Nangmah emaw, i hmangaih tak emaw hian hnute cancer i nei a nih chuan enkawlna chungchangah ‘immunotherapy’ tih thumal hi an paih chhuak tih i hre tawh ngei ang. I doctor pawhin a sawi tawh mai thei. Chuti a nih chuan, mi tam tak tan he enkawlna thar hi eng nge ni? Cancer a do thei tak tak em? I hriatthiam theih khawpin a awlsam zawngin sawi ila.
Chuti a nih chuan, Immunotherapy chu eng nge ni?
A awlsam zawngin sawi ila, immunotherapy hi i taksain natna dotu system (immune system) hmanga cancer cell zawng chhuak leh tihchhiat puitu enkawlna a ni. I taksa ngei "sipai" chu cancer cell an tih "hmêlma" hriatchhuah leh beih theihna tura training tir ang mai a ni.
Tunah hian he enkawlna hi hnute cancer chi khat ``Triple-negative breast cancer'' tih enkawlna atan hman a ni ber a, enkawl harsa tak, a lo lang leh theihna a sang hle a, taksa hmun dangah pawh a darh tawh (metastatic). He enkawlna hi ``HER2-positive'' leh ``ER-positive'' hnute cancer tan engtiang chiahin nge a hlawk tih hriat tumin zirchianna neih mek a ni bawk.
Engtin nge he enkawlna hian hna a thawh?
Kan taksa invenna (immune system) hi ram venghimtu sipai angin han ngaihtuah teh. He sipaite hian taksa chhunga lut hrik leh virus ang chi hmelma te chu an zawng reng a, an tichhia reng bawk. Mahse, cancer cell te hi hmelma fing tak tak an ni. A chang chuan heng cancer cell te hian kan sipaite man an nih loh nan kawng hrang hrangin an inthuam thin. Hmelma spy ang maiin.
Immunotherapy hian a tih dan chu hetiang hi a ni:
1. Hmelma hriat theihna tura tanpui: Immunotherapy damdawi thenkhat chuan cancer cell te chu an khuh a, kan immune system chu "hetah hian hmêlma a awm" tih chiang takin a lantir a ni.
2. Sipai chakna: Damdawi chi dangte hian kan taksa hriselna (immune system) cell (sipai) te tichakin hna a thawk a, cancer cell do turin chakna nasa zawk a pe a ni.
Chutianga tih theih dan tlangpui pahnih a awm a, chungte chu:
- Active Immunotherapy: Hei hian i hnute cancer cell-a marker (antigen) bikte zirchian a, chu marker chauh bei turin i immune system chu training a huam a ni.
- Passive Immunotherapy: Hetah hian laboratory-a siam damdawi bikte chu taksaah cancer dona theihna awmsa tihpun nan taksaah pek a ni.
Hnute cancer enkawlna atana immunotherapy damdawi hmante chu engte nge ni?
Tunah hian hnute cancer atana immunotherapy damdawi lian pahnih pawm a ni.
1. Pembrolizumab (Keytruda®) hmanga damdawi hman tur:He damdawi hi `(Triple-negative breast cancer)` tan hman a ni. He damdawi hian cancer cell-te’n immune system atanga an thup nan an hman protein pakhat a block a ni. Hei hian immune system tan cancer cells te chu a hriat awlsam phah a ni. A chang chuan he damdawi hi operation hma leh operation hnuah pek thin a ni a, chu chu cancer a lo let leh tawh loh nan a ni. He damdawi hi taksa hmun danga cancer darh tawh tan pawh hman a ni a, cancer tumor DNA-ah ``Biomarker`` engemaw zat a awm chuan.
2. Dostarlimab (Jemperli®): He damdawi hi hnute cancer enkawlna dang hnua lo kir leh tawh leh tumor marker bik nei tan hman a ni.
A pawimawh ber chu heng damdawi zawng zawng hi damlo tin tan a tha vek lo. I doctor chauh hian he enkawlna hi i tan a tha em tih a hre thei a, chu chu i cancer-a biomarker chi hrang hrang, a stage leh a awm dan a zirin a ni.
Engtin nge immunotherapy hi pek thin?
He enkawlna hi saline solution angin vein (intravenous - IV) kaltlangin pek thin a ni. I dinhmun a zirin enkawl dan tur ruahmanna a inang lo thei. Mahse mi tam zawk chuan he enkawlna hi kar 3 atanga kar 6 danah an dawng thin . A chang chuan he enkawlna hi thla engemaw zat atanga kum hnih chhung chhunzawm a ngai thei bawk.
Side effects te pawh i zir ve ang u.
Cancer enkawlna dang ang bawkin immunotherapy hian side effect a nei thei a ni. Mahse mi zawng zawng an nghawng dan inang lo. Mi thenkhat chuan hrehawmna tenau te an tawng thei a, thenkhat erawh chuan engmah an hre lo thei bawk. A pawimawh ber chu i doctor hnenah i rilru hahna eng pawh a rang thei ang bera hrilh hi a ni.
Side effect awm fo leh pawi tak takte chu eng nge ni tih hi han thlir ila.
| Side effect chi hrang hrang | Beisei tur thilte |
|---|---|
| Side effect awm fo thin |
|
| Side effect na tak tak a awm tlem hle |
|
Heng side effects te hi hlauthawng suh. I doctor leh medical team te chuan an lo thlir reng thin. Damdawi mamawh leh enkawl dan tur thurawn an pe ang che.
He enkawlna hi engtiang chiahin nge a hlawhtlin?
Immunotherapy hi cancer enkawlna kawnga enkawlna thar ber leh beisei awm berte zinga mi a ni. A bik takin, a hmaa cancer enkawl harsa tak tak, triple-negative breast cancer vei damlote dam rei theihna tur leh dam rei theihna tur a pui a ni.
Zirchianna lian tak pakhatah chuan chemotherapy nena immunotherapy drug Pembrolizumab dawngtu damlote chu chemotherapy chauh dawngtu damlote aiin an dam rei zawk tih a tarlang.
Khawvel hmun hrang hrangah hian hnute cancer chi hrang hrang tana immunotherapy hman tangkai dan zirchian nan zirchianna za tam tak neih mek a ni. Chuvang chuan he field hi ni tin hma a sawn zel a ni.
Take-Home Thuchah a ni
- Immunotherapy hi chemotherapy angin cancer cell thattu damdawi a ni lo. Cancer dona atana pui turin i taksa ngeia immune system a tichak a ni.
- Hei hi enkawlna pawimawh tak a ni a, a bik takin `(Triple-negative breast cancer)` tan chuan a pawimawh hle.
- Treatment zawng zawng ang bawkin, side effects a awm a, mahse enkawl theih a ni , chuvangin i doctor nen eng harsatna pawh sawipui hlau suh.
- Immunotherapy hi cancer enkawlnaah beiseina lian tak a ni.Hemi chungchangah hian zirchianna an la nei zel a, nakin lawkah chuan mi tam takin an hlawkpui thei a ni.
- He enkawlna hi i tan a tha em tih hriat theihna tha ber chu i oncologist nen inbiakna neih hi a ni. I zawhna zawng zawng chu an chhang thei vek ang.
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