Hetiang damdawi chi hi i hre tawh em? A chungchang hi awlsam takin i zir ang u (Phosphodiesterase Inhibitors)

Viagra ang damdawi hi i hre tawh ngei ang. Mi tam zawk chuan heng damdawi hi mipat hmeichhiatna lama harsatna nei tura pek an ni tih an hria. Mahse, damdawi class danglam tak, Phosphodiesterase Inhibitors tia koh chu natna chi hrang hrang, lung natna atanga lung natna, vun natna leh ruh natna thlenga enkawlna atan hman a ni tih i hria em? Vawiin hian he ruihhlo class mak tak hi han sawi ila. Eng nge an nih, engtin nge an hnathawh tih, a thatna leh that lohna chu i hrethiam mai ang u.

A awlsam zawngin Phosphodiesterase Inhibitors (PDE inhibitor) hi eng nge ni?

Hengte hi damdawi chi khat, kan taksa chhunga thisen kalna kawngte tizautu, a khauhna tiziaawmtu, thisen kal awlsamna tur damdawi chi khat a ni. Tui pipe a inkhar chuan tlem a lian deuh i siam chuan tui chu a luang awlsam zawk ang tih han ngaihtuah teh. Hei hian thisen sang a tihniam bakah taksa peng hrang hrangah thisen kal a titha a ni. Hetiang theihna avang hian he damdawi chi hi natna chi hrang hrang enkawlna atan hman a ni.

He damdawi hian engtin nge hna a thawh?

Hei hi hrethiam tur chuan kan taksaa chemical messenger tlemte kan hriat hmasak a ngai a ni. A hming chu Phosphodiesterases , a tawi zawngin PDE a ni. He PDE hi enzyme chi khat a ni a . Enzyme te hi kan taksaa chemical process dangte ti chak leh ti awlsamtu tanpuitu te tak te ang an ni.

Kan taksaah hian heng PDE enzyme te hi chi hrang hrang a awm a. Scientist ten an thliar hrang nan number an hmang a. Thil danglam bik chu PDE chi hrang hrang hi taksa hmun bik ah an thawk nasa ber a ni.

• PDE-3: Hetiang chi hi i thinlung leh i thisen kalna kawngah a awm ber . Thisen zam (blood clotting process)-ah pawh a inrawlh bawk.
• PDE-4: Hei hi lungah a awm tam ber . Thlawhna kawng chhunga thau (muscles) te a tikhauh a, hna a thawk thin.
• PDE-5: Hetiang chi hi lung leh mipa serh chhungah a awm a .

Chuvangin, Phosphodiesterase Inhibitors (PDE inhibitors) an tih damdawi te hian a chunga kan sawi tak PDE enzyme te hnathawh kha block in hna an thawk a ni. Kawngkhar khar ang mai a ni. PDE inhibitor damdawi thenkhat chuan thlan bik takin hna an thawk thin . Chu chu, PDE-5 ang chi chi khat chauh an target tihna a ni. Damdawi dang pawh nonselective taka hnathawk an awm bawk . Chu chu PDE chi hrang hrang hi eng emaw chen chu an nghawng thei tihna a ni.

He damdawi hmang hian eng dinhmun nge enkawl?

PDE inhibitor tia koh damdawi class hi U.S. Food and Drug Administration (FDA) ang agency-te chuan damdawi lam dinhmun sawmhnih chuang enkawl turin an pawm a ni. Chung zinga ṭhenkhat chu hetiang hi a ni.

PDE Inhibitors hian eng hlawkna nge a neih?

Hetiang damdawi chi hi damdawi lam harsatna thenkhat enkawlnaah a hlawk hle. Hei hi chhan hrang hrang a awm a.

• Hman awlsam: Heng damdawi te hi chi hrang hrang a awm a. Oral pill, topical cream, leh IV injection angin an lei theih bawk. Damdawi thenkhat chu nitin ei a ngai a, thenkhat erawh chu a tul hunah chauh ei theih a ni thung.
• Targeted treatment: Ka sawi tawh ang khan damdawi thenkhat hian PDE chi khat chauh an target a, chuvangin taksa peng dangah duh loh zawng (side effects) a thlen tam lo hle. Damdawi hian natna awmna hmunah chiah hna a thawk ang mai a ni.
• Damdawi pakhat hlawkna engemaw zat: A châng chuan mi pakhatah hian thil inzawm pahnih a awm thei. Entirnan, benign prostatic hyperplasia (BPH) leh erectile dysfunction (ED) te hi a awm dun thei a ni. PDE-5 inhibitor tadalafil hi natna pahnih enkawlna atan pawm a ni. Chutiang bawkin gout leh a kaihhnawih arthritis te pawh tidam thei damdawi a awm bawk.

He damdawi hian eng side effect leh risk nge a neih?

Side effect lian ber chu damdawi hi eng PDE inhibitor chi nge a nih tih ah a innghat.

He damdawi hi tuin nge ei loh tur?

Mi thenkhat tan chuan he damdawi chi PDE inhibitor an tih hi an damdawi lam dinhmun dang emaw, damdawi dang an ei avang emaw hian a tha lo mai thei. Hengte hi contraindications kan ti a ni . Hengte hi chi hnih a awm a:

1. A dik lo tak tak:

• To any PDE inhibitor: Tun hmain he damdawi emaw, a ang chi emaw avanga allergic reaction na tak (hypersensitivity) i neih tawh chuan.
• Cilostazol tan: Lung lam natna chi hrang hrang i neih chuan.
• PDE-5 inhibitor (Sildenafil, Tadalafil ang chi) tan chuan: thinlung natna nasa tak, rilru natna nghet lo (angina nghet lo), tun hnaia heart attack emaw stroke emaw.

2. Relative contraindications: A rilru a hah lutuk chuan a rilru a buai em em a.

• PDE-5 inhibitor tan: Nitrates emaw alpha-blockers emaw i ei a nih chuan doctor nen inbiakna neihpui tur a ni a, hei hian i thisen sang a ti tlahniam thei a, hlauhawm takin a ti tlahniam thei a ni.
• Cilostazol tan: Thisen chhuahna lama harsatna i neih chuan.
• Pentoxifylline tan: Tun hnaia thluak emaw mit emaw atanga thisen chhuak i neih chuan.

Naupai, nau pai tum emaw, nau hnute i pek emaw a nih chuan damdawi eng pawh i ei hmain doctor nen inbia fo ang che. Rannung zirchiannaah PDE inhibitor thenkhatin nausen a nghawng thei tih finfiahna a awm.

Engtikah nge doctor i hmuh ang?

I natna lan chhuah dan a danglam emaw, nitin hnathawhna a nghawng emaw a nih chuan doctor hnenah hrilh la a tha ber. Mahse, a hnuaia mi hi i tawn chuan damdawi in emaw emergency room (ETU) ah kal nghal rawh.

• Heart attack chhinchhiahna: rilru na, thawk hah, thawk hah, luak chhuak, luak chhuak.
• Priapism: Mipat hmeichhiatna lama tihchakna tel lova darkar 4 aia rei awm thei erection na tak a ni. Hei hi enkawl vat loh chuan chhiatna nghet tak a thlen thei a ni.
• Mit emaw, hriatna hloh thut: Mit hloh thut, mit hloh emaw, hriatna hloh emaw i neih chuan damdawi lam pan nghal rawh. Delay hian chhiatna nghet tak a thlen thei.