Trodelvy fɔ brɔst kansa - wetin yu nid fɔ no (Trodelvy)

If yu ɔ pɔsin we yu sabi gɛt bɔdi kansa, fɔ lan bɔt nyu tritmɛnt kin mek yu gɛt op ɛn i kin ful-ɔp wit kwɛstyɔn dɛn. Tide, wi go tɔk bɔt wan pan dɛn kayn nyu op ya, wan drɔg we dɛn kɔl Trodelvy. Na tritmɛnt fɔ tu spɛshal kayn bɔdi kansa (Triple-negative breast cancer - TNBC ɛn HR+/HER2- brɔst kansa) we dɔn skata tumɔs fɔ mek dɛn pul am bay ɔpreshɔn ɔ we nɔ dɔn ansa tu ɔda tritmɛnt. Lɛ wi tɔk bɔt dis simpul wan ɛn wit padi biznɛs.

Aw Trodelvy de wok insay di bɔdi?

Fɔ tɔk am simpul wan, Trodelvy na "targeted therapy." Dis min se instead fɔ jɔs go rawnd di bɔdi, dis drɔg de go dairekt fɔ fɛn ɛn atak di kansa sɛl dɛn.

Tink bɔt dis lɛk mishɔl we de go stret to di say we dɛn want fɔ go.

1. Fכ no di kεnsar sεl dεm: bכku brεst kεnsar sεl dεm gεt wan protin we dεn kכl Trop-2 na dεn sכfa. di dכg we dεn kכl Trodelvy gεt wan spεshal pat (monoclonal antibody) we kin atak dis Trop-2 protin. Dis na wetin de sho klia wan di kansa sɛl.

2. Fɔ gi di mɛrɛsin: Afta i dɔn atak di kansa sɛl, Trodelvy de pul wan pawaful kemikal drɔg (wan kemotɛrapi drɔg we dɛn kɔl SN-38) we ayd insay di kansa sɛl.

3. fכ pwεl di kεnsar sεl dεm: we i de insay di kεnsar sεl, dis SN-38 dכg de stכp di sεl fכ divayd εn mek mכr sεl dεm (i de kכpi in DNA). Dɔn di kansa sɛl nɔ kin ebul fɔ gro igen ɛn i kin day.

Aw dɛn kin gi dis tritmɛnt?

Trodelvy na mɛrɛsin we dɛn kin gi as salin sɔlvushɔn insay wan vein (IV Infusion) . Yu go gɛt dis na ɔspitul ɔ kansa tritmɛnt sɛnta, ɔnda di sɔpɔtishɔn fɔ dɔktɔ ɔ tren nɔs staf.

Dɛn kin gi di tritmɛnt insay 21 dez saykl. Dat min se dɛn kin gi di mɛrɛsin di fɔs de ɛn di de we mek et . Dɔn, dɛn kin dɔn di 21 dez saykl, ɛn di nɛks saykl kin bigin bak.

• Di fɔs tɛm we dɛn gi di mɛrɛsin, i kin tek lɛk 3 awa so.
• Afta dat, yu kin dɔn am insay 1-2 awa na di tɛm dɛn we dɛn gi yu .

Bifo yu gi yu di mɛrɛsin, yu dɔktɔ go gi yu asetaminofɛn (lɛk Panadol), antihistamin (lɛk Pyridoxine) , ɛn sɔntɛm stɛroyd fɔ mek yu nɔ gɛt tin dɛn lɛk fiva, nɔs, ɛn alɛji na yu skin.

Us risach dɛn dɔn du fɔ no aw dis mɛrɛsin de wok fayn?

Dɛn dɔn du sɔm big klinik stɔdi fɔ kɔnfɔm di sef ɛn efyushɔn fɔ Trodelvy. ASCENT ɛn TROPiCS-02 na tu pan di men stɔdi dɛn.

Dɛn stɔdi ya kɔmpia di pasɛnt dɛn we bin gɛt Trodelvy wit di wan dɛn we bin gɛt standad kemotɛrapi. Dɛn bin pe atɛnshɔn mɔ pan tu men pɔynt dɛn:

• Progression-Free Survival (PFS): Dis na di lɔng tɛm we pɔsin we sik kin liv we di kansa nɔ de wɔs.
• Overall Survival (OS): Dat na di totכl tεm we di sikman de liv.

Risach dɔn sho fayn fayn tin dɛn

Dɛn tu stɔdi ya sho se di tin dɛn we dɛn dɔn du bin rili fayn.

ASCENT stɔdi (fɔ TNBC kansa):

• Pan ɔl we di wan dɛn we bin de tek Trodelvy bin gɛt dɛn kansa we dɛn bin kɔntrol fɔ 5.6 mɔnt we i nɔ bin de wɔs, na bin 1.7 mɔnt nɔmɔ fɔ di wan dɛn we bin de tek mɛrɛsin ɔltɛm.
• Di ɔvala sɔvayv (OS) fɔ di pasɛnt dɛn we tek Trodelvy na bin lɛk 11.8 mɔnt , we yu kɔmpia am wit 6.9 mɔnt na di ɔda grup.

TROPiCS-02 stכdi (fכ HR+/HER2- kεnsar dεm):

• Wail di pasɛnt dɛn we tek Trodelvy bin gɛt dɛn kansa kɔntrol fɔ 5.5 mɔnt we i nɔ bin de skata, na bin 4 mɔnt fɔ di wan dɛn we tek di ɔspitul mɛrɛsin.
• Di pasɛnt dɛn we tek Trodelvy bin liv avɛj 3.2 mɔnt lɔng pas ɔda wan dɛn (14.4 mɔnt vs 11.2 mɔnt).
• Di rεt כf tכmכro shrinkage bin כlso hכy pan di wan dεm we tek Trodelvy (21% vs 14%).

Di sayd ɛfɛkt dɛm wae mɛrɛsin kin gɛt ɛn aw fɔ dil wit dɛm

Lɛk ɛni mɛrɛsin, Trodelvy kin gɛt sayd ɛfɛkt. Di tin we impɔtant pas ɔl na fɔ no bɔt dɛn ɛn wok wit yu dɔktɔ fɔ mɛn dɛn. Na di sayd ɛfɛkt dɛm wae kin kam ɛn wetin yu kin du bɔt dɛm.

Spɛshal ɔwe bɔt bɛlɛ ɛn fɔ gi pikin in bɛlɛ

I nɔ kin fayn fɔ trit trodelvy we uman gɛt bɛlɛ . I kin ambɔg di pikin we nɔ bɔn yet. So, i impɔtant fɔ yuz wan fayn we fɔ kɔntrol bɔn pikin we dɛn de trit am ɛn fɔ 6 mɔnt afta di las doz. di mama dεm we de gi pikin bεlε fכ avכyd fכ gi pikin bεlε we dεn de trit dεm εn fכ 1 mכnt afta di las doz.

Ɛni intarakshɔn de wit ɔda mɛrɛsin ɛn it dɛn?

No spesifik it intarakshɔn nɔ bin ripɔt fɔ Trodelvy. Bɔt if yu drink rɔm, dat kin mek yu gɛt bɔku bad bad tin dɛn we kin apin to yu.Di sayd ɛfɛkt dɛm lɛk nɔs, dayarɛa, ɛn taya kin tranga pasmak.

Intarakshɔn wit ɔda mɛrɛsin dɛn kin apin. Sɔm mɛrɛsin kin ridyus di ifɛkt dɛm we Trodelvy gɛt, ɔda wan kin mek di ifɛkt dɛm we Trodelvy gɛt bɔku ɛn mek di sayd ɛfɛkt dɛn wɔs.

Udat nɔ fɔ yuz dis mɛrɛsin?

Nɔ yuz dis mɛrɛsin if yu gɛt alɛji fɔ Trodelvy ɔ ɛni wan pan di tin dɛn we de insay am. Sɔm pipul dɛn kin gɛt siriɔs alɛji. Wach fɔ di sayn dɛm lɛk dis:

• I nɔ izi fɔ blo (we yu de blo) .
• Swel na di fes, di trot
• Lɔw blɔd prɛshɔn
• Sivɛri skin rash

If yu gɛt ɛni wan pan dɛn sik ya, na imejensi. Go na di ɔspitul we de nia yu Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.

Tin dɛm fɔ tɛl yu dɔktɔ bifo yu bigin tritmɛnt

• Liva sik: Tɛl yu dɔktɔ if yu gɛt ɛni liva sik.
• UGT1A1 jin: Sכm pipul dεn gεt wan vεryכnt fכ dis jin, we de put dεm pan hכy risk fכ sayd ifekt lεk lכw wayt blכd sεl kכnt. Yu dɔktɔ kin tɛst fɔ dis if nid de.
• Plan fɔ gɛt bɛlɛ: Tɛl yu dɔktɔ if yu ɔ yu patna de plan fɔ gɛt bɛlɛ. If di man patna de tek tritmɛnt, dɛn fɔ yuz wan kayn we fɔ kɔntrol di pikin, lɛk kɔndɔm, we dɛn de trit am ɛn fɔ 3 mɔnt afta di las doz.