Tu pawhin "colorectal cancer" tih thumal an hriat hian hlauhna leh mak tihna nasa tak an neih hi thil pangngai a ni. Amaherawhchu, tûn laia damdawi lama hmasâwnna avângin, chutiang natnate kan hmachhawn theih nâna min ṭanpui theitu damdawi thar leh hlawhtling tak tak tam tak a awm a. Vawiin hian "targeted therapy" method kan sawi dawn a, chu chu traditional chemotherapy nen a danglam a, a bik takin cancer cells te target leh attack a ni.
A awlsam zawngin, heng Monoclonal Antibodies te hi engte nge ni?
Hei hi kan hriatthiam hmain kan taksain defense system mak tak a neih hi han thlir ila. Bacteria emaw, virus emaw ang chi hrik kan taksaa a luh chuan kan taksaah hian kan immune system hian heng invader-te hi a hre thei a, a inzawm thei a, a tichhe thei a, protein bik a siam chhuak a ni. Hengte hi "bodyguard," emaw, chiang zawka sawi chuan antibodies kan ti a ni.
Tunah chuan heng ``Monoclonal Antibodies`` te hi lab-a special technology hmanga siam artificial antibodies chi khat a ni ta. Chungte chu target bik pakhat chauh beih tura siam a ni. A dik tak chuan, cancer cell chunglama protein bik hriat theihna tûra siam an ni a, chu chu a inzawm tlat a, chu cancer cell chu tichhe thei tûra siam an ni .
Hei hi a bik taka training nei commando, mipui tamna hmuna hmêlma zawng chhuakin, chu hmelma chauh chu midang tichhe lovin a bei thei ang mai a ni. Chuvangin, chemotherapy pangngai ang maia taksaa cell tha tihchhiat ai chuan he enkawlna dan hian side effect a neih tlem zawk beisei theih a ni a, a chhan chu a chiang zawk a ni.
Cancer natna a thisen kalna kawng thang tikhawlo thei damdawi (Angiogenesis Inhibitors) .
Cancer hi a lo thang lian mai mai a ni lo. Thlai ang mai a ni. A dam theih nan, a thanlen theih nan leh a thanlen theih nan chaw tha a mamawh a ni. He chaw tha hi dawng tur hian cancer cell te hian anmahni chhehvelah thisen kalna kawng thar an siam chhuak thin. Hetiang kalphung hi ``angiogenesis`` kan ti a ni.`` Chuvangin, heng "ei leh in" te hi cancer hnena pe tu thisen kalna kawngte hi kan tihtawp chuan cancer lo thang lian zel hi kan titawp thei ang, a dik em? Chu chu chutiang titu ruihhlo class kan tih chu a ni.
Hei hi Bevacizumab (Avastin) hnathawh dan chu a ni:
He class-a damdawi pawimawh tak chu Bevacizumab (brand name: Avastin) a ni. Cancer cell te hian signal an thawn chhuak a, chu chuan "thisen kalna kawng siam" turin a hrilh a ni. He signal hi vascular endothelial growth factor, a nih loh leh VEGF an ti a. Avastin hian a tih chu chu signal chu target site a thlen loh nan a block a ni. A awlsam zawngin sawi ila, cancer-in a thawn "thisen kalna tur lehkha" chu a lo intercept a, a tichhia a ni.
Hei hian cancer hian thisen kalna kawng thar a siam a titawp a, chu chuan cancer thanna a tikhawtlai a ni. He damdawi hi colon cancer taksa peng dang a darh (metastasized) tan phalsak a ni. Cancer hi a tidam kim thei lo nain, zirchiannaah chuan Avastin hi chemotherapy nena pek a nih chuan damlo dam rei zawng thla 5 velin a ti rei thei tih hmuhchhuah a ni
`Fruquintinib (Fruzaqla)`, `ramucirumab (Cyramza)`, leh `ziv-aflibercept (Zaltrap)` te hi `VEGF` pawh targettu damdawi thar thenkhat an ni.
Engtin nge Avastin hi pek a nih? A side effects te chu engte nge ni?
Avastin hi thisen zam (IV) injection a ni. Chemotherapy nen kar hnih atanga kar thum danah pek thin a ni.
He damdawi hian side effect a neih theih dan hriat a pawimawh hle.
| Side effect chi hrang hrang | Hrilhfiahna |
|---|---|
| Side effect awm fo thin |
|
| Side effect na tak tak a awm |
|
Cancer cells thanna tur direct-a nghawng thei damdawi
Cetuximab (Erbitux) leh panitumumab (Vectibix) te hi monoclonal antibody chi dang pahnih an ni. Chungte chuan hna an thawk dan a inang lo. Cancer cell chunglama protein pakhat, epidermal growth factor receptor (EGFR) an tih chu an target a ni.
He `EGFR` hi cancer cell chu `inthen thuai la, lo thanglian lehzual turin` hrilhtu `On` switch angin ngaihtuah teh. Tichuan, cell lo thanglian tura hrilhtu natural signal chuan switch chu a on thei lo. Chutiang chuan cancer cells te than dan chu control a ni.
He damdawi hi tute hnenah nge pek a nih?
Erbitux leh Vectibix te pahnih hi colon cancer, taksa peng dang a darh tawh enkawlna atana pawm a ni.
Erbitux vaccine hi kar khatah vawi khat pek thin a ni a, amah chauh emaw, chemotherapy damdawi irinotecan (Camptosar) nen emaw pek thin a ni. Vectibix vaccine hi kar hnih danah chemotherapy damdawi dang nena inkawp hian pek thin a ni.
He damdawi hi i pek hmain i cancer cell-ah hian special genetic mutation test tih hmasak phawt a pawimawh hle a , chu damdawi hian chu cancer tan chuan a thawk thei ang em tih hriat a pawimawh hle. Hengte hi cancer zawng zawng tan a tha vek lo. Chuvangin he test hi tih a ni ngei ang.
Erbitux leh Vectibix te hian eng side effect nge an neih?
Heng damdawi te hian side effect bik a nei bawk.
| Erbitux leh Vectibix te hian side effect an nei tlangpui | |
|---|---|
| Vun lama harsatna nei | Acne ang chi blister, vun rawng, leh vun vawt. Mahse thil mak tak chu, a chang chuan heng vun natna hian damdawi hian cancer lakah hna a thawk tha hle tihna a ni. |
| Side effect dang a awm bawk |
|
Take-Home Thuchah a ni
- Monoclonal Antibodies hi enkawlna hmasawn tak a ni a, cancer cells te chu a bik takin a target a, a bei bawk. Chemotherapy hmanga enkawlna pangngai nen an danglam hle.
- Damdawi thenkhat chuan cancer hnena thisen pekna chu a titawp a, thenkhat chuan cancer cell thanna tichaktu signaling system chu a tikhawlo thung.
- Heng damdawi zawng zawng hian side effect hrang hrang an nei vek a. Enkawlna i tan hmain hengte hi i doctor nen sawiho hmasa phawt ang che.
- Heng enkawlnate hi mi zawng zawng tan a tha lo. I doctor chuan i cancer chi hrang hrang, a darh zau zia leh special genetic test result a zirin eng damdawi nge i tana tha ber tih a rel ang.
- Nangmah emaw, i chhungte zinga tu emaw cancer vei an nih chuan hlauthawng suh. I oncologist nen enkawlna kawng awm zawng zawng, an thatna leh that lohna te sawipui la, enkawlna hmachhawn turin huaisenna nei rawh.
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