Kodi mumamva kupweteka chifukwa cha mankhwala oletsa ululu? Tiyeni tiphunzire za (Pseudocholinesterase Deficiency)?

Kodi munayamba mwachitapo mantha pang'ono ndi mankhwala oletsa ululu omwe mumapatsidwa pa opaleshoni? Ndizachilendo kuti anthu ena azimva choncho. Koma taganizirani zomwe zingachitike ngati mankhwala ena oletsa ululu omwe mumapatsidwa sangakhale oyenera thupi lanu. Lero tikambirana za vuto limodzi losowa, koma lofunika kwambiri lomwe muyenera kulidziwa. Limenelo ndi vuto lotchedwa `(Pseudocholinesterase Deficiency)`.

Kodi `(Pseudocholinesterase Deficiency)` ndi chiyani? Tiyeni timvetse mosavuta, sichoncho?

Chabwino, dzina ili likumveka lalitali pang'ono, sichoncho? Tiyeni tisunge mosavuta. `(Pseudocholinesterase)` ndi enzyme yapadera `(Enzyme)` m'thupi lathu. Chimodzi mwa ntchito zazikulu za `(Enzyme)` iyi ndikuphwanya (ndiko kuti, `(metabolism)`) m'thupi mankhwala ena omwe amaperekedwa kuti apumule minofu , makamaka tikapatsidwa mankhwala oletsa kupweteka (timatcha awa `(Choline esters)`). Tangoganizirani, panthawi ya opaleshoni, minofu yanu iyenera kupunduka kwakanthawi. Awa ndi mankhwala omwe amaperekedwa chifukwa cha zimenezo.

Tsopano, mu vuto lotchedwa `(Pseudocholinesterase Deficiency)`, chomwe chimachitika ndi chakuti `(Enzyme)` iyi yotchedwa `(Pseudocholinesterase)` m'thupi lanu mwina siipangidwa mokwanira , kapena sikugwira ntchito bwino . Ndiye chimachitika ndi chiyani? Mankhwala omwe amaperekedwa kuti apumule minofu (`(Succinylcholine)` ndi `(Mivacurium)` ndi zitsanzo ziwiri za izi) sachotsedwa m'thupi mwachangu. Amakhala m'thupi kwa nthawi yayitali.

Motero, minofu yanu ingakhale yopanda mphamvu kwa nthawi yayitali mutagwiritsa ntchito mankhwala oletsa ululu, ndipo mwina mungavutike kupuma. Izi zikutanthauza kuti simungathe kuyenda kapena kupuma nokha mpaka zotsatira za mankhwala zitatha.

Kodi vutoli ndi lofala bwanji?

Kwenikweni, vuto limeneli lotchedwa `(Pseudocholinesterase Deficiency)` si lofala kwambiri . Pa avareji, munthu m'modzi yekha mwa anthu 3,200 kapena 5,000 mwa anthu onse ndi amene amakumana ndi vutoli. Ndiye kuti, ndi anthu ochepa kwambiri.

Kodi zizindikiro zake ndi ziti? Kodi mumazindikira bwanji izi?

Anthu ambiri omwe ali ndi vutoli sadziwa mpaka atalandira mtundu wa mankhwala oletsa ululu omwe ndatchula kale, otchedwa ``Choline esters.'' Apa ndi pamene zizindikiro zazikulu zimawonekera:

• Minofu yomwe imakhala yomasuka kwambiri (monga yopanda moyo) kwa nthawi yayitali kuposa momwe anthu amayembekezera.
• Ngakhale minofu yomwe imakuthandizani kupuma imakhala yosagwira ntchito kwakanthawi .

Zingatenge maola angapo kuti zizindikirozi zithe. Nthawi imeneyi imasiyana malinga ndi munthu. Panthawiyi, gulu lanu lachipatala lidzakusungani pansi pa mankhwala oletsa ululu ndipo lidzakuthandizani kupuma kudzera mu "ventilator", makina opumira opangidwa, mpaka mutakwanitsa kupuma nokha.

Kodi zimayambitsa chiyani? Kodi izi zimachitika bwanji?

Vutoli (Pseudocholinesterase Deficiency) likhoza kutengera kwa munthu (kutanthauza kuti ndi lobadwa nalo), kapena likhoza kukulirakulira mtsogolo..

Zoyambitsa zobadwa nazo

Anthu omwe amabadwa ndi vutoli amakhala ndi kusintha, kapena kusintha kwa majini otchedwa `(BCHE)`. Jini iyi ya `(BCHE)` ndiyo imauza thupi lathu kuti lipange enzyme `(Pseudocholinesterase)`. Chifukwa chake, pakachitika kusintha kwa jini iyi, thupi lanu limapanga enzyme yochepa kwambiri iyi, kapena silingapange konse.

Zifukwa zomwe zimachitika pa moyo (Zomwe Zapezeka)

Nthawi zina, vutoli (Pseudocholinesterase Deficiency) limatha kuchitika moyo wonse. Lingayambitsidwe ndi matenda osiyanasiyana ndi mankhwala ena.

Matenda ena omwe angayambitse vutoli:

• Kusowa zakudya m'thupi
• Kuvulala kwambiri kwa moto
• Matenda a impso
• Matenda a chiwindi
• Hypothyroidism (chithokomiro chosagwira ntchito mokwanira)
• Khansa
• Mimba

Mankhwala ena omwe angawonjezere chiopsezo cha matendawa ndi awa:

• MAO inhibitors (monga Phenelzine (Nardil®))
• Mapiritsi oletsa kubereka (Mapiritsi oletsa kubereka)
• Madontho a m'maso a Echothiophate
• Metoclopramide
• Cyclophosphamide
• Pyridostigmine

Kodi madokotala amazindikira bwanji izi?

Ngati mukuvutika kulamulira minofu yanu kapena kupuma mutagwiritsa ntchito mankhwala oletsa kupweteka, dokotala wanu angaganize kuti pseudocholinesterase siigwira ntchito. Kuti atsimikizire izi, akhoza kuyesa magazi kuti awone kuchuluka kwa pseudocholinesterase m'thupi lanu.

Ngati wina m'banja mwanu ali ndi vutoli, dokotala akhoza kuchita mayeso a majini kuti adziwe ngati inunso muli nalo. Izi zimaphatikizapo kutenga magazi ndikuwona ngati muli ndi kusintha kwa majini (BCHE).

Ngati dokotala wanu akukayikira kuti muli ndi vutoli, adzagwiritsa ntchito mitundu ina ya mankhwala opumulira minofu omwe sadalira enzyme ya ``Pseudocholinesterase''.

Kodi chithandizo chake ndi chiyani?

Ngati mukupeza zizindikiro za `(Pseudocholinesterase Deficiency)` mutapatsidwa mankhwala oletsa ululu, mungafunike thandizo lachipatala mwachangu. Gulu lachipatala lidzakuyang'anirani mosamala mpaka mutachira. Ngati pakufunika kutero, adzakusungani pansi pa mankhwala oletsa ululu ndipo adzagwiritsa ntchito makina oletsa kupuma a `mechanical ventilation`` kuti akuthandizeni kupuma mpaka mutatha kupuma nokha.

Kodi muyenera kuyembekezera chiyani ngati muli ndi vutoli?

Ngati mwapezeka ndi `(Pseudocholinesterase Deficiency)`, chinthu chabwino kwambiri chomwe mungachite ndikudziwitsa madokotala anu za vutoli - makamaka madokotala omwe adzakuwoneni kuti akuchitireni opaleshoni .

Komanso, muyenera kuuza banja lanu za izi., kenako akhozanso kuyesedwa kuti aone ngati ali ndi kusintha kwa majini kwa `(BCHE)`. Ngati ndi choncho, ayeneranso kudziwitsa madokotala awo asanachite opaleshoni iliyonse.

Ndibwinonso kuvala chibangili cha dokotala kuti madokotala adziwe ngati mukufunikira opaleshoni yadzidzidzi.

Kodi izi zingapewedwe?

Kusowa kwa Pseudocholinesterase ndi vuto lobadwa nalo lomwe silingathe kupewedwa. Komabe, ngati wina m'banja mwanu ali nalo, mutha kuyesedwa kuti muwone ngati ali ndi kusintha kwa majini a BCHE musanachite opaleshoni. Izi zingathandize kupewa mavuto panthawi ya opaleshoni.

Ngati muli ndi kusintha kwa majini, dokotala wanu mwina sadzagwiritsa ntchito mankhwala oletsa ululu a Choline esters ndi kusankha mankhwala ena oletsa ululu. Rocuronium ndiye mankhwala oletsa ululu omwe amagwiritsidwa ntchito kwambiri kwa anthu omwe ali ndi Pseudocholinesterase Deficiency.

Mungathe kuchepetsa chiopsezo chanu chokhala ndi Acquired Pseudocholinesterase Deficiency mtsogolo mwa kuchiza matenda enaake, monga kusowa zakudya m'thupi kapena matenda a impso osatha (CKD). Komanso, ngati mukumwa mankhwala aliwonse omwe amachepetsa kupanga kwa enzyme ya Pseudocholinesterase, mungafune kulankhula ndi dokotala wanu za kusintha mankhwala anu.

Kodi ndi zinthu ziti zomwe sizili bwino kugwiritsa ntchito, kapena kuti, ndi mankhwala ati omwe si abwino kugwiritsa ntchito kwa anthu omwe ali ndi vutoli?

Ngati mwapezeka ndi `(Pseudocholinesterase Deficiency)`, muyenera kupewa mitundu iyi ya mankhwala oletsa ululu :

• Succinylcholine `(Succinylcholine)`
• Mivacurium
• Procaine
• Chloroprocaine
• Benzocaine
• Tetracaine

Mafunso oti mufunse dokotala wanu

Ngati muli ndi vuto lotchedwa ``Pseudocholinesterase Deficiency'', kaya munabadwa nalo kapena munayamba nalo pambuyo pake, mungafune kufunsa dokotala wanu mafunso monga:

• Kodi ndi zinthu ziti zomwe zimatsutsana ndi ine, ndiye kuti, ndi mankhwala ati omwe ndiyenera kupewa?
• Kodi vutoli ndi limene ndinabadwa nalo kapena layamba chifukwa cha matenda ena?
• Kodi ndi bwino kuti banja langa liyesedwe majini?

Kupita ku opaleshoni kungakhale kovuta pang'ono. Ambiri aife timayang'ana kwambiri pa opaleshoni kotero kuti sitiganiza nkomwe za kuthekera kwa zotsatirapo zoyipa chifukwa cha mankhwala oletsa ululu. Palibe mankhwala a Pseudocholinesterase Deficiency. Komabe, kudziwa ngati muli nayo kungakuthandizeni kupewa kufooka kwakanthawi kwa minofu ndi mavuto opuma omwe angachitike mutachita opaleshoni. Ngati muli ndi Pseudocholinesterase Deficiency, uzani abale anu za izi. Angathenso kuyezetsa jini ndikupewa mavuto aliwonse osafunikira omwe angabuke paulendo wawo waumoyo.

Pomaliza, zinthu zoti muzikumbukira

Chifukwa chake, `(Pseudocholinesterase Deficiency)` ndi dzina loopsa pang'ono, koma ndikofunikira kwambiri kudziwa za izi. Makamaka ngati mukufuna kuchitidwa opaleshoni, kapena ngati wina m'banja mwanu wakumanapo ndi vuto lotere , ndi bwino kulankhula ndi madokotala anu za izi. Kumbukirani, kuzindikira nthawi zambiri ndiye chishango chabwino kwambiri chomwe chingatipulumutse ku mavuto osafunikira!

Mankhwala oletsa ululu, pseudocholinesterase, kusowa kwa ma enzyme, mavuto a opaleshoni, vuto la majini, kusokonekera kwa minofu, mankhwala oletsa ululu