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Is Your High Blood Pressure Caused by Your Adrenal Glands? Here Is What You Need to Know About Adrenal Venous Sampling (AVS)

Dr. Priya Sammani (MBBS)
Medically Reviewed by Dr. Priya Sammani (MBBS) ✓ Medically Reviewed
📅 Updated: Oct 22, 2026 • ⏱ 8 min read • Editorial Policy
Is Your High Blood Pressure Caused by Your Adrenal Glands? Here Is What You Need to Know About Adrenal Venous Sampling (AVS)
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Do you have high blood pressure that refuses to drop? Even after taking multiple medicines, your blood pressure numbers might still stay too high. Sometimes, the root cause hides inside two tiny glands sitting right above your kidneys. Today, we will talk about a special test called Adrenal Venous Sampling, or AVS, that helps find out if these glands are the source of your problem.

High blood pressure affects millions of people around the world every single day. When standard treatments fail to work, your doctor looks deeper into your body's hormone systems. Understanding your own health choices gives you power and peace of mind.

Key Takeaways

  • AVS is a special test that finds out which adrenal gland makes too much hormone.
  • Doctors use local numbing medicine so you will not feel sharp pain during the test.
  • Test results help your doctor choose between surgery or medicine for your high blood pressure.
  • You will need to rest for a few days at home after the procedure finishes.
  • Always talk openly with your doctor if you have any questions or fears about your health.
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What Is Adrenal Venous Sampling (AVS)?

Simply put, AVS is a medical test that checks your adrenal glands. It shows your doctor if one adrenal gland or both glands make too much of a specific hormone. These two small glands sit right on top of your kidneys like tiny hats.

One very important hormone these glands make is called aldosterone. This hormone helps keep your blood pressure and salt levels balanced in your body. However, if your body makes too much aldosterone, your blood pressure goes up and your blood potassium levels drop too low.

During the AVS test, a special doctor called an interventional radiologist puts a tiny tube into your blood vessels. They inject a safe liquid dye and take two blood samples from the veins near your adrenal glands. Then, the lab checks these samples to see if the extra aldosterone comes from your right gland, your left gland, or both glands. Your doctor uses this result to decide your next treatment step.

Why Do You Need This Test?

Doctors usually suggest this test when they think you might have Primary Aldosteronism, also known as Conn's syndrome. This is the medical condition caused when your adrenal glands make too much aldosterone hormone.

Imagine your home water tank is overflowing. When you look for the cause, you find that one pipe or both pipes are leaking. AVS works in the exact same way. It helps your doctor figure out if the problem comes from just one gland or from both glands.

Knowing the exact source of the problem makes treatment much easier. Sometimes, doctors also use this test to find rare growths in the adrenal gland, such as a pheochromocytoma.

How to Prepare for This Test

AVS is a hospital procedure, but you usually go home on the exact same day as an outpatient. You stay awake during the test, but you will not feel pain. Doctors use a local numbing medicine on your skin, and they often give you a mild medicine to help you relax into a light, calm sleep called conscious sedation.

If your doctor gives you medicine to help you relax and sleep, someone must drive you home after the procedure is complete. Do not try to drive yourself.

Your doctor might also ask you to stop taking certain medicines a few days before the test. Tell your doctor about every single medicine and supplement you take. You will also need to stop eating and drinking on the morning of your test.

What Happens During the Test?

Here are the simple steps of what happens during your AVS procedure:

  • First, a nurse puts a small IV line into a vein in your arm. They give you a medicine through this line to stimulate your adrenal glands, or to help you relax if needed.
  • Next, the doctor numbs the skin in your groin area so you do not feel any sharp pain.
  • The specialist makes a tiny cut in your groin skin and gently guides a thin tube called a catheter inside. They use an ultrasound scan to find your blood vessels easily.
  • Then, the doctor injects a special contrast dye through the tube. They use X-ray pictures to guide the tube all the way up to the veins of your adrenal glands.
  • Once the tube is in the correct spot, the doctor takes blood samples from both your right and left adrenal veins.
  • Finally, the doctor removes the tube and places a clean bandage over the tiny cut.

Does It Hurt?

No, the test does not hurt. The numbing medicine stops pain in the area. Some people report feeling a brief warm sensation inside their body when the special dye moves through the veins. However, that warm feeling goes away in just a few seconds.

What Do the Results Mean?

After the lab tests your blood samples, your doctor can tell you exactly where the problem is located.

  • If only one adrenal gland makes too much aldosterone, your doctor might recommend a simple surgery to remove that single gland, known as an adrenalectomy.
  • If both glands make too much aldosterone, the best treatment is usually taking specific daily medicines to control your hormone levels.

Your entire treatment plan depends on the results of this important test.

What Are the Risks of This Test?

AVS is generally a very safe and successful procedure. Just like any medical procedure, it carries a few small risks to keep in mind.

Risk Factor Simple Explanation
Bleeding Minor bleeding can happen if a blood vessel gets irritated, but this is very rare.
Infection There is a very small chance of getting an infection where the doctor made the skin cut.
Allergic Reaction Some people can have an allergic reaction to the contrast dye, though this is rare.
Kidney Strain If you already have kidney disease, the contrast dye might place extra strain on your kidneys.
Vein Damage A blood vessel can sometimes tear during catheter placement. If this happens, doctors reschedule the test.

Recovery Time and When to See a Doctor

After your AVS test, it takes a few days to recover your full energy. Getting plenty of rest is extremely important during this time. If you rush back to your normal routine too fast, you might cause bleeding or other issues near the small skin cut.

Your doctor will likely tell you to avoid the following activities for about 3 days:

  • Driving a car.
  • Operating heavy machinery or power tools.
  • Lifting heavy objects or boxes.
  • Doing heavy workouts or hard physical labor.
  • Soaking in a bathtub or swimming in a pool.
  • Signing important legal documents while relaxing medicine is still in your system.

When to Call Your Doctor Right Away

Contact your doctor or call emergency services (911 in the US/Canada, 999 in the UK, or visit your nearest Emergency Department) if you notice any of these signs after your test:

  • Bleeding from the groin cut that does not stop.
  • Pain in your groin or abdomen that gets worse over time.
  • Fever or chills.
  • Nausea or vomiting that will not stop.

The AVS test might sound a bit complex at first glance. However, it is the best way to prove if your adrenal glands cause your high blood pressure. Talk openly with your doctor about any questions, fears, or worries you have.

❓ FAQ

Frequently Asked Medical Questions (FAQ)

Evidence-based clinical answers to common patient questions

What is Adrenal Venous Sampling (AVS) used for?

AVS is a specialized medical test used to find out which adrenal gland is producing too much aldosterone hormone. This hormone imbalance is a common cause of hard-to-treat high blood pressure. The test results help your doctor choose the right treatment.

Does the AVS procedure hurt?

No, the test does not hurt. Doctors use local numbing medicine on your skin so you will not feel the catheter insertion. Some people report a brief warm feeling when the contrast dye travels through the veins, but this feeling passes quickly.

How long does the AVS test take?

The procedure itself usually takes between one and two hours. However, you should expect to spend extra time at the hospital for preparation and a short recovery monitoring period before you can go home.

Can I drive home after having an AVS test?

No, you cannot drive yourself home if you receive sedative medicine to help you relax during the test. You must arrange for a family member or trusted friend to drive you home safely.

What happens after the AVS results are ready?

Your doctor reviews the lab results to see if the hormone overproduction comes from one gland or both. If only one gland is overactive, surgery may be an option. If both are involved, targeted medicines are usually prescribed.

📚

Verified Scientific & Medical References (PubMed / WHO)

✓ Peer-Reviewed Sources
  1. Cleveland Clinic. (2023). Primary Aldosteronism and Adrenal Venous Sampling.
  2. Mayo Clinic. (2024). Conn's Syndrome Diagnosis and Treatment Options.
  3. NHS UK. (2023). High Blood Pressure (Hypertension) Testing Procedures.
  4. Centers for Disease Control and Prevention (CDC). (2024). High Blood Pressure Facts and Management.
  5. National Institutes of Health (NIH) / PubMed. (2022). Clinical Outcomes of Adrenal Venous Sampling in Primary Aldosteronism.
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