Yala aw bɛ siran JƆGƆ sɛgɛsɛgɛli ɲɛ wa? An ka nin jamu sɛgɛsɛgɛli in (Fluorescence in Situ Hybridization - FISH Test) dɔn cogo nɔgɔman na.

Yala aw ka dɔgɔtɔrɔ y’a fɔ aw ye walima aw ka denbaya kɔnɔmɔgɔ dɔ ye ko aw ka ‘JƆGƆ sɛgɛsɛgɛli’ kɛ wa? Yala i siranna dɔɔni wala i siran dɔɔni n’i y’o tɔgɔ mɛn wa? Yala aw y'a miiri ko "Nin ye kɔrɔbɔli kabakoma sugu jumɛn ye wa?"? A bɛnnen don kosɛbɛ ka miiri o cogo la. Nka kun t'a la ka hami. A man gɛlɛn i n’a fɔ i b’a miiri cogo min na, wa a tɛ fɛn ye min ka kan ka siran. Bi, an ka kuma nin FISH sɛgɛsɛgɛli in ye min ye, a bɛ min ɲini, ani a bɛ kɛ cogo min na, nɔgɔya la kosɛbɛ, an ka kan na.

Fɔlɔ, nin FISH sɛgɛsɛgɛli in ye mun ye?

N’an y’a fɔ cogo nɔgɔman na, FISH ye laboratuwari sɛgɛsɛgɛli kɛrɛnkɛrɛnnen ye min bɛ fɛn dɔw ɲini walima ka filiw ɲini an farikolo yɔrɔw kɔnɔ jamu ni kolosinsinnanw na. A bɛ iko an farikolo ka jamu karti sɛgɛsɛgɛli.

Walasa k’o faamuya dɔɔnin, an k’an farikolo miiri iko gafemarayɔrɔba.

• Chromosomes: Chromosomes bɛ i n’a fɔ gafemarayɔrɔ minnu bɛ o gafemarayɔrɔ la. Adamaden selilɛri kelen-kelen bɛɛ kɔnɔ, o gafebon fila-fila 23 bɛ yen.
• Jɛnɛya: O gafe minnu bɛ etajɛriw kan, olu ye jɛnɛya ye. An farikolo mago bɛ cikan minnu na walasa ka baara kɛ, olu bɛɛ bɛ o gafew kɔnɔ. An kunsigi kulɛri, an ɲɛ kulɛri, an janya dɔrɔn tɛ, nka an farikolo baara bɛɛ bɛ mara kunnafoniw fɛ minnu bɛ o gafew kɔnɔ minnu bɛ wele ko jeninida.
• ADN: Sɛbɛnw ni daɲɛ minnu sɛbɛnnen bɛ o gafew kɔnɔ, olu ye ADN ye. O kɔrɔ ye ko an farikolo mago bɛ cikan dafalen minnu na, olu bɛ ADN kɔnɔ.

Sisan, i k’a miiri ko gafe dɔw (jeniw) minnu bɛ nin gafemarayɔrɔ in kɔnɔ, ɲɛw tɛ yen (deletion), dɔw farala u kan (amplification), walima gafe min ka kan ka kɛ tabali dɔ kan, o jiginna ka taa tabali wɛrɛ la (translocation). Mun tun bɛna kɛ ni o kɛra? Farikolo bɛ cikan minnu sɔrɔ, olu tun bɛna kɛ filiw ye. O cikan jugu suguw de kosɔn banaw bɛ sɔrɔ i n’a fɔ kansɛri ani jamu bana wɛrɛw.

Nin FISH sɛgɛsɛgɛli in bɛ baara kɛ cogo di?

Hali n’a y’a sɔrɔ fɛɛrɛ in ye dɔnniya ye dɔɔnin, n b’a ɲɛfɔ aw ye ni misali nɔgɔmanba ye.

Miiri k’a filɛ, i ka kan ka kumasen kɛrɛnkɛrɛnnen dɔ sɔrɔ gafeba dɔ kɔnɔ. E bɛ mun baara kɛ? I b’o kumasen Sɔrɔ k’a taamaʃyɛn Kɛ ni ɲɛfɔlilan kulɛrilen ye. O kɔ, a ka nɔgɔn k’a sɔrɔ tuguni.

O de bɛ Kɛ FISH sɛgɛsɛgɛli la. Laboratowari kɔnɔ, dɔnnikɛlaw bɛ ADN yɔrɔw dilan minnu bɛ bɛn u b’a fɛ ka jɛnɛya yɔrɔ kɛrɛnkɛrɛnnen min ɲini i ka selilɛri kɔnɔ. Olu bɛ wele ko ‘sondew’. O kɔfɛ, u bɛ fluorescent labels siri o ADN yɔrɔ dilannen ninnu na. Olu bɛ i n’a fɔ sɛbɛnnikɛlanw minnu bɛ fɛnw ɲɛfɔ.

O kɔfɛ, u bɛ aw ka farikolokisɛw ta (i n’a fɔ joli walima farikolo yɔrɔ) ka nin ‘sonda’ kulɛrilenw fara a kan minnu sɛbɛnnen don. O kɔ, kabako dɔ kɛra. ‘Sɛgɛsɛgɛli’ bɛ jɛnɛya min bɛ Bɛn a ma, o yɔrɔ tigitigi Sɔrɔ k’a ni ɲɔgɔn cɛ.

O kɔfɛ, ni banakɔtaa dɔnbaga y’a lajɛ ni mikroskɔpu kɛrɛnkɛrɛnnen ye (mikɔrɔskɔpu fluorescent), ‘sonda’ minnu sirilen bɛ o jɛnɛya yɔrɔ la, olu bɛ yeelen bɔ i n’a fɔ yeelen kulɛrilenw, i n’a fɔ dolow bɛ yeelen bɔ dibi la.

• Seli normal kɔnɔ: Kulɛri yeelen hakɛ min bɛ makɔnɔ, o bɛ ye yɔrɔ bɛnnenw na.
• Selilɛri min tɛ cogo la: Aw bɛ se ka kulɛri caman ye ka tɛmɛ aw tun bɛ miiri min na (amplification), walima aw tɛ se ka kulɛri dɔ ye aw b’a fɛ ka min ye (deletion), walima aw bɛ se ka kulɛri fila ye minnu ka kan ka kɛ ɲɔgɔn fɛ nka u ni ɲɔgɔn cɛ ka jan (translocation).

O yeelen cogoya min bɛ manamana, dɔgɔtɔrɔw bɛ se k’a fɔ i ye tigitigi fɛn minnu bɛ i ka jamu kɔnɔ.

FISH sɛgɛsɛgɛli bɛ fɛn jumɛnw de ɲini kosɛbɛ?

FISH sɛgɛsɛgɛli bɛ kɛ kɛrɛnkɛrɛnnenya la kun caman de kama. A bɛ se ka fɛn minnu dɔn jamu caman na ani bana minnu bɛ tali kɛ u la, an ka olu lajɛ.

Bana jumɛnw bɛ se ka dɔn o fɛn caman Changements (Yɛlɛma) fɛ?

FISH sɛgɛsɛgɛli nafa ka bon kosɛbɛ bana suguya caman sɛgɛsɛgɛli la, kɛrɛnkɛrɛnnenya la kansɛriw, ani furakɛli bolodacogo la.

• Kansɛri suguyaw: 1 .
• Sinna kansɛri : Kɛrɛnkɛrɛnnenya la, aw bɛ a ɲini ka amplification de la gène (HER2). Ni o ɲɔgɔnna bonya sugu bɛ yen, furakɛli kɛrɛnkɛrɛnnenw bɛ se ka kɛ minnu ɲɛsinnen bɛ kɛrɛnkɛrɛnnenya la o jamu ma.
• Jolidɛsɛ : Aw bɛ jolidɛsɛ jugumanba ni jolidɛsɛ basigilen suguyaw dɔn.
• Linfoma (Linfoma) bɛ sɔrɔ
• Kolotugudaw kansɛri (Multiple Myélome) .
• Fogonfogon, kɔnɔbara ani sugunɛbara kansɛriw
• Jiginni ɲɛfɛ ani jiginni kɔfɛ jamu : Aw bɛ den sɛgɛsɛgɛ sani a ka bange walima a bangenen kɔfɛ walasa ka a dɔn ni kolosinsinnanw bɛ u la, i n’a fɔ Down syndrome.
• In vitro fertilization (IVF): Nin fɛɛrɛ in bɛ kɛ fana ka denw sɛgɛsɛgɛ ni u ka kolosinsinnanw tɛ u la sani u ka taa ni u ye in vitro fertilization (IVF) fɛ.

Ne ka kan ka n yɛrɛ labɛn cogo di FISH sɛgɛsɛgɛli kama?

Aw bɛ aw labɛn cogo min na nin sɛgɛsɛgɛli in kama, o bɛ bɔ aw bɛ sɛgɛsɛgɛli min ta. Sɛgɛsɛgɛli suguya wɛrɛw bɛ yen minnu bɛ se ka ta o baara kama.

• Joli sɛgɛsɛgɛli : Ni dɔgɔtɔrɔ bɛ sigasiga ko bana dɔ bɛ aw walima aw den na, o sɛgɛsɛgɛli bɛ se ka kɛ ni aw ye joli dɔɔni ta i n’a fɔ a bɛ kɛ cogo min na. O tɛ labɛn kɛrɛnkɛrɛnnen si wajibiya.
• Jiginni ɲɛfɛ sɛgɛsɛgɛli : Ni den ka jamu bɛ ka sɛgɛsɛgɛ kɔnɔmaya waati, dɔgɔtɔrɔ bɛna sɛgɛsɛgɛli dɔ kɛ min bɛ wele ko ``amniocentesis,'' o ye ka densoji dɔɔni ta ka bɔ ba kɔnɔbara la.
• Biyopisi : Ni kansɛri bɛ siga la, aw bɛ farikolo yɔrɔ fitinin dɔ ta ka bɔ kuru walima kolotuguda la walasa ka a sɛgɛsɛgɛ (kolotuguda biyɔpisi). Sani aw ka biyopisi kɛ, aw ka dɔgɔtɔrɔ bɛna laadilikanw di aw ma a labɛncogo kan, barisa anestezi de ka kan.
• Sugunɛ sɛgɛsɛgɛli : Sugunɛ sɛgɛsɛgɛli bɛ kɛ tuma dɔw la walasa ka sugunɛbilenni kansɛri sɛgɛsɛgɛ walima k’a kɔlɔsi.

Mun bɛ kɛ sɛgɛsɛgɛli rapɔɔri sɔrɔlen kɔfɛ?

A ka ca a la, a bɛ se ka dɔgɔkun kelen ni naani cɛ walasa ka FISH sɛgɛsɛgɛli jaabi sɔrɔ. Aw ka dɔgɔtɔrɔ bɛna kɔn ka o waati ladɔnniya aw la.

O kɔlɔlɔ ye ‘ko ɲuman’ ye.Ni a ko, o kɔrɔ ye ko jamu walima kolosinsinnan dɔw bɛ i ka selilɛri la.

A bɛnnen don ka siran ani ka jɔrɔ ni aw ye nin ɲɔgɔnna nɔ ye. Nka aw hakili to a la ko nin nɔ in ye sababu ye ka faamuyali jɛlen sɔrɔ aw ka bana kan. Wa, ka da o kunnafoniw kan, aw ka dɔgɔtɔrɔ bɛna se ka furakɛli min bɛnnen don aw ma, min ɲɛsinnen don aw ma, o latigɛ.

Misali la, ni nin sɛgɛsɛgɛli in ye jamu jiginni dɔ ye kansɛri la, furakɛli laɲininen bɛ se ka kɛ walasa k’o fɛn falen in laɲini, o bɛ na ni kɔlɔlɔw dɔgɔyali ye ani ka ɲɛtaa sɔrɔ.

O la, sanni aw ka hami a nɔfɛkow la ani ka hami aw kelen na, aw bɛ kuma aw ka dɔgɔtɔrɔ fɛ ka ɲɛ ani ka a kɔrɔ faamu ka jɛya ani aw ka kan ka fɛɛrɛ minnu tigɛ o kɔfɛ.