I taksa ngeiin i liver a rawn beih hian? Autoimmune hepatitis chungchang hi han sawi ila.

I taksa ngeia invenna, immune system hian nangmah ngeiin i thin a rawn bei tan ang tih i ngaihtuah ngai em? Mak tak mai a ni lawm ni? Mahse, autoimmune hepatitis hi chutiang chiah chu a ni. Hei hi thil buaithlak deuh angin lang mah se, awlsam takin, i hriatthiam theih angin sawi ila.

Autoimmune hepatitis hi eng nge ni?

A awlsam zawngin sawi ila, autoimmune hepatitis hi hun rei tak chhung natna a ni a, i liver a tichhe thei a ni. I taksa invenna system, immune system -a tihsual tlemte atanga tan a ni . Hetiang hian han ngaihtuah teh: kan immune system hi kan ram venghimtu sipai ang a ni. A hna chu ramdang mi rawn lut, hrik leh virus ang chi te dona a ni. Mahse, autoimmune hepatitis-ah hian he sipai, immune system hian a liver cell hrisel tak takte chu hmelma niin a ngai sual a, a bei tan ta a ni.

Hetianga immune system hian liver tissue a beih chuan liver inflammation , a nih loh leh hepatitis a thlen thin. He attack hi a kal zel chuan he inflammation hi a chronic ta zel a ni. Hun a kal zel a, he chronic inflammation hian liver a tichhe nasa thei hle. A bik takin liver tissue chu a hliam a, liver chu zawi zawiin a chak lo thei a ni. Hei hi cirrhosis an ti a .

Thu lawmawm tak chu damdawi hmanga enkawl hian thin (liver) a ti na a, natna avanga harsatna lo thleng tur a veng thei a ni. Mahse, a chang chuan he natna hi a tir lamah hian symptoms i nei lo mai thei.

Autoimmune hepatitis chi hrang hrangte chu engte nge ni?

Autoimmune hepatitis (AIH) hi chi hnih lian tak a awm a. Chungte chu autoantibodies hrang hrang awmna a\angin a danglam a, chu chu kan scientist-te chuan antibody test hmangin an hmu thei a ni . Heng antibody hrang hrangte hian liver chhunga cell chi hrang hrang an bei a.

Type 1 a ni

Hei hi "classic" type a ni a, a hman tlanglawn ber pawh a ni. Damlo hmuhchhuah zinga 80% vel chuan he chi hi an nei a ni. Kum eng pawhah a lo thang lian thei. Type 1 autoimmune hepatitis-ah chuan ASMA (anti-smooth muscle antibodies) an tih antibodies te hian liver chhunga smooth muscle cells te chu an bei thin. He type 1 condition hi "lupoid hepatitis" tia sawi a ni fo a, a chhan chu a symptoms hi Systemic Lupus Erythematosus nen a inang a ni. Mahse, ASMA thisen test hian natna pahnih hi a thliar hrang thei a ni.

Type 2 a ni

Type 2 autoimmune hepatitis hi hepatitis natna hmuh tur awm lo leh na zawk a ni. A tlangpuiin a hma deuh, naupan lai a lo lang thin. Type 1 aiin a kal chak zawk thei bawk a, he chi hi anti-LKM-1 (anti-liver-kidney microsome type 1 antibodies) emawAntibody inrawlh te hi anti-LC1 (anti-liver cytosol type 1 antibodies) an ti a. Anti-LKM-1 antibodies hian liver cell-a protein pakhat cytochrome P450-2D6 (CYP2D6) an tih chu an target a ni. Anti-LC1 hi type 2 AIH tan chuan liver antibody bik a ni.

Autoimmune hepatitis hi engtiang chiahin nge a tlem?

Autoimmune hepatitis hi natna a awm vak lo. Mi engzat nge nei tih erawh hriat chian a la ni lo. European zirchianna atanga a lan dan chuan he natna hian Europe mipui 0.010% leh 0.025% inkar a nghawng a ni. Hnam leh chi eng pawh a nghawng thei a, mahse Alaska Natives (chu mipui zinga 0.043% vel) zingah chuan a tam zawk deuh hlek a ni. Hmeichhiaah pawh mipa aiin a tam zawk a , ratio 4:1 a ni.

Eng nge a lan chhuah dan?

Autoimmune hepatitis vei zawng zawng hian symptoms an nei vek dawn lo. A chang chuan symptoms hi a hnuah a lo lang thin a, chu chu natnain liver hnathawh a nghawng tan hnuah a ni. Hei hian taksaah side effect hrang hrang a thlen thei a ni.

A hmaa a lan chhuah dan tlangpui thenkhat chu:

• Pum natna emaw, nuam lo emaw.
• Liver lian vanga pum a hring.
• Chau .
• Joint natna.
• Skin rashes tih awmzia chu irritation tihna a ni.
• Acne a awm.

I liver a thawk tha lo tan chuan i thisenah bile a pung thei a ni. Hei hian symptoms a thlen thei a, chungte chu:

• Jaundice ( vun leh mit sen).
• Zun rawng dum emaw, bawlhhlawh rawng hring emaw.
• Hriselna (Pruritus) .
• Nausea emaw ei duh lohna emaw.

Side effect dang tlai tak takte chu:

• Spider angiomas (vunah hmun sen, spider web ang maia lang) .
• Anus chhunga veins lian tham (varices) .
• Bruising leh thisen chhuah awlsam.
• Hmeichhia thla tin thlasik hun hloh.
• Pum chhunga tui awm (ascites) emaw, ke leh ke ruh (edema) .
• Buaina, mut theih lohna, emaw mut theih lohna (hepatic encephalopathy) .

Autoimmune hepatitis hi engte nge ni?

Autoimmune natna hi i immune system-in i cell thenkhat chu hlauhawm anga a tihsual hian a lo awm thin. Immune system hian he "threat" hi a hriat chian hnu chuan chu cell te chu a bei ta a ni. Hei hian taksa peng bik pakhatah chronic inflammation a thlen thin. Autoimmune hepatitis-ah chuan immune system hian antibodies bik a thawn a, liver chhunga cell chi hrang hrang a bei thin. Hei hi a takah chuan thil kalphung buaithlak tak a ni.

He natna hi a lo intan kum zatve vel chu engzat nge ni?

Autoimmune hepatitis hi engtik lai khan nge a lo intan tih chiang taka hriat theih a ni lo. Hei hi a chhan chu a tir lamah chuan symptom a awm loh fo vang a ni. Type 1 AIH hi kum tir atanga kum chanve vel, kum 15 leh 40 inkar ah hmuhchhuah a ni tlangpui a, mahse kum eng pawhah a awm thei. Type 2 AIH hi a hma zawk zawk, naupan lai, kum 4 leh 14 inkar a lo lang tlangpui a, chuti chung pawh chuan thin natna chhinchhiahna na tak tak a awm thei bawk.

Engtin nge autoimmune hepatitis hi a lo awm?

Engvangin nge miten autoimmune natna an vei tih hi zawhna buaithlak tak a ni. A chhan pakhat chauh a awm lo niin a lang a, thil hrang hrang inzawmkhawm a ni zawk.

• Genetic influence: A then phei chuan i genes hian autoimmune natna thenkhat i vei theihna a tipung thei a ni. Amaherawhchu, chutiang genes nei zawng zawng chuan natna chu an nei vek dawn lo va, chu natna nei apiangin chutiang genes chu an nei vek dawn lo.
• Environmental factors: Genetic factors ni lo dang, "environmental factors" tia koh bawk hian hei hi a thlen thei a ni. Chungte chu toxin emaw, i immune system-a harsatna thlentu thil thleng emaw pawh a ni thei. Mi thenkhatah chuan heng thilte hian immune system a ti nasa lutuk a, chu chuan chronic autoimmune disease a thlen thei a ni.

Damdawi thenkhat leh virus infection te chu autoimmune hepatitis thlentu nia hriat a ni. Tin, autoimmune disease dang i neih tawh chuan autoimmune hepatitis i vei theihna a sang zawk bawk.

Eng virus nge autoimmune hepatitis thlen thei?

Heng virus infection te hi i neih tawh chuan autoimmune hepatitis i vei theihna a sang zawk:

• Viral hepatitis (A, B, C, D emaw E emaw) a ni.
• A rilru a hah lutuk chuan a rilru a buai em em a, a rilru a hah lutuk chuan a rilru a buai em em bawk a .
• Measles natna a ni .
• Herpes natna (Herpes) a awm .

Eng damdawi nge autoimmune hepatitis thlen thei?

Drug-induced autoimmune hepatitis hi heng damdawi te nen hian a inzawm tih hmuhchhuah a ni a:

• Nitrofurantoin ( zun kawng natna tan).
• Minocycline ( hmai vun natna atan).
• Atorvastatin ( cholesterol sang tan).
• Isoniazid ( antibiotic) a ni.

Autoimmune natna dang engte nge autoimmune hepatitis nena inzawm?

Mi thenkhat chuan an bile ducts tichhe thei autoimmune disease dang nen autoimmune hepatitis an vei bawk. Entir nan:

• A rilru a hah lutuk chuan a rilru a buai em em a. .
• A rilru a buai em em a, a rilru a hah em em bawk a. Primary sclerosing cholangitis (PSC) .

Hei hi autoimmune hepatitis "variant type" anga ngaih a ni.

Mahse a tlangpuiin autoimmune disease i neih tawh chuan natna dang i vei theihna a sang zawk. Hmun khata chronic inflammation hian hmun dangah inflammation a thlen thei niin a lang. Autoimmune natna pahnihna vei theihna chance hi 25%-50% vel a ni. Autoimmune hepatitis hi i autoimmune natna hmasa ber a nih chuan a pahnihna vei theihna chance i nei ve tho.

AIH natna dang hmuh tur awmte chu:

• Graves-a natna .
• Celiac natna a ni .
• Inflammatory bowel natna a ni .
• Rheumatoid arthritis natna a ni.
• Type 1 zunthlum vei a ni.
• Vitiligo ( vunah var a awm).

Autoimmune hepatitis hi a kai theih em?

No. Viral hepatitis (hepatitis A, B, leh C ang chi) hi hrik kai theih a ni. Heng hri kai te hi mi dangah pawh kai theih a ni. Amaherawhchu autoimmune hepatitis hi infection a nih loh avangin midang tan a kai thei lo.

Engtin nge autoimmune hepatitis hi hmuhchhuah a nih?

AIH symptoms langsar tak tak i nei thei a, i nei lo thei bawk. Doctor chuan taksa a enfiah hmasa ang che a, test bulpui thenkhat, imaging test leh thisen test te a ti ang che. Thisen test comprehensive metabolic panel an tih hian liver natna a awm tih finfiahna a zawng thei a ni. He panel-ah hian liver function test engemawzat a awm a, chu chuan liver enzyme level leh inflammation ang chi thilte a teh a ni.

Mahse heng indicator te hi autoimmune hepatitis tan bik a ni lo. I doctor chuan thisen test dang a ti ang a, virus bik leh hepatitis thlentu dang a zawng ang. Autoantibodies pawh an zawng dawn a ni . A chhan dang an paih chhuah hnuah leh autoimmune hepatitis nena inzawm antibodies an hriatchhuah hnuah chuan an diagnosis chu nemnghet turin an inpeih tawh ang. Hei hi finfiah theih dan tha ber chu liver biopsy tih hi a ni . Hei hian liver atanga tissue te tak te lak a, microscope hmanga enfiah a huam a ni.

Autoimmune hepatitis hi eng enkawlna nge ni?

Standard treatment chu inflammation leh autoimmune response control nan corticosteroids dose sang tak atanga tan a, chutah chuan zawi zawiin dose tihhniam a ni. Prednisone hi autoimmune hepatitis damdawi pek chhuah tam ber leh zirchian tha ber a ni. Mi tam tak tan a thawk tha hle a, mahse side effect a nei thei. Damdawi dang, budesonide te hian side effect a nei tlem zawk niin a lang.

I doctor chuan steroid nen hian immunosuppressant azathioprine an tih chu a pe thei ang.Damdawi hi a pe thei bawk. A nih loh leh steroid enkawlna i zawh hnuah pawh a ni thei bawk. Steroid aiin azathioprine hian side effect a nei tlem zawk avangin hun rei tak chhunga enkawlna atan a thawk tha ber a, chu chu i immune system chu a overactive leh tawh loh nan a veng tihna a ni. I dam chhungin a hun hunah i ei a ngai mai thei.

Damdawi hian eng side effect nge a neih?

Heng enkawlnate hian side effect engemaw zat a nei thei bawk. Chuvang chuan doctor in a enkawl reng ang che.

Steroid (Corticosteroids) hun rei tak hman avanga nghawng tha lo awm thei:

• Ei duhna a tipung a, taksa rihna a tipung bawk.
• Mood disorder te, lungkhamna leh lungngaihna te.
• Glaucoma ( mit hmuhna fiah lo).
• Osteopenia emaw osteoporosis (ruh chak lohna) emaw a ni thei.
• Zunthlum .
• Thisen sang sang .

Immunosuppressant ei hian a nghawng tha lo a awm thei:

• Infection tam tak (immune system tlahniam vang).
• Nausea leh luak chhuak.
• Vun natna (itching) a awm.
• Bruising leh thisen chhuah awlsam.
• Kidney hnathawh that lohna.
• Pancreatitis natna a ni .

Heng damdawi te hi i ei lai hian i doctor chuan side effects a awm leh awm loh a enfiah ang che. I damdawi ei avanga side effect a na lutuk a nih chuan, a nih loh leh a puih tawk loh chuan a dang an rawn rawt ang che. Heng zawng zawng hi i doctor nen sawi dun hlau suh.

Enkawlna hian eng chen nge hna a thawh theih?

Damdawi hman tum ber chu natna hi remission ah dah a ni . Chutiang ti thei tur chuan thla engemaw zat atanga kum engemaw zat chhung damdawi i ei a ngai mai thei. Hemi chhung hian i doctor chuan i liver chu a enfiah fo ang a, enkawlna chu a thawk tha em tih a chiang ang. Liver function test-ah chuan i liver enzyme level chu zawi zawiin a normal leh ta tih a chiang ang. Remission tih awmzia chu natna chhinchhiahna leh chhinchhiahna zawng zawng a bo vek tihna a ni.

American Association for the Study of Liver Diseases (AASLD) chuan damdawi i chawlhsan hmain kum thum tal steroid ei tur a ni. Kum hnih tal remission i neih hnuah chuan immunosuppressants te hi tihtawp an ngaihtuah ang. Damdawi an chawlhsan hnuah mi 50% vel chuan thla thum chhungin an natna a lo let leh thei a ni. Mi dangte tân chuan kum tam tak a daih thei a, a nih loh leh an natna chu an nei leh ngai lo thei bawk.

Mi thenkhat chuan enkawlna hmangin hmasawnna engemaw zat an hmu a, mahse remission-a kal tur chuan a tawk lo. Chutiang a nih chuan i doctor chuan damdawi dang a enchhin ang. Mi thenkhat chuan enkawlna an dawng lo tak tak. Chutiang a nih chuan natna kal dan chu a zual zel a ni. Heng mite hian harsatna an nei thei a, chu chu enkawl belh ngai a ni. A tawpah chuan an ni mai theiLiver transplant pawh a ngai thei bawk.

Autoimmune hepatitis hi a dam kim thei em?

Ni lo, a dam kim thei lo. Mahse natna chu remission-ah dah theih a ni. Chumi awmzia chu inflammatory process hi hun engemaw chen a bo a, a chang chuan rei tak a bo tihna a ni. Mahse enkawlna i chawlhsan hnuah a lo let leh thei. Hei hi relapse an ti a . Damdawi ei tawh lo tam zawk (80%) chuan a tawpah chuan natna hi an nei leh a, damdawi ei tan leh a ngai ta a ni. Damdawi hian natna hi a thunun thei tlangpui a, mahse i dam chhung zawngin a hun hunah i ei a ngai mai thei.

Autoimmune hepatitis vei dam rei zawng hi engzat nge ni?

Enkawlna tel lo chuan kum nga chhung damchhuah zat chu 50% a ni. Mahse enkawlna nen chuan kum 10 dam chhung chu 90% a ni a, kum 20 dam chhung chu 70% a ni. Enkawlna hmang pawhin mi 15% velin a tawpah cirrhosis an nei a, a tlangpuiin kum 10 atanga kum 20 hnuah an vei thin. Hei hi enkawlna a hlawhchham chuan a thleng thei a, enkawlna a dawng kim lo a nih chuan emaw, natna hi vawi tam tak a lo lang leh a nih chuan a thleng thei a ni. Natna a lo awm leh chuan a lo let leh thuai thei a ni.

Autoimmune hepatitis natna vei lai hian engtin nge ka in enkawl ang?

Hei hi thil pawimawh tak a ni. Natna thunun tur leh nun hrisel tak nei turin nangmah lam atanga i tih theih tur a awm.

• Doctor appointment te chu bawhchhiat loh tur a ni. I doctor chuan i dam chhung zawng i liver chu a enkawl a ngai dawn a ni. Hun engemaw chen chu remission-ah i awm tawh a nih pawhin, vaukhânna emaw, a lan chhuahna chiang tak emaw awm lovin natna hi a lo kir leh thei a ni. I doctor chuan i liver-a fibrosis (scarring hmaa chhiatna) awm zat chu non-invasive methods, elastography hmangin a enfiah thei a ni. Symptoms i neih tan leh chuan doctor rawn nghal rawh.
• I ei leh in hi uluk takin enkawl rawh. Liver natna nei tan chuan ei leh in hrisel hi a pawimawh hle. A bik takin AIH chungchangah hian zirchianna hrang hrangah chuan mi 30% velin non-alcoholic fatty liver disease symptoms an nei tih hmuhchhuah a ni . Hei hian i taksa hian liver-ah thau tam zawk a khawlkhawm duh tihna a ni a, hei hi inflammation thlentu dang a ni. Hei hi i do let thei a, i taksa rihna hrisel tak i neih a, i ei leh in atanga sugar leh saturated fats tihtlem a ni. Hei hian i enkawlna result a tichangtlung thei bawk.
• I immune system humhim rawh. Liver natna leh immunosuppressant damdawi te hian i immune system a tichak lo hle. Chumi awmzia chu i damloh loh nan i in enkawl that a ngai tihna a ni. I doctor chuan natna hrik laka invenna atan vitamin supplement leh vaccine thenkhat a rawn rawt thei che a ni. I doctor-in a pawm loh supplement engmah ei suh.
• Zu in loh tur. Zu in hian i immune system a tichak lo va, i liver a tichhe bawk.

Autoimmune hepatitis hi natna khirh tak a ni a, mahse mi tam tak chuan enkawlna an dawng tha hle. Natna hi remission-ah a kal thei a, rei tak chhung chu a bo vek tawh mai thei. A lo let leh chuan chutiang bawka enkawlna chu hman leh theih a ni. Enkawlna hian side effect a nei thei a, mahse i ei leh in leh immune system i enkawl chuan nun pangngai tak i hmang thei a ni. Enkawlna a hlawhtlin loh chuan liver transplant hi duhthlan tur a ni.

He thuziak atanga hriatreng tur thil (Take-Home Message) .

Okay, chuvangin, kan sawi tawh atang chuan hengte hi i hriat reng tur pawimawh ber berte chu an ni:

• Autoimmune hepatitis hi natna rei tak a ni a, nangmah ngeiin i immune system hian i liver a bei thin.
• Hei hi natna hrik kai theih a ni lo.
• A tir lamah chuan symptoms a awm lo mai thei a, mahse symptoms, hahna, pum na lo, jaundice te a lang thei.
• Diagnosis dik tak atan thisen test leh liver biopsy neih a ngai mai thei.
• Enkawlna (steroids, immunosuppressants) hian natna hi remission-ah a dah thei a ni. Amaherawhchu, tihdamna famkim a awm lo va, a lo let leh thei bawk.
• Enkawlna hian side effect a nei thei a, chuvangin doctor enkawl a pawimawh hle.
• Nunphung hrisel (ei leh in tha, zu in loh, damdawi lam thurawn zawm) hi natna enkawl nan a pawimawh hle.
• Hlau suh. Hetiang dinhmunah pawh hian nun tha tak i hmang thei a ni. I doctor nen engkim sawiho la, a thurawn zawm rawh.

Hemi chungchanga zawhna dang i neih chuan doctor zawt ngei ang che. Dam leh thuai turin duhsakna kan hlan e!

` Liver natna, autoimmune hepatitis, immune system, Liver inflammation, cirrhosis, autoimmune natna, thin enkawlna