Siklɔs sik na wan sik wae kin bi rial chalenj na layf. Na di wan dɛn nɔmɔ we dɔn gɛt am no aw i nɔ kin izi fɔ liv wit pen ɔltɛm, taya, ɛn ɔda prɔblɛm dɛn. Bɔt we di sayɛns bɔt mɛrɛsin dɔn go bifo, dɛn dɔn kam fɔ no se nyu mɛrɛsin dɛn de fɔ kɔntrol dɛn kayn sik dɛn de. Wan pan dɛn kayn nyu ɛn saksesful tritmɛnt ya na Voxelotor. So if yu dɔktɔ dɔn gi yu dis mɛrɛsin, i rili impɔtant fɔ mek yu no bɔt am gud gud wan. Tide, lɛ wi tɔk bɔt dɛn Voxelotor pils ya.
Us kayn mɛrɛsin na Voxelotor?
Fɔ tɔk am simpul wan, Voxelotor na spɛshal kayn mɛrɛsin we dɛn kin yuz fɔ mɛn siklɛt sik . fכ mεdikal tεm, i de insay di klas כf dכg dεm we dεn kכl `hεmoglobin S polimεrayzeshn inhibito dεm`.
Naw yu go de wɔnda wetin na dat. I rili simpul. Pɔsin we gɛt siklɛt sik gɛt wan prɔtin we dɛn kɔl ɛmoglobin na in rɛd blɔd sɛl we difrɛn smɔl. We di ɔksijɛn nɔ bɔku, dɛn ɛmoglobin mɔlyul ya kin stik togɛda, ɛn dɛn kin mek lɔng chen dɛn we kin chenj di shep we di rɛd blɔd sɛl dɛn gɛt. di nכmal rawnd rεd bכdi sεl dεm de bεnd fכ bi sikl shep. dis sikl sεl dεm na dεn kin stכk na di sכm sכm bכdi bכdi, we kin mek prכblεm lεk pen εn כgan dεm we de pwεl.
so, wetin Voxelotor de du na fכ mek di hεmoglobin mכlikul dεm nכ kכlכp tכgeda (polimεrayzeshn). Dis kin mek di rɛd blɔd sɛl dɛn we tan lɛk sikl nɔ bɔku ɛn i kin ɛp dɛn fɔ kɔntinyu fɔ gɛt di rayt shep. Dis kin mek blɔd flɔ bɛtɛ ɛn i kin ridyus di prɔblɛm dɛn we di sik kin kam wit bɔku bɔku wan.
Tin dɛm fɔ tɛl yu dɔktɔ bifo yu bigin dis mɛrɛsin
Bifo yu bigin fɔ tek Voxelotor tritmɛnt, i impɔtant fɔ gi yu dɔktɔ kɔmplit diskripshɔn bɔt yu wɛlbɔdi kɔndishɔn. Mek shɔ se yu tɔk mɔ bɔt dɛn tin ya.
- If yu gɛt liva kɔndishɔn: If yu liva nɔ de wok fayn, i kin afɛkt di we aw dɛn de pul di mɛrɛsin na yu bɔdi. So, yu dɔktɔ kin nid fɔ chenj di doz.
- If yu dɔn gɛt alɛji fɔ Voxelotor ɔ ɛni ɔda mɛrɛsin ɔ it: Sɔm pipul dɛn gɛt alɛji to sɔm mɛrɛsin dɛn. So mek shɔ se yu tɛl wi if yu dɔn gɛt ɛni ɛkspiriɛns bifo.
- If yu gɛt bɛlɛ ɔ yu de plan fɔ gɛt bɛlɛ: Yu nid fɔ tek tɛm bad bad wan fɔ yuz mɛrɛsin we yu gɛt bɛlɛ. So mek shɔ se yu tɔk to yu dɔktɔ bɔt dis.
- If yu na mama we de gi pikin in mama in bɛlɛ: Sɔm mɛrɛsin kin pas to yu pikin tru in mama in milk. So, tɛl yu dɔktɔ bɔt dis bak.
Aw a fɔ yuz dɛn pils ya?
Fɔ mek yu gɛt di bɛst pan di mɛrɛsin, i rili impɔtant fɔ yuz am di rayt we.
- Swɛla dis tablɛt ɔl wit wan glas wata. Nɔ ɛva brok, krɔs, ɔ chew di tablɛt. Swɛla di tablɛt ɔl. If yu nɔ du dat, dat kin chenj di we aw di mɛrɛsin de go insay di bɔdi, ɛn dis kin mek i nɔ wok fayn.
- Yu kin tek dis mɛrɛsin wit it ɔ yu nɔ it am. Bɔt if yu bɛlɛ at ɔ yu nɔs, i go fayn fɔ mek yu tek am afta yu dɔn it.
- Tek yu mɛrɛsin ɛvride, lɛk aw yu dɔktɔ tɛl yu. Nɔ tek am wan de ɛn skip am di nɛks de.
- Ivin if yu fil fayn, nɔ stɔp fɔ tek di mɛrɛsin if yu dɔktɔ nɔ advays yu.
Impɔtant: Dɛn dɔn gi yu dis mɛrɛsin fɔ yu nɔmɔ. Nɔ gi dis mɛrɛsin to ɛni ɔda pɔsin we gɛt di sem sik lɛk yu. I kin bi se i denja.
If yu giv dis mɛrɛsin to pikin dɛn...
Dɔktɔ dɛn kin gi dis mɛrɛsin bak to pikin dɛn we dɔn pas 12 ia pan sɔm spɛshal kes dɛn. Bɔt na dɔktɔ we de mɛn pikin dɛn fɔ disayd fɔ du dat. So, if yu de gi yu pikin dis mɛrɛsin, tek tɛm tɔk to yu dɔktɔ ɛn gɛt advays.
Wetin fɔ du if yu mis wan doz fɔ mɛrɛsin?
If yu fɔgɛt fɔ tek wan doz, nɔ wɔri. Skip di doz we yu mis ɛn tek di nɛks doz di tɛm we yu kin tek. Nɔ ɛva tek dɛbul doz fɔ mek di doz we yu dɔn fɔgɛt.
Wetin a go du if a tek bɔku mɛrɛsin?
If yu tink se yu dɔn tek mɔ pas di doz we dɛn tɛl yu fɔ tek, kɔl di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta na di Kɔlɔmbɔ Nashɔnal Ospital wantɛm wantɛm. If nɔto dat, go na di Imejɛnsi Tritmɛnt Yunit (ETU) na di ɔspitul we de nia yu ɛn nɔ de te.
Ɔda mɛrɛsin dɛm wae kin intarakt wit Voxelotor
Ɔda mɛrɛsin dɛn we yu de tek kin afɛkt aw Voxelotor de wok. Voxelotor kin chenj bak aw ɔda mɛrɛsin dɛn de wok. So, tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud vaytamɛn dɛn, ɛbul mɛrɛsin dɛn, ɛn sɔpɔtmɛnt dɛn) .
| Tayp fɔ mɛrɛsin | Not |
|---|---|
| Antifכngal dεm (e.g. flukonazכl, kεtokonazכl) . | dis kin mek di lεvεl fכ Voxelotor na di bכdi go כp. |
| Mɛrɛsin fɔ TB (e.g. `rifampin`) . | Dis kin mek di Voxelotor nɔ wok fayn. |
| HIV tritmɛnt (e.g. efavirenz) . | Di ifekt dɛm we Voxelotor kin gɛt kin inflɔws. |
| Sɔm mɛrɛsin dɛn we de mek pɔsin fil fayn (e.g. midazolam) . | Voxelotor kin chenj di ifekt dɛm fɔ dɛn mɛrɛsin ya. |
Dis list nɔ kɔmplit. So tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek, if yu de smok, ɛn if yu de drink rɔm.
Sayd ɛfɛkt dɛn we kin apin bikɔs ɔf dis mɛrɛsin
Lɛk ɛni mɛrɛsin, Voxelotor kin mek sɔm pipul dɛn gɛt sayd ɛfɛkt. Sɔm pan dɛn tin ya kin denja, so i impɔtant fɔ no bɔt dɛn.
| Siriɔs sayd ɛfɛkt dɛm we dɛn fɔ ripɔt to di dɔktɔ wantɛm wantɛm | |
|---|---|
| Alɛji Riakshɔn dɛn | Skin rash, it, swel na di lip, tong ɔ fes, i nɔ izi fɔ blo. |
| Di sayn dɛn we de sho se Blɔd dɔn Klɔt | Chɛst kin pen wantɛm wantɛm, i nɔ kin izi fɔ blo, i kin pen wantɛm wantɛm, i kin swel, ɔ i kin rɛd na yu leg. |
| Sayd ɛfɛkt dɛm wae nɔr kin denja, bɔt dɛn fɔ ripɔt to di dɔktɔ if dɛn kɔntinyu fɔ de | |
| Prɔblɛm dɛn we de na di dijestiv sistɛm | Bɛlɛ pen, dayarɛa, nɔs. |
| Ɔda smɔl smɔl tin dɛn we kin ambɔg am | Ed pen, taya, fiva. |
If yu gɛt ɛni ɔda kayn sik we nɔ kɔmɔn we dɛn nɔ tɔk bɔt na dis list, tɔk to yu dɔktɔ bɔt dɛn bak.
Aw yu fɔ kip di mɛrɛsin?
- Kip am usay smɔl pikin dɛn nɔ go ebul fɔ rich .
- Stɔr am na rum tɛmpracha, we nɔ rich 30 digri sɛlshiɔs (86 digri F). Protɛkt frɔm ɔt ɛn mɔs we pasmak.
- Trowe di mɛrɛsin we dɔn pas ɛn yu nɔ yuz am.
Mɛsej we dɛn kin kɛr go na os
- Voxelotor na imכtant drog we de mek di rεd bכdi sεl dεm nכ de chenj shep na sikεl sεl sik εn i de ridyus di kכmplikεshכn dεm fכ di sik.
- Bifo yu bigin dis mɛrɛsin, tɛl yu dɔktɔ bɔt ɔl yu wɛlbɔdi infɔmeshɔn ɛn ɔl ɔda mɛrɛsin dɛn we yu de tek.
- Swɛla di pil ɔl, nɔ brok, krɔs, ɔ chew am. Tek di doz we dɛn tɛl yu fɔ tek di tɛm we yu gi yu.
- If yu gɛt ɛni bad bad sayd ɛfɛkt lɛk we yu fes de swel, i nɔ izi fɔ blo, ɔ yu chɛst de pen, go to dɔktɔ wantɛm wantɛm.
- Dis mɛrɛsin na fɔ yu nɔmɔ. Nɔ ɛva sheb am wit ɔda pipul dɛn. If yu gɛt ɛni prɔblɛm, tɔk to yu dɔktɔ ɔltɛm.
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