Tose takambonzwa nezvemhando dzakasiyana dzemishonga yezvirwere zvakasiyana, handiti? Nhasi tichataura nezvemhando yakasiyana yemishonga. Iyi inonzi 'Protease Inhibitors'. Ungave usina kunzwa nezvezita iri, asi rudzi urwu rwemushonga rwakakosha pakudzivirira hutachiona hwakakomba hwakaita seHIV/AIDS, Hepatitis C, uye COVID-19. Saka ngatitarisei kuti iyi chii, kuti inoshanda sei, uye ndezvipi zvinhu zvakakosha zvaunofanira kuziva nezvazvo.
Zvichitaurwa zviri nyore, chii chinonzi protease inhibitors?
Zvichitaurwa zviri nyore, mishonga inodzivirira mapuroteni imhando yemishonga inoshandiswa kurapa hutachiona . Basa rayo guru nderekumisa hutachiona kuti husazviite hwega kana hwapinda mumuviri wedu, zvinoreva kuti hahugone kupararira zvakanyanya. Mushonga uyu 'unovhara' hutachiona kuti husapararire.
Mushonga uyu unonyanya kuzivikanwa semushonga unoderedza hutachiona hweHIV/AIDS. Unoshandiswawo kurapa hepatitis C neCOVID-19.
Dzimwe nguva mishonga iyi inodzivirira protease inopihwa yega (monotherapy). Asi kazhinji, inopihwa pamwe chete nemimwe mishonga inorwisa mavhairasi. Izvi zvinoitirwa kuwedzera kushanda kwekurapa. Muchiitiko ichi, inonziwo "booster".
Ndezvipi zvirwere zvikuru zvinorapwa nemushonga uyu?
Rudzi rwemishonga inonzi protease inhibitors inotenderwa kurapa hutachiona hushoma. Ngationei kuti chii.
| Dambudziko rehutano | Mashandisirwo |
|---|---|
| HIV/AIDS | Pakurapa HIV, vanachiremba vanopa mishonga iyi yega kana kuti mu "cocktail" pamwe chete nemimwe mishonga yakati wandei. Musanganiswa wemishonga iyi unonzi antiretroviral therapy (ART) . Dzimwe nguva inoshandiswawo kudzivirira hutachiona mushure mekusangana nehutachiona (post-exposure prophylaxis). |
| Chiropa Chisingaperi (Hepatitis C) | Mishonga inodzivirira mapuroteni inoshandiswa sechikamu chemishonga inorwisa mavhairasi kuti irape zvachose hutachiona hwehepatitis C. |
| COVID 19 | Vanachiremba vanokurudzira musanganiswa wemishonga miviri inodzivirira protease (semuenzaniso Paxlovid®) kuderedza njodzi yekurwara zvakanyanya kunokonzerwa nehutachiona hweCOVID-19. |
Mushonga uyu unoshanda sei?
Kuti tinzwisise izvi, ngatitorei muenzaniso mudiki. Fungidzira kuti vhairasi ifekitari inogadzira cheni refu yemapuroteni. Kuti cheni iyi ishande, inofanira kuchekwa kuita zvidimbu zvidiki, zvinoshanda. 'Chigero' chakakosha chinoshandiswa nevhairasi pakucheka uku ma enzymes anonzi 'proteases' .
Saka, zvinoitwa neboka remishonga inonzi 'Protease Inhibitors' kumisa kushanda kwe'chigero' ichocho. Zvakafanana nekugonya chigero. Ipapo hutachiona hahugone kucheka zvidimbu zveprotein zvahunoda. Nekuda kweizvozvo, hutachiona hahugone kugadzira mamwe makopi matsva ehutachiona hwehutachiona uye kutapurira masero edu.
Ndeapi marudzi emishonga inodzivirira protease?
Nekuti hutachiona hwega hwega hune enzyme yahwo yeprotease, mhando dzakasiyana dzemishonga inodzivirira protease dzinoshandiswa kurapa HIV, hepatitis C, uye COVID-19. Kunewo nzira iri nyore yekuziva.
- Mazita emishonga inoshandiswa kurapa HIV anowanzo guma ne "-navir" .
- Mazita emishonga inoshandiswa pakurapa hepatitis C anowanzo guma na "-previr" .
Mishonga inodzivirira mapuroteni muHIV
Izvi zvinovhara enzyme yeprotease inonzi HIV-PR, iyo hutachiona hweHIV hunoshandisa kugadzira makopi emuviri wayo.
- Atazanavir
- Darunavir
- Fosamprenavir
- Indinavir
- Lopinavir
- Nelfinavir
- Ritonavir
- Saquinavir
- Tipranavir
Inhibitors dzeprotease dzehepatitis C
Izvi zvinovhara enzyme inonzi NS3/4A serine protease, iyo hutachiona hwehepatitis C hunoshandisa kugadzira makopi ayo.
- Boceprevir
- Glecaprevir
- Grazoprevir
- Paritaprevir
- Simeprevir
- Telaprevir
Mishonga inodzivirira mapuroteni yeCOVID-19
Paxlovid® musanganiswa wemishonga miviri inodzivirira protease, nirmatrelvir neritonavir, inoshandiswa kurapa COVID-19.
Ndingasarudza sei mushonga wakakodzera ini?
Zvino ungave uchishamisika kuti mishonga iyi ingandibatsirei.Chiremba wako chete ndiye anogona kusarudza. Achafunga nezvezvinhu zvakati wandei pakusarudza mushonga wakakodzera iwe.
- Utachiona hupi chaihwo hwaunahwo?
- Hutano hwako hwese pamwe chete nezvimwe zvirwere zvaungave nazvo (semuenzaniso chirwere cheshuga, chirwere chemwoyo).
- Ndeipi mimwe mishonga yauri kutora parizvino (sezvo pangave paine kupindirana pakati payo).
- Wakambotora mimwe mishonga yechirwere ichi here?
- Kubudirira kwemushonga kunoenderana nerudzi rwehutachiona hwawakabatwa nahwo.
- Nezve migumisiro kana matambudziko anokonzerwa nemushonga.
Saka, zvakakosha kutsanangura zvakajeka mishonga yese yauri kutora pamwe nezvimwe zvirwere zvaunazvo paunoshanyira chiremba wako. Izvi zvinogona kuderedza njodzi yemigumisiro yakaipa.
Ndezvipi migumisiro uye mabhenefiti emishonga iyi?
Kufanana nemishonga chero ipi zvayo, mishonga inodzivirira protease ine zvakanakira uye migumisiro yakaipa.
Zvakanakira zvikuru
- Sechikamu chekurapa kweART kune munhu ane HIV, zvinobatsira kuchengetedza huwandu hweHIV mumuviri husingaonekwe.
- Inobatsira kurapa hepatitis C.
- Zvinobatsira kudzivirira kuti hutachiona hweCOVID-19 husanyanya kuipa.
Migumisiro inogona kuitika
Migumisiro yacho inoenderana nemushonga wauri kutora, mimwe mishonga yauri kutora, uye hutano hwako. Zvakakosha kutaura nachiremba wako nezveizvi uye kugara uchiziva.
| Rudzi rwemhedzisiro yakaipa | Mienzaniso |
|---|---|
| Migumisiro inowanzoonekwa | |
| Matambudziko akajairika | Kurwadziwa kwemudumbu, kuda kurutsa uye kurutsa, manyoka |
| Mapundu eganda | |
| Kukosora, kuneta, kuravira kusinganzwisisike mumuromo | |
| Matombo eitsvo | |
| Kuchinja kwekupararira kwemafuta mumuviri (lipodystrophy) | |
| Migumisiro yakakomba inoda kutarisirwa nekukurumidza | |
| Matambudziko akakomba | Kukuvara kwechiropa, kubuda ropa mukati |
| Chirwere cheganda chakakomba chine mapundu anorwadza uye anoputika (Stevens-Johnson syndrome) | |
| Mazinga eshuga akakwira muropa (hyperglycemia), mazinga echolesterol akakwira (hyperlipidemia) | |
| Kurwiswa kwemoyo (myocardial infarction), matambudziko nemagetsi emoyo | |
Chii chandingaita kuti kurapwa kuve nyore?
Paunenge uchirapwa nenzira iyi, pane zvinhu zvakati wandei zvaunogona kuita kuti uderedze mimwe migumisiro uye kuti kurapwa kuve nyore.
- Inwa mushonga wako sezvawakarairwa nachiremba wako, panguva yakakodzera, nemupimo wakakodzera. Usadarike kana wangopihwa mushonga mumwe chete.
- Inwa mvura yakawanda. Izvi zvinogona kuderedza kukanganiswa kweitsvo.
- Dzivisa kushandisa mimwe mishonga inogona kukanganisa mushonga wako. Bvunza chiremba wako nezvazvo.
- Mimwe mishonga inoshanda zviri nani kana ikatorwa nechikafu . Mimwe inoda chikafu chine mafuta akawanda. Bvunza chiremba wako kuti ungatora sei mushonga wako wotevedzera zano iroro.
Ndinofanira kuona chiremba rini?
Kana ukasangana nematambudziko asingatarisirwi panguva yekurapwa kana kuti uine zvinokunetsa nezvekurapa, taura nachiremba wako nekukasika.
Zvikuru sei, kana ukasangana nemhedzisiro yakaipa inotevera, tsvaga rubatsiro rwechiremba nekukasika pasina kunonoka kana kuenda kuchipatara chiri pedyo neEmergency Department (ETU).
- Kupindwa nechando
- Kuvhiringidzika kana kuchinja kwepfungwa
- Kutsvuka kweganda kana maziso (jaundice)
- Mapundu, anorwadza, kana kuti akapararira
- Kurwadziwa kwakanyanya mudumbu
- Kurutsa kwakanyanya
Mharidzo Yekuenda Nayo Kumba
- Mishonga inodzivirira mapuroteni iboka rine simba remishonga inoshandiswa kurapa hutachiona hwakadai seHIV, hepatitis C, uye COVID-19.
- Izvi zvinodzivirira hutachiona kuti husawande (kuita makopi) mumuviri.
- Mishonga iyi inofanira kutorwa chete kana yakurudzirwa nachiremba . Zvakakosha kunyatsotevedzera mwero nenguva inokurudzirwa nachiremba.
- Migumisiro inogona kuitika, kubva pakusanzwa zvakanaka kusvika kumatambudziko akakomba. Kana ukaona zviratidzo zvakakomba, enda kuna chiremba nekukasika.
- Haufanirwe kurega kutora mushonga kana kuchinja mwero wemushonga usina kupiwa mazano nachiremba chero chikonzero chipi zvacho.
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