Èbu nu wɔnuku nenie dzɔna le míaƒe ŋutilã me ŋu kpɔa? Ɣeaɖewoɣi, esi míenya gɔ̃ hã o la, mɔnu wɔnuku geɖewo li siwo nana míaƒe ŋutilã nɔa lãmesẽ me. Le kpɔɖeŋu me, esi kpena ɖe mía ŋu míeɖua míaƒe ʋu ƒe sisi dzi la ŋkɔe nye Renin. Egbea, mina míaƒo nu tso nusi Renin nye, alesi wòwɔa dɔe, kple alesi wòle vevie na míaƒe lãmesẽ ŋu.

Nukae nye Renin? Kpuie ko la,...

Enyo, azɔ mina míakpɔ nusi renin sia nye ɖa. Kpuie ko la, renin nye enzyme si lãmenugbagbevi tɔxɛ siwo le wò ayiku me wɔ. Mègavɔ̃ enzyme aɖeke o, enye protein si kpena ɖe ame ŋu be atike vovovowo ƒe dɔwɔwɔ kabakaba le míaƒe ŋutilã me.

Ŋutsu sia si woyɔna be renin la, menye eya ɖeka koe wɔa dɔ o. Enye mɔ̃ si lolo wu si woyɔna be renin-angiotensin-aldosterone system (RAAS) ƒe akpa aɖe. Ele abe kɔsɔkɔsɔ ƒe nuwɔna ene. Taɖodzinu vevitɔ si le ɖoɖo blibo sia ŋue nye be wòana wò ʋu ƒe sisi naɖu dzi. Etɔxɛe la, renin kpɔa ŋusẽ ɖe lãmetsi aɖe si woyɔna be aldosterone, si míaƒe adrenal glands (gland sue siwo le ayiku tame) wɔna dzi.

Eyata aleke Renin sia wɔa dɔe?

Azɔ akpa vevitɔae nye esi. Renin ƒe dɔ vevitɔe nye be wòaɖu ʋu ƒe sisi dzi. Ewɔa esia kpe ɖe lãmetsi vevi eve bubu siwo woyɔna be angiotensin kple aldosterone ŋu. Ne wotsɔ ame etɔ̃ siawo ƒo ƒui la, wokpena ɖe ŋuwò be sodium (dze) kple potassium ƒe agbɔsɔsɔ si le wò ŋutilã me natsi.

Kpɔe ɖa le susu me be esia le dzɔdzɔm:

1. Gbã la, renin trɔa angiotensinnogen (si nye angiotensin ƒe ŋgɔdonya) si wò aklã wɔ la wòzua angiotensin I ( angiotensin, si nye lãmetsi si nana wò ʋukawo tsia).

2. Emegbe, angiotensin I sia trɔna zua angiotensin II .

3. Fifia angiotensin II siae nye dɔwɔsɔ ŋutɔŋutɔ. Enaa wò ʋukawo me mekɔna o eye wòkpena ɖe ŋuwò hã be lãmetsi si nye aldosterone la dona.

4. Mlɔeba la, aldosterone sia kpena ɖe wò ayiku ŋu be tsi kple dze (sodium) nɔa wò ŋutilã me. Esia nana tsi si le wò ŋutilã me dzina ɖe edzi. Esiae nana wò ʋu ƒe sisi dzina ɖe edzi.

Kpuie ko la, ne ʋu ƒe sisi ɖiɖi la, ŋutsuvi aɖe si woyɔna be renin gena ɖe eme, xɔa ame ʋɛ bubuwo ɖe dɔ me, xea ʋuka aɖewo, eléa tsi aɖe ɖe ŋutilãa me, eye wònana ʋu ƒe sisi gaɖoa eƒe nɔnɔme nyuitɔ me.

Aleke woɖea renin donae? Ɣekaɣie?

Enyo, fifia biabia aɖe le asiwò: ɖeko wowɔa renin sia le ŋutilãa mea, alo ɖe wòdona le ɣeyiɣi aɖewo koŋ mea? Renin dona ɖe wò ʋukawo me ne wò ʋu ƒe sisi ɖiɖi akpa, alo ne sodium (dze) si sɔ le wò ŋutilã me bu.

Etɔxɛe la, nu siwo gbɔna kpɔa ŋusẽ ɖe renin ƒe dodo dzi:

• Baroreceptors (esiawo nye nusiwo sea nyaƒoɖeamenu) siwo le wò ʋukawo me la sea ʋu ƒe sisi ƒe ɖiɖi.
• Ne wò ayikuwo de dzesi dze (sodium) si mesɔ gbɔ o le wò ŋutilã me.
• Beta 1 adrenergic receptors, siwo kpɔa wò dzi ƒe tsotso dzi la dea dzesi dɔwɔwɔ le wò veveseseɖeamenu ƒe lãmekawo me (esia dzɔna ne míetsi dzimaɖi alo vɔvɔ̃ ɖo).

Ðe renin ɖeɖe dzaa dzia ʋu ƒe sisi ɖe edzia?

Ao, menye nenema tututue o. Renin ɖeɖe mekpɔa ŋusẽ ɖe wò ʋu ƒe sisi dzi o. Ke boŋ abe alesi wògblɔe va yi ene la, ewɔa dɔ ɖekae kple angiotensin kple aldosterone. Angiotensin nana wò ʋukawo me mekɔna o, eye aldosterone kpena ɖe wò ayikuwo ŋu be tsi kple dze nɔa wo me. Esiae nana tsi geɖe nɔa wò ŋutilã me eye wònana wò ʋu ƒe sisi dzina ɖe edzi.

Afikae wowɔa renin le?

Ðewohĩ ènya esia fifia. Wowɔa renin le wò ayiku me. Ne wò ʋu ƒe sisi le ʋuka me (xexlẽme si le ŋgɔ wu ne èle ʋu ƒe sisi dzidzem) ɖiɖi, alo ne wò ayikuwo kpɔe be tsi mesɔ gbɔ ɖe yeƒe ŋutilã me o la, woɖea renin ɖea wò ʋukawo me.

Nukae wotsɔ wɔa renin? (Esia nye dzɔdzɔmeŋutinunya vie, gake enyo be nànya.)

Esia nye nya si me goglo vie, gake ne míagblɔe kpuie la, amino acid ƒe nugbagbevi siwo ade 340 ye le renin me. Amino acidwo le abe proteinwo ƒe xɔtunu suesuesuewo ene. Esiawo va ƒoa ƒu wɔa enzyme si nye renin. Ele abe anyikpe gbogbo aɖewo siwo le ƒoƒom ɖekae tsɔ wɔ gli ene.

Atikewɔwɔ me nɔnɔme kawoe ate ŋu ado ƒome kple renin ƒe wɔwɔ?

Ɣeaɖewoɣi la, renin ƒe agbɔsɔsɔ ate ŋu adzi ɖe edzi le ŋutilãa me. Nu siawo tɔgbe ate ŋu ahee vɛ:

• Ʋusɔgbɔdɔ (Hypotension) .
• Ne ʋu geɖe bu le ŋuwò (e.g. tso afɔku me).
• Ne wò ayikuwo me ʋu ƒe sisi dzi ɖe kpɔtɔ .
• Volume ƒe ɖiɖi (e.g., tsikuɖiɖi le ʋuʋudedi alo dɔgbo ƒe vevesese ta).
• Veveseseɖeamenu ƒe lãmekawo ƒe dɔwɔwɔ ƒe dzidziɖedzi (Sympathetic nerve activation) (le go sia me la, dzi ƒe tsotso, gbɔgbɔ ƒe tsotso, ʋu ƒe sisi dzina ɖe edzi, eye ŋkuawo ƒe gotagome yibɔwo va lolona).

Ðe dodokpɔwo li woatsɔ akpɔ renin ƒe agbɔsɔsɔa?

Ẽ, keŋkeŋ. Wò ɖɔkta ate ŋu awɔ renin ƒe dɔwɔwɔ dodokpɔ kple aldosterone ƒe agbɔsɔsɔ dodokpɔ. Esia ana wòanya aldosterone agbɔsɔsɔme si wò adrenal glandwo le wɔwɔm.

Ne ʋusɔgbɔdɔ le ŋuwò, vevietɔ ne atike siwo nèzãna ɖaa mekpɔ ŋusẽ ɖe edzi o la, wò ɖɔkta ate ŋu aɖe gbe be nàdoe kpɔ.Ðewohĩ dɔléle aɖe si woyɔna be primary aldosteronism (PA) (si woyɔna hã be Conn ƒe dɔléle) le ŋuwò . Le nɔnɔme sia me la, wowɔa aldosterone fũ akpa, si hea ʋusɔgbɔdɔ vɛ. Renin dodokpɔ ate ŋu akpe ɖe ŋuwò nànya ne PA gbɔe wò ʋusɔgbɔdɔ tso.

Aleke wodzidzea renin?

Zi geɖe la, wotsɔa nane si woyɔna be plasma renin activity (PRA) dzidzea renin . Esia dzidzea alesi renin le angiotensin I (si nye angiotensin II ƒe ŋgɔdonya) wɔm nyuie. Woate ŋu adzidzee hã be enye renin tẽ .

Nukae wòfia ne wò renin ƒe agbɔsɔsɔ sɔ gbɔ?

Ne wò renin ƒe agbɔsɔsɔ sɔ gbɔ la, ate ŋu atso:

• Addison ƒe dɔléle (afisi wò adrenal glands mewɔa lãmetsiŋusẽ si sɔ o) - vevietɔ ne ŋutilã me tsi dzi ɖe kpɔtɔ.
• Tsikuɖiɖi (tsi ƒe anyimanɔmanɔ le ŋutilã me).
• Potassium ƒe agbɔsɔsɔ si bɔbɔ ɖe ʋu me (hypokalemia) .
• Ʋudodo (ʋu gbogbo aɖe si sina le ŋutinu aɖe me alo egodo).
• Ayiku me dɔdzẽ siwo naa renin .
• Ayiku me ʋusɔgbɔdɔ (ʋu ƒe sisi si tsoa ʋuka siwo kplɔa ame yia ayiku gbɔ ƒe ʋuʋu gbɔ).
• Ʋusɔgbɔdɔ vɔ̃ɖi (esia nye ʋusɔgbɔdɔ si va kpata, nuxlɔ̃ame aɖeke manɔmee ).
• Ʋusɔgbɔdɔ gbãtɔ (esia nye ʋusɔgbɔdɔ si menye atikewɔwɔ me nɔnɔme bubu aɖe gbɔe wòtso o).
• Dzi ƒe dɔmawɔmawɔ nyuie alo aklã ƒe ʋuʋu (ne ʋu ƒe agbɔsɔsɔ si le dɔ wɔm le ŋutilãa me dzi ɖe kpɔtɔ le nɔnɔme siawo me).

Ke ne renin ƒe agbɔsɔsɔ le sue ɖe?

Susu aɖewo hã li siwo tae renin ƒe agbɔsɔsɔ ate ŋu aɖiɖi ɖo. Le kpɔɖeŋu me:

• Aldosteronism (PA) ƒe dɔléle gbãtɔ .
• Ne èle steroid-tike siwo nana dze nɔa ŋutilãa me zãm.
• Salt-sensitive hypertension (ʋusɔgbɔdɔ le ame aɖewo ŋu ne woɖu dze sɔ gbɔ vie gɔ̃ hã, nɔnɔme aɖee nye ema).

Aleke mawɔ ana nye renin ƒe agbɔsɔsɔ nanɔ lãmesẽ me?

Ne wò renin ƒe agbɔsɔsɔ sɔ gbɔ alo le sue le mɔ si mesɔ o nu la, wò ɖɔkta akpɔ nusi gbɔ wòtso eye wòawɔ atikewɔwɔ ƒe ɖoɖo. Menye ɖeko womaŋlɔ atike na wò be nàtsɔ aɖe wò ŋkume ƒe dɔwɔwɔ dzi akpɔtɔ alo adoe ɖe dzi o.

Le kpɔɖeŋu me, ne renin sɔ gbɔ ɖe lãme na wò eye ʋusɔgbɔdɔ le ŋuwò la, wò ɖɔkta ate ŋu aŋlɔ atike siwo ɖea ʋu ƒe sisi dzi kpɔtɔna abe beta-blockers kple clonidine ene na wò.

Mlɔeba la, nusi dzi nàɖo ŋkui (Take-Home Message) .

Eyata, menye enzyme aɖe koe renin nye o. Enye renin-angiotensin-aldosterone system (RAAS) ƒe akpa vevi aɖe ŋutɔ. Ewɔa akpa gã aɖe le wò ʋu ƒe sisi dzi ɖuɖu me.

Susu vovovowo ate ŋu anɔ anyi siwo tae wò renin ƒe agbɔsɔsɔ mesɔ o. Eyata ne ɖikeke aɖe le mewò la, nu nyuitɔ si nàwɔe nye be nàyi ɖɔkta gbɔ, anya nusi tututu gbɔ wòtso, eye nàxɔ atike si hiã. Mègayi kple wò dɔgbo ƒe seselelãme ko o, elabena nu siawo sesẽ vie.

Wò ɖɔkta ate ŋu akpe ɖe ŋuwò pɛpɛpɛ. Nɔ lãmesẽ me!

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