Ðe nètsi dzi ɖe viwòa ƒe lãmesẽ ŋua? Ekema ele be nànya nu tso NIPT (Noninvasive Prenatal Testing) ŋu!

Esi wònye be èle mɔ kpɔm fifia be yeazu vidada ta la, ànya nɔ tame bum geɖe le ɖokuiwò kple viwò sue si le wò dɔme ƒe lãmesẽ ŋu, alo? Eyata egbea míele nu ƒom tso dodokpɔ tɔxɛ aɖe si woate ŋu awɔ le fufɔɣi ŋu. Woyɔa esia be NIPT (Noninvasive Dodokpɔ Do Ŋgɔ Na Vidzidzi). Esia wɔnɛ be nète ŋu srɔ̃a nyatakaka vevi aɖewo tso viwòa ƒe lãmesẽ ŋu evɔ magblẽ nu le wò ŋutɔ alo vidzĩa ŋu o.

Nukae nye NIPT (Dodokpɔ Do Ŋgɔ Na Vidzidzi Si Me Womezãa Nu Le O)?

Kpuie ko la, NIPT nye dodokpɔ si wowɔna le wò fufɔɣi be woakpɔe ɖa be domenyiŋusẽfianu ƒe dɔléle aɖewo le viwò si le dɔ me hã ŋu . Le kpɔɖeŋu me, eléa ŋku ɖe afɔku si le nɔnɔmewo abe Down ƒe dɔléle ( Trisomy 21) , Trisomy 18 ( Edwards ƒe dɔléle) , kple Trisomy 13 (Patau ƒe dɔléle) ene ŋu hã. Ate ŋu agblɔ viwòa ƒe gbɔdɔdɔ hã na wò.

Wowɔa esia kple ʋu si woɖe le asiwò. Megawɔ nuku o be viwòa ƒe DNA (Deoxyribonucleic Acid) ƒe agbɔsɔsɔ sue aɖe ŋutɔ le wò ʋu me . DNA ye nye nusi wotsɔ wɔ míaƒe domenyiŋusẽfianuwo kple domenyiŋusẽfianuwoe. Ele abe míaƒe ŋutilã ƒe nɔnɔmetata ene. Eyata ne ɖɔktawo do DNA kakɛ siawo kpɔ la, woate ŋu akpɔ vidzĩa ƒe domenyiŋusẽfianu ŋuti nyatakaka aɖewo. Woɖoa ʋu sia ɖe dodokpɔxɔ aɖe be woadoe kpɔ. Gake ɖo ŋku edzi be NIPT mate ŋu ade dzesi domenyiŋusẽfianu alo domenyiŋusẽfianu ƒe nɔnɔme ɖesiaɖe o.

Wotsɔ ŋkɔ bubuwo yɔa NIPT dodokpɔ sia. Ame aɖewo yɔnɛ be DNA dodokpɔ si me lãmenugbagbeviwo mele o alo cfDNA dodokpɔ . Ame bubuwo yɔe be dodokpɔ si wowɔna do ŋgɔ na vidzidzi si me womewɔa nuvevi ame o alo NIPS . Mègavɔ̃ ne èse ŋkɔ siawo o, wo katã nye dodokpɔ ɖeka.

Ele vevie ŋutɔ be míade dzesii be dodokpɔ si wowɔna tsɔ doa ame kpɔe nye esia , ke menye dodokpɔ si wotsɔ dia dɔlélewoe o . Esia fia be ɖeko wògblɔa alesi wòanya wɔ be viwòa naxɔ dɔléle aɖe alo madze edzi o. Mate ŋu agblɔe kple kakaɖedzi be, ‘Ẽ, dɔléle sia le viwò ŋu’ alo ‘Ao, dɔléle sia mele viwòa ŋu o.’ Mate ŋu agblɔe kple kakaɖedzi o.

Ne ètiae be yeado NIPT dodokpɔa alo màtiae o la nye wò nyametsotso bliboe. Wò ɖɔkta ana nyatakaka wò tso esia ŋu eye wòakpe ɖe ŋuwò nàwɔ nyametsotso nyuitɔ kekeake na wò.

Nuka tututue NIPT dodokpɔa dia?

Abe alesi míegblɔe va yi ene la, NIPT mate ŋu ade dzesi domenyiŋusẽfianu ƒe nɔnɔmewo alo vidzidzidɔlélewo katã o. Zi geɖe la, NIPT dodokpɔwo dia:

• Down ƒe dɔléle (Trisomy 21) .
• Trisomy 18 ƒe dɔwɔwɔ
• Trisomy 13 ƒe dɔwɔwɔ
• Nusiwo mesɔ o siwo do ƒome kple gbɔdɔdɔ ƒe domenyiŋusẽfianu (X kple Y) .

Dzɔdzɔmenugbagbevi bubu aɖe gbɔe Down syndrome, trisomy 18, kple trisomy 13 tsona. Gbɔdɔdɔ ƒe domenyiŋusẽfianu dodokpɔ ate ŋu anya vidzĩa ƒe ŋutsu alo nyɔnu nyenye eye ate ŋu alé ŋku ɖe tɔtrɔ ɖesiaɖe si le gbɔdɔdɔ ƒe domenyiŋusẽfianu ƒe xexlẽme si sɔ me hã ŋu. Gbɔdɔdɔ ƒe domenyiŋusẽfianu ƒe nɔnɔme siwo bɔ dometɔ aɖewoe nye Turner ƒe dɔléle , Klinefelter ƒe dɔléle , Triple X ƒe dɔléle, kple XYY ƒe dɔléle . Gake nenɔ susu me na wò be menye NIPT dodokpɔwo katãe dea dzesi nɔnɔme siawo katã o. Eyata ele vevie be nàƒo nu kple wò ɖɔkta tso nusi wò NIPT dodokpɔa adi ŋu.

Nukatae wowɔa NIPT dodokpɔ sia? Amekae wònyo na?

NIPT kpena ɖe ame ŋu wònyaa afɔku si le vidzĩ si woadzi kple domenyiŋusẽfianu ƒe dɔmawɔmawɔ nyuie me. Ðɔktawo ate ŋu akafu dodokpɔ sia le nɔnɔme siwo gbɔna me:

• Ne vi aɖe le asiwò xoxo si ƒe domenyiŋusẽfianu ƒe dɔmawɔmawɔ nyuie.
• Ne ultrasound scan na wò ɖee fia be vidzĩa ate ŋu anye nusi mesɔ o.
• Ne wodo dodokpɔ aɖe na wò va yi si ɖee fia be kuxi aɖe ate ŋu anɔ ŋuwò.

Tsã la, Amerika Vidzidzi Kple Nyɔnuwo ƒe Dɔléleŋutinunyalawo ƒe Kɔledzi (ACOG) kafua NIPT tsã ne èfɔ fu si me afɔku le ŋutɔ . Ema fia be ɖewohĩ ne èxɔ wu ƒe 35, alo ne nɔnɔme siawo dometɔ ɖeka nɔ wò ƒomea me kpɔ. Gake fifia wole gbɔgblɔm be ele be woana funɔwo katã, afɔku ka kee ɖale eme o, nanya nu tso NIPT ŋu eye woana mɔnukpɔkpɔ wo be woaxɔe.

Le NIPT dodokpɔa me tsonu nu la, wò vidzidziŋutinunyala ate ŋu aɖo aɖaŋu na wò be nàwɔ dodokpɔ siwo ana nànya dɔlélea . Abe alesi míegblɔe va yi ene la, dodokpɔ si wowɔna tsɔ doa ame kpɔna koe gblɔa alesi wòanya wɔe na wò. Dodokpɔ si wotsɔ dia dɔlélewoe nye esi ate ŋu ana ŋuɖoɖo si ŋu kakaɖedzi le be ‘ɛ̃’ alo ‘ao’ nanya nenye be dɔléle aɖe le viwòa ŋu.

Ɣekaɣie wòle be woawɔ NIPT dodokpɔa le fufɔɣi?

Zi geɖe la, wowɔa NIPT dodokpɔa le fufɔfɔ ƒe kwasiɖa 10 megbe, gake woate ŋu awɔe ɣesiaɣi vaseɖe esime woadzi vidzĩa . Zi geɖe la, womewɔnɛ do ŋgɔ na kwasiɖa 10 o. Esia le alea elabena ɖewohĩ fugboe ƒe DNA masɔ gbɔ le vidadaa ƒe ʋu me do ŋgɔ na ɣeyiɣi ma be woate ŋu awɔ dodokpɔa pɛpɛpɛ o.

Aleke gbegbee NIPT dodokpɔwo de pɛpɛpɛe?

Nya sia nye nya si ame geɖe biana. Dodokpɔa ƒe nyateƒenyenyeEnɔ te ɖe nɔnɔme si me wole dodokpɔ wɔm le dzi. Azɔ hã, nuwo abe ne èle mɔ kpɔm na venɔviwo, ne èle vi tsɔm na ame bubu (fufɔfɔ teƒe), alo ne èlolo akpa ate ŋu akpɔ ŋusẽ ɖe NIPT me tsonu dzi.

Zi geɖe la, NIPT dea pɛpɛpɛ abe 99% ene le Down ƒe dɔlélea didi me. Ðewohĩ made pɛpɛpɛ vie le trisomies 18 kple 13 didi me o. Le nusianu me la, alakpadɔléle ʋɛ aɖewo koe le NIPT me wu dodokpɔ bubu siwo wowɔna do ŋgɔ na vidzidzi, abe quad screen ene. Esia fia be dodokpɔa meɖea alakpanya fiana o ne womekpɔ ŋusẽ ɖe vidzĩa dzi o.

Ðe NIPT dodokpɔa ate ŋu anya vidzĩa ƒe gbɔdɔdɔa?

Ẽ, NIPT dodokpɔa ate ŋu agblɔ fugboea ƒe gbɔdɔdɔ ɖi. Dzila geɖe dina vevie be yewoanya esia, alo?

Ðe wòhiã be woado NIPT kpɔ le fufɔɣia?

Ao, esia menye sedziwɔwɔ o. Esia nye ame ŋutɔ ƒe nyametsotso kura. Enye nusi sɔ be nyabiasewo nanɔ ame si tso esia ŋu. Wò ɖɔkta agblɔ dodokpɔ bubu siwo nàte ŋu awɔ do ŋgɔ na vidzidzi, siwo dome NIPT hã le, la katã na wò. Nu geɖe ate ŋu akpɔ ŋusẽ ɖe nyametsotso be woawɔ NIPT dzi. Ne nyametsotsowɔwɔ le kuxi me tom na wò, alo ne èdi be yeaƒo nu tso dodokpɔ sia ŋu tsitotsito la, domenyiŋusẽfianu ŋuti aɖaŋuɖola ate ŋu aɖe dodokpɔ siawo siwo woate ŋu awɔ do ŋgɔ na vidzidzi me na wò eye wòakpe ɖe ŋuwò nàtia esi nyo na wò.

Aleke ɖɔktawo wɔa NIPT dodokpɔ siae?

Esia le bɔbɔe ŋutɔ. Nusi wò ɖɔkta wɔna koe nye be wòaɖe ʋu tso ʋuka aɖe si le wò alɔnu me . Woɖoa ʋu sia ɖe dodokpɔxɔ aɖe be woakpɔe ɖa be naneke mesɔ le vidzĩa ƒe DNA me hã.

DNA le mí katã si le míaƒe lãmenugbagbeviwo me. Lãmenugbagbevi siawo le mamam ɣesiaɣi hele lãmenugbagbevi yeyewo wɔm. Ne lãmenugbagbeviwo gblẽ la, DNA (DNA kakɛwo) suesuesuewo va wu enu ɖe ​​míaƒe ʋu me. Ne èfɔ fu la, viwòa ƒe DNA ƒe akpa sue aɖe ŋutɔe ƒoa xlã wò ʋu. Woyɔa esia be DNA si me lãmenugbagbeviwo mele o, alo cfDNA . NIPT dodokpɔa dia viwòa ƒe DNA ƒe akpa aɖewo le wò ʋu me.

Ele vevie be nàɖo ŋku edzi be exɔa abe kwasiɖa 10 ene hafi vidzĩa ƒe DNA si sɔ la ƒoa ƒu ɖe wò ʋu me. Esia tae womewɔa dodokpɔ sia o vaseɖe kwasiɖa 10 le fufɔfɔa megbe.

Ðe afɔku aɖewo le NIPT dodokpɔa mea?

NIPT dodokpɔwo le dedie ŋutɔ. Afɔku aɖeke mele vidzĩa ŋu o. Elabena ɖeko wòbia be woaxɔ ʋu sue aɖe tso vidada si fɔ fu la gbɔ. Eyata naneke meli si ŋu woatsi dzi ɖo o.

Ɣekaɣie maxɔ nye dodokpɔa me tsonu?

Ate ŋu axɔ kwasiɖa eve ɣeaɖewoɣi hafi woakpɔ NIPT dodokpɔa me tsonu.Àte ŋu ayi. Gake ɣeyiɣi aɖewo li siwo me nèkpɔa emetsonuwo do ŋgɔ. Wò ɖɔktae xɔa emetsonuwo gbã. Emegbe ana nànya nu tso emetsonu mawo ŋu.

Nukae NIPT dodokpɔa me tsonu gblɔ?

Esi wònye be NIPT nye dodokpɔ si wotsɔ doa ame kpɔ ta la, menaa ŋuɖoɖo ‘ɛ̃’ alo ‘ao’ nenye be dɔléle aɖe le viwòa ŋu o. Nusiwo do tso eme ɖee fia nenye be afɔku si le viwòa ŋu be wòaxɔ dɔlélea dzi ɖe edzi alo edzi ɖe kpɔtɔ . Wò dodokpɔ me tsonuawo gɔmesese ate ŋu asesẽ vie ɣeaɖewoɣi. Eyata ne mèka ɖe edzi o la, bia wò ɖɔkta be wòana eme nakɔ wò.

Nudokpɔƒe geɖe naa emetsonu vovovowo le nɔnɔme ɖesiaɖe si wodo kpɔ me. Le kpɔɖeŋu me, àte ŋu akpɔ Trisomy 13 ƒe dodokpɔ nyui (afɔku gã aɖe) , gake Down ƒe dɔlélea ƒe dodokpɔ me tsonu manyomanyo (afɔku si le sue) .

Azɔ hã, ɣeaɖewoɣi la, ate ŋu ado tso eme o, elabena vidzĩa ƒe DNA mesɔ gbɔ le wò ʋu me o, alo womate ŋu ade dzesi vidzĩa ƒe DNA nyuie o. Le nɔnɔme ma me la, àte ŋu ana woagawɔ NIPT dodokpɔa ake. Le nɔnɔme mawo me la, wò ɖɔkta ate ŋu ana mɔfiame nyuitɔ kekeake wò.

Ke ne emetsonuwo nye nu nyuiwo/afɔku gã aɖe ya ɖe?

Ne NIPT dodokpɔa ɖee fia be viwòa le afɔku me be domenyiŋusẽfianu ƒe dɔmawɔmawɔ nyuie aɖe nadze viwòa ŋu la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàdoe kpɔ be yeakpɔ dɔlélea . Dodokpɔ siawo ate ŋu agblɔe godoo be ‘ɛ̃’ alo ‘ao’ nenye be nɔnɔme aɖe li. Dodokpɔ siawo dometɔ aɖewoe nye:

• Amniocentesis: Esia bia be nàɖe vidzidɔ me tsi sue aɖe ɖa le wò vidzidɔ me. Woate ŋu awɔ dodokpɔ sia le fufɔfɔ ƒe kwasiɖa 15 megbe.
• Chorionic Villus Sampling (CVS): Dodokpɔ sia xɔa lãmenugbagbeviwo ƒe kpɔɖeŋu tso vidzidɔa me. Woɖoa lãmenugbagbevi sia ƒe kpɔɖeŋu ɖe dodokpɔxɔ aɖe be woadoe kpɔ. Woate ŋu awɔ esia le fufɔfɔ ƒe kwasiɖa 10 va ɖo 13 dome.

Ele vevie ŋutɔ be nàƒo nu kple wò ɖɔkta nyuie tso wò NIPT me tsonu ŋu eye nàxɔ nyatakaka siwo katã nèhiã tso nusi nàwɔ emegbe ŋu.

Ðe NIPT dodokpɔa ate ŋu anye nusi mesɔ o le Down ƒe dɔlélea gomea?

Esi wònye be NIPT nye dodokpɔ si wotsɔ doa ame kpɔ ta la, mede pɛpɛpɛ 100% o. Esia tae míegblɔna be afɔku koe wòfia. Eyata ele vevie be nàƒo nu kple wò ɖɔkta be nànya nu geɖe tso wò dɔwɔwɔ me tsonu kple wò tiatia siwo nàgawɔ ŋu.

Ðe wòsɔ be woawɔ NIPT dodokpɔa?

Wò ŋutɔ gbɔe wòtso be nàtso nya me nenye be woawɔ dodokpɔ si woatsɔ adoe kpɔ do ŋgɔ na vidzidzi abe NIPT ene alo domenyiŋusẽfianu ƒe dodokpɔ bubu. Wò ɖɔkta ate ŋu aɖo nyabiase ɖesiaɖe si anɔ asiwò ŋu. Gake mlɔeba la, wò ŋutɔ gbɔe wòtso be nàtso nya me le alesi domenyiŋusẽfianu alo domenyiŋusẽfianu ƒe dɔmawɔmawɔ nyuie aɖe akpɔ ŋusẽ ɖe wò kple wò ƒomea dzii, le wò nɔnɔme tɔxɛa nu.

Nyabiase siawo akpe ɖe ŋuwò nàwɔ nyametsotso:

• Aleke mase le ɖokuinye me ne dodokpɔ me tsonu nyui aɖe?
• Ðe malɔ̃ be mawɔ dodokpɔ siwo me woakpɔ dɔlélewo le abe amniocentesis alo CVS enea?
• Ne mekpɔe be domenyiŋusẽfianu ƒe dɔléle aɖe le vinye ŋu, alo domenyiŋusẽfianu ƒe dɔléle aɖe le afɔku me wu la, ɖe mawɔ tɔtrɔ aɖewoa?
• Ðe nyatakaka siawo nyanya ana malé blanui alo atsi dzimaɖia, alo ɖe wòakpe ɖe ŋunye madzra ɖo ɖe vidzĩa dzi kpɔkpɔ ŋua?
• Ðe nyatakaka siawo nyanya akpe ɖe nye ɖɔktawo ŋu be woakpɔ vinye dzi nyuie wua?

Ga home nenie NIPT dodokpɔa xɔna?

Ga si woatsɔ awɔ NIPT dodokpɔ ate ŋu ato vovo. Lãmesẽnyawo ŋuti nugblẽfexeha akpa gãtɔ xea ga sia ƒe akpa gãtɔ (alo wo katã gɔ̃ hã). Ame aɖewo ya teti ƒoa nu tso ɖewo ŋu. Eyata anyo be nàbia wò nugblẽfexeha hafi awɔ dodokpɔa. Ne nugblẽfexeɖoɖo mele asiwò o, alo wò nugblẽfexeha mexea fe ɖe NIPT dodokpɔ ta o la, wò ŋutɔ àte ŋu axe fe ɖe eta.

Ðe woate ŋu awɔ NIPT le kwasiɖa 14 megbea?

Ẽ, woate ŋu awɔ NIPT ɣesiaɣi le fufɔfɔ ƒe kwasiɖa 10 megbe. Ema fia be kuxi aɖeke menɔa eŋu le kwasiɖa 14 gɔ̃ hã me o.

Nukae wòle be mabia nye ɖɔkta tso NIPT dodokpɔa ŋu?

Dodokpɔ abe NIPT ene wɔwɔ nye ame ŋutɔ ƒe nyametsotso. Nyabiase aɖewo ate ŋu anɔ asiwò ku ɖe nusi wò dodokpɔa me tsonu fia ŋu, alo nenye be ele be nàwɔ NIPT dodokpɔa. Mègavɔ̃ be yeabia nya o. Ðo ŋku edzi be wò ɖeka koe ate ŋu atso nya me le nusi anyo na wò kple wò ƒomea ŋu.

Nyabiase siwo bɔ siwo nàte ŋu abia wò ɖɔktae nye esi:

• Ne nyee nènye la, ɖe nàwɔ NIPT dodokpɔa?
• Ne nye dodokpɔ si me wodo kpɔ la ɖee fia be dɔlélea le ŋunye la, afɔɖeɖe kawoe kplɔe ɖo?
• Ðe domenyiŋusẽfianu ŋuti aɖaŋuɖola aɖe li si aƒo nu tso nye tiatiawɔblɔɖe ŋua?
• Nukae nye alesi wòanya wɔ be woakpɔ alakpanya nyuiwo?

Tsɔ gbedasi yi aƒeme

Enyo, eyata NIPT dodokpɔa nye dodokpɔmɔnu si ŋu kakaɖedzi le ŋutɔ si doa ŋgɔ na vidzidzi si daa afɔku si le domenyiŋusẽfianu ƒe dɔmawɔmawɔ nyuie me le vidzĩ si le dɔ me ŋu. Dodokpɔ sia ate ŋu ana nyatakaka tso vidzĩa ƒe gbɔdɔdɔ hã ŋu. NIPT dodokpɔa mekpɔa dɔléle aɖeke o – ɖeko wòfia be nɔnɔme aɖe ate ŋu anɔ vidzĩa ŋu wu . Ne woxɔ NIPT ƒe dodokpɔ me tsonu vɔ la, woate ŋu akafui be woado dɔlélewo kpɔ. Dodokpɔ siwo wowɔ do ŋgɔ na vidzidzi abe NIPT ene menye sedziwɔwɔ o, eye wò ŋutɔ gbɔe wòtso bliboe ne woadoe kpɔ alo womawɔe o.Ðo dze kple wò ɖɔkta alo domenyiŋusẽfianu ŋuti aɖaŋuɖola tso nusiwo ŋu nètsi dzi ɖo ŋu. Ele vevie be nàse nusi tututu dim dodokpɔa le kple nusi emetsonuwo fia gɔme, eye nàwɔ nyametsotso si ŋu wonya nu tsoe. Mele nu nyuiwo dim na wò kple viwòa!

` NIPT, Noninvasive Do ŋgɔ na Vidzidzi Dodokpɔ, dodokpɔ do ŋgɔ na vidzidzi, Down syndrome, domenyiŋusẽfianu ƒe tɔtrɔ, fufɔfɔ, cfDNA, vidzĩ ƒe lãmesẽ