Yala kuruw bɛ se ka kɛ i farikolo yɔrɔw la wa? An ka kuma Nerve Sheath Tumors kan cogo nɔgɔman na!

Nɛrɛ minnu bɛ boli an farikolo bɛɛ la, olu bɛ i n’a fɔ nɛgɛw rezo minnu bɛ kuran cikanw ta. Olu de bɛ kunnafoniw ta ka taa ka segin ka bɔ kunkolo la ka taa farikolo tɔ la, ka bɔ farikolo la ka taa kunkolo la. Miiri k’a filɛ, o nɛrɛmuguma ninnu, u kuluw, u bɛɛ sirilen bɛ lakananifɛn kɛrɛnkɛrɛnnenw na, i n’a fɔ plastiki min bɛ nɛgɛ lamini, walasa k’u lakana ani ka kuran taamasiɲɛw dɛmɛ u ka taa teliya la. O lakanani-minɛnw de la, nin fɛn minnu bɛ wele ko nɛrɛmuguma kuruw, olu bɛ sɔrɔ tuma dɔw la.

Nɛrɛmuguma Tumuw ye mun ye?

N'an y'a Fɔ cogo nɔgɔman na, o kuru ninnu bɛ Kɛ lakanani "sɔgɔsɔgɔninjɛ" la minnu bɛ an ka nɛrɛmugu lamini. O "sɔgɔsɔgɔninjɛ" walima datugulan in bɛ Kɛ ni layini damadɔ ye:

• Schwann selilɛriw : Olu ye farikolokisɛw ye minnu bɛ axon lamini, n’o ye nɛrɛmuguma yɔrɔ jan ye, i n’a fɔ insulasi min bɛ nɛgɛ lamini.
• Endoneurium (Endoneurium) : Nin ye jɛɲɔgɔnya ye min bɛ farikolojidɛsɛ kelen-kelen bɛɛ lamini, i n’a fɔ a bɛ kɛ cogo min na nɛgɛbere kelen lamini nɛgɛso kɔnɔ.
• Perineurium (Perineurium) : O de bɛ farikolojidɛsɛbanakisɛw lamini.

An ka farikolo-ɲɛnajɛ bɛ se ka tila yɔrɔ fila ye:

• Cɛmancɛ farikolo yɔrɔ: O bɛ an kunkolo ni an kɔkolo sen don a la.
• Nɛrɛmuguma : O ye nɛrɛmuguma ye min bɛ bɔ kunsɛmɛ ni kɔkolo la ka taa farikolo yɔrɔ bɛɛ la.

Tuma caman na, o neurofibromes bɛ sɔrɔ farikolo yɔrɔw la .

Numukɛ suguya jumɛnw bɛ yen?

Sɔgɔsɔgɔninjɛ suguya kunbaba damadɔ bɛ yen. An k’a lajɛ u ye min ye.

Schwannomas (Schwannomas) ye

O kurukuru ninnu bɛ sɔrɔ Schwann selilɛriw la minnu kofɔra ka tɛmɛ. Schwannomas 60% ɲɔgɔn bɛ sɔrɔ an tulo kɔnɔna na . O nɛrɛmuguma bɛ an farikolo dɛmɛ ka balansi mara. Schwannoma wɛrɛw bɛ se ka sɔrɔ tuma dɔw la an fari jukɔrɔ, walima farikolo yɔrɔw ni farikolo yɔrɔw kɔnɔna na. Nin kuru ninnu bɛ ye yɔrɔ minnu na kosɛbɛ olu ye:

• Bolo ni senw na
• Kungolo la
• Kɔnɔbara la (o kɔrɔ ye ko yɔrɔ min bɛ kamankunw ni kɔkiliw cɛ) .

Schwannomas ye kuru ye min ka teli ka datugu farikolo yɔrɔ finman dɔ kɔnɔ, min bɛ wele ko kapisi. A ka ca a la, u tɛ kansɛri ye (benign)**. Nka, a man teli kosɛbɛ, kuru min bɛ mɛn sen na, o bɛ se ka kɛ bana jugu ye (kansɛri).

Neurofibromes (banakisɛfagalanw).

Nin kuru suguya in bɛ kɛ ni farikolo yɔrɔ suguya caman ye minnu bɛ wele ko Schwann cellules, endoneurium ani perineurium minnu bɛ nɛrɛmuguma datugu. A ka ca a la, olu bɛ ye i n’a fɔ kurukuruw fari jukɔrɔ, nka tuma dɔw la u bɛ se ka kɛ farikolo kɔnɔna na nɛrɛmugumaw kan.

A tɛ i n’a fɔ schwannomas, neurofibromes tɛ don a kɔnɔ. U bɛ falen nɛrɛmuguma kɔnɔ. Plexiform neurofibromes ye kuru suguya ye min bɛ jɛnsɛn i n’a fɔ nɛgɛ, a bɛ farikolojidɛsɛ caman lamini ani a bɛ se ka jɛnsɛn ka taa a lamini farikolo yɔrɔw la.

Neurofibromes fanba tɛ kansɛri ye. Nka, o kuru ninnu 5% fo 10% ɲɔgɔn bɛ se ka kɛ kansɛri ye . U bɛ wele ko tumu jugumanw (MPNST) . Nin kuru jugu ninnu bɛ mɔgɔ minnu na, olu tilancɛ ɲɔgɔn jɛnsɛnna farikolo yɔrɔ wɛrɛw la kaban, u sɔrɔ waati la.

O jiriden in ka ca cogo di?

Nɛrɛmuguma kuruw minnu tɛ kansɛri ye, olu man ca.

• Schwannomas ka teli ka ye mɔgɔw la minnu si bɛ san 50 ni san 60 cɛ.
• Neurofibromes ka teli ka sɔrɔ mɔgɔw la minnu si bɛ san 20 ni san 40 cɛ.
• A ka ca a la, farikolojidɛsɛbanakisɛw (plexiform neurofibromes) bɛ sɔrɔ sani u ka se san 5 ma.

Malignant Peripheral Nerve Sheath Tumors ye kansɛri suguya ye min man ca kosɛbɛ , a bɛ mɔgɔ kelen ɲɔgɔn dɔrɔn de minɛ mɔgɔ miliyɔn tan o miliyɔn 10 na san o san.

Mun na nin ɲɔgɔnna kurukuruw bɛ sɔrɔ? O sababu ye mun ye?

Yɛlɛma minnu bɛ kɛ jamu kɔnɔ, olu bɛ nɔba bila o neurofibromes (banakisɛfagalanw ) yiriwali la.

• Schwannomas ka yiriwali bɛ tali kɛ fɛn caman Changements dans la gène min bɛ wele ko NF2.
• Neurofibromes bɛ tali kɛ jɛnɛya dɔ la min bɛ wele ko (NF1).

Tuma caman na, o fɛn caman Changements gènes bɛ kɛ tuma dɔw la, k’a sɔrɔ sababu ɲɛnama si tɛ u la . Nka, schwannomas ni neurofibromas hakɛ fitininw bɛ sɔrɔ jamu bana dɔ fɛ min man ca, n’o bɛ wele ko neurofibromatose , o bɛ se ka kɛ denbayaw kɔnɔ.

Neurofibromatose suguyaw

Nin bana in suguya saba de bɛ yen:

• Neurofibromatose type 1 (NF1): NF1 bɛ mɔgɔ minnu na, olu bɛ neurofibroma caman sɔrɔ. U fana ka farati ka bon ka ɲɛsin plexiform neuromas ni malignant peripheral nerve sheath tumors (MPNST) sɔrɔli ma. Bana wɛrɛ minnu bɛ ye NF1 bɛ mɔgɔ minnu na , olu ye kungolodimi , sɔgɔsɔgɔninjɛ ani kalanbaliya ye .

• Neurofibromatose suguya 2 (NF2):NF2 bɛ mɔgɔ o mɔgɔ la, a bɛ se ka fɔ ko tulo fila bɛɛ bɛ vestibular schwannomas sɔrɔ sani u ka se san 30. Ka fara o kan, schwannomas ni kuru suguya wɛrɛw fana bɛ se ka sɔrɔ u fari la, u ɲɛw la ani u cɛmancɛ la.

• Schwannomatosis : Nin bana in na, schwannoma caman bɛ sɔrɔ vestibular nerve (tulo fila bɛɛ la) sanni ka kɛ vestibular nerve la.

Nin kuru ninnu taamasiɲɛw ye mun ye?

farikolojidɛsɛ bɛ mɔgɔ minnu na , olu fanba tɛ dimi walima taamasiɲɛ wɛrɛw sɔrɔ . Nka, ni kuru in bonyalen don walima ni a digilen don nɛrɛmuguma dɔ kan, a taamasiɲɛw i n’a fɔ:

• Kuru walima kuru dɔ bɛ fari jukɔrɔ (a bɛ se ka dimi ni a digilen don).
• Farikolo fanga dɔgɔyali .
• Ɲɛgɛnɛsiraw .
• Dimi, dimi, walima dimi gɛlɛn .
• A bɛ kɛ ni sɔgɔsɔgɔninjɛ ye, i n’a fɔ kuran ye i gosi .

Ka kɛɲɛ ni kurukuru yɔrɔ ye, taamasiɲɛ kɛrɛnkɛrɛnnen wɛrɛw fana bɛ se ka kɛ. Misali damadɔw filɛ nin ye:

• Sciatic nerve tumor : Dimi min bɛ bɔ kɔ la ka jigin sen na (sciatique).
• Tumu dɔ bɛ bolokɔni na: A taamasiɲɛw ni Carpal Tunnel Syndrome ta bɔlen don.
• Vestibulaire nerve tumor : Tumu min bɛ mɛnni kɛ, tulo gerenni, balansi gɛlɛyaw.

A ka ca a la, ni farikolojidɛsɛ bɛ mɔgɔ dɔ la, o ye kuru kelen ye. Nka, bana min kofɔra ka tɛmɛ, n’o ye neurofibromatose ye, olu la, kuru caman bɛ se ka ye (a ka ca a la fari la).

Aw bɛ a dɔn cogo di ni nin nɔnɔ ninnu bɛ aw la?

Aw ka dɔgɔtɔrɔ bɛna aw farikolo sɛgɛsɛgɛ fɔlɔ ani ka aw ka kɛnɛya bɛɛ jateminɛ. O bɛna kɛ sababu ye ka ɲininkali kɛ i ka furakɛli tariku la, i ka denbaya ka furakɛli tariku la, ani i bɛ se ka taamasiɲɛ minnu sɔrɔ.

Walasa ka kuru dɔ sɛgɛsɛgɛ ka taa a fɛ min bɛ ye kaban walima kuru min bɛ siga la, dɔgɔtɔrɔ bɛ se ka nin sɛgɛsɛgɛli ninnu fɔ:

• Dɔgɔtɔrɔso ja sɛgɛsɛgɛliw: Olu ye MRI sɛgɛsɛgɛliw ye, ultrasound sɛgɛsɛgɛliw ani PET sɛgɛsɛgɛliw walasa ka kuru ye ka jɛya.
• Biopsie (Byopsie) : Farikolo yɔrɔ fitinin dɔ bɛ bɔ tumu na ka a lajɛ ni mikroskɔpu ye walasa ka a dɔn farikolokisɛ suguya min bɛ a la. O de bɛ se k’a jira aw la k’a jɛya ni kuru ye kansɛri ye walima ni kansɛri tɛ.

Ni kuru caman bɛ aw la, dɔgɔtɔrɔ bɛ se ka a fɔ fana ko aw ka jamu sɛgɛsɛgɛli kɛ walasa ka a dɔn ni bana dɔw bɛ aw la minnu bɛ wele ko (NF1), (NF2), ani Schwannomatosis.

O furakɛcogo jumɛnw bɛ yen?

Ni taamasiɲɛ si tɛ aw la ka bɔ neuromastoïde la, aw ka dɔgɔtɔrɔ bɛ se ka a fɔ aw ye ko aw ka "aw kɔlɔsi ani ka kɔnɔni kɛ."Aw bɛ se ka taa ni fɛɛrɛ ye min bɛ wele ko "kɔlɔsili". O kɔrɔ ye ka to ka kuru lajɛ ni a bɛ ka bonya walima ni a bɛ ka Changé.

Ni kuru taamasiɲɛw bɛ u la, walima ni aw b’a fɛ ka kuru bɔ ɲɛgɛnɛsira la, a ka ca a la opereli dɔrɔn de ye fɛɛrɛ ye .

Neurofibroma dɔw, kɛrɛnkɛrɛnnenya la minnu bɛ wele ko plexiform neurofibromes, olu bɔli ka gɛlɛn pewu barisa u bɛ bonya farikolo kɔnɔ ani datugulan layiniw ni ɲɔgɔn cɛ. Ni kuru tɛ se ka bɔ pewu opereli kɔfɛ, aw ka dɔgɔtɔrɔ bɛna aw kɔlɔsi kosɛbɛ, barisa kuru bɛ ​​se ka segin ka bonya.

Schwannomas furakɛli kunkolo la

Schwannomas minnu bɛ sɔrɔ kunkolo la, i n’a fɔ vestibular schwannomas, olu bɛ se ka nɔ bila farikolo yɔrɔw la minnu bɛ baara nafamaw ɲɛnabɔ an farikolo la. Nin ko ninnu na, dɔgɔtɔrɔw bɛ fɛɛrɛ dɔ kɛ min bɛ wele ko stereotactic radiosurgery (misali la, Gamma Knife®) walasa ka farikolo yɔrɔw tiɲɛni bali.

Nin tɛ laadala opereli ye min bɛ kɛ ni tigɛda ye. O ye ka fiɲɛbɔlan dɔ ci fari la min ɲɛsinnen don tigitigi kosɛbɛ walasa ka kuru tiɲɛ walima k’a dɔgɔya.

Kansɛri banakisɛw furakɛli

Ka fara opereli kan, kansɛri furakɛli i n’a fɔ fiɲɛbana ni chimiothérapie fana bɛ se ka kɛ ka farikolo yɔrɔw kuru jugumanba furakɛ.

Gɛlɛya jumɛnw bɛ se ka sɔrɔ opereli fɛ?

I n’a fɔ opereli tɔw bɛɛ, gɛlɛya caman bɛ yen minnu bɛ se ka sɔrɔ nin opereli ninnu na:

• Joli bɔli
• Joginda banakisɛ
• Dimi
• Scarring (Sɔgɔsɔgɔninjɛ).

Ka fara o kan, farikolojidɛsɛ opereli bɛ se ka kɛ sababu ye ka farikolo yɔrɔw tiɲɛ ani ka kɛ naloman ye kudayi . Aw ka dɔgɔtɔrɔso jɛkulu bɛna aw dɛmɛ ka bana kuntaalajan fɛn o fɛn ɲɛnabɔ opereli kɔfɛ. Furakɛli suguya caman (farikoloɲɛnajɛ, baarakɛyɔrɔ furakɛli, ani kuma furakɛli) bɛ se ka aw dɛmɛ ka kɛnɛya.

Yala o kurukuru ninnu bɛ se ka bali ka kɛ wa?

Fɛɛrɛ dɔnnen tɛ yen min bɛ se ka nin kuru ninnu bali ka bɔ. Nka, dɔgɔtɔrɔ bɛ se ka a fɔ aw ye ko aw ka jamu sɛgɛsɛgɛli kɛ ni aw ye:

• Ni mɔgɔ dɔ bɛ aw ka denbaya kɔnɔ min ka teli ka kɛ ni neurofibromes ye.
• Ni farikolojidɛsɛ caman bɛ aw la (o bɛ se ka kɛ bana taamasiɲɛ ye min bɛ wele ko neurofibromatose).

An ka kan ka mun miiri nin nɔnɔ ninnu na ka taa ɲɛ? (Laɲini)

neurofibromes fanba tɛ kansɛri ye . U bɛ se ka kɛnɛya ni opereli ye, wa u man teli ka segin. Nka, ni aw ka kuru tɛ se ka bɔ pewu ni opereli ye, aw ka kan ka taa a fɛ ka kɛ dɔgɔtɔrɔw ka kɔlɔsili kɔnɔ.

mɔgɔ 4 o 4 , minnu bɛ furakɛli kɛ vestibular schwannoma la , 3 ɲɔgɔn bɛ se k' u ka mɛnni mara .

Farati min bɛ farikolojidɛsɛbanakisɛ dɔ la ka kɛ kansɛri ye, o ka dɔgɔn kosɛbɛ. A farati ka bon kosɛbɛ bana in bɛ mɔgɔ minnu na (NF1) minnu bɛ ni Plexiform neurofibroma ye. Kuru juguw (MPNST) ɲɛfɔli man ɲi o cogo la, kɛrɛnkɛrɛnnenya la ni kuru ka bon ni santimɛtɛrɛ 2 ye. Nin bana in bɛ mɔgɔ minnu na, olu tilancɛ tɛ se ka balo san duuru sɔrɔlen kɔfɛ.

Aw ka kan ka taa dɔgɔtɔrɔso la tuma jumɛn?

Ni aw ye kuru dɔ ye aw fari jukɔrɔ, walima ni aw ye taamasiɲɛ dɔw ye aw hakili la minnu bɛ se ka kɛ neurofibromatose ye , aw bɛ taa dɔgɔtɔrɔso la joona . Ani fana, aw bɛ a fɔ aw ka dɔgɔtɔrɔ ye ni aw ka denbaya kɔnɔmɔgɔ dɔ ye nin kuru suguya ninnu sɔrɔ.

Take-Home cikan laban

Aw ye aw hakili to a la ko farikolojidɛsɛbanakisɛ fanba ye falenfɛn ɲumanw ye, minnu tɛ kansɛri ye, minnu bɛ bonya dɔɔni dɔɔni . Ni bana taamasiɲɛ si tɛ aw la, aw ka dɔgɔtɔrɔ bɛ se k’a latigɛ ka aw kɔlɔsi dɔrɔn. Ni kuru dɔ ka kan ka bɔ, a ka ca a la opereli bɛ ɲɛ kosɛbɛ. A man teli kosɛbɛ gɛlɛyaw (i n’a fɔ a tɛ se ka kuru bɔ pewu, farikolojidɛsɛ) ka kɛ, walima kuru ka kɛ kansɛri ye. Aw ka dɔgɔtɔrɔ bɛna aw dɛmɛ ka furakɛli bolodacogo dɔ labɛn ani ka waati boloda sɛgɛsɛgɛli nataw kama walasa ka aw dɛmɛ ka aw ka bana kunbɛn. O la, aw kana siran ka kuma aw ka dɔgɔtɔrɔ fɛ fɛn o fɛn kan.

` nɛrɛmuguma kuruw, schwannoma, neurofibroma, neurofibromatose, nɛrɛmuguma, kansɛri, jamu banaw, nɛrɛmuguma kuruw