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What Is Asenapine Sublingual Tablet and How Do You Take It Safely?

Dr. Priya Sammani (MBBS)
Medically Reviewed by Dr. Priya Sammani (MBBS) ✓ Medically Reviewed
📅 Updated: Oct 21, 2026 • ⏱ 9 min read • Editorial Policy
What Is Asenapine Sublingual Tablet and How Do You Take It Safely?
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If your doctor recently prescribed asenapine for you or a loved one, you probably have many questions about how it works. Feeling uncertain when starting a new medicine is completely normal. Having clear and simple information helps you feel confident and in control of your health journey.

Asenapine is a prescription medicine that helps manage specific mental health conditions by balancing natural chemicals in your brain. Taking it correctly is very important for your health and safety. Let us walk through everything you need to know about this medicine in simple, friendly terms.

Key Takeaways About Asenapine

  • Asenapine is an antipsychotic medicine used mainly for schizophrenia and bipolar disorder.
  • It must dissolve entirely under your tongue—never swallow, chew, or crush the tablet.
  • Wait at least 10 minutes after the tablet dissolves before eating or drinking anything.
  • Tell your doctor about all other medicines, vitamins, and health conditions before starting.
  • Never stop taking your medicine suddenly without talking to your doctor first.
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What Is Asenapine?

Simply put, asenapine is a prescription medicine used to treat specific mental health conditions. Doctors most commonly prescribe it for schizophrenia and bipolar disorder. These conditions can change how you think, feel, and act every day.

Your brain relies on natural chemical messengers like dopamine and serotonin to regulate your mood, thoughts, and behavior. When these chemical messengers fall out of balance, mental health challenges can happen. Asenapine helps bring these brain chemicals back into balance, which stabilizes your mood and thoughts over time. This medicine belongs to a group of drugs called antipsychotics.

Things to Tell Your Doctor Before Starting

Before you take your first dose, your doctor needs a complete picture of your health history. If you have any of the medical conditions listed below, share them openly with your doctor without holding anything back.

  • Dementia or memory-related issues in older adults.
  • Diabetes or a family history of high blood sugar.
  • Trouble swallowing food, liquids, or pills.
  • Heart disease or a history of irregular heartbeats.
  • High cholesterol or triglyceride levels.
  • A history of a previous stroke or mini-stroke.
  • Liver disease or reduced liver function.
  • Low blood pressure that causes dizziness.
  • Parkinson's disease or movement disorders.
  • A history of seizers or epilepsy.
  • Blood cell disorders, such as low white blood cells or platelets.
  • A personal history of breast cancer.
  • Any past allergic reaction to asenapine, other medicines, or foods.
  • If you are pregnant or actively trying to get pregnant.
  • If you are a breastfeeding mother.

Why this matters: Sharing these details helps your doctor choose the safest treatment plan tailored specifically for your body and lifestyle.

How to Use This Medicine Correctly

This is not a regular pill that you swallow with a glass of water. It is a special sublingual tablet designed to dissolve underneath your tongue. Follow these step-by-step instructions carefully to get the best results.

  1. Wash and dry your hands thoroughly before touching the tablet packet.
  2. Keep the tablet inside its sealed blister pack until the exact moment you are ready to take it.
  3. When you are ready, peel open the pack carefully and take out the tablet. If the tablet breaks or crumbles, throw it away and open a fresh new tablet.
  4. Place the intact tablet gently underneath your tongue.
  5. Allow the tablet to dissolve completely. This usually takes only a short time. Once dissolved, you may swallow your saliva naturally.
  6. Never cut, crush, chew, or swallow the tablet whole.
  7. Most important rule: After the tablet dissolves, wait at least 10 minutes before eating or drinking anything.
  8. Take your medicine at the exact times your doctor prescribed. Never stop taking it on your own.

What If You Miss a Dose?

If you forget to take your scheduled dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose entirely and stay on your normal routine. Never take two doses at the same time to make up for a missed one.

What If You Take Too Much?

If you think you have taken too much medicine, try to stay calm and act quickly. In the US, call Poison Control right away at 1-800-222-1222 or call 911. In the UK, call 999 or NHS 111. If you are in another country, contact your local emergency number right away or go straight to the nearest hospital Emergency Department (ER or A&E).

Other Things That Can Interact With This Medicine

Asenapine can interact with several other medicines and substances. Make sure your doctor knows about every product you use, including vitamins, herbal remedies, and over-the-counter drugs.

Interaction Category Substances & Medicines to Watch
Never Combine With Asenapine Cisapride, Dronedarone, Metoclopramide, Pimozide, Thioridazine
Share With Your Doctor
  • Alcohol and recreational substances .
  • Cold, cough, and allergy antihistamines .
  • Certain antibiotics and antifungals .
  • Depression, anxiety, and sleep medicines .
  • Blood pressure medicines .
  • Parkinson's disease treatments .
  • Narcotic pain relievers and muscle relaxants .
  • Medicines that affect heart rhythm (QT interval) .
  • Tobacco smoking products .

Things to Watch While Taking This Medicine

  • Dizziness and Drowsiness: This medicine can make you feel sleepy or dizzy. Avoid driving cars, operating heavy machinery, or doing tasks that need sharp focus until you know how the medicine affects you.
  • Stand Up Slowly: Do not jump up quickly from a sitting or lying position. Stand up slowly, especially if you are an older adult, to prevent dizziness and accidental falls.
  • Blood Sugar Levels: Asenapine can increase blood sugar levels. If you have diabetes, check your blood sugar more often and talk with your doctor about your diet or medicine routine.
  • Dry Mouth: If your mouth feels dry, try chewing sugar-free gum, sucking on sugar-free hard candies, or sipping small amounts of water throughout the day.
  • Body Temperature: This medicine can affect how your body regulates temperature. You might be more sensitive to extreme heat or cold. Stay hydrated in warm weather, avoid staying out in the sun too long, and wear warm layers in cold weather.

What Side Effects Can You Expect?

Like all medicines, asenapine can cause side effects, though not everyone experiences them. Many side effects are mild, but some require prompt medical attention.

Side Effect Type Signs and Symptoms
Call Your Doctor Right Away
  • Allergic reactions: Skin rashes, itching, swelling of face, lips, tongue, or throat.
  • Heart changes: Fast or irregular heartbeat, severe dizziness, chest pain, or trouble breathing.
  • High blood sugar: Increased thirst, frequent urination, unusual fatigue, or blurred vision.
  • Neuroleptic Malignant Syndrome: High fever, stiff muscles, heavy sweating, or confusion.
  • Stroke signs: Sudden numbness or weakness in face, arm, or leg, speech trouble, or confusion.
  • Movement issues (EPS): Uncontrolled body movements, muscle stiffness, tremors, or restlessness.
Common and Mild Side Effects
  • Changes in how food tastes .
  • Drowsiness or feeling tired during the day .
  • Mild dizziness .
  • Numbness, tingling, or burning feeling on your tongue, mouth, or throat .
  • Gradual weight gain .

When to Seek Emergency Help

If you experience severe chest pain, sudden breathing trouble, signs of a severe allergic reaction, or extremely high fever with muscle stiffness, call 911 (US/Canada), 999 (UK), or go to your nearest hospital emergency room right away.

💡 Take-Home Message

  • Asenapine is a prescription medicine for mental health conditions that must be taken strictly as your doctor directs.
  • Never swallow the pill whole. Let it dissolve completely under your tongue, and avoid eating or drinking for 10 minutes afterward.
  • Always tell your doctor about every other medicine, vitamin, and health condition before you start treatment.
  • Contact your doctor right away if you notice unusual symptoms like heart rhythm changes, severe muscle stiffness, or allergic reactions.
  • Never change your dose or stop taking your medicine without talking to your doctor first.
❓ FAQ

Frequently Asked Medical Questions (FAQ)

Evidence-based clinical answers to common patient questions

Can I swallow my asenapine tablet with water like a normal pill?

No, you should never swallow this tablet with water. It is specially designed to dissolve underneath your tongue so your body can absorb it correctly. Swallowing it whole will make the medicine much less effective.

Why do I have to wait 10 minutes before eating or drinking?

Waiting at least 10 minutes gives the medicine enough time to fully dissolve and absorb through the lining under your tongue. Eating or drinking too soon can wash the medicine away and reduce its effectiveness.

Can I stop taking asenapine suddenly if I start feeling better?

No, you should never stop taking your medicine abruptly. Stopping suddenly can cause your original symptoms to return or trigger unwanted withdrawal effects. Always talk to your doctor first if you want to adjust or stop your treatment.

Does asenapine cause weight gain?

Yes, weight gain can happen when taking asenapine. Eating a balanced diet and staying physically active can help manage your weight. Talk with your doctor or a dietitian if you notice significant weight changes.

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Verified Scientific & Medical References (PubMed / WHO)

✓ Peer-Reviewed Sources
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⚠️ Important: Medical articles and information on Nirogi Lanka are strictly for educational and awareness purposes and do not substitute professional medical advice, diagnosis, or treatment. Always consult a qualified physician for any medical concerns.