I fa chu a lo seilian chak lutuk em? Gigantism chungchang hi i zir dawn teh ang!

A chang chuan kan fate hi an thang chak hle a ni lawm ni? Mahse naupang dang aiin a sang zawk, ke leh ke lian zawk neia an lo thanglian nghal mai hi thil pangngai a ni lo. Hei hi thil awm dan tlemte vang pawh a ni thei. Vawiin hian chutiang dinhmun chu kan sawi dawn a, chu chu ‘Gigantism’ a ni.

‘Gigantism’ chu eng nge ni?

A awlsam zawngin, gigantism hi naupang emaw, tleirawl emawin growth hormone (GH) a siam tam lutuk hi thil awm lo tak a ni. Hei vang hian heng naupangte hi midang aiin an sang zawk hle. A tlangpuiin he growth hormone (GH) hi kan thluak bul hnaia awm, pea ang maia lian gland te tak te atanga siam a ni. Pituitary gland an ti a. Mahse, he pituitary gland-ah hian tumor te tak te a lo awm chuan a mamawh aia tam growth hormone (GH) a siam chhuak thei a ni. Chutah chuan gigantism a lo awm ta a ni.

Pituitary Gland hi thluak bul, Hypothalamus hnuai lama awm gland te tak te a ni. A takah chuan hormone 8 vel a tichhuak thin. Growth Hormone (GH) hi chutiang zinga mi a ni.

Growth Hormone, Human Growth Hormone (hGH) tia hriat bawk hi naupang puitlin nan a pawimawh hle. Taksa peng tam tak a nghawng a, naupang thang tha turin a pui bawk. Mahse, kan ruhah hian growth plate chi hrang hrang Epiphyses/Growth Plates an tih a awm a, vawi khat chu a khar vek (i.e. puberty hnuah) growth hormone (GH) hian a sanna a tisang lo. A tih chu ruh, ruhro leh taksa peng dangte structure leh metabolism enkawl hi a ni. He growth hormone (GH) hi kan thin atanga siam Insulin-like Growth Factor 1 (IGF1) tih hormone nen hian a inzawm tlat a ni. Heng pahnih hian an thawhhona chuan thanlenna leh metabolism a pui thin.

Gigantism hi taksain growth hormone (GH) a siam tam lutuk a, chu chuan taksa ruh, ruh leh connective tissue te chu a ti thang chak hle a ni. Hei hian a san zawng a tidanglam a, taksa soft tissue-ah pawh eng emaw zat a inthlak danglam thin. Enkawl loh chuan gigantism vei thenkhat chu feet 8 aia sangin an thang lian thei a ni.

Chuvangin, natna hi hriatchhuah a, gigantism a awm chuan a rang thei ang bera enkawl tan a pawimawh hle.

‘Gigantism’ leh ‘Acromegaly’ hi eng nge an danglamna?

Gigantism leh acromegaly te hi growth hormone (GH) tam lutuk avanga lo awm an ni. A danglamna chu tuin nge dawng tih hi a ni. Acromegaly hian puitling a nghawng a ni. Gigantism hian naupang leh tleirawl puitling, la puitling, chu chu puitlin hun la thleng lote a nghawng a ni.

A awlsam zawngin, naupang ruh chhunga growth plate te a khar hma (i.e., puberty a zawh hma) growth hormone (GH) level a san chuan gigantism hi a lo awm thin.

I growth plate a khar hnua i growth hormone (GH) level a san chuan acromegaly a thlen thei. I sang zawk dawn lo a, mahse GH tam lutuk hian i ruh pianzia, i taksa peng lian leh te, leh hriselna lama harsatna dangte a nghawng thei a ni.

Gigantism hi acromegaly aiin a tlem zawk hle.

Tuin nge gigantism hi hmu? Engtiang chiahin nge a hluar?

Hei hi thil awm lo tak ni mahse, naupang eng pawh, an growth plate la khar lo (i.e., puberty an la zo lo) ah chuan gigantism hi a lo awm thei a ni. Hmeichhia aiin mipaah ​​a tam zawk.

Gigantism hi a takah chuan thil awm lo tak a ni. Entirnan, tun thlengin United States-ah hian hri kai 100 vel chauh hmuhchhuah a ni. Chuvangin a tlem zia chu i ngaihtuah thei ang.

Engtin nge naupangte hi an thanlenna pangngai chu a awm? Gigantism nen hian eng nge a danglamna?

Growth hormone (GH) hi naupan laia thanlenna control tu a ni. Chu chu, ruh, ruh leh tissue-a thanna teh theih a siam laiin metabolism a control tihna a ni. A tlangpuiin naupangin puitlin hun a thlen hma loh chuan thanlenna hi a nghet tawk hle.

Puberty lai hian sex hormone (estrogen leh testosterone) secretion a pung nasa hle. Hei hian naupang ruh sei tak tawp lama epiphyses (growth plate) te chu a khar zauh zauh thin. Epiphyses te chu a khar vek chuan, chu chu puitlin hun a zawh chuan height growth a tawp tihna a ni.

Naupang chu engtiang chiahin nge a lo seilian chak ang tih leh a puitlin hnua a san zawng hnuhnung ber tur chu an nu leh pate hnen atanga an rochun gene engemaw zat, an chhehvel thil te, leh an sex te inzawmkhawm a\angin a innghat a ni.

Gigantism-ah chuan naupang chu a thang chak hle a, kum leh mipa leh hmeichhia inang naupang dangte aiin a sang zawk hle bawk. Mahse, gigantism symptoms hi a tir lamah chuan naupan laia thanlenna pangngai ang maiin a lang thei a, nu leh pate tan chuan hriat a harsa hle.

I fate than chhoh dan chungchangah zawhna emaw, ngaihtuahna emaw i neih chuan an doctor nen inbia ngei ang che.

Gigantism natna lan chhuahna chu engte nge ni?

Gigantism hi growth hormone (GH) tam lutuk vang a ni. Tin, pituitary gland-a tumor hian a bul hnaia thluak leh nervous tissue-ah pressure a siam thei a, symptom thenkhat a thlen thei bawk. Gigantism chhinchhiahna ber chu a lo thang tam lutuk hi a ni.Naupang gigantism nei te hi an san zawngin an thang chak hle.

Kum aia sang/lian zawk a nih bakah, gigantism-a taksa pianphung hmuh theihte chu:

• Hmai langsar tak leh jawline langsar tak.
• Ha inkar ah gap awm.
• Hmai lam hawi thickening.
• Kut leh ke lian tak tak, leh kut zungtang thuk tak tak.

Symptom dang hmuh theihte chu:

• Chhungril peng lian, a bik takin naupang thinlung tihzauh.
• Thaw chhuak lutuk (hyperhidrosis).
• Double vision emaw, peripheral vision lama harsatna emaw.
• Lu na.
• Joint natna.
• Puberty hun sawn hlat.
• Thlasik mumal lo.
• Mut lama harsatna, entirnan, sleep apnea.
• Muscle chak lohna.

I fa hian heng symptoms te hi a nei a nih chuan a rang thei ang bera doctor biak a pawimawh hle.

Gigantism awm chhante chu engte nge ni?

Gigantism hi naupang pituitary gland-a benign tumor (pituitary adenoma) vang a ni fo thin. Hei hian growth hormone (GH) a tichhuak nasa lutuk a ni. Naupang gigantism vei an hriat chuan pituitary adenoma lian tak (tumor 10 mm aia lian), macroadenoma an tih chu an nei fo mai. Gigantism hi pituitary gland lian lutuk vang pawh a ni thei a, chu chu pituitary hyperplasia an ti a ni.

Naupang gigantism nei tam tak chuan genetic mutation an nei a, chu chuan pituitary tumor a siam a ni. Gigantism nena inzawm genetic mutation awm tam ber chu AIP gene-a mutation emaw deletion emaw a ni. Hei hian gigantism vei zinga 29% vel a nghawng a ni.

Gigantism hi genetic disorder awm lo tak tak, growth hormone (GH) chhuaktu pituitary tumor vei theihna a tipung thei bawk. Chung natna thenkhat chu:

• Carney complex: Hei hi genetic condition a ni a, vun rawng a tichhe a, vun, thinlung leh endocrine system-a benign tumor a thlen thin. Carney complex vei zinga 10% atanga 13% vel chuan growth hormone (GH)-secreting pituitary adenomas an nei a, a tlangpuiin a thang zawi zawi thin.
• McCune-Albright natna vei te hi:Hei hi genetic condition a ni a, ruh, vun leh endocrine system te a nghawng a ni. Vunah café-au-lait spot a siam a, ruhah scar tissue a siam a, precocious puberty a thlen bawk. McCune-Albright syndrome vei zinga 20% atanga 30% vel chuan growth hormone (GH) tam lutuk an nei a ni. Hei hi pituitary gland lian (hyperplasia) vang emaw, pituitary adenoma vang emaw a ni fo thin.
• Multiple Endocrine Neoplasias (MEN) chi 1 emaw 4 emaw: Hengte hi genetic condition a ni. Chutiang a nih chuan i endocrine gland pakhat emaw a aia tam emaw chu a thawk nasa lutuk a, a nih loh leh tumor a lo awm ta a ni. Hei hian pituitary tumor a huam thei a, chu chuan growth hormone (GH) a tichhuak thei a ni.
• Neurofibromatosis: Hei hi genetic condition a ni a, neurocutaneous disorders an ti a. Hengte hian vun leh nervous system a nghawng a ni. Heng dinhmunte hi cell than dan pangngai lo taka tihpun vang a ni. Hei hian taksa pumpuiah tumor a siam thei a ni. Chung zingah chuan growth hormone (GH) chhuaktu tumor pawh a tel thei.
• Familial Isolated Pituitary Adenomas (FIPA): Hei hi thlahtute atanga lo piang a ni. Pituitary adenomas lo awm tur a ni. Chung zingah chuan growth hormone (GH)-secreting adenomas te pawh a tel thei.

Engtin nge gigantism hi hmuhchhuah a nih?

Gigantism hi hriat a harsa deuh thei a, a chhan chu a awm lo hle a, naupangte than dan pawh hi genetic leh environmental factors vangin a danglam thei hle a ni.

A tlangpuiin, doctor-te chuan naupang san zawng chu an sex leh kum zat aṭanga standard deviation thum aia sang a nih chuan, emaw, naupang nu leh pate san zawng aṭanga chhut a san zawng aiin standard deviation hnih aia sang a nih chuan gigantism an ringhlel ṭhin.

I fa doctor chuan i fain gigantism a nei tih a rinhlelh chuan endocrinologist (hormone nena inzawm natna lama tui doctor) hnenah a refer mai thei che a ni. Doctor chuan i fate medical history, chhungkaw medical history, taksa enfiahna uluk tak, leh thisen test leh imaging test ang chi specialized test te hmangin diagnosis a siam ang.

Gigantism tih hriat nan eng test nge hman thin?

I fa doctor-in gigantism a nei nia a rinhlelh chuan a natna hriat chian nan a hnuaia test te hi tih theih a ni:

• Growth Hormone leh IGF-1 (Insulin-like Growth Factor 1) thisen test: Heng test te hian naupang thisen sample lak atanga hormone chi hrang hrang awm zat a teh thin. Level hi a tlangpui aia sang a nih chuan gigantism chhinchhiahna a ni thei.
• Glucose Tolerance Test: He test hian naupang growth hormone level-in glucose a chhan dan a teh a ni. He test atan hian doctor chuan naupangin glucose (sugar) solution a in hnuah vein atanga thisen sample chu interval hrang hrangah a la thin.
• Imaging test: Thisen test-in i fain gigantism a nei tih a hriat chian chuan i doctor chuan MRI (Magnetic Resonance Imaging) scan emaw CT (Computed Tomography) scan emaw a rawt fo ang. Hengte hian pituitary tumor lian tham leh awmna hmun chiang takin a hmu thei a ni. Enkawlna mamawh dik tak hriat theihna turin an pui thei bawk.

I fa chu gigantism a vei tih hmuhchhuah a nih chuan doctor chuan test dang engemaw zat a ti leh thei a, chu natna chuan taksa peng dang a nghawng em tih a enfiah thei bawk. Heng test-ah hian:

• Lung lam harsatna a awm leh awm loh enfiahna tur echocardiogram.
• Sleep study test hmanga sleep apnea i neih leh neih loh enfiah thin.
• X-ray emaw DEXA/DXA scan emaw hmangin i ruh hriselna enfiah rawh.

Engtin nge gigantism hi enkawl a nih?

Gigantism enkawlna tum berte chu:

• ‘Growth hormone’ (GH) leh ‘insulin-like growth factor 1’ (IGF1) level him taka control theih a ni.
• ‘Pituitary tumor’ lo thang lian zel dan enkawl.
• Pituitary tumor hian a bul hnaia thluak tissue leh optic nerve a nghawng dan tihtlem.
• Growth hormone (GH) hian taksa system dang a nghawng dan enkawl emaw tihtlem emaw.

Doctor-te chuan gigantism -a enkawlna chi hrang hrang an hmang tlangpui a , surgery leh radiation therapy hi enkawlna ber a ni.

Puitling (acromegaly)-a growth hormone (GH) tam lutuk enkawlna tur damdawi tha tak tak awm mahse, heng damdawi te hian naupangte chunga nghawng a neih dan hi zirchian a la ni lo.

Gigantism tan operation tih a ni

Surgery hi gigantism enkawlna atana hman tlanglawn ber a ni. A tum ber chu pituitary tumor hi lakchhuah emaw, a lian zawng tihtlem emaw a ni. Gigantism thlentu pituitary tumor hi a lian fo avangin naupang chu growth hormone (GH) level tha taka control turin operation vawi tam tak neih a ngai mai thei.

I fa surgeon chuan pituitary tumor lakchhuah nan transsphenoidal surgery tih surgical procedure a hmang thei ang. Hei hian i fa hnar kaltlangin leh sphenoid sinus (hnar hnung lama luruh chhunga awm, thluak hnuai lam) hmanga operation tih a huam a ni.

Gigantism te tan Radiation Therapy hmanga enkawl a ni

Surgery hmanga growth hormone level tihhniam loh chuan radiation therapy hian a pui thei ang. Hei hian tumor lam hawia radiation beams aim nan hmanraw bik hman a huam a ni. He enkawlna hian hna a thawk zawi zawi a. Enkawlna engemaw zat a ngai thei a, a inkar ah chawlh rei tak a awm thei bawk. Results kimchang hmuh theih nan kum engemawzat a ngai thei bawk.

Enkawlna avanga harsatna awmte chu engte nge ni?

Surgery leh/ emaw radiation therapy avang hian gigantism vei zinga 60% vel chuan enkawl hnuah hypopituitarism an tih natna an nei thin. Hei hi pituitary gland siam hormone pakhat, engemaw zat emaw, a zawng zawng emaw a siam chhuah tlem chuan a ni. Hypopituitarism hi hormone thlakna damdawi hmanga enkawl a ni.

Pituitary tumor lakchhuahna atana operation avanga harsatna awm thei te chu:

• Thisen chhuak.
• Cerebrospinal Fluid (CSF) a chhuak thin.
• Meningitis (thluak khawsik) natna.
• Taksa chhunga sodium (salt) leh tui balance hloh.

Radiation therapy hmanga side effects awm thei chu:

• Fertility tihchhiat.
• Mit hmuh hloh leh thluak chhiatna (rare).
• Enkawl hnu kum engemaw zat hnuah tumor a lo piang (rare).

Gigantism hi tihtawp theih a ni em? Prognosis chu eng nge ni?

Vanduaithlak takin gigantism venna tur engmah i tih theih a awm lo. Mahse, a hmaa hriatchhuah a pawimawh hle. Enkawl hmasak hian i fa sang lutuk chhan danglamna chu a veng thei a, a tidanglam thei bawk.

Naupang leh puitling tleirawl gigantism vei nia hriatte tan prognosis chu thil engemaw zatah a innghat a ni:

• Engtiang chiahin nge natna hi a hriat hma emaw, a tlai emaw.
• Growth hormone level enkawlna atana enkawlna hi engtiang chiahin nge a hlawk?
• Gigantism nena inzawm harsatna a awm em tih.

A tlangpuiin, kum upa zawkte chu natna hmuhchhuah a nih laiin kum naupang zawka hmuhchhuah te aiin harsatna an nei tam zawk thin. Hei hi growth hormone leh insulin-like growth factor 1 (IGF1) rei zawka inhriat vang a nih a rinawm.

Chuvangin, i fate thanlenna leh/ emaw taksa pianphungah thil danglam tak, beisei loh taka inthlak danglamna i hmuh chuan an doctor nen a rang thei ang bera inbiakna neih a pawimawh hle.

Gigantism nei mi pakhat dam rei zawng chu engzat nge ni? Hun rei tak chhunga harsatna awm thei te chu engte nge ni?

Gigantism hi a hmaa hriatchhuah leh enkawl hi a pawimawh hle a, chu chu a san lutuk leh a kaihhnawih harsatna awm thei tur venna atan leh dam rei zawng tihpun nan a ni.

Enkawl loh chuan gigantism hi harsatna lian tham a thlen thei a, thihna rate hi a tlangpui aiin a let hnih thleng a ni thei bawk.

Gigantism vei thenkhatin an san lutuk avanga hun rei tak chhunga harsatna an tawh thin leh growth hormone tam lutuk avanga a nghawng zawng zawng chu:

• Muscle chak lohna avanga kal kual harsa (Mobility).
• Osteoarthritis (ruh natna (joint inflammation) a awm thei.
• Peripheral Neuropathy (rilru lam natna (peripheral nerve natna)) a ni.
• 'Sleep Apnea' tih hi a ni.
• Lung lian (cardiomegaly) leh thinlung valve lama harsatna nei.
• Metabolic complication hrang hrang, Type 2 Diabetes ang chi te.

Tin, enkawl loh gigantism nei te nunphung pawh a tlahniam thei a, hei hi nitin hnathawhna lama harsatna an neih avangin thawmhnaw lei leh zin chhuah te hi an sang lutuk vang a ni.

Engtikah nge i fa doctor hnenah gigantism chungchangah i hmuh ang?

I fa chu gigantism a vei tih hmuhchhuah a nih chuan, enkawlna kal zel dan enfiah tur leh an hormone level a inthlau em tih enfiah nan an doctor leh/ emaw endocrinologist te a pan fo a ngai dawn a ni .

I fate thanlenna rate leh/ emaw taksa pianphungah inthlak danglamna i hmuh chuan i fa doctor nen a rang thei ang bera inbiakna neih a pawimawh. Gigantism hi a chhan a nih a rinawm loh nain, rinhlelh awm taka inthlak danglamna a awm chuan chhui chian a phu hle. Gigantism hi hriat hmasak a tha ber a, gigantism vei te hian nun hrisel an hmang tlangpui. I fa than dan tur chungchanga zawhna i neih chuan i doctor hnenah zawh hreh suh. I tanpui turin an awm reng a ni.

Hriat reng tur pawimawh ber berte (Take-Home Message) .

Gigantism hi a awm lo hle a, mahse na tak a ni thei. A pawimawh ber chu i fate thanlen danah thil danglam emaw, rinhlelhna emaw i hmuh chuan, beisei aia sang zawk emaw, ke leh ke lian zawk nei emaw i hmuh chuan damdawi lam thurawn la nghal mai tur a ni.

Hriat hmasak leh enkawl hian i fate nun hrisel, nun pangngai a neih theihna chance nasa takin a tipung tih hre reng ang che. Ngaihtuah buai suh, nang leh i fate tanpui turin doctor te an awm reng a ni. I ngaihtuahna eng pawh sawipui rawh.

` Gigantism, Growth Hormone, Pituitary Gland, Naupang thanlenna, San zawng tihsan, Acromegaly