Ðe nèdɔa alɔ̃ zi ɖeka le ŋkekea mea? Esia ate ŋu anye (Narcolepsy)! Mina míaƒo nu tso esia ŋu

Ðe nèse le ɖokuiwò me kpɔ be yedɔ alɔ̃ ale gbegbe esime nèle dɔ wɔm le ŋkeke me alo nèle dze ɖom kple xɔ̃wòwoa? Àte ŋu asusu be, "Oo... Nyemedɔ alɔ̃ nyuie le zã si va yi me o." Gake menye ɖeɖiteameŋu ƒe nya koe wònye o. Egbea míele nu ƒom tso alɔ̃dɔdɔ ƒe kuxi aɖe si to vovo vie ŋu. Ema nye nɔnɔme aɖe si woyɔna be Narcolepsy . Togbɔ be mebɔ boo o hã la, enye nusi ŋu ame geɖe se le dzesi siwo do ƒome kplii ta . Woate ŋu adae, gake ate ŋu akpɔ ŋusẽ gã aɖe ɖe wò agbenɔnɔ, dɔwɔɖui, kple hadomekadodowo dzi.

Nukae Nye Alɔ̃madɔmadɔ?

Kpuie ko la, Narcolepsy nye ahɔhɔ̃mekawo ƒe dɔléle si naa alɔ̃dɔdɔ kpata, si dzi womate ŋu aɖu o le ŋkekea me. Etɔxɛe la, wò ahɔhɔ̃ mate ŋu aɖɔ alɔ̃dɔdɔ kple ŋudzɔnɔnɔ ɖo nyuie o. Esia ate ŋu ana nàse le ɖokuiwò me be yedɔ alɔ̃ akpa le ŋkeke me, eɖanye aleke kee nèdɔ alɔ̃ le zã me o.

Nukawoe nye Narcolepsy ƒe dzesi veviwo?

Dzesi vevi enee le Narcolepsy ŋu. Gake ame akpa gãtɔ mekpɔa eneawo katã zi ɖeka o. Ame aɖewo ate ŋu akpɔ ɖeka alo eve. Na míakpɔ nusiwo dzesi siawo nye ɖa.

• Ŋkeke me alɔ̃dɔdɔ fũu akpa : Esia nye Narcolepsy ƒe dzesi si bɔ. Ele abe "alɔ̃dɔdɔ ƒe amedzidzedze" si me nèdɔ alɔ̃ le zi ɖeka ene. Nuka kee nèɖawɔ o, èsena le ɖokuiwò me be yeatɔ adɔ alɔ̃.
• Cataplexy: Esia nye lãmekawo ƒe ŋusẽmanɔamesi kpata . Ɣeaɖewoɣi la, ate ŋu anɔ bɔbɔe, abe lãmeka siwo le mo alo kɔ ƒe akpa ɖeka ƒe ʋuʋu ene. Ne esẽ la, àte ŋu adze anyigba kasia. Mina míaƒo nu tso esia ŋu tsitotsito.
• Alɔ̃dɔdɔ ƒe susumenuwo : Esiawo nye susumesusu siwo dzɔna ne èle alɔ̃ dɔm alo ne èle nyɔnyrɔ ge, eye woate ŋu ado vɔvɔ̃ na ame ŋutɔ.
• Alɔ̃dɔdɔ ƒe Dɔmawɔmawɔ nyuie : Ðewohĩ èse esia be "vɔvɔ̃ le ame ŋu le drɔ̃e me eye mete ŋu ʋãna o" alo abe alesi ame aɖewo gblɔna ene la, "sese le ɖokuiwò me abe gbɔgbɔ vɔ̃ aɖe lia yi dzi ene." Esia nye ɣeyiɣi si me mète ŋu ʋãa wò ŋutilã o ne ènyɔ gɔ̃ hã, alo ɖewohĩ mènyɔ bliboe o. Mina míagalé ŋku ɖe esia ŋu vie.

Nya geɖe tso (Cataplexy) ŋu vie .

Míegblɔ va yi be cataplexy nye lãmekawo ƒe ŋusẽ si bu kpata. Woma alɔ̃madɔmadɔ ɖe hatsotso vevi eve me le nenye be cataplexy ƒe dzesi sia le ame ŋu alo mele eme o nu:

• (Narcolepsy Type 1) : Dzesi siae nye (Cataplexy) . (Narcolepsy) dɔnɔ siwo ade 20% nye ƒomevi sia tɔ.
• (Narcolepsy Type 2) : Dzesi si nye (Cataplexy) mele ƒomevi sia ŋu o. Ame akpa gãtɔ, si fia be anɔ abe 80% ene, dzea ƒomevi sia me.

Zi geɖe la, ne míedɔ alɔ̃ la, míaƒe ahɔhɔ̃a ƒe akpa gãtɔ dzudzɔa míaƒe lãmekawo dzi ɖuɖu ale be míagawɔ nu ɖe ​​míaƒe drɔ̃ewo nu o. Amesiwo ŋu cataplexy le la ƒe lãmekawo buna kpata, si sɔ kple esi wokpɔna le REM alɔ̃dɔdɔ me, ne wole ŋudzɔ gɔ̃ hã.

Le nɔnɔme siwo mesẽ o me la, cataplexy ateŋu akpɔ ŋusẽ ɖe mo kple kɔ ƒe lãmekawo ko dzi - le kpɔɖeŋu me, aɖu ateŋu aɖiɖi. Alo ate ŋu agblẽ nu le ŋutilãa ƒe akpa ɖeka ko ŋu. Le nɔnɔme sesẽwo me la, cataplexy ate ŋu ana ame nadze anyi kpata, si ate ŋu awu ame. Zi geɖe la, nudzɔdzɔ siawo xɔa miniti ʋɛ aɖewo, gake ɖewohĩ màte ŋu aƒo nu alo aʋuʋu le ɣeyiɣi sia me o.

Nu tɔxɛ bubu si le cataplexy ŋue nye be seselelãme aɖewo ate ŋu aʋãe . Ate ŋu adzɔ vevietɔ ne èle dzidzɔ kpɔm, nèle nu kom, alo nèle fefem. Ate ŋu adzɔ hã ne ewɔ nuku na wò, vɔvɔ̃ ɖo wò, alo nèdo dziku, gake mebɔ o.

Cataplexy ate ŋu ato vovo vie le ɖeviwo kple amesiwo xɔ abe ɣleti ade ene esime dzesiawo dze zi gbãtɔ. Woate ŋu awɔ mo yaa zi ɖeka, ado woƒe aɖe ɖe go, alo lãmekawo nagbɔdzɔ si medo ƒome kple seselelãmea o.

Nya geɖe tso alɔ̃dɔdɔ ƒe lãmetutudɔ ŋu vie

Ne míedɔ alɔ̃ la, ahɔhɔ̃a dzudzɔa míaƒe lãmekawo dzi ɖuɖu ale be woagawɔ nu ɖe ​​nusi míekpɔna le míaƒe drɔ̃ewo me nu o. Gake ne míenyɔ la, ele be dziɖuɖu sia nagawɔ dɔ nyuie ake. Gake ne alɔ̃dɔdɔ ƒe lãmetutudɔ le ŋuwò la, wò ŋutilã megakpɔa lãmekawo dzi ɖuɖu ma ake o. Àte ŋu agbɔ ya ahaʋuʋu wò ŋkuwo, gake màte ŋu aƒo nu alo aʋuʋu wò ŋutilã ƒe akpa bubuwo o.

Susumeŋutetewo bɔ ŋutɔ le alɔ̃dɔdɔ ƒe lãmetutudɔ me. Woate ŋu adze ƒã ŋutɔ, eye ɣeaɖewoɣi la, wodoa vɔvɔ̃ na ame si womate ŋu asusu o. Dzɔgbenyuietɔe la, zi geɖe la, alɔ̃dɔdɔ ƒe lãmetutudɔ nɔa anyi aɖabaƒoƒo ʋɛ aɖewo (togbɔ be ate ŋu ase le eɖokui me abe ɣeyiɣi didi aɖe ene na amesi le ekpɔm hã).

Ðe dzesi bubuwo hã lia?

Tsɔ kpe ɖe dzesi vevi eneawo ŋu la, amesiwo ŋu alɔ̃madɔmadɔ le ate ŋu akpɔ dzesi kple nuwɔna bubu aɖewo. Wo dometɔ aɖewoe nye:

• Ʋuʋu le Eɖokui Si : Ame siwo ŋu alɔ̃dɔdɔ ƒe dɔléle le ate ŋu ayi edzi anɔ ŋutilã ƒe akpa aɖewo abe woƒe asiwo ene ʋuʋum ɣeaɖewoɣi ne wodɔ alɔ̃ gɔ̃ hã.
• Ŋkuɖodzinyawo alo Ŋkuɖoɖo Be : Ebɔ be amesiawo ŋlɔa nusi wowɔ hafi mlɔa anyi be.
• Dzodzo/nuƒoƒo kpata le alɔ̃dɔdɔ ƒe amedzidzedze me : Ame si ŋu alɔ̃dɔdɔ ƒe dɔléle le ate ŋu agblɔ nya aɖe zi ɖeka (zi geɖe la, susu mele eme o alo mehiã o ɣemaɣi). Ne esia dzɔ la, woate ŋu anyɔ keŋkeŋ ake. Gake zi geɖe la, womeɖoa ŋku edzi o.

Amekae xɔa alɔ̃dɔdɔ ƒe dɔléle? Aleke gbegbe wòbɔe?

Zi geɖe la, ɖɔktawo kpɔa alɔ̃madɔmadɔ le amesiwo xɔ tso ƒe 5 va ɖo ƒe 50. Gake ebɔ wu le sɔhɛ tsitsiwo , siwo xɔ tso ƒe 18 va ɖo 25. Ŋutsuwoe ate ŋu axɔ dɔlélea wu.

Alɔ̃madɔmadɔ menye dɔléle si bɔ ŋutɔ o.Numekukuwo ɖee fia be ame 25 va ɖo 50 le ame 100,000 ɖesiaɖe me le xexeame katã. Gake esi wòxɔa ƒe geɖe hafi woate ŋu anya dɔlélea ta la, esesẽna be woagblɔ ame neni tututue wòxɔe le.

Aleke Narcolepsy kpɔa ŋusẽ ɖe nye ŋutilã dzii?

Be míase alɔ̃dɔdɔ gɔme la, ekpena ɖe mía ŋu be míanya ale si míaƒe alɔ̃dɔdɔ wɔa dɔe vie. Míaƒe alɔ̃dɔdɔ ƒe akpa vevi geɖewo li:

• Afɔɖeɖe 1: Alɔ̃dɔdɔ Fafɛ . Esia nye afɔɖeɖe kpui aɖe. Edzea egɔme ne ènya dɔ alɔ̃ ko. Ewɔa wò alɔ̃dɔdɔ bliboa ƒe 5% lɔƒo.
• Afɔɖeɖe 2: Alɔ̃dɔdɔ Deto ((Alɔ̃dɔdɔ Deto)) . Esia de to vie wu. Alɔ̃dɔdɔ bliboa ƒe 45%-50% lɔƒo (agbɔsɔsɔ sia dzina ɖe edzi ne míele tsitsim).
• Afɔɖeɖe 3: Ƒutsotsoewo ƒe Alɔ̃dɔdɔ Blewu . Alɔ̃dɔdɔ bliboa ƒe 25% lɔƒo (esia dzi ɖena kpɔtɔna ne ame tsi). Esesẽna ŋutɔ be woanyɔ ame aɖe le afɔɖeɖe sia me. Ne ènyɔ wo kpata la, woayi susu me ƒe afu ƒe nɔnɔme si woyɔna be "alɔ̃dɔdɔ ƒe dɔmawɔmawɔ" me. Alɔ̃dɔdɔ kple alɔ̃dɔdɔ ƒe nuƒoƒo hã dzɔna le afɔɖeɖe sia me.
• (REM) Alɔ̃dɔdɔ : (REM) tsi tre ɖi na (Ŋku ƒe Ʋuʋu Kaba) , si fia be ŋkuwo ʋãna kabakaba. Afɔɖeɖe sia mee míekua drɔ̃e le. Ne ame le alɔ̃ dɔm (REM) la, àte ŋu akpɔ ŋkuawo woanɔ ʋuʋum le ŋkumeʋuʋu te.

Ne alɔ̃madɔmadɔ mele ŋuwò o la, ne èdɔ alɔ̃ la, èdzea egɔme tso afɔɖeɖe 1 lia me, emegbe nèyia afɔɖeɖe 2 kple 3. Èdoa gasɔ le akpa siawo dome, eye mlɔeba nègena ɖe REM alɔ̃dɔdɔ me, afisi nèdzea drɔ̃ekuku gɔme le. Le REM ƒe tsatsam gbãtɔ megbe la, èdzea tsatsam yeye gɔme eye nègatrɔna yia afɔɖeɖe 1 alo 2. Zi geɖe la, tsatsam ɖeka xɔa abe miniti 90 ene. Ame akpa gãtɔ toa tsatsam abe ene va ɖo atɔ̃ ene le zã ɖeka me (ne wodɔ alɔ̃ gaƒoƒo 8).

Gake ne alɔ̃madɔmadɔ le ŋuwò la, wò alɔ̃dɔdɔ medzɔna nenema o. Ke boŋ ne èdɔ alɔ̃ ko kloe la, èyia REM alɔ̃ me . Le zã bliboa me la, èdɔa alɔ̃ kpuie, eye zi geɖe la, mèwua alɔ̃dɔdɔ ƒe ɣeyiɣi si sɔ nu o.

Le alɔ̃dɔdɔ me la, aleke kee nèɖadɔ alɔ̃ nyuie le zã me o, èsena le ɖokuiwò me be yedɔ alɔ̃ le ŋkeke me ale gbegbe. Esesẽna ŋutɔ be woadzudzɔ alɔ̃dɔdɔ. Gake alɔ̃dɔdɔ sia si va le ŋkeke me hã nɔa kpuie (anɔ abe miniti 15-30 ene). Ne ènyɔ la, èsena le ɖokuiwò me be yeƒe dzi dze eme eye yesu te be yeagawɔ nusi wɔm nènɔ tsã. Gake esi esia dzɔna zi geɖe gbesiagbe tae alɔ̃dɔdɔ va gblẽa nu le wò agbenɔnɔ ŋu ale gbegbe.

Nukawoe hea alɔ̃dɔdɔ ƒe dɔléle vɛ?

Nusiwo gbɔ alɔ̃dɔdɔ tsona la toa vovo le alɔ̃dɔdɔ ƒomevi si le ŋuwò nu, gake wo katã ku ɖe wò ahɔhɔ̃ ƒe akpa tɔxɛ aɖe si woyɔna be hypothalamus , si kpɔa alɔ̃dɔdɔ kple ŋudzɔnɔnɔ dzi.

Nusiwo Hea (Alɔ̃madɔmadɔ Ƒomevi 1) vɛ .

Le ƒe 1998 me la, numekulawo ke ɖe atike aɖe si woyɔna be orexins (si woyɔna ɣeaɖewoɣi be hypocretins) ŋu . Ahɔhɔ̃meka aɖewo (ahɔhɔ̃mekawo) zãa esiawo tsɔ ɖoa ​​gbedasiwo ɖa. Ahɔhɔ̃meka siwo zãa orexins la le ahɔhɔ̃a ƒe akpa aɖe si woyɔna be hypothalamus. Ahɔhɔ̃meka siawoe kpena ɖe mía ŋu koŋ be míanɔ ŋudzɔ.

Zi geɖe la, orexin ƒe agbɔsɔsɔ nɔa ahɔhɔ̃mekawo me tsi (CSF) – tsi ƒe ƒuƒoƒo tsɛ si ƒo xlã ahɔhɔ̃ kple aklã me. Gake le amesiwo ŋu alɔ̃dɔdɔ ƒe dɔléle le gome la, orexin ƒe agbɔsɔsɔ le CSF me medea dzesii kura o alo womate ŋu ade dzesii o. Esia fia be lãmenugbagbevi siwo wɔa orexin la dzudzɔ dɔwɔwɔ alo nane gblẽ wo dome.

Numekuku bubuwo ɖee fia be nusita ahɔhɔ̃meka siawo mewɔa dɔ o la anya nye dɔlélenutsiŋutete ƒe kuxi . Esia fia be wò ŋutilã ŋutɔ ƒe dɔlélenutsiŋutete dzea ahɔhɔ̃meka siwo wɔa orexin hezãnɛ, alo orexin ŋutɔ, alo evea siaa dzi.

Domenyiŋusẽ ƒe tɔtrɔ tɔxɛ aɖe le amesiwo ŋu Alɔ̃madɔmadɔ Ƒomevi 1 le dometɔ siwo ade 90%-95% si kpɔa ŋusẽ ɖe woƒe dɔlélenutsiŋutete dzi (wode dzesii be HLA-DQB1*06:02 ). Ke hã, amehawo katã ƒe 25% lɔƒo hã ƒe tɔtrɔ sia le wo ŋu gake Narcolepsy mele wo ŋu o. Eyata eŋutinunyalawo medoa domenyiŋusẽfianu sia kpɔna o, eye womeka ɖe akpa si wòwɔna dzi o. Kpeɖodzi aɖewo hã li be nɔnɔmea ate ŋu anɔ ƒomewo me. Ne Narcolepsy le ƒometɔ si le ɖoƒe gbãtɔ (dzila, nɔviwò, vi) ŋu la, ke èle afɔku me be wò hã nàxɔe.

Gake Alɔ̃madɔmadɔ Ƒomevi 1 ate ŋu adze dɔlékui kple dɔlékui aɖewo xɔxɔ vɔ megbe hã, vevietɔ asrãdɔlékuiwo abe H1N1 dzamezã kple dɔlékui siwo hea strep throat vɛ. Eŋutinunyalawo xɔe se be ɖewohĩ esi dɔlékuiwo ate ŋu ana dɔlélenutsiŋutete natrɔ eye wòawɔ dɔ nyuie ɣeaɖewoɣi tae esia tso.

Nusiwo Hea (Alɔ̃madɔmadɔ Ƒomevi 2) vɛ .

Togbɔ be wonya nu geɖe tso nusiwo gbɔ Alɔ̃madɔmadɔ Ƒomevi 1 tsona ŋu hã la, womenya nu geɖe tso Alɔ̃madɔmadɔ Ƒomevi 2 ŋu nenema gbegbe o. Eŋutinunyalawo mese nusita Alɔ̃madɔmadɔ Ƒomevi 2 lia dzea ame dzi la gɔme bliboe haɖe o. Gake wosusu be ɖewohĩ nu mawo tɔgbe gbɔe wòtso. Le kpɔɖeŋu me, ate ŋu atso ahɔhɔ̃meka siwo zãa orexin ƒe gbegblẽ si mesẽ boo o gbɔ, alo kuxi aɖe si le alesi orexin zɔa mɔ le ahɔhɔ̃a me ŋu.

Alɔ̃madɔmadɔ Evelia

Le go siwo mebɔ o me la, alɔ̃madɔmadɔ ate ŋu atso wò hypothalamus ƒe gbegblẽ gbɔ. Nusiwo gblẽ le ame ŋu sia ate ŋu atso nusiwo le abe ta ƒe abixɔxɔ (ʋuʋudedi), ahɔhɔ̃ me abi si nu sẽ (ahɔhɔ̃ ƒe abi si nu sẽ), ʋusɔgbɔdɔ, kple ahɔhɔ̃ me dɔdzẽ gbɔ.

Alɔ̃madɔmadɔ ate ŋu anye nɔnɔme bubu siwo medo ƒome kple wo nɔewo o siwo ate ŋu anye wò dome la ƒe dzesi. Kpɔɖeŋuwo:

• (Autosomal Dominant Cerebellar Ataxia, Alɔ̃madɔmadɔ Kple Tokunɔnyenye (ADCADN))
• (Autosomal Dominant Narcolepsy, Suklidɔ Ƒomevi 2 Kple Lolo akpa)

Ðe Narcolepsy xɔa ame mea?

Ao, Narcolepsy menye dɔléle si xɔa ame me o. Màte ŋu alée le ame bubu gbɔ o, eye ame aɖeke hã mate ŋu alée le gbɔwò o.

Aleke woawɔ ade dzesi alɔ̃dɔdɔ ƒe dɔléle?

Wò dzesiwo ate ŋu ana ɖɔkta nasusui be alɔ̃madɔmadɔ le ŋuwò. Gake alɔ̃madɔmadɔ ƒe dzesiwo sɔ kple ahɔhɔ̃ kple alɔ̃dɔdɔ ƒe kuxi bubu geɖewo tɔ. Eyata ele vevie be nànya ne alɔ̃madɔmadɔ le ŋuwò.Dodokpɔ tɔxɛ siwo wowɔna tsɔ dea dzesi dɔlélea ko hafi woate ŋu anya dɔlélea si ŋu kakaɖedzi le.

Hafi ɖɔkta nawɔ alɔ̃dɔdɔ ƒe dodokpɔ vevi geɖe la, alé ŋku ɖe eŋu gbã akpɔe ɖa be èle alɔ̃ dɔm nyuie hã. Zi geɖe la, wozãa mɔnu bɔbɔe siwo léa ŋku ɖe wò alɔ̃dɔdɔ kple nyɔnyrɔ̃ ƒe nɔnɔmewo ŋu tsɔ wɔa esiae. Kpɔɖeŋu aɖee nye actigraphy . Esia bia be nàzã mɔ̃ aɖe abe asiƒomegaƒoɖokui ene atsɔ alé ŋku ɖe wò ʋuʋu ƒe ɖoɖowo ŋu (abe ne èle alɔ̃ dɔm kple ne èle ŋudzɔ hele ʋuʋum ene).

Dodokpɔ kawoe wozãna tsɔ dea dzesi alɔ̃madɔmadɔ?

Dodokpɔ geɖe li woate ŋu awɔ atsɔ anya alɔ̃dɔdɔ ƒe dɔléle:

• Alɔ̃dɔdɔ Ŋuti Nusɔsrɔ̃ ((Alɔ̃dɔdɔ Ŋuti Nusɔsrɔ̃ - Polysomnogram)) : Dodokpɔ sia zãa sensor vovovowo tsɔ léa ŋku ɖe alesi nèdɔa alɔ̃e ŋu. Nu vevitɔ si le alɔ̃dɔdɔ ŋuti numekuku blibo me, si nye polysomnogram ((Polysomnogram)) enye be woazã (EEG) sensorwo . Sensor siawo léa ŋku ɖe wò ahɔhɔ̃ ƒe ƒutsotsoewo ŋu ((Brain Waves)). Esia wɔnɛ be ɖɔktawo te ŋu kpɔa alɔ̃dɔdɔ ƒe akpa si nèle aɖabaƒoƒo ɖesiaɖe. Ame siwo ŋu (Narcolepsy) le la dɔa alɔ̃ (REM) kabakaba wu ame dzɔdzɔewo, eyata dodokpɔ sia ate ŋu ade dzesii. Eŋlɔa ɣeyiɣi siwo me wofɔna le woƒe alɔ̃dɔdɔ titina hã ɖi. Susu bubu si ta dodokpɔ sia le vevie enye be alɔ̃dɔdɔ fũu akpa le ŋkeke me ate ŋu anye nɔnɔme aɖe si woyɔna be alɔ̃dɔdɔ ƒe gbɔgbɔtsixetsixe ((Alɔ̃madɔmadɔ)) ƒe dzesi hã . Alɔ̃dɔdɔ ŋuti numekuku ate ŋu aɖo kpe edzi be alɔ̃dɔdɔ ƒe gbɔgbɔtsixetsixe mele ŋuwò o.
• Multiple Sleep Latency Test (MSLT) : Dodokpɔ sia dzidzea alesi nèdɔa alɔ̃ bɔbɔe le ŋkekea me. Ebia be woadɔ alɔ̃ zi geɖe le ɣeyiɣi aɖe koŋ me. Ate ŋu afia nenye be alɔ̃ dɔm le ŋkeke me fũu akpa. Esia nye alɔ̃madɔmadɔ ƒe dzesi si bɔ. Zi geɖe la, wowɔa esia le ŋkeke si kplɔ zã me alɔ̃dɔdɔ ŋuti nusɔsrɔ̃ ɖo.
• Beléle na Ŋudzɔnɔnɔ Dodokpɔ : Dodokpɔ sia dzidzea alesi nàte ŋu anɔ ŋudzɔ le ŋkekea me, ne èle alɔ̃ dɔm bɔbɔe gɔ̃ hã. Womezãnɛ zi geɖe tsɔ léa ŋku ɖe alɔ̃madɔmadɔ ŋu o, gake ate ŋu akpe ɖe ame ŋu be woaɖe kuxi bubuwo ɖa. Anyo hã be nàkpɔe ɖa be atike siwo doa ŋusẽ ame le dɔ wɔm hã.
• Spinal Tap (Lumbar Puncture) : Dodokpɔ sia ate ŋu ade dzesi orexin ƒe agbɔsɔsɔ sue aɖe le wò ahɔhɔ̃mekawo me tsi (CSF) me. Esia nye mɔ vevi aɖe si dzi woato anya Alɔ̃madɔmadɔ Ƒomevi 1 lia. Orexin ƒe agbɔsɔsɔ si bɔbɔ ate ŋu anye dzesi be ame aɖe si ŋu Narcolepsy le mele cataplexy me tom haɖe o, gake ate ŋu anye dzesi be ate ŋu anɔ cataplexy xɔm le etsɔme. Gake esi wònye be orexin ƒe agbɔsɔsɔ metrɔna le amesiwo ŋu Alɔ̃madɔmadɔ Ƒomevi 2 le me o ta la, menye ɣesiaɣie esia nyea dodokpɔ si wotsɔ dea dzesi dɔlélea o.

Dodokpɔ bubuwo

Woate ŋu awɔ dodokpɔ bubu geɖe na amesiwo ŋu alɔ̃madɔmadɔ le. Le kpɔɖeŋu me, ne cataplexy le ŋuwò la, ate ŋu asɔ kple ahɔhɔ̃medɔ bubuwo abe alɔ̃madɔmadɔ ene ƒe dzesi siwo dona tso ʋuʋu me. Eyata ɖɔktawo ate ŋu ado nɔnɔme siwo nu sẽ wu, abe asrãdɔ ene, kpɔ gbã. Eyata ate ŋu axɔ ɣeyiɣi aɖe hafi woate ŋu anya alɔ̃dɔdɔ ƒe dɔléle. Wò ɖɔktae nye ame nyuitɔ kekeake si aɖe dodokpɔ siwo wòle be nàwɔ kple nusita wole wo wɔm la me na wò.

Aleke wodaa alɔ̃madɔmadɔe? Ðe woate ŋu adaea?

Woate ŋu ada alɔ̃madɔmadɔ, gake womate ŋu adae o . Zi geɖe la, wodzea atikewɔwɔ gɔme kple atikewo. Gake tɔtrɔwo wɔwɔ le wò gbesiagbenuwɔnawo kple agbenɔnɔ ŋu hã ate ŋu akpe ɖe ŋuwò. Zi geɖe la, alɔ̃madɔmadɔ wɔa nu nyuie ne wowɔ atike nɛ. Esia ate ŋu akpe ɖe ŋuwò nàɖe tɔtɔ si dzesiawo hena vɛ dzi akpɔtɔ.

Ðo ŋku edzi be alɔ̃madɔmadɔ nye dɔléle si nɔa ame ƒe agbemeŋkekewo katã me, gake megagblẽna ɖe edzi le ɣeyiɣi aɖe megbe o.

Nukawoe nye atike siwo wozãna na alɔ̃madɔmadɔ?

Atikewoe nye atike vevitɔ na alɔ̃madɔmadɔ. Atike akpa gãtɔ tɔa ŋku alɔ̃dɔdɔ fũu akpa le ŋkeke me. Gake atike aɖewo kpɔa ŋusẽ ɖe dzesi bubuwo hã dzi. Atike ƒomevi aɖewo siwo woate ŋu ana na dɔléle siae nye esi:

• Nyɔnyrɔ̃ ƒe Atikewo : Zi geɖe la, esiawoe nye atike gbãtɔwo. Kpɔɖeŋu aɖewoe nye Modafinil kple Armodafinil . Atike siawo doa ŋusẽ wò lãmekawo. Esia ate ŋu akpe ɖe ŋuwò nàɖe alɔ̃dɔdɔ le ŋkeke me ƒe sesẽ kple enuenu dzi akpɔtɔ.
• Amphetamines kple Amphetamine-like Stimulants : Atikewo abe methylphenidate (si woyɔna le ŋkɔ Ritalin®, Concerta®, Qullivant®) kple amphetamine/dextroamphetamine ƒokpli (si woyɔna le ŋkɔ Adderall® te).
• Blanuilélenutsitikewo : Esiawo ateŋu anye Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) (e.g. Venlafaxine - si woyɔna be Effexor®), Selective Serotonin Reuptake Inhibitors (SSRIs) (e.g. Fluoxetine - si woyɔna be Prozac®), alo Tricyclic Antidepressants (e.g. Clomipramine alo Protriptyline - esiawo womegazãnɛ fifia o).
• (Sodium Oxybate) : Atike sia kpena ɖe ŋuwò nèdɔa alɔ̃ nyuie eye wòɖea (Cataplexy) ƒe dzidziɖedzi hã dzi kpɔtɔna. Le atike sia ƒe ŋusẽkpɔɖeamedzi ta la, wokpɔa edzi vevie le dukɔ geɖe me. Gake zi geɖe la, wozãnɛ tsɔ daa dɔe (Type 1 Narcolepsy).
• Atike siwo gblẽa nu le histamine ŋu : Atike sia tɔgbe ƒe kpɔɖeŋu aɖee nye Pitolisant.. Esia nye histamine xɔla ƒe mɔxenu. Receptor antagonists nye atike siwo xea mɔ na atike aɖewo siwo le wò ŋutilã me be woagalé ɖe lãmenugbagbeviwo ŋu o. Esia ɖea lãmenugbagbeviawo ƒe nu aɖewo wɔwɔ dzi kpɔtɔna alo xea mɔ na wo.

Togbɔ be atikewɔmɔnu vovovowo li na ame tsitsiwo (alɔ̃madɔmadɔ) hã la, atikewɔmɔnu siwo woate ŋu azã na ɖeviwo la mesɔ gbɔ kura o. Viwò ƒe ɖeviwo ƒe dɔdala alo eŋutinunyala bibi ate ŋu agblɔ atikewɔmɔnu siwo li na wò kple esiwo wokafu na wò nyuie wu.

Kuxiwo/dɔdamɔnu ƒe nugbegblẽ le ame ŋu

Mɔnukpɔkpɔ gã aɖe li be atike geɖe siwo wozãna tsɔ daa alɔ̃madɔmadɔ kple eƒe dzesiwo be woawɔ dɔ kple atike bubuwo. Ʋusɔgbɔdɔ kple dzi ƒe tsotso si mesɔ o nye kuxi siwo ate ŋu ado mo ɖa le atike ƒomevi ɖesiaɖe si doa ŋusẽ ame ŋu la dometɔ eve ko. Sodium Oxybate, vevietɔ, nye afɔku gã aɖe ne wotsɔe kpe ɖe atike bubu siwo tea lãmekawo ƒe dɔwɔwɔ ɖe anyi ŋu. Azɔ hã, mègazã atike sia kple aha sesẽ gbeɖe o .

Le goawo katã me la, wò ɖɔktae nye ame nyuitɔ kekeake si agblɔ nusiwo wògblẽna le ame ŋu, kuxi siwo dona tso eme, kple atikewo ƒe dɔwɔwɔ ɖe wo nɔewo ŋu siwo ŋu wòle be nànya nu tsoe na wò. Ate ŋu ana nyatakaka siwo sɔ ɖe wò nɔnɔme tɔxɛa, lãmesẽ ŋutinya, kple wò ŋutɔ wò nɔnɔmewo nu.

Aleke mawɔ akpɔ ɖokuinye dzi ahakpɔ nye dzesiwo gbɔ?

Mele be wò ŋutɔ nàdze agbagba akpɔ alɔ̃madɔmadɔ alo adae gbeɖe o . Esia le alea elabena nɔnɔme sia ƒe dzesiwo bɔ ɖe nɔnɔme sesẽ bubuwo hã me, abe alɔ̃dɔdɔ ƒe gbɔgbɔtsixetsixe kple asrãdɔ ene. Azɔ hã, nɔnɔme sia ate ŋu ana nuwɔna aɖewo, abe ʋukuku kple tsiƒuƒu ene, nanye afɔku. Eyata yi ɖɔkta gbɔ ɣesiaɣi be wòakpɔ dɔlélea ahadae .

Aleke gbegbee nye lãme asẽ le atikewɔwɔ vɔ megbe kpuie?

Ɣeyiɣi si wòxɔna hafi atikewɔwɔ nadze dɔwɔwɔ gɔme, alo hafi woate ŋu ase atikewɔwɔ ƒe ŋusẽkpɔɖeamedziwo gɔme la nɔ te ɖe nu geɖe dzi. Wò ɖɔktae nye ame nyuitɔ si agblɔ nusi nàkpɔ mɔ na na wò le wò nɔnɔmea, ɣeyiɣi didi si wòaxɔ hafi atikeawo nawɔ dɔ, kple ɣeyiɣi didi si wòaxɔ hafi nàkpɔ tɔtrɔ le wò dzesiwo ŋu nu.

Ðe woate ŋu aɖe alɔ̃madɔmadɔ ƒe dzɔdzɔ dzi akpɔtɔ alo axe mɔ ɖe enua?

Zi geɖe la, alɔ̃madɔmadɔ dzea ame dzi le vome. Eyata manya wɔ be woaɖe afɔku si le eŋu be wòaxɔe dzi akpɔtɔ alo axe mɔ nɛ be wòagaxɔe o.

Nukae wòle be makpɔ mɔ na ne Narcolepsy le ŋunye?

Zi geɖe la, afɔku mele alɔ̃madɔmadɔ ŋutɔ me o. Gake alɔ̃dɔdɔ kpata si dzi womate ŋu aɖu o ate ŋu anye tɔtɔ gã aɖe le agbe me. Ame siwo ŋu nɔnɔme sia le la mate ŋu aku ʋu o (ɣeyiɣi kpui aɖe alo tegbee - enɔ te ɖe woƒe dzesiwo kple nɔnɔmea dzi).

Togbɔ be zi geɖe la, afɔku mele alɔ̃madɔmadɔ me o hã la, le alɔ̃dɔdɔ Ƒomevi 1 me la, afɔku si le abixɔxɔ le anyidzedze me le cataplexy ƒe ɣeyiɣi aɖewo me dzina ɖe edzi. Alɔ̃dɔdɔ ate ŋu ahe nɔnɔme siwo me afɔku le hã vɛ ne wole ʋu kum, le elektrikdɔwɔnuwo alo mɔ̃ sesẽwo zãm, alo le tsi ƒum.

Ne ɖeviwo va xɔ alɔ̃dɔdɔ ƒe dɔléle

Zi geɖe la, ɖevi siwo ŋu alɔ̃madɔmadɔ le la wɔa avu kple nɔnɔmea ƒe ŋusẽkpɔɖeamedziwo. Ŋkeke me alɔ̃dɔdɔ ate ŋu ana wòasesẽ be eƒe susu nanɔ sukudɔwo ŋu, alé hadomekadodowo me ɖe asi, eye wòakpɔ gome le suku kple sukudɔdasiwo godo me.

Gake Narcolepsy nye atikewɔwɔ me dɔléle. Esi wòle alea ta la, ɖevi siwo ŋu Narcolepsy le la dze na ametakpɔkpɔ le se nu. Se bia tso sukuwo hã si be woawɔ dzeƒe. Le kpɔɖeŋu me, klass ƒe ɖoɖowɔɖiwo tɔtrɔ, ɣeyiɣi ɖoɖo ɖi na alɔ̃dɔdɔ alo ɖiɖiɖeme, kple nana be wòanɔ bɔbɔe na ɖeviwo be woano woƒe atikewo le suku. Viwòa ƒe ɖeviwo ƒe dɔdala alo eŋutinunyala bibi bubuwo ate ŋu akpe ɖe ŋuwò nàkpɔ egbɔkpɔnu siwo akpe ɖe viwòa ŋu.

Le ame tsitsi siwo le dɔ wɔm gome (Narcolepsy) .

Abe alesi se kpɔa ɖeviwo ta le sukuwo me ene la, se kpɔa ame tsitsi siwo ŋu alɔ̃madɔmadɔ le hã ta. Wode se ɖe vovototodedeameme ɖe ame aɖe ŋu le atikewɔwɔ ƒe nɔnɔme aɖe ta, si me alɔ̃madɔmadɔ hã le (le kpɔɖeŋu me, le United States la, le Amerikatɔ Nuwɔametɔwo ƒe Sea nu).

Le se ƒe ametakpɔkpɔ ma ta la, amesiwo ŋu alɔ̃madɔmadɔ le ate ŋu aƒo nu kple woƒe dɔtɔwo le woƒe dɔwɔƒewo eye woakpɔ dzeƒe ale be woate ŋu ayi dɔ dzi esime wole woƒe nɔnɔmea dzi kpɔm.

Aleke wòle be malé be na ɖokuinye? (Aɖaŋuɖoɖo nyuiwo)

Ne alɔ̃madɔmadɔ le ŋuwò la, nu geɖe li nàte ŋu awɔ atsɔ akpɔ wò nɔnɔmea gbɔ eye nàkpɔ viɖe geɖe tso wò atikewɔwɔ me. Nu siawo dometɔ geɖe bia be nàlé alɔ̃dɔdɔ ƒe nɔnɔme nyuiwo me ɖe asi (Good Sleep Hygiene) eye nàtrɔ wò ɖoɖowɔɖi kple ɖoɖowɔɖi.

• Lé alɔ̃dɔdɔ ƒe ɖoɖo si mewɔa tɔtrɔ o me ɖe asi : Ne èzu numame na wò be nàmlɔ anyi ahafɔ le ɣeyiɣi ɖeka me la, ate ŋu ana wò alɔ̃dɔdɔ nanyo ɖe edzi.
• Ðo anyimlɔɣi : Ðo anyimlɔɣi si ana nàdɔ alɔ̃ agbɔsɔsɔme si sɔ ɖe wò ƒexɔxɔ nu. Azɔ hã, ɖo ɣeyiɣi ɖi be nàɖe dzi ɖi ahana wò susu nadze akɔ anyi hafi amlɔ anyi.
• Seɖoƒe li na kekeli si klẽna kple elektrɔnikmɔ̃wo : Kekeli si tso mɔ̃ siawo me si gogo mlɔƒe ate ŋu agblẽ wò ŋutilã ƒe alɔ̃dɔdɔ kple nyɔnyrɔ̃ ƒe dzɔdzɔmeŋusẽ me.
• Ƒo asa na aha sesẽ nono, caffeine nono, atama nono, kple nuɖuɖu si gogo hafi mlɔ anyi.: Ne dɔ le wuwòm hafi mlɔ anyi la, nuɖuɖu fafɛ anyo wu. Ne èle atike aɖewo zãm la, ele be nàdzudzɔ ahanono keŋkeŋ (wò ɖɔkta agblɔe na wò ne woŋlɔ atike mawo na wò). Eŋutinunyalawo kafui vevie hã be woadzudzɔ atamanuwo keŋkeŋ (siwo dometɔ aɖewoe nye sigaret, elektrɔnik sigaret ((vaping)), kple atama si me dzudzɔ mele o ((atama si me dzudzɔ mele o))).
• Kamedede : Ne nane abe azɔlizɔzɔ ene koe wònye hã la, kamedede ate ŋu akpe ɖe ŋuwò le wò alɔ̃dɔdɔ ƒe nyonyome me.
• Na alɔ̃dɔdɔ : Zi geɖe la, amesiwo ŋu alɔ̃dɔdɔ ƒe dɔléle le la ƒe lãme sẽna ne wodɔ alɔ̃ vɔ. Ate ŋu akpe ɖe ŋuwò nànya ŋkekea ƒe ɣeyiɣi siwo me nèsena le ɖokuiwò me be yedɔ alɔ̃ wu eye nàwɔ ɖoɖo ɖe wò alɔ̃dɔdɔ ŋu le ɣeyiɣi mawo me lɔƒo.

Ƒo asa na nuwɔna siwo me afɔku le, alo nàwɔ afɔɖeɖewo.

Alɔ̃madɔmadɔ ate ŋu ahe afɔku gãwo vɛ, eye wòate ŋu awu ame gɔ̃ hã. Be nàkpɔ ɖokuiwò kple amesiwo ƒo xlã wò ta la, mègaku ʋu gbeɖe o negbe ɖe ɖɔkta aɖe na wò koŋ hafi .

Ne èkpɔ alɔ̃madɔmadɔ ƒe dzesiwo esime nèle ʋu kum la, dzudzɔ ʋukuku enumake eye nàte ɖe wò ɖɔkta ŋu. Togbɔ be esia maɖe dzi ɖi o hã la, ele vevie be woaxe mɔ ɖe afɔku si wua ame alo atrɔ ame ƒe agbe nu le alɔ̃dɔdɔ le tasiaɖamfɔa dzi ta.

Nu bubu si me alɔ̃madɔmadɔ ate ŋu anye afɔku le etɔxɛe nye tsi me . Ne alɔ̃madɔmadɔ le ŋuwò la, ele vevie ŋutɔ be nàdo agbetsiwui nyuie ɣesiaɣi ne èle tsi ƒum alo le tɔdziʋu alo tsidziʋu ɖesiaɖe si kafu agbetsiwui aɖe me. Ne agbeɖenu aɖeke meli o la, alɔ̃dɔdɔ le tsia me ate ŋu ahe ku vɛ.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne èdɔ alɔ̃ kpata, le vome la, enye dzesi be ehiã be nàyi ɖɔkta gbɔ. Menye alɔ̃madɔmadɔ koe esia nye o, ke ate ŋu afia atikewɔwɔ me nɔnɔme vovovowo hã. Wo dometɔ aɖewo nyea nu veviwo. Zi geɖe la, zi alesi nèhe dɔlélea didi kple edada ɖe megbe la, zi nenemae kuxiwo ate ŋu ado mo ɖa alo zi nenemae atikewɔwɔa mewɔa dɔ nyuie o.

Ɣekaɣie wòle be mayi Atikewɔwɔ Kpata ƒe Dɔwɔƒe (ETU) ?

Ne èdze anyi kpata alo mègatsi dzodzodzoe la, yi atikewɔƒe enumake le kɔdzi alo xɔ si me wokpɔa dɔnɔwo gbɔ kpata le. Esia nye nɔnɔme geɖe ƒe dzesi vevi aɖe, siwo dometɔ aɖewoe nye dzidɔ, ʋusɔgbɔdɔ, kple dzi ƒe tsotso si mesɔ o. Nɔnɔme siawo nye atikewɔwɔ kpata eye wohiã be woawɔ atike na wo enumake.

Nuveviwɔame siwo dona tso anyidzedze me nye abi siwo dzɔna ne èdze anyi le vome, abe le esi wohe wò alo wò susu ƒe dɔwɔwɔ ene.Afɔku li be woaxɔ abi. Di atikewɔlawo ƒe aɖaŋuɖoɖo ɣesiaɣi ne èsusu be ɖewohĩ yexɔ abi le yeƒe ta, kɔ, alo yeƒe akɔta ƒe akpa aɖe. Akɔta ƒe gbagbã kple abi ate ŋu agblẽ nu le eŋu tegbee, wòazu lãmetututɔ, eye wòaku gɔ̃ hã.

Ne èdze anyi, eye nèle ʋukaɖitike ƒomevi ɖesiaɖe zãm, vevietɔ ne èƒo ta la, ele be nàyi atikewɔƒe enumake. Amedzidzedze kple abixɔxɔ ate ŋu ana ʋu nado le ememe si me afɔku le. Ele be nàkpɔ egbɔ be yekpɔ egbɔ be abi aɖeke mele ye ŋu si ate ŋu ahe kuxi siwo ate ŋu ade wò agbe afɔku me vɛ o.

Nu vevitɔ kekeake siwo dzi wòle be nàɖo ŋkui (Take-Home Message) .

Eyata, mele mɔ kpɔm be ète ŋu ɖo ŋku nu vevi aɖewo dzi tso nusiwo ŋu míeƒo nu tsoe (Narcolepsy) me.

• Menye alɔ̃dɔdɔ si ɖeɖiteameŋu hena vɛ koe alɔ̃madɔmadɔ nye o. Enye kuxi si le ahɔhɔ̃a ƒe ŋutete be wòaɖɔ alɔ̃dɔdɔ kple ŋudzɔnɔnɔ ɖo ŋu.
• Nya nu tso alɔ̃dɔdɔ fũu akpa le ŋkeke me, cataplexy (lãmekawo ƒe gbɔdzɔgbɔdzɔ kpata), susumesusu siwo do ƒome kple alɔ̃dɔdɔ, kple alɔ̃dɔdɔ ƒe lãmetutudɔ ƒe dzesi veviwo ŋu . Menye dzesi siawo katãe dzena le amesiame ŋu o.
• Zi geɖe la, nusi gbɔ nɔnɔme sia tsonae nye atike si nye orexin si le ahɔhɔ̃a me ƒe ɖiɖi, alo dɔlélenutsiŋutete ƒe kuxiwo.
• Alɔ̃dɔdɔ bia be woawɔ dodokpɔ tɔxɛwo le atikewɔwɔ me hafi anya dɔlélea. Eyata mègati kpo aƒo nya ta le ɖokuiwò si o.
• Togbɔ be womate ŋu ada esia keŋkeŋ o hã la, enye dɔléle si dzi woate ŋu aɖu akpa gãtɔ to atikewo kple agbenɔnɔ ƒe tɔtrɔ me .
• Bu dedienɔnɔ ŋu nyuie. Kpɔ nyuie vevietɔ ne èle ʋu kum, le tsi ƒum, eye nèle dɔ wɔm le teƒe kɔkɔwo. Wɔ ɖe atikewɔlawo ƒe aɖaŋuɖoɖowo dzi.
• Ne dzesi siawo le ŋuwò la, mègavɔ̃ be yeayi ɖɔkta gbɔ o. Menye wò ɖeka koe o. Kpekpeɖeŋu li.

Mele mɔ kpɔm be nyatakaka sia akpe ɖe ŋuwò. Ne wò ŋutɔ alo ame aɖe si nènya le kuxi sia ƒomevi me tom la, anyo wu be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo kaba ale si nàte ŋui.

` Alɔ̃dɔdɔ, alɔ̃dɔdɔ fũu akpa le ŋkeke me, cataplexy, alɔ̃dɔdɔ ƒe gbɔgbɔtsixetsixe, alɔ̃dɔdɔ ƒe susumenuwo, orexin, ahɔhɔ̃medɔlélewo