Mina míasrɔ̃ nu tso Anaplastic Large Cell Lymphoma (ALCL) ŋu le nya bɔbɔewo me.

Èse Anaplastic Large Cell Lymphoma (ALCL) ŋu nya kpɔa? Ðewohĩ ŋkɔ sia ɖi nya sesẽ vie. Gake mègatsi dzi o, esia nye kansa ƒomevi si mebɔ kura o. Egbea míaƒo nu tso nusi ALCL nye, alesi wòdzenae, nusiwo nye dzesiawo, nusiwo nye atikewɔwɔwo, kple nu bubu geɖewo ŋu le mɔ bɔbɔe ŋutɔ si gɔme nàte ŋu ase nu. Abe alesi nèle nu ƒom na xɔ̃wò ene.

Nukae nye ALCL (Anaplastic Lãmenugbagbevi Gãwo ƒe Lãmetsiŋusẽ)?

Kpuie ko la, ALCL nye kansa ƒomevi aɖe si mebɔ o, si mebɔ o, si le kansa ƒe hatsotso gã aɖe si woyɔna be Non-Hodgkin Lymphoma me. Ènya be abe Non-Hodgkin Lymphoma katã ene la, ALCL hã nye kansa ƒomevi aɖea? Edzɔna ne ʋumenugbagbevi ɣi ƒomevi aɖe si woyɔna be lymphocytes le míaƒe ŋutilã me tsi le mɔ si dzi womate ŋu aɖu o nu eye wòtsi kabakaba wu alesi wòle be wòanɔ.

Bu ʋumenugbagbevi dzĩ siawo be wonye asrafo suewo le míaƒe ŋutilã me. Wonye míaƒe dɔlélenutsiŋutete ƒe akpa aɖe, eye wokpɔa mía ta tso dɔlékuiwo kple dɔlélewo me. Lãmetsiŋusẽ ƒomevi vevi eve li: B lãmenugbagbeviwo kple T lãmenugbagbeviwo . Le ALCL me la, wò T lymphocytes, alo T cells, tsina le mɔ si mesɔ o nu.

Azɔ mina míakpɔ nusi ŋkɔ sia "anaplastic large cell lymphoma" fia ɖa.

• Anaplastic : Nya sia fia be ne wotsɔ nusuekpɔmɔ̃ kpɔ kansa lãmenugbagbevi siawo la, woƒe dzedzeme wɔ nuku ŋutɔ eye woto vovo ne wotsɔe sɔ kple T lymphocyte lãmenugbagbevi siwo le lãmesẽ me. Ðeko wòle abe ɖe wotro woƒe nɔnɔme kple dzedzeme ene.
• Lãmenugbagbevi Gãwo : Esia fia be T ʋumenugbagbevi siwo mewɔa nu nyuie o la dzena lolo wu T lãmenugbagbevi siwo sɔ. Vovototo sia dzena nyuie le nusuekpɔmɔ̃ me.
• Lymphoma : Lymphoma nye kansa si dzɔna le ʋumenugbagbevi ɣi siwo woyɔna be lymphocytes ƒe tsitsi si dzi womeɖu o ta. ALCL dzɔna tso T ʋumenugbagbevi dzĩwo me koŋ.

See? Kpuie ko la, ALCL nye kansa si me T lãmenugbagbeviwo lolona le mɔ si mesɔ o nu, trɔna, eye wotsina le mɔ si dzi womate ŋu aɖu o nu.

Ðe ALCL ƒomevi vovovowo lia?

Ẽ, ALCL ƒomevi vovovowo li. Woda esiawo ɖe hatsotsowo me le afisi kansa le le wò ŋutilã me kple kansa lãmenugbagbeviwo ƒe nɔnɔmewo nu.

ALCL si wowɔ ɖe ɖoɖo nu

Esiae nye ƒomevi vevitɔ. "Systemic" fia be ateŋu akpɔ ŋusẽ ɖe ŋutilã bliboa dzi. Ate ŋu akpɔ ŋusẽ ɖe wò ʋukawo , alo "glands" abe alesi míeyɔna wo ene, kple ŋutinu ememetɔwo abe wò aklã kple lãkusiwo ene, eye ɣeaɖewoɣi wò ŋutigbalẽ hã dzi.

Woma ɖoɖowɔɖi ƒe ALCL ɖe hatsotso eve me. Ðeka nɔ te ɖe nenye be tɔtrɔ aɖe le domenyiŋusẽfianu si woyɔna be ``Anaplastic Lymphoma Kinase (ALK)'' domenyiŋusẽfianu me alo meli o dzi . Domenyiŋusẽfianu le abe mɔfiamegbalẽ suewo ene na míaƒe lãmenugbagbeviwo, eye domenyiŋusẽfianu siawo gblɔa alesi T ʋumenugbagbevi dzĩ gɔ̃ hã wɔa dɔe.

• ALK-positive ALCL: Esia nye kansa ƒomevi aɖe si ƒe domenyiŋusẽfianu trɔ le ALK domenyiŋusẽfianu me. Zi geɖe la, esia nyea kansa si nu sẽ ŋutɔ. Gake ebɔ ɖe ɖeviwo kple sɔhɛ tsitsiwo me wu . Dzɔgbenyuietɔe la, atike sia ƒomevi wɔa nu nyuie ne wozã atikewo .
• ALK-negative ALCL : ALK domenyiŋusẽfianu ƒe tɔtrɔ mele ƒomevi sia me o. Esia hã nye kansa si le dzidzim ɖe edzi kabakaba (si nu sẽna). Gake edzea ame tsitsiwo dzi wu , zi geɖe la, amesiwo xɔ wu ƒe 60. Esia ƒomevi ate ŋu ayi ɖe dɔlélea nu le atikewɔmɔnu zazã vɔ megbe eye emegbe wòagadzɔ ake. Eyata ALK-negative ALCL dada sesẽ wu, eye ŋgɔdonya vɔ̃ɖi wu ALK-positive ALCL.

ALCL ƒomevi bubuwo

ALCL ƒomevi aɖewo hã li siwo tsina blewu wu esiwo le ɖoɖo nu.

• Primary cutaneous ALCL : Esia nye ƒomevi aɖe si gblẽa nu le ŋutigbalẽ ŋu koŋ. Dzesiwo abe ʋuʋudedi, ʋuʋudedi, kple ʋuʋudedi ene ate ŋu ado mo ɖa. Le go geɖe me (anɔ abe 90%) mekakana wu ŋutigbalẽa o.
• Breast implant-associated ALCL (BIA-ALCL) : Esia nye ALCL ƒomevi aɖe si dona ƒo xlã no dodo. Zi geɖe la, wokpɔnɛ le no dzi ɖeɖe kpɔtɔ alo no gbugbɔgatu ƒe dɔwɔwɔ abe ƒe 10 ene megbe.

Amekae xɔa ALCL?

Togbɔ be ALCL ate ŋu adze ame siwo xɔ ƒe ɖesiaɖe dzi hã la, ƒomevi aɖewo gblẽa nu le ƒuƒoƒo aɖewo ŋu wu.

• ALK-positive ALCL : Esia gblẽa nu le ɖevi siwo xɔ ƒe 20 kple 30 siwo mexɔ ƒe 20 kple 30 haɖe o siwo tsi megbe, ƒewuiviwo, kple sɔhɛ tsitsi siwo xɔ ƒe 20 kple 30 ŋu wu . Ebɔ ɖe ŋutsuwo me wu .
• ALK-negative ALCL : Esia gblẽa nu le amesiwo xɔ wu ƒe 60 koŋ ŋu.Ebɔ ɖe ŋutsuwo hã me vie wu.
• Primary cutaneous ALCL : Esia dzɔna zi geɖe le ame tsitsi siwo xɔ wu ƒe 40. Ebɔ ɖe ŋutsuwo kple yevuwo me wu.
• BIA-ALCL : Zi geɖe la, wokpɔa esia le amesiwo xɔ ƒe 50-awo ŋu . Ate ŋu adze amesiwo wotsɔ silicone kple saline siaa de no me la me. Wokpɔe be edo ƒome kple no siwo me woŋlɔ nu ɖo koŋ .

Aleke gbegbee ALCL bɔe?

Le nyateƒe me la, ALCL nye kansa si mebɔ kura o . Ame tsitsiwo ƒe ʋumenugbagbeviɣidɔ siwo menye Hodgkin o ƒe 2% koe wokpɔna be wonye ALCL. Ema nye alafa memamã sue aɖe ŋutɔ.

Nukae nye ALCL ƒe dzesiwo?

ALCL ƒe dzesiwo toa vovo le eƒe ƒomevi nu.

Dzesiwo le ALCL si le ɖoɖo nu ŋu

Le ALK-positive kple ALK-negative ALCL siaa me la, ʋuka siwo vuvu bɔ ɖe afisi kansa la le tsitsim le. Woate ŋu ase le wo ɖokui me abe ƒunukpeƒetetedɔ ene le teƒewo abe wò kɔ, akɔta, alo akɔta ene . Dzesi bubuwoe nye:

• Asrã si nɔa ame ŋu enuenu.
• Sese le eɖokui me be ɖeɖi te ye ŋu ŋutɔ (`Ðɖiteameŋu`).
• Fifia le zã me (`Zã me fifia`).
• Kpekpeme dzi ɖeɖe kpɔtɔ si womeɖe o.

Ne wokpɔ dɔlélea le ame akpa gãtɔ ŋu la, ɖewohĩ kansa la kaka vie, si fia be ele `afɔɖeɖe si de ŋgɔ wu` me . Ne edzɔ alea la, ɖewohĩ kansa la kaka ɖe ŋutinuwo abe wò lãkusi, aklã, alo ƒuwo ene me. Emegbe, dzesiwo ate ŋu ado mo ɖa le ŋutinu si ŋu dɔlélea le nu. Le kpɔɖeŋu me, ne akɔta tena ɖe dziwò alo nèkɔa akɔta enuenu la, ALCL ate ŋu akpɔ ŋusẽ ɖe akɔta dzi.

ALCL gbãtɔ ƒe ŋutigbalẽ ƒe nɔnɔmewo

Woate ŋu akpɔ ŋutigbalẽ ƒe tɔtrɔ le ƒomevi sia me.

• Aŋɔ dzĩ alo aŋutiɖiɖi si mebɔ o dzena le ŋutigbalẽa ƒe akpa ɖeka alo esi wu nenema, eye ate ŋu adzi ɖe edzi le ɣeyiɣi aɖe megbe.
• Raised lumps , si lolo wu gaku. Esiawo ate ŋu anye ʋuʋudedi ɣeaɖewoɣi.
• Ate ŋu adzɔ be ʋuʋudediawo nazu abi eye emegbe woazu abi .

BIA-ALCL (No me Dodokpɔ-Associated ALCL) ƒe nɔnɔmewo .

Le esia me la, woate ŋu akpɔ tɔtrɔ siwo dze ƒã le noawo me.

• No me vevesese.
• No ƒe vuvu.
• Ŋutilã me ʋuʋudedi alo ʋuʋudedi.
• Ʋuʋudedi alo tsi ƒe ƒoƒo ɖe wò no si te ɖe wò no me ŋu.
• Nu sesẽ aɖe si te ɖe no si wotsɔ de no me ŋu.

Zi geɖe la, wokpɔa tɔtrɔ siawo le no ɖeka me, gake ɣeaɖewoɣi la, woate ŋu akpɔ tɔtrɔwo le no eveawo siaa me.

Nukae hea ALCL vɛ?

ALCL dzɔna ne ʋumenugbagbevi dzĩ siwo ŋu míeƒo nu tsoe va yi la dzi ɖe edzi le mɔ si dzi womate ŋu aɖu o nu eye wodze tsitsi gɔme wu lãmenugbagbevi siwo le lãmesẽ me siwo ƒo xlã wo. Numekulawo menya nusita tututu ʋumenugbagbevi dzĩ siawo zua kansa (lãmenugbagbevi vɔ̃ɖiwo) haɖe o.

Gake wode dzesi domenyiŋusẽfianu ƒe tɔtrɔ geɖe siwo wokpɔna zi geɖe le ALCL ŋu. Wosusui be domenyiŋusẽfianu ƒe tɔtrɔ siawo ate ŋu ana lãmenugbagbevi siwo le lãmesẽ me natrɔ azu kansa lãmenugbagbeviwo.

Le kpɔɖeŋu me, ALK-positive ALCL ƒe nɔnɔme vevitɔe nye ALK domenyiŋusẽfianu ƒe tɔtrɔ . Nenema ke domenyiŋusẽfianu ƒe tɔtrɔ bubuwo hã bɔ ɖe ALCL ƒomevi bubuwo me.

Aleke wowɔa dea dzesi ALCL? (Dɔléle ƒe dzesi) .

Wò ɖɔkta awɔ ŋutilãmedɔdada gbã atsɔ akpɔe ɖa be ALCL ƒe dzesiwo, abe ʋuka siwo vuvu ene hã. Ne wosusu be esia la, woawɔ dodokpɔ kple dɔdamɔnu vovovo geɖe.

• Nɔnɔmetatawo ɖeɖe ƒe ɖoɖowo: Esiawo ate ŋu akpe ɖe ame ŋu woanya afisi kansa la le. Nɔnɔmetata dodokpɔ ƒomevi si nèhiã la ato vovo le ALCL ƒe ƒomevi nu. Wò ɖɔkta ate ŋu awɔ akɔta ƒe X-ray , CT scan , alo MRI atsɔ adi dɔdzẽwo. PET/CT scan alo PET scan ate ŋu akpe ɖe ame ŋu wòanya ne kansa la kaka ɖe ŋutilã bliboa me. Ne wosusu be BIA-ALCL le eŋu la, woate ŋu awɔ no me ultrasound .
• Ʋudodo : Ðɔktaa awɔ ʋudodokpɔ vovovowo, abe ʋudodo blibo (CBC) ene, be yeakpɔe ɖa be ALCL ƒe dzesiwo le eŋu hã. Ne ʋumenugbagbevi dzĩwo (ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, alo ʋumenugbagbevi dzĩwo) ƒe xexlẽme mesɔ o la, ate ŋu anye ALCL ƒe dzesi. Woadi enzyme aɖewo kple dzesi bubu siwo le ʋua me hã, elabena esiawo hã ate ŋu anye ALCL ƒe dzesiwo.
• Biopsy : Mɔ ɖeka kolia si dzi woato aɖo kpe ALCL ƒe dzesi dzi enye be woawɔ biopsy. Le ŋutilã ƒe akpa aɖe ɖeɖe me la, ɖɔktaa ɖea lãkusi sue aɖe si ŋu ɖikeke le hedoa wo kpɔna le nusuekpɔmɔ̃ me. Ne ɖɔktaa srɔ̃ nu tso lãmenugbagbevi siawo ŋu la, ate ŋu anya ALCL ƒomevi si tututu le ŋuwò. Esia kpena ɖe ame ŋu hã be woawɔ ɖoɖo ɖe atikewɔwɔ si awɔ dɔ nyuie wu ŋu.

Aleke wowɔa atike na ALCL?

Atike si wozãna zi geɖe na ALCL si wozãna le ɖoɖo nu enye atikewɔmɔnu . Amekokoe nye atike si wodi wu na ŋutigbalẽ ƒe ALCL gbãtɔ kple BIA-ALCL.

ALCL si wowɔna le ɖoɖo nu ƒe atikewɔwɔ

Zi geɖe la, ALK-positive kple ALK-negative anaplastic large cell lymphomas wɔa nu nyuie ɖe ɖoɖowɔɖi ƒe atikewɔwɔ ŋu. Dɔdamɔnu si wozãna ɖe ɖoɖo nu bia be woana atike siwo wua kansa to ʋuka aɖe me, si zɔa mɔ toa ŋutilã bliboa me to ʋukawo me tsɔ wua kansa lãmenugbagbeviwo.

Zi geɖe la, wozãa atike vovovo siwo wɔa dɔ ɖekae wua kansa lãmenugbagbeviwo. Kpɔɖeŋu aɖewoe nye:

• BV-CHP : Esia lɔ atike siwo nye `Brentuximab Vedotin`, `Cyclophosphamide`, `Doxorubicin (Hydroxydaunorubicin)`, kple `Prednisone` ɖe eme.
• CHOP : Esia lɔ atike siwo woyɔna be `Cyclophosphamide`, `Doxorubicin (Hydroxydaunorubicin)`, `Vincristine (Oncovin®)`, kple `Prednisone` zazã ɖe eme.
• CHEOP : Esia lɔ atike siwo woyɔna be `Cyclophosphamide`, `Doxorubicin (Hydroxydaunorubicin)`, `Etoposide`, `Vincristine (Oncovin®)`, kple `Prednisone` zazã ɖe eme.

Zi geɖe la, atikewɔwɔ siawo ateŋu ana kansa ƒe dzesiwo katã nabu le ɣeyiɣi kpui aɖe me (míeyɔa esia be `keɖeɖe`).(Woyɔa esia be "gbugbɔgadzɔ") Ke hã, kansa ate ŋu atrɔ ava. Ne wò ɖɔkta susu be anɔ eme be kansa la agatrɔ ava la, ate ŋu aɖo aɖaŋu be nàdo lãmenugbagbeviwo na wò esime nèle gbɔdzɔgbɔdzɔm. Lãmenugbagbevi siwo wodona na ame bubuwo tsɔa lãmenugbagbevi siwo le lãmesẽ me ɖɔlia lãmenugbagbevi siwo dome gblẽ to atikewɔmɔnu me. Emegbe lãmenugbagbevi siawo siwo le lãmesẽ me la wɔa ʋumenugbagbevi siwo le lãmesẽ me (siwo menye kansa o).

Ne kansa la gava la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàzã atike vovovo siwo ŋu wotrɔ asi le be woatsɔ ada ʋumenugbagbeviɣidɔ.

Atikewɔwɔ na ŋutigbalẽ ƒe ALCL gbãtɔ

Esia ƒe atikewɔwɔ si bɔ wue nye amekoko . Ne kansa la kaka ɖe ʋukawo me la, àte ŋu ahiã keklẽŋusẽdɔdamɔnu hã . Kekeli ƒe atikewɔwɔ wɔa dɔ to ŋusẽ ɖoɖo ɖe kansa lãmenugbagbeviwo ŋu kple wo tsɔtsrɔ̃ me.

Zi geɖe la, ŋutigbalẽ ƒe ALCL gbãtɔ ate ŋu agadzɔ le ƒe atɔ̃ me tso esime woda dɔa nɛ. Ne edzɔ alea la, agahiã be woawɔ dɔ na ame kple keklẽŋusẽdɔdamɔnu ake.

Ne dɔdzẽ siwo le teƒe ɖeka si womate ŋu aɖe le amekoko me o, alo ne kansa la yi edzi le tɔtrɔm la, ɖewohĩ ahiã be woawɔ atike bubuwo na wò. Esiawo ate ŋu anye:

• Methotrexate si woano : Atike si wozãna tsɔ daa ʋumenugbagbeviɣidɔ si menye Hodgkin o.
• Bexarotene : Atike si wozãna tsɔ daa T-cell lymphoma si gblẽa nu le ŋutigbalẽ ŋu.
• Brentuximab Vedotin : Atike si wozãna tsɔ daa ALCL si le ɖoɖo nu kple ALCL ƒomevi bubu siwo gbugbɔna.
• Interferon : Atike si kpena ɖe wò dɔlélenutsiŋutete ŋu wòdea dzesi kansa lãmenugbagbeviwo, siwo dome ʋumenugbagbeviɣidɔ hã le, eye wòwɔa avu kpli wo.

BIA-ALCL ƒe atikewɔwɔ

Zi geɖe la, woate ŋu ada BIA-ALCL to amekoko me be woaɖe wò no si wodo kple kansadɔlékui ɖesiaɖe si ƒo xlãe ɖa. Ne amekoko mate ŋu adzɔ o la, woate ŋu awɔ keklẽŋusẽdɔdamɔnu atsɔ awu kansadɔlékuiawo.

Ne kansa la gatrɔ gbɔ alo kaka ɖe no la godo la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàzã atike siwo wozãna tsɔ daa ALCL si me ALK mele o. Esiawo ate ŋu anye CHOP atikewɔmɔnu kple atikewɔwɔ abe Brentuximab Vedotin ene.

Aleke gbegbee ALCL nye nu vevii?

Eɖanye ƒomevi ka kee ALCL nye o, kansa sesẽ aɖe si hiã be woalé ŋku ɖe eŋu nyuie ahadae nyuie. Gake wò ŋgɔdonya kple atikewɔwɔ ƒe ɖoɖoa nɔ te ɖe nusiwo le abe ALCL ƒomevi si le ŋuwò, alesi nèwɔa nui ɖe atikewɔwɔ ŋu, kple wò Dukɔwo Dome Nyagblɔɖi ƒe Dzesi (IPI) ƒe dzesi dzi.

Kansadɔdalawoe to IPI vɛ be wòakpe ɖe ame ŋu wòagblɔ nusi ado tso ʋumenugbagbeviɣidɔ siwo menye Hodgkin o siwo le dzidzim ɖe edzi kabakaba, siwo dome ALCL si le ɖoɖo nu hã le, me. Nu siwo gbɔna dzie wotu dzesidea ɖo:

• wò ƒexɔxɔ.
• Wò ŋutete be nàwɔ gbesiagbedɔwo.
• Afisi wò kansa kaka ɖo (kansa ƒe afɔɖeɖe).
• Ami ƒe lãkusi siwo ŋu wògblẽ nu le ƒe xexlẽme.

Ne ALCL si wowɔna le ɖoɖo nu le ŋuwò la, bia wò ɖɔkta alesi wò IPI ƒe dzesi kpɔa ŋusẽ ɖe wò hayahaya ƒe mɔnukpɔkpɔ dzii.

Nukae nye agbetsitsi ƒe agbɔsɔsɔme na ALCL?

Agbetsitsi ƒe agbɔsɔsɔme le ɖoɖowɔɖi ƒe ALCL me to vovo ŋutɔ. ALK-positive ALCL do ƒome kple agbetsitsi ɣeyiɣi didi wu ALK-negative ALCL. Le nusiwo le abe wò kansa ƒomevi kple IPI ƒe dzesi ene nu la, ƒe atɔ̃ ƒe agbetsitsi ƒe agbɔsɔsɔme na ALK-positive ALCL ateŋu atso 33% va ɖo 90%. Nenema ke ƒe atɔ̃ ƒe agbetsitsi ƒe agbɔsɔsɔme na ALK-negative ALCL ateŋu atso 13% va ɖo 74%.

Agbetsitsi ƒe agbɔsɔsɔme nyo ŋutɔ le ŋutigbalẽ ƒe ALCL gbãtɔ kple BIA-ALCL ŋu. Togbɔ be zi geɖe la, ŋutigbalẽ ƒe ALCL gbãtɔ yia tsɔtsɔke me eye wògatrɔna vaa le ƒe atɔ̃ me hã la, atikewɔwɔ siwo kplɔe ɖo ate ŋu ana wò agbenɔƒe nadidi ɖe edzi. Agbetsitsi ƒe agbɔsɔsɔme anɔ abe 80% ene le ƒe atɔ̃ le dɔlélea didi vɔ megbe. Le BIA-ALCL me la, ne woɖe kansa la ɖa keŋkeŋ to amekoko me la, zi geɖe la, kansa la nu yina keŋkeŋ.

Nya kawoe wòle be mabia nye ɖɔkta?

Nya vevi aɖewo siwo wòle be nàbia wò ɖɔktae nye esi:

• ALCL ƒomevi ka ƒomevie le asinye?
• Ðe nye kansa la le teƒe ɖeka ko, alo ɖe wòkaka?
• Amekawoe nye eŋutinunyala bibi siwo le nye belélenameha me?
• Atikewɔwɔ kae nèkafu nam?
• Aleke mawɔ akpɔ atikewɔwɔ ƒe nugbegblẽ le ame ŋu gbɔe?
• Nukae nye nye IPI ƒe dzesi?
• Nukae nye mɔnukpɔkpɔ siwo li be nye kansa nayi `remission` me?
• Mɔnukpɔkpɔ kawoe li be nye kansa nagatrɔ ava?
• Zi nenie wòhiã be mava sasrãkpɔ siwo akplɔm ɖo be malé ŋku ɖe nye nɔnɔmea ŋu?

Enye nusi sɔ be vɔvɔ̃ naɖo ŋuwò ne èse be kansa le ye ŋu. Gake nu vevitɔ kekeake si dzi wòle be míaɖo ŋkui enye be ALCL menye kansa ƒomevi ɖeka si me tsonu ɖekae o . ALCL ƒomevi si le asiwò lae afia ne ekaka kabakaba alo blewu. Ema atrɔ asi le wò atikewɔwɔ ƒe tiatia kple nukpɔsusu ŋu. Ame aɖewo ƒe ALCL kaka kabakaba. Le ame bubuwo gome la, etsina vivivi, si wɔnɛ be ɣeyiɣi si sɔ na wò be nàwɔ atike siwo ate ŋu akpe ɖe ŋuwò nàɖu kansa la dzi. Ƒo nu kple wò ɖɔkta tso nusiwo ate ŋu ado tso eme ŋu le dɔléle si wokpɔ le ŋuwò nu.

Nu vevitɔ kekeake siwo dzi wòle be nàɖo ŋkui (Take-Home Message) .

Enyo, eyata mina míaƒo nu vevi aɖewo siwo dzi wòle be nàɖo ŋkui tso nusiwo ŋu míeƒo nu tsoe me kpuie.

• ALCL nye kansa ƒomevi aɖe si mebɔ o, eye eƒe ƒomevi vovovowo li.
• Menye ALCL ƒomeviwo katãe sɔ o. Ðewo kaka kabakaba, ɖewo kaka vivivi.
• Atikewɔwɔ kple mɔnukpɔkpɔ si li be nàhaya la toa vovo le ALCL ƒomevi si le ŋuwò, ƒe si nèxɔ, kple wò lãmesẽ bliboa nu.
• Togbɔ be ALK-positive ALCL dzɔna zi geɖe le sɔhɛwo me hã la, ewɔa nu nyuie ne wowɔ atike nɛ.
• ALK-negative ALCL gblẽa nu le ame tsitsi geɖe ŋu eye ate ŋu asesẽ vie wu be woadae.
• Zi geɖe la, ŋutigbalẽ ƒe ALCL kple no me ALCL si do ƒome kple no me dodo (BIA-ALCL) ƒe nyagblɔɖi nyo.
• Mègatsi dzodzodzoe o. Ne ɖikeke alo dzesi aɖe le ŋuwò la, di atikewɔlawo ƒe aɖaŋuɖoɖo enumake.
• Ðo dze kple wò ɖɔkta gaglãa tso wò nɔnɔmea, wò atikewɔwɔ, kple nyabiase ɖesiaɖe si anɔ asiwò ŋu. Woawoe ate ŋu akpe ɖe ŋuwò nyuie wu.

Ðo ŋku edzi be menye kansadɔléle siwo katã wokpɔna la nu sẽna sɔsɔe o. Ne wozã ALCL gɔ̃ hã, ne wokpɔ dɔlélea nyuie, wodae kaba, eye wokpɔe nyuie la, ame geɖe ate ŋu akpɔ dzidzedze.

` Anaplastic Lãmenugbagbevi Gãwo ƒe Lãmetsiŋusẽ, ALCL, Lãmenugbagbeviwo, Kansa, T Lãmenugbagbeviwo, ALK Domenyiŋusẽfianu, Atikewɔwɔ