Let's learn about Caplacizumab injection.

Do you or someone you know have aTTP (acquired thrombotic thrombocytopenic purpura), a rare and serious blood disorder? If so, you've probably heard of a drug called Caplacizumab. Since it's a specialized drug with a somewhat complicated name, let's talk about it simply, in a way that you can understand, and in a friendly way, shall we?

What kind of medicine is Caplacizumab?

Simply put, aTTP is a serious problem with our blood clotting and bleeding. What happens is that small blood clots form in blood vessels throughout the body, and our platelets rapidly decrease in number. Platelets are a type of cell that helps stop bleeding. When they are used to form unnecessary blood clots in this way, they become insufficient to stop bleeding where it is really needed.

This is where a drug called Caplacizumab comes to our rescue. It works by stopping those blood clots from sticking together and forming unnecessary blood clots. It is a type of specific protein (monoclonal antibody) . This means that it is designed to act only on a very specific target.

Things you need to tell your doctor before taking this medicine

Before you start taking this medicine, it is very important that you give your doctor a complete account of your health. Do not hide anything. Be sure to tell them, especially:

• If you have a bleeding disorder.
• If you have to have any surgery soon.
• If you have liver disease.
• If you have any allergies to Caplacizumab, other medicines, foods, or dyes.
• If you are pregnant, trying to get pregnant, or breastfeeding.

How to use the medicine?

This is a medicine that is given as an injection. It can be injected into a vein or under the skin. It is usually given in a hospital or clinic. But sometimes you may need to use this injection at home.

If so, the doctor or the nursing staff will provide you with the full training you need. So don't be afraid. They will explain everything clearly, including how to prepare the medicine and how to inject it. Use the exact dose, at the exact time, as the doctor tells you.

Very important:Never throw used needles and syringes in the trash. Instead, put them in a special sharps container. If you don't have one, ask your doctor to get one.

What if I miss a dose of medicine?

If you miss a dose, take it as soon as you remember. However, if it is more than 12 hours late, skip the missed dose and take your next dose at the regular time. Do not take two doses at once.

What to do if you take too much medicine?

If you think you have taken too much medicine, go to a hospital's Emergency Unit (ETU) immediately. Or call the National Poisons Information Centre at the Colombo National Hospital .

Things to be careful about when taking medication

You need to think a little more about your safety while taking this medicine.

• Bleeding risk: Since the main function of this medicine is to stop blood clotting, the risk of bleeding is a little higher. This means that even a small wound can bleed more than usual. You may even get bruises on your body. Therefore, be careful with activities that can cause injuries, such as using sharp objects.
• Surgery and dental treatment: If you are going to have any surgery or other medical treatment, be sure to tell the doctor that you are taking this medicine. You should also inform your dentist before having any dental surgery.
• Other medications: Tell your doctor about all the medications you are taking, not just those prescribed by a doctor, but also over-the-counter medications, vitamins, herbal remedies, and supplements. Blood thinners (e.g., warfarin, enoxaparin, apixaban, rivaroxaban) may interact with this medication.
• Medical check-ups: Go to the clinics on the scheduled dates as directed by the doctor and check your condition.

What are the possible side effects?

Like any medicine, Caplacizumab can cause some side effects. Some of these are serious, while others are common. The important thing is to be aware of these symptoms and take action quickly if necessary.

How should I store the medicine?

To maintain the quality of the medicine, it is important to store it correctly.

• Keep away from small children and pets.
• Can be stored in the refrigerator or at room temperature (below 30°C). Never place in the freezer.
• Keep the medicine in the original box it came in, away from light.
• If you store it at room temperature, it can be kept for up to 2 months. But do not put any medicine that has been stored that way back in the refrigerator. If there is any left over after 2 months, throw it away.
• Do not use expired medicine.