taya ɛn taya
• Fil fɔ it
• Nɔs ɛn vɔmit
• Low fiva
• Dak yɔlɔ ɔ brawn urine
• Abdominal distension, ɔ asayt
• I de it (Pruritus) .
• Pepul spat ɔ pat dɛn na di skin

Wetin na di men tin dɛm wae kin mek pɔrsin gɛt Toxic Hepatitis?

As wi bin dɔn tɔk, bɔku rizin dɛn de. Lɛ wi luk dɛn smɔl smɔl.

Mɛrɛsin ɛn vaytamɛn dɛn (Drug-induced hepatotoxicity) .

Dis na tin we rili kɔmɔn fɔ si.

• Pen kil: Sɔm pen kil, mɔ di wan dɛn we yu kin bay ova di kɔwnta na di famasi, fɔ ɛgzampul, `(Acetaminophen)` (we dɛn kin si na mɛrɛsin lɛk `Panadol` na Sri Lanka) ɛn `(NSAID)` (Nonsteroidal anti-inflammatory drugs) (e.g. `Ibuprofen`, `Diclofenac`) kin mek di liva pwɛl if dɛn tek am pasmak di doz we dɛn kin gi.
• Di mɛrɛsin dɛn we dɛn kin gi: Sɔm mɛrɛsin dɛn lɛk di mɛrɛsin dɛn we de mek pɔsin nɔ gɛt bɔku bɔku kɔlɔstrel, mɛrɛsin dɛn we de mek pɔsin gɛt ɛpilepshi, ɛn di mɛrɛsin dɛn we de mek pɔsin gɛt antibayɔtik, kin afɛkt di liva bak pan sɔm pipul dɛn. Bɔt nɔ stɔp fɔ tek yu mɛrɛsin dɛn bikɔs ɔf dis. If yu gɛt ɛnitin we de mɔna yu, tɔk to yu dɔktɔ bɔt am.
• Ɛbul ɛn Ayurveda mɛrɛsin: Dɛn kin tink na sosayti se ‘Sinhala mɛrɛsin’ ɔ ‘tradishɔnal tin’ nɔ de kɔz ɛni bad tin. Bɔt dat nɔto tru atɔl. Sɔm ɛbul mɛrɛsin dɛn kin gɛt tin dɛn we kin ambɔg di liva. So, i bad fɔ yuz dɛn tin ya if yu nɔ gɛt advays frɔm dɔktɔ we sabi du di wok.
• Vitamin: If yu it sɔm vaytamɛn dɛn pasmak, lɛk vaytamɛn A, i kin bi pɔyzin bak to di liva.

Lan spɛshal wan bɔt Acetaminophen pɔyzin

`Acetaminophen` na mɛrɛsin wae wi kin yuse fɔ fiva ɛn bɔdi pen. Na Sri Lanka, i de ɔnda nem dɛn lɛk `Panadol` ɛn `Paramol`. Pan ɔl we dis na mɛrɛsin we rili sef, i kin mek di liva pwɛl bad bad wan if dɛn tek am pasmak.

Imajin, sɔmbɔdi tek tu Panadol tablɛt fɔ ed we de at. Afta sɔm awa, dɛn kin tek ɔda paket na di famasi fɔ mek dɛn kol. Dɛn nɔ no se da paket de gɛt Acetaminophen bak. Dis we ya, dɛn kin pas di maksimal doz we dɛn kin gi ɛvride we dɛn nɔ no.

In jɛnɛral, big pɔsin nɔ fɔ tek pas 4,000 miligram asetaminofɛn (dat na 8 500mg tablɛt) insay 24 awa. If yu dɔn gɛt liva sik, dis amɔnt fɔ ivin smɔl. If yu aksidɛntli tek tumɔs mɛrɛsin, ivin if yu nɔ gɛt ɛni sik, go to ɔspitul in imejensi dipatmɛnt (ETU) wantɛm wantɛm. If nid de, yu kin kɔl bak di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta na di Nashɔnal Ospital fɔ gɛt advays.

Yuz rɔm (Alcohol-induced toxic hepatitis) .

Fɔ drink pasmak na di men tin we kin mek pɔsin in liva pwɛl. Alkol na pɔyzin we de go dairekt to di liva sɛl dɛn. We dɛn drink rɔm fɔ lɔng tɛm, di fat kin gɛda na di liva, we kin gɛt inflamɛns, ɛn leta di liva kin gɛt skata ɔlsay ɛn i nɔ kin ebul fɔ wok (Cirrhosis).

Udat de pan big risk fɔ gɛt dis sik?

Pan ɔl we ɛnibɔdi kin gɛt `Toxic Hepatitis`, sɔm pipul dɛn kin gɛt bɔku risk.

• Fɔ uman dɛn: Bikɔs uman dɛn bɔdi de mɛtabolayz difrɛn we pas man dɛn, dɛn kin gɛt smɔl risk fɔ mek dɛn liva pwɛl bikɔs ɔf sɔm mɛrɛsin ɛn rɔm.
• Fɔ di wan dɛn we de drink rɔm pasmak.
• Fɔ di wan dɛn we dɔn ɔlrɛdi gɛt ɔda sik na di liva (e.g. Epataytis B, Epataytis C, Fat Liva).
• Fɔ di wan dɛn we de yuz bɔku mɛrɛsin dɛn di sem tɛm.
• Fɔ di wan dɛn we de wok wit kemikal (e.g. peint industri, plastic industri, dray klin savis).
• fכ pipul dεm we gεt sכm jεnεtik sik dεm (e.g. `Alpha-1 antitrypsin deficiency`, `Hemochromatosis`).

Yu tink se dis kin mek pɔsin denja? Wetin na di prɔblɛm dɛn we kin apin?

Yɛs, if dɛn nɔ trit Toxic Hepatitis kwik ɛn dɛn nɔ pul di bad tin, i kin mek yu gɛt siriɔs prɔblɛm dɛn. Di men prɔblɛm na di sirosis na di liva.

Sirosis na wan kכndyushכn we di hεlty liva sεl dεm de pwεl εn skata tisu dεm de riples dεm. Dis kin ambɔg di nɔmal wok we di liva de du kpatakpata. Dɔn, dis kin mek di liva nɔ wok fayn . If dɛn kayn tin ya apin, di wangren tin we pɔsin kin du fɔ sev pɔsin in layf na fɔ transplant in liva .

Aw dɔktɔ kin fɛn dis?

We yu go to dɔktɔ, i go aks yu bɔku kwɛstyɔn dɛn fɔs bɔt yu sik, di mɛrɛsin dɛn we yu de tek, if yu de drink rɔm, ɛn wetin yu de du. Dɔn i go chɛk yu bɔdi. I kin du sɔm tɛst dɛn bak fɔ no if pɔsin gɛt di sik.

• Blɔd tɛst dɛn:
• Tεst dεm fכ di liva fכnshכn: dεn kin chεk di liva εnzym lεvεl fכ si if di liva de damej.
• kכmprεhεnsiv mεtabolik panεl `(CMP)`: dis tεst de εp fכ gεt kכmprεhεnsiv כndastandin fכ di bכdi in mεtabolik prכsεs dεm εn di כgan fכnshכn.
• Test fɔ rɔm ɔ ɔda drɔg lɛvɛl.
• Ɔda tɛst dɛn:
• Skan: CT skan ɔ MRI skan kin chɛk wit yu yay aw di liva de.
• Liva Bayopsi: Sɔntɛnde, dɛn kin tek smɔl pat pan di liva bay we dɛn de yuz wan rili smɔl nidul ɛn chɛk am ɔnda maykroskɔp. Dis kin ɛp fɔ no di rayt say we di prɔblɛm dɔn pwɛl.

Aw dɛn kin trit am? Yu tink se dɛn go ebul fɔ mɛn dis?

Di bɛst tritmɛnt fɔ `Toxic Hepatitis` na fɔ avɔyd di tin we de pwɛl di liva wantɛm wantɛm. Di tritmɛnt dipen pan aw di liva dɔn pwɛl.

• Fɔ stɔp di mɛrɛsin we de ambɔg yu: If yu dɔktɔ tink se wan patikyula mɛrɛsin ɔ vaytamɛn de mek yu liva pwɛl, i go advays yu fɔ stɔp fɔ tek am wantɛm wantɛm.
• Fɔ lɛf fɔ drink rɔm ɔltogɛda.
• Di chenj dɛn we dɛn mek na di wokples:If na kemikal de mek yu gɛt dis sik, yu kin nid fɔ wɛr tin dɛn fɔ protɛkt yusɛf (mask, glɔv) na yu wokples ɔ dɛn kin transfa yu to ɔda wok.
• Fɔ wan asɛtaminofɛn ɔvados: Dɛn kin gi wan spɛshal antidɔt na di ɔspitul. If dɛn gi am kwik, dis kin mek bɔku pan di damej we di liva nɔ gɛt.

Ustɛm yu fɔ go to dɔktɔ wantɛm wantɛm?

If ɛni wan pan dɛn bad bad sayn ya apin, i kin bi sayn fɔ se di liva dɔn pwɛl kpatakpata. So , go na di ɔspitul we de nia yu Imejɛnsi Dipatmɛnt (ETU) ɛn nɔ de te.

• Blɔd we de vɔmit.
• Blak, tarry stɔl dɛn.
• Wantɛm wantɛm, sɔm say dɛn we tan lɛk brus kin apin ɔlsay na di bɔdi.
• I kin rili yɔlɔ (Jaundice).
• Sivɛri anorexia.
• Delirium, stet we de mek pɔsin fil bad.
• I nɔ izi fɔ waka.