Ðe wò hã nèsea ŋeŋe, atɔ, kple ŋku siwo biã eye tsi le ƒoƒom ne èka asi ke ŋu, do go le vuvɔ me, alo ɖu nanea? Ðe gbɔgbɔ sesẽna na wò ɣeaɖewoɣia? Zi geɖe la, míeyɔa esia be ‘nulɔdɔ’. Eyata egbea míele nu ƒom tso ame vevi siwo le megbe na nulɔdɔ sia dometɔ ɖeka ŋu. Eyae nye histamine. Ðewohĩ èse ŋkɔ sia tso ɖɔkta aɖe gbɔ alo tso atike si nènona na wò nulɔdɔwo ƒe ŋkɔ gbɔ. Na míakpɔ nusi histamine nye kple nusi wòwɔna ɖe ŋutilãa ŋu ɖa.

Kpuie ko la, amekae nye histamine sia?

Bu míaƒe ŋutilã be enye dukɔ si wokpɔ ta na nyuie. Ne dutatɔ aɖe ge ɖe dukɔ sia me, nane si megblẽa nu le míaƒe ŋutilã ŋu o gɔ̃ hã (le kpɔɖeŋu me, ke sue aɖe, seƒoƒo ƒe aŋgba, alo nuɖuɖu abe shrimp ene) gɔ̃ hã la, míaƒe ametakpɔnu (dɔlélenutsiŋutete) bua vodadatɔe ɣeaɖewoɣi be enye futɔ.

Ɣemaɣi la, lãmenugbagbevi siwo le míaƒe dɔlélenutsiŋutete me ɖea atike aɖe doa goe be wòaƒo nu kple lãmenugbagbevi bubuwo , atsɔ aɖɔli gbedasiwo. Ele abe nuxlɔ̃ame gbedasi si gblɔna be, "Futɔ aɖe va, wɔ nu kaba!" Woyɔa dɔla ma be histamine.

Lãmenugbagbevi ƒomevi eve koŋ mee wodzraa atike sia si woyɔna be histamine ɖo ɖe míaƒe ŋutilã me.

1. Mast cells: Esiawo nye ʋumenugbagbevi ɣi ƒomevi aɖe si le kadodoŋusẽ me le míaƒe ŋutilã katã me. Wobɔ ɖe ŋutigbalẽa te, le ʋukawo kple ʋukawo gbɔ, le lãmekawo, lãkusiwo, kple dɔgbowo me koŋ.

2. Basophils: Esia nye ʋumenugbagbevi ɣi ƒomevi bubu si le ʋua me.

Ne nane si gblẽa nu le ame ŋu va ka ŋutilãa ŋu la, lãmenugbagbevi siawo ɖea histamine ɖe go, si wɔnɛ be nulɔdɔ ƒe dzesiwo dzena. Zi geɖe la, ŋutilã ƒe akpa ɖeka koe dzesi siawo dzena le, gake ɣeaɖewoɣi la, nuwɔna sia ate ŋu asẽ ŋutɔ . Míeyɔa esia be anaphylaxis . Esia nye nudzɔdzɔ kpata si gblẽa nu le ŋutilã bliboa ŋu eye ate ŋu ade ame ƒe agbe afɔku me gɔ̃ hã.

Nukae histamine wɔna le ŋutilãa me? Nukae nye esia tso receptors ŋu?

Menye ame vɔ̃ɖi aɖe si naa nulɔdɔwo koe histamine nye o. Ewɔa dɔ vevi aɖewo ŋutɔ le ŋutilãa me. Nusi histamine wɔna le ŋutilã me nɔ te ɖe nusi wòbla ɖe eŋu dzi. Abe ale si ko safui ɖeka ate ŋu aʋu ʋɔtru geɖe ene la, xɔ si me nàge ɖo hã ato vovo le ʋɔtru si nàʋu nu. Dzɔdzɔmeŋutinunyalawo de dzesi histamine-xɔla ƒomevi ene.

Mina míalé ŋku ɖe esia ŋu be míase egɔme nyuie.

Nukawoe nye atikewɔwɔ me nɔnɔme vevi siwo ate ŋu ado ƒome kple histamine?

Dɔla histamine ƒe dɔwɔwɔ koŋ gbɔe nulɔdɔ ƒe nɔnɔmewo tsona. Kpɔɖeŋu aɖewoe nye esi:

• Atopic dermatitis (si woyɔna hã be eczema): Nɔnɔme si nana ŋutigbalẽa ƒuna, biãna, ƒoa ƒu, eye wòʋãna vevie, si woyɔna zi geɖe be ‘eczema’.
• Contact dermatitis: Nulɔdɔ si dzɔna ne nane ka ŋutigbalẽa. Le kpɔɖeŋu me, ʋeʋẽ lilili siwo wowɔ, ga aɖewo (abe nikel ene), kple nusiwo wotsɔ dzraa nu ɖo.
• Nulɔdɔ (si wogayɔna be hay fever): Esia nye dɔléle si bɔ si ame geɖe tona. Nusiwo abe ke, aŋɔ, aƒemelãwo ƒe ƒuƒu, kple ke ƒe ʋetsuviwo ene gbɔe wòtsona, si wɔnɛ be ŋɔti me tsi, ŋɔti me tsi, kple ŋɔti me ʋuʋu.
• Asrã si ŋu nulɔdɔ le: Nu mawo ke gbɔe wòtsona abe alesi míegblɔe ene, gake le afisia la, yaƒoƒomɔ̃wo va xaxa, si wɔnɛ be gbɔgbɔ sesẽna eye wòtsia dzodzodzoe.
• Allergic conjunctivitis: Nɔnɔme si me ŋku ƒe ŋkumeʋuʋu vuvu, biãna, ʋãna, eye tsi le ƒoƒom le nusi nana nulɔna le ame ŋu ta.

Nukae Nye Histamine ƒe Mɔmaɖemaɖeɖenuŋu?

Esia to vovo vie. Ɣeaɖewoɣi la, histamine ƒe agbɔsɔsɔ si le míaƒe ŋutilã me dzina ɖe edzi akpa. Esia le alea elabena ŋutilãa mete ŋu gblẽa histamine me nyuie o. Ne esia dzɔ la, dzesi vovovowo ate ŋu ado mo ɖa.

• Taɖuame alo taɖuame
• No me ʋuʋu
• Ðeɖi tea eŋu ɣesiaɣi
• Aɖuɖɔtoewo
• Nuɖuɖumeŋusẽ ƒe kuxiwo
• Dzinukpɔkpɔ si mebɔ o le nyɔnuwo me

Ne dzesi siawo le ŋuwò ɣesiaɣi la, ele vevie be nàkpɔ ɖɔkta ahaƒo nu tso eŋu.

Eyata aleke nàwɔ aɖu histamine sia dzi?

Atikewɔwɔ vovovowo li siwo ɖɔktawo kafu be woatsɔ aɖu vevesese si histamine hena vɛ dzi. Esiawoe vaa susu me na wò ne èse nya nulɔdɔ ƒe atike.

• H1 antihistamines: Esiawoe nye atike siwo míenya zi geɖe be ‘allergy pills’. Wowɔa dɔ to mɔxexe ɖe H1-xɔla siwo míeyɔ ɖe etame nu me. Esia xea mɔ na histamine be megabla ɖe lãmenugbagbevi mawo ŋu o eye wòhea ʋuʋudedi kple aɖuɖɔtoe vɛ. Esiawo le nɔnɔme vovovowo me, siwo dometɔ aɖewoe nye atikekuiwo, tsinyegoewo, atike siwo wotsɔna ƒoa ɖae, kple ŋkumeɖonu. Woate ŋu ano wo dometɔ aɖewo ɖɔkta ƒe atikewɔmɔnu manɔmee, gake anyo wu be nàbia wò ɖɔkta be atike kae nyo na wò.
• H2 antihistamines: Wozãa esiawo koŋ na dɔgbo me kuxiwo. Wotsɔa wo naa nɔnɔmewo abe dɔgbo ƒe dɔléle, dɔgbo ƒe tsi si trɔna yia lãme na ame (GERD), kple nuɖuɖumadzroame (nuɖuɖu ƒe dɔmawɔmawɔ nyuie) ene. Wowɔa dɔ to mɔxexe ɖe H2 xɔla siwo le dɔgboa me siwo wɔa acid la nu.
• Corticosteroids: Míeyɔa esiawo be ‘steroids’. Wokpena ɖe ame ŋu be woaɖe abi si histamine hena vɛ dzi akpɔtɔ. Le kpɔɖeŋu me, steroid-tike siawo le atike geɖe siwo wozãna tsɔ léa asrãdɔ nu.
• Epinephrine dodo: Esia le vevie ŋutɔ. Wodoa atike sia abe atike kpata ene le nɔnɔme siwo ate ŋu ade ame ƒe agbe afɔku me, abe nulɔdɔ sesẽ, alo anaphylaxis ene me. Eʋua yaƒoƒomɔ̃wo kabakaba eye wònana ʋu ƒe sisi gaɖoa wo me.
• Numekuku aɖewo ɖee fia be vitamin aɖewo, abe vitamin C, akɔbli, kple vitamin B6 ene, ate ŋu akpe ɖe ame ŋu be histamine ƒe agbɔsɔsɔ si le ŋutilãa me dzi naɖe akpɔtɔ. Gake mègano atike siawo dometɔ aɖeke ne mèƒo nu kple wò ɖɔkta gbã o.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne ɣeyiɣi aɖe ƒe nulɔdɔ le ŋuwò alo nèle nane ƒe nulɔdɔ ƒe dzesiwo kpɔm, vevietɔ ne wole nu gblẽm le wò gbesiagbedɔwo ŋu la, ele vevie be nàyi ɖɔkta gbɔ. Wò ɖɔkta ate ŋu awɔ dodokpɔwo atsɔ anya nusi tututu ŋu wò nulɔdɔ le eye wòakafu atike nyuitɔ kekeake na wò. Azɔ hã, ƒo nu tso histamine ƒe dɔmawɔmawɔ nyuie ƒe dzesi ɖesiaɖe si míeyɔ ɖe etame ŋu na wò ɖɔkta.

Togbɔ be histamine le vevie na míaƒe ŋutilã ƒe dɔwɔwɔ nyuie hã la, ɣeaɖewoɣi ne eva le dɔ wɔm akpa la, ate ŋu ahe kuxi geɖe vɛ na mí. Eyata mehiã be woakpe fu le vevesese ma tɔgbe me o. Woate ŋu aɖu nɔnɔme siawo dzi nyuie wu ne wobia atikewɔlawo ƒe aɖaŋuɖoɖo nyuitɔ.