Sometimes the pain we experience is not relieved by one or two ordinary painkillers, right? When you have unbearable pain that is unbearable, and other painkillers are not working for you or have not helped, your doctor may prescribe a stronger painkiller. Celecoxib and Tramadol are a combination of two medications that are given in such cases. Let's talk about this simply.
What is this medicine called Celecoxib and Tramadol?
Simply put, this is a combination of two main types of painkillers. It may come under the brand name SEGLENTIS.
1. Celecoxib: This belongs to the class of drugs called NSAID (Nonsteroidal Anti-inflammatory Drug) . It works by reducing inflammation, which causes pain and swelling in our bodies.
2. Tramadol: This is a powerful painkiller that belongs to the opioid class. It works by reducing the sensation of pain by controlling pain signals that travel directly to the brain.
The combination of these two medications often helps control severe pain.
Things you need to tell your doctor before taking this medicine
Before using this medicine, you should definitely tell your doctor if you have any of the following conditions. Some of these can cause dangerous side effects with this medicine.
| Your health condition or habit | Why should you inform the doctor about it? (Simply) |
|---|---|
| Bleeding disorders | This medicine may increase the risk of bleeding. |
| Brain tumor or head injury | There is a risk of increased pressure in the brain. |
| Recent bypass surgery (CABG) | The risk of heart attack and stroke may increase. |
| Addiction to drugs or alcohol | Tramadol is an opioid, so there is a high risk of addiction. |
| Heart disease, high blood pressure | The risk of heart attack and stroke may increase. |
| Kidney or Liver disease | The medication may be difficult to remove from the body and may increase side effects. |
| Bleeding or ulcers in the stomach or intestines | This medicine may aggravate these conditions. |
| Asthma or other lung diseases (Asthma, COPD) | Breathing difficulties may occur. |
| Drinking alcohol, smoking | Increases the risk of stomach bleeding and other side effects. |
| Pregnancy, trying to get pregnant, breastfeeding | This medicine may harm the unborn baby. |
| Other medications (especially blood thinners , psychiatric medications, steroids, MAOIs) | Dangerous interactions with other medications may occur. |
| Allergies to anything | Because this medicine can also cause allergies. |
How should I use this medicine?
- Take this medicine with a glass of water .
- Take it exactly as prescribed by your doctor, at the prescribed time . It's best to take it at the same time every day.
- You can take it with or without food. However, if you experience stomach upset or heartburn, take it with a meal.
- Do not take more than the dose prescribed by your doctor for any reason.
- If you are over 65 years of age, you may feel the effects of this medicine more. Therefore, a lower dose may be prescribed.
Most importantly: If you think you have taken too much of this medicine, do not delay. Immediately call the National Poisons Information Centre at the Colombo National Hospital . Or go to the Emergency Department (ETU) of the nearest hospital.
This medicine has been prescribed for you only. Never share this medicine with anyone else. It is dangerous and illegal.
What to do if you miss a dose of medication?
If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take two doses at once for any reason.
Other drugs that may interact with this medicine (Drug Interactions)
This medicine can interact with other medicines, so it is important to tell your doctor about all the medicines, vitamins, and herbal products you are taking.
| Never take these with you! | |
|---|---|
| Ketorolac (another strong NSAID) | MAOIs (an old class of medication for mental illness) |
| Linezolid (an antibiotic) | Methylene blue |
| Be very careful when taking these together (only on medical advice) | |
| Alcohol | Other opioid painkillers |
| Other NSAIDs such as Aspirin, Ibuprofen, Naproxen | Medicines that prevent blood clotting (such as Warfarin, Apixaban) |
| Medications for depression and anxiety | Sleeping pills |
| Medicines for seizures | Steroids such as Prednisone |
| Diuretics | Antifungals and some antibiotics |
This list is not complete, so tell your doctor about all the medications you are taking.
Things to be careful about when taking medicine
Sleepiness and attention
This medicine may make you feel drowsy or dizzy . So do not drive or operate machinery until you know how it affects you. Especially if you are elderly, do not get up from a sitting position suddenly. This can make you feel dizzy and fall.
Drinking alcohol
Avoid drinking alcohol completely while taking this medication. Combining this medication with alcohol can cause dangerous conditions such as shortness of breath, excessive sleepiness, and loss of consciousness.
Constipation
Constipation is a common side effect of Tramadol. If you have not had a bowel movement for 3 days, talk to your doctor. Drinking plenty of water and eating foods high in fiber (fruits, vegetables) can help.
Stomach bleeding
Celecoxib (an NSAID) in this medicine can cause stomach or intestinal ulcers or bleeding. This can happen without warning . Smoking, drinking alcohol, being older, and having poor health increase your risk. If you have severe stomach pain, vomit that looks like coffee grounds, or black, tarry stools , see a doctor right away.
Getting used to the medicine and stopping it all at once
When you take this medicine for a long time, your body becomes accustomed to it (tolerance). This means that you may need a slightly higher dose to get the same pain relief as before. This is normal.
The most important thing is, never stop taking this medicine suddenly without your doctor's advice. Doing so can cause severe withdrawal symptoms. If you need to stop taking the medicine, your doctor will gradually reduce the dose.
Possible severe skin reactions
Although rare, some people may experience severe skin reactions to this medicine. This can happen even weeks after starting the medicine. If you experience fever, body aches, and a red rash, blisters, or peeling skin, seek medical advice immediately.
What are the expected side effects?
Like any medicine, this one can have side effects. Some are dangerous, some are normal.
| Serious side effects that should be reported to the doctor immediately | |
|---|---|
| Severe allergies | Skin rash, itching, swelling of the face/lips/tongue, difficulty breathing. |
| Difficulty breathing (CNS Depression) | Slow , shallow breathing, excessive sleepiness, unconsciousness. |
| Bleeding symptoms | Black, tarry stools, vomit that looks like coffee grounds, blood in the urine, and red/purple spots on the skin. |
| Symptoms of a heart attack | Chest pain, tightness, pain radiating to the shoulder/arm/jaw. |
| Symptoms of a Stroke | Numbness, weakness, difficulty speaking on one side of the face/arm/leg. |
| Liver/kidney damage | Pain in the upper right abdomen, yellowing of the eyes/skin, decreased urine output, and swelling of the legs. |
| It's normal, but if it's bothersome, tell your doctor. | |
| Constipation | Nausea/vomiting |
| Drowsiness/dizziness | Appetite |
| Dry mouth | Headache |
Take-Home Message
- Take this medicine exactly as prescribed by the doctor .
- Tell your doctor about any other illnesses you have and any other medications you take.
- Do not share this medicine with anyone else for any reason. Keep it out of the reach of children and pets.
- If you experience difficulty breathing, severe stomach pain, black stools, or a severe skin rash, seek medical advice immediately.
- Do not stop taking the medication suddenly without your doctor's advice.
- Avoid alcohol completely while taking this medicine.
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