Ènya nu tso atike wɔnuku sia si tɔa ŋku kansa lãmenugbagbeviwo ko ŋua? (Tyrosine Kinase Mɔxenuwo) .

Ne míese be kansa le mía ŋu la, vɔvɔ̃ ɖoa mí katã vevie. Le ɣeyiɣi ma ke me la, míebua atikewɔmɔnuwo abe atikewɔmɔnu ene ŋu. Atikewo zazã gblẽa lãmenugbagbevi siwo mãna kabakaba la dome. Ke hã, menye kansa lãmenugbagbeviwo koe ate ŋu atsrɔ̃ o, ke ate ŋu atsrɔ̃ lãmenugbagbevi siwo le lãmesẽ me le míaƒe ŋutilã me hã, le kpɔɖeŋu me, taɖa ƒe lãmenugbagbeviwo, lãmenugbagbevi siwo naa nu me dɔdzẽ, kple lãmenugbagbevi siwo le dɔgboa me. Esia tae chemo nana taɖa vuvu, nu me ƒoƒo, kple dɔgbo ƒe dɔmawɔmawɔ nyuie. Gake, bu eŋu kpɔ... aleke gbegbe wòaloloe ne atike ƒomevi aɖe li si ate ŋu atɔ ŋku kansa lãmenugbagbeviwo ɖeɖeko, abe tu si wotsɔna ƒoa tu ene? Emae nye nusi ŋu míele nu ƒom tsoe egbea. Woyɔa esiawo be Tyrosine Kinase Inhibitors , alo TKIs kpuie.

Kpuie ko la, nukawoe nye TKI siawo?

TKI nye atikewɔmɔnu si woɖo taɖodzinu na ƒomevi aɖe si wozãna le kansa dada me. Wowɔa dɔ to nu aɖewo siwo le kansa lãmenugbagbeviwo me si kpena ɖe wo ŋu wotsina hemãna la xexe me. Ne míagblɔe bubui la, dzesiɖoɖo aɖe le kansa lãmenugbagbeviwo si si gblɔna na wo be "woatsi ahama." TKI-wo wɔa dɔ to nudede dzesiɖoɖo ma me kple etɔtrɔ me.

Ðewohĩ atike siawo mada kansa keŋkeŋ o, gake woate ŋu akpe ɖe dɔnɔwo ŋu be woaɖu kansa dzi ɣeyiɣi didi (aɖee ɖa), alo anɔ agbe nyui gɔ̃ hã kple kansa la.

Aleke atike sia wɔa dɔ ŋutɔŋutɔe? Mina míalé ŋku ɖe eŋu tsitotsito vie.

Be míase esia gɔme la, ele be míanya nu vi aɖe tso ale si lãmenugbagbeviwo mamã le míaƒe ŋutilã me le mɔ si sɔ nu ŋu gbã. Tsɔe be míaƒe ŋutilã nye dɔwɔƒe gã aɖe. Woyɔa dɔwɔla siwo le dɔwɔƒe sia be lãmenugbagbeviwo.

1. Tsitsi ƒe nusiwo: Esiawoe nye dɔla siwo tso dɔwɔƒea godo siwo tsɔa gbedasi si nye "Dze ewɔwɔ gɔme fifia" vɛ.

2. Tyrosine kinases: Esiawo nye enzyme siwo le lãmenugbagbeviwo me siwo xɔa gbedasi la hegblɔna na ame bubuwo be "OK, mina míadze dɔ gɔme."

Nusi dzɔna le lãmenugbagbevi si le lãmesẽ me si sɔ me enye si. Dɔla (tsitsi ƒe nuwɔna) va tsɔa gbedasia naa dɔdzikpɔla (tyrosine kinase). Dɔdzikpɔla la xɔa gbedasi ma eye wògblɔna na lãmenugbagbevi la be woama. Ne lãmenugbagbeviawo ma alesi wohiã vɔ la, dɔdzikpɔla la tsia ʋuƒoa. Esia nye ɖoɖo si dzi wokpɔna ŋutɔ .

Gake le kansa lãmenugbagbeviwo me la, nuɖoanyi sia zɔna le mɔ gbegblẽ nu. Le kansa ƒomevi aɖewo me, vevietɔ la, dɔdzikpɔla siawo (Tyrosine kinases) ƒe tagbɔ gblẽna. Woƒe switch la le dɔ wɔm tegbee. Womehiã gbedasi tso egodo o, ɖeko wonɔa gbɔgblɔm na lãmenugbagbeviawo be "woama, woama, woama." Lãmenugbagbeviwo ƒe mama sia si dzi womeɖu o lae nye nusi míeyɔna be kansa.

Kpɔɖeŋu nyuitɔ kekeake: Ʋumenugbagbeviɣidɔ si Nɔa Anyi Didi (CML) .

Esia nye ʋumenugbagbeviɣidɔ ƒomevi aɖe. Tsã la, ne CML va do la, enye dɔléle si wua ame. Gake esi woke ɖe TKIwo ŋu vɔ la, fifia CML va zu dɔléle si nɔa anyi didi si woate ŋu atsɔ atikewo abe suklidɔ kple ʋusɔgbɔdɔ ene aɖu.

Le lãmenugbagbevi siwo le CML dɔnɔwo ƒe ƒumeŋuɖui me la, Tyrosine kinase enzyme si míeyɔ la dzɔna le mɔ si mesɔ o nu, eye eƒe tɔtrɔ ‘ʋuna’ tegbee. Eyata ƒumeŋuɖui wɔa ʋumenugbagbevi ɣiwo evɔ womeɖua wo dzi o. Esia xea mɔ na ʋumenugbagbevi dzĩ siwo le lãmesẽ me, ʋumenugbagbevi ɣiwo, kple ʋumenugbagbevi dzĩwo wɔwɔ. TKIwo, abe Imatinib (Gleevec®) ene, tɔa ŋku enzyme ma si mesɔ o eye wotsia eƒe ‘ʋu’ ƒe ʋuƒoa ‘tsi’. Esia nye tɔtrɔ gã aɖe le kansa dada ƒe ŋutinya me.

Kansa ƒomevi kawoe wozãa TKI-wo na?

Wole atikewɔwɔ sia si woɖo taɖodzinu na zãm fifia na kansa ƒomevi geɖe. Mewɔa dɔ na kansa katã o. Esia le alea elabena menye kansa katãe Tyrosine kinase si ‘ʋu’ la le o. Ðɔktawo ɖea kansadɔlékuiawo ƒe lãmenugbagbeviwo kpɔna be molecule sia si ŋu woate ŋu aɖo taɖodzinu ɖo la le wo me hã. Ne ewɔe ko hafi woana atike sia.

Kansa ƒomevi vevi siwo wotsɔ TKI da dɔe la dometɔ aɖewo le ete.

Fifia la, United States ƒe FDA da asi ɖe TKI siwo wu 50 dzi be woatsɔ ada kansa vovovowo. Wozãa atike gbãtɔ si dzi woda asi ɖo, Imatinib (Gleevec®), tsɔ daa kansa ƒomevi 7.

Aleke mawɔ akpɔ atike sia? Ɣeyiɣi didi kae wòxɔna?

Esia hã nye atikewɔwɔ sia ƒe bɔbɔe gã bubu. TKI akpa gãtɔ va le atikekui alo tsi ƒe nɔnɔme me. Eyata mehiã be nànɔ kɔdzi ana woado atikea to dzetsi me o. Ðeko wòle be nàno atikekui ɖeka alo eve le ɣeyiɣi ɖeka me gbesiagbe tso aƒeme.

Ɣeyiɣi didi si wòle be nàno atike la nɔ te ɖe kansa ƒomevi si le ŋuwò, afisi dɔlélea le, kple alesi wò ŋutilã wɔa nu ɖe ​​atikeawo ŋui dzi. Le kpɔɖeŋu me, ne CML le ŋuwò la, ahiã be nàno atikeawo le wò agbemeŋkekewo katã me. Le kansa ƒomevi bubuwo gome la, wò ɖɔkta ate ŋu atso nya me be yeadzudzɔ atikeawo zazã ne wonya ɖu kansa la dzi ko.

Mina míanɔ ŋudzɔ ɖe eƒe nugbegblẽ le ame ŋu hã ŋu.

Esi wònye be TKI-wo nye atikewɔmɔnu siwo woɖo taɖodzinu na ta la, zi geɖe la, woƒe nugbegblẽ le ame ŋu mesɔ gbɔ o wu atikewɔmɔnu. Esia le alea elabena womegblẽa nu boo aɖeke le lãmenugbagbevi siwo le lãmesẽ me ŋu o. Gake manya wɔ be woagblɔ be "nu gbegblẽ aɖeke mele wo ŋu kura o." Esia le alea elabena menye kansa lãmenugbagbeviwo me koe molecule si woɖo taɖodzinu na, si woyɔna be Tyrosine kinase, le o, ke boŋ le agbɔsɔsɔ sue aɖe me le lãmenugbagbevi aɖewo siwo le lãmesẽ me hã me. Eyata ate ŋu akpɔ ŋusẽ ɖe lãmenugbagbevi mawo hã dzi.

Nusiwo wògblẽna le ame ŋu la toa vovo tso ame ɖeka gbɔ yi bubu gbɔ eye wònɔa te ɖe TKI atike si wozã hã dzi.

Nusiwo dona tso eme zi geɖe:

• Ðeɖiteameŋu: Esia nye nɔnɔme si bɔ si ame geɖe tona.
• Aɖuɖɔtoe: Ate ŋu atso lãmenugbagbevi siwo le dɔgboa me ƒe gbegblẽ gbɔ.
• Aɖuɖɔtoe kple Ʋuʋudedi: Ame aɖewo ate ŋu ato nɔnɔme sia me.
• Ŋutilã ƒe Ʋuʋudedi: Ŋutilã ƒe ʋuʋudedi, ƒuƒu, kple ʋuʋudedi bɔ.
• Nuɖuɖudzroame kple lolo ƒe tɔtrɔ: Ame aɖewo ƒe lolo dzi ɖena kpɔtɔna, evɔ ame bubuwo ya ate ŋu adzi ɖe edzi le ʋuʋudedi ta.
• Asrã

Nusiwo ate ŋu agblẽ nu le ame ŋu vevie:

TKI aɖewo ate ŋu agblẽ nu le dzi, aklã, alo lãkusi ŋu. Woate ŋu ahe ŋutigbalẽ ƒe dɔléle sesẽ siwo ate ŋu ade ame ƒe agbe afɔku me gɔ̃ hã vɛ, abe Stevens-Johnson ƒe dɔléle , si gblẽa nu le ŋutigbalẽ ŋu ene. Gake nusiawo mebɔ kura o. Ʋusɔgbɔdɔ (ʋusɔgbɔdɔ) hã nye nu bubu si ŋu wotsi dzi ɖo.

Nukae mate ŋu awɔ be atikewɔwɔ sia nanɔ bɔbɔe nam?

Kansa dada ate ŋu anye ɣeyiɣi sesẽ aɖe, le ŋutilã kple susu siaa me. Nu ʋɛ aɖewo li nàte ŋu awɔ be ɣeyiɣi sia nanɔ bɔbɔe vie.

1. Gbɔɖeme: Ðeɖiteameŋu nye eƒe nugbegblẽ le ame ŋu vevie. Eyata dɔ alɔ̃ alesi nàte ŋui, ɖi ɖe eme vie le ŋkekea me, eye nàɖo to wò ŋutilã.

2. Nunyiame: Nuɖuɖu ate ŋu asesẽ le nuwo abe nuɖuɖu ƒe dzodzro kple lãmetutudɔ ene ta. Dze agbagba nàɖu nu suesuesuewo zi geɖe gbesiagbe. No tsi geɖe abe tsi, atikutsetse me tsi, mɔli, kple mɔli ene. Ne èle lolo dzim ɖe edzi alo nèle lolom ɖe edzi madzemadzee la, ele vevie ŋutɔ be nàdi aɖaŋuɖoɖo tso nuɖuɖuŋutinunyala gbɔ.

3. Nusiwo wògblẽna le ame ŋu dzi ɖuɖu: Ne aɖuɖɔtoe le ŋuwò la, ɖu nusiwo le abe ami, si me nu ʋeʋĩ mele o, amagbe siwo wotsɔ dzo wɔe, bli, kple akɔɖu ene. Nunono abe Jeevani ene nono nyo ŋutɔ. Ne ŋutigbalẽa le ʋuʋum la, zã atike si me adzalẽ mele o, si me ʋeʋẽ lilili mele o. Ðo dze kple wò ɖɔkta tso esia ŋu eye nàxɔ atike nyuitɔ.

4. Wɔ ɖoɖo ɖe nu ŋu: Ŋlɔ wò dzesiwo kple eƒe nugbegblẽ le ame ŋu ƒe ŋkekenyuigbalẽ ɖi. Tsɔe fia wò ɖɔkta ne èkpɔe. Ðo ŋku edzi nàno wò atikewo le ɣeyiɣi si tututu wòhiã.

5. Susu ƒe lãmesẽ: Ele vevie ŋutɔ be susu nasẽ ŋu le ɣeyiɣi sia me. Ðo dze kple ƒometɔwo kple xɔlɔ̃wo. Gblɔ wò kuxiwo. Ne ehiã la, di aɖaŋuɖoɖo.

6. Beléle na dɔlélea: Esia mefia be womate ŋu ada dɔlélea o. Esia nye eŋutinunyalawo ƒe ƒuƒoƒo aɖe si kpena ɖe ŋuwò nènɔa agbe nyuie wu to dzesiwo abe vevesese, ʋuʋudedi, kple ɖeɖiteameŋu si dona tso kansa dada me dzi ɖuɖu me. Àte ŋu aƒo nu kple wò ɖɔkta hã tso subɔsubɔdɔ sia ŋu.

Afɔku kawoe le atikewɔwɔ sia me?

Togbɔ be TKI-wo wɔa dɔ nyuie na kansa geɖe hã la, ɣeaɖewoɣi la, kuxiwo ate ŋu ado mo ɖa le ɣeyiɣi aɖe megbe. Vevietɔ enye tsitretsiɖeŋu ƒe ŋgɔyiyi .

Kpuie ko la, kansa lãmenugbagbeviwo nye lãmenugbagbevi siwo me ayedzedze le ŋutɔ. Ne wona atike ma ke le ɣeyiɣi aɖe megbe la, woate ŋu atrɔ asi le wo ŋu be woanɔ te ɖe atike ma nu. Abe alesi dɔlékuiwo va nɔa te ɖe dɔlékuiwutikewo nu ene. Ne edzɔ alea la, ɖewohĩ TKI-tike si wɔ dɔ nyuie le gɔmedzedzea me magawɔ dɔ o.

Gake menye xexeame ƒe nuwuwue o. Esi dzɔdzɔmeŋutinunyalawo nya esia ta la, "dzidzime evelia" kple "dzidzime etɔ̃lia" TKI siwo woateŋu ana ne tsitretsiɖeŋu va do mo ɖa la li fifia. Eyata ne atike ɖeka mewɔ dɔ o la, wò ɖɔkta ate ŋu atrɔ wò ɖe TKI bubu ŋu.