Do you also experience severe pain in your legs, especially your calves, when you walk for a short distance? Does the pain subside after you sit down and rest for a while, and then the pain returns when you start walking again? This is something that many people experience. In medicine, we call this condition intermittent claudication . The reason for this is the narrowing of the blood vessels that supply blood to the legs. So, a special medicine that doctors prescribe to treat this condition is called Cilostazol. Today, we will talk about this medicine clearly and simply.
What kind of medicine is Cilostazol?
Simply put, this medicine called Cilostazol works by dilating the blood vessels in your legs, making it easier for blood to flow through them. Think of it like when a water pipe is clogged, the water flows slowly, but if you widen the pipe, the water flows better.
When the blood supply to the legs is good, the muscles get the oxygen and nutrients they need. This is why the pain when walking is reduced, and you can walk longer without pain . This is the main function of this medicine.
Things you need to tell your doctor before taking medicine
Before starting Cilostazol, it is essential to inform your doctor about some important information about your health condition, as this medication is not suitable for everyone.
| Your health status | Reasons to inform the doctor |
|---|---|
| Bleeding disorder or hemophilia | Since this medication can increase the risk of bleeding, it is essential to inform your doctor if you already have such a condition. |
| A history of heart attack or heart failure | This medicine is not suitable for people with certain heart conditions. Therefore, please be clear about your heart health history. |
| Allergies to Cilostazol or other medications or foods | If you have had any previous allergies to any medicine or food, inform your doctor. |
| If you are pregnant or trying to get pregnant | Since there is still not complete information about the safety of this medication during pregnancy, it is very important to talk to your doctor about this. |
| If a mother is breastfeeding her child | It is not confirmed whether the medicine passes to the baby through breast milk, so discuss the decision with your doctor. |
How to use the medicine correctly?
To get the most out of a medication, you need to take it correctly.
- Take this pill with a full glass of water.
- The most important thing is that this medicine should be taken on an empty stomach. That means at least 30 minutes before a meal or 2 hours after a meal.
- Try to take your medicine at the same time every day, as prescribed by your doctor. This will help keep the levels of the medicine in your body consistent.
- Be sure to talk to your doctor about giving this medicine to children, as they may require special care.
What if you take too much medicine? (Overdose)
If you think you have taken too much medicine, do not panic and take immediate action. Call the National Poisons Information Centre at the Colombo National Hospital , or go to the Emergency Treatment Unit (ETU) of the nearest hospital.
This medicine has been prescribed for you only by your doctor. Never share it with anyone else.
What if I miss a dose of medication?
If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take two doses at once for any reason.
Other things that may interact with this medicine (Interactions)
Some foods and other medications can interact with Cilostazol and affect its effectiveness or side effects.
Very important: Avoid drinking grapefruit juice completely while taking this medication. Grapefruit juice can dangerously increase the level of Cilostazol in the body.
| Type of medicine/food | Reason to be concerned |
|---|---|
| Medicines that prevent blood clotting (e.g. Warfarin, Enoxaparin, Aspirin ) | Cilostazol and these medications both increase the risk of bleeding. Taking them together can increase that risk even more. |
| Some antifungals (e.g. Ketoconazole, Itraconazole ) | These can increase the levels of Cilostazol in the body. |
| Some antibiotics (e.g. Erythromycin, Clarithromycin ) | These medications can also increase the levels of Cilostazol in the body. |
| Omeprazole (a medicine for gastritis) | Interactions can also occur when taking Cilostazol with Omeprazole. |
| Some antidepressants (e.g. Fluoxetine, Fluvoxamine ) | These can also cause interactions with Cilostazol, so inform your doctor. |
This list is not complete. Therefore, tell your doctor about all the medications you take (including vitamins and herbal remedies). Also, tell your doctor if you use alcohol or smoke.
Things to consider when taking medication
- Be patient: This medicine takes some time to show results. You will usually start to feel a difference in 2 to 4 weeks . However, for some people it can take up to 3 months . So, don't stop taking it suddenly because you think it's not working.
- Dizziness: This medication may cause dizziness and drowsiness in some people. Therefore, avoid activities that require alertness, such as driving, working at heights, or operating machinery , until you know how this affects you. Drinking alcohol can make this condition worse.
- Smoking: If you are a smoker, it may reduce the effectiveness of this medicine. Therefore, if you are thinking of quitting smoking, talk to your doctor about it.
- Surgery: If you are going to have any surgery, MRI, or CT scan, tell the medical team in advance that you are taking this medicine. You may need to stop taking the medicine a few days before the procedure .
What are the possible side effects?
Like any medicine, Cilostazol can cause side effects. Some of these are serious, while others are common.
| Serious side effects that should be reported to your doctor immediately | |
|---|---|
| Allergic Reactions | Skin rash, itching, swelling of the face, lips, tongue. |
| Chest pain, changes in heart rate | Heart rate that is fast, slow , or irregular. |
| Bleeding symptoms | Black or bloody stools; red or dark brown urine; vomiting coffee grounds; red spots on the skin; unusual bleeding from the nose or gums. |
| Swelling of the legs or ankles | New or increasing swelling. |
| Common side effects that should be reported to the doctor if they persist or are bothersome: | |
| Diarrhea | Abdominal distension. |
| Headache | General headache. |
| Nausea or stomach discomfort | Feeling like vomiting. |
If you experience any other unusual symptoms not mentioned in this list, talk to your doctor about them as well.
Take-Home Message
- Cilostazol is a medication used to treat intermittent claudication (pain in the legs when walking).
- This medicine should always be taken before or after meals (on an empty stomach).
- Avoid drinking grapefruit juice completely while taking the medication.
- Tell your doctor about all other medications you are taking, especially blood thinners .
- Watch for signs of bleeding (black stools, unusual bruising). If you notice anything, tell your doctor immediately.
- It may take several weeks or months for the medication to show results, so be patient and continue with the treatment.
- In case of any problem, never hesitate to seek advice from your doctor.


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